  | Today's Top Story |  |  | | - Mayo Clinic to launch sequencing project for individual care
Mayo Clinic plans to initiate a pilot trial early next year to sequence the genomes of thousands of volunteers as part of a landmark project aimed at personalizing medical care. The genetic information will be stored and linked to the patients' medical records to help their doctors choose the most effective drugs for them while reducing side effects. "The advantage of whole genome sequencing is that you go after everything," said Dr. Gianrico Farrugia, director of Mayo Clinic's Center for Individualized Medicine in Minnesota. "... [I]t allows you to draw complex interaction pathways that you cannot draw by going after select genes." The Guardian (London) (12/27)        | The Plum Card®
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  - NovaTarg to file IND for hepatitis C candidate in 2012
NovaTarg is preparing to submit to the FDA next year an investigational new drug application for a hepatitis C drug, its first drug candidate. The firm received a $30,000 loan from the North Carolina Biotechnology Center to finance its research centered on AMPK, an enzyme that plays a role in how cells use energy. The research has applications in cancer, diabetes and liver disease treatments, NovaTarg said. MedCityNews.com (12/29) - Researchers use stem cells to develop treatment for diseases
Researchers at Stempeutics Research in Bangalore, India, are developing treatments for eight diseases, including heart problems and cerebral strokes, by growing mesenchymal stem cells from a donor's bone marrow in the lab. The cultured cells are intended to replace or regenerate diseased cells in a patient. The company plans to establish a facility that can produce large volumes of the cells. Business Standard (India) (12/28) - Study links gene mutation to familial pancreatic cancer
A study in Cancer Discovery found that people with mutations in the ATM gene are more prone to develop hereditary pancreatic cancer. Researchers sequenced 166 pancreatic cancer patients and found that four of them carried the ATM mutation while none of the 190 healthy individuals sequenced had the gene variant. The findings could result in the development of a new pancreatic cancer screening method for those who could be at hereditary risk, according to the researchers. HealthDay News (12/29) - Research finds early warning sign for diabetes
Mapping the variations in DNA methylation helped reveal a clear-cut, disease-predisposing DNA methylation "signature" in type 2 diabetes patients, Israeli researchers reported in Human Molecular Genetics. The technique may help provide an early warning for patients at risk of the disease and may also lead to the development of new treatment approaches in diabetes, researchers said. The Jerusalem Post (free registration) (12/29)  | Principles of Checkweighing - Building an Effective Program
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  | Active Directory (AD) is the heart of your IT infrastructure, so a solid monitoring and backup and recovery solution is vital! In this Quest tech brief, discover best practices for protecting your AD environment, and how to understand — and resolve — performance problems in record time. |
- Hormone pathway could improve drought tolerance
A team of plant cell biologists from the University of California, Riverside, have learned how to modify a plant's stress response pathway to increase its ability to respond to droughts. The discovery increases the ability of plant stress hormone receptors to turn on and continue working, and it could offer a new way of engineering crops suited to dry conditions. Minnesota Farm Guide (12/28)  | Inside-ERP experts have new research on the state of the ERP market today. Read this brief to understand the ERP market and how it affects your business. Whether you're considering a new solution or just want to see what’s changed, our brief has you covered. Download the report now! |
 | Industrial & Environmental | | | | | News from BIO | | | | - Ship with FedEx
FedEx is now offering member companies discounts of up to 35% off select FedEx services, both U.S. and international services. The BIO program with FedEx is one of the many cost-savings programs offered by BIO through its Business Solutions program. There is no charge for BIO member companies to participate in any of the BIO Business Solutions programs -- it is a benefit of membership. Learn more about the BIO and FedEx program.
| Editor's Note | | | | - SmartBrief will not publish Monday
In observance of the New Year's holiday, SmartBrief will not publish Monday. Publication will resume Tuesday. Enjoy the holiday! | SmartQuote | | | |  | Anger makes dull men witty, but it keeps them poor."
--Francis Bacon,
British philosopher and statesman  |
| | This SmartBrief was created for jmabs1@gmail.com
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