Molecular Systems Biology - New articles published 6 December 2011

Latest Articles 6 December 2011   Featured Article Research Articles News and Views   Web feeds About Open access Advertisement FROM 'OMICS' TO SINGLE MOLECULES Download & Discover our new podcast, featuring interviews with Dr Peer Bork, Prof Peter Sorger and Dr Jan Ellenberg. A POWERFUL PLACE TO BE Watch our video interview of Nobel Prize winner Eric Wieschaus.   Featured Article Temporal competition between differentiation programs determines cell fate choice An important cell fate decision in Bacillus subtilis is shown to be the result of a ‘molecular race’ between competing differentiation programs. The programs controlling competence initiation and spore formation progress independently, and without cross-talk, before cell fate choice. Anna Kuchina, Lorena Espinar, Tolga Çaǧatay, Alejandro O Balbin, Fang Zhang, Alma Alvarado, Jordi Garcia-Ojalvo & Gürol M Süel Molecular Systems Biology 7:557; doi:10.1038/msb.2011.88; published 6 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Research Articles Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex Genome-scale analysis of the DNA binding properties of the protein complex that regulates yeast sulfur metabolism identifies a specific DNA motif that directs the recruitment of key non-DNA-binding cofactors, revealing a powerful mechanism for selective target gene regulation. Trevor Siggers, Michael H Duyzend, Jessica Reddy, Sidra Khan & Martha L Bulyk Molecular Systems Biology 7:555; doi:10.1038/msb.2011.89; published 6 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico A genetic tug-of-war system is used to explore the sensitivity of the fission yeast cell cycle to changes in gene dosage, revealing a deeply conserved fragile core. A mathematical model can reproduce the robustness of the cell cycle, and points to currently unknown regulatory mechanisms. Hisao Moriya, Ayako Chino, Orsolya Kapuy, Attila Csikász-Nagy & Béla Novák Molecular Systems Biology 7:556; doi:10.1038/msb.2011.91; published 6 December 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process News and Views Winner takes all in a race for cell fate David Dubnau Molecular Systems Biology 7:558; doi:10.1038/msb.2011.92; published 6 December 2011 Full Text | PDF

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