Nature Reviews Immunology Contents December 2011 Volume 11 Number 12 pp 799-880

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TABLE OF CONTENTS
December 2011 Volume 11 Number 12
Impact Factor 35.196 * Subscribe to Nature Reviews Immunology Recommend to your library Sign up to Twitter for updates from Nature Reviews Immunology	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Vaccines for the twenty-first century society Rino Rappuoli, Christian W. Mandl, Steven Black & Ennio De Gregorio
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From the editors p799 | doi:10.1038/nri3123 PDF
RESEARCH HIGHLIGHTS Top Inflammation: Under the skin p800 | doi:10.1038/nri3113 Three recent studies reveal different levels of control of skin inflammation. PDF Innate immunity: A new path uncovers a wrongful conviction p801 | doi:10.1038/nri3120 A non-canonical inflammasome engages caspase 11, and this caspase (not caspase 1) promotes lethal septic shock. PDF Infectious disease: A ray of sunshine for TB treatment p802 | doi:10.1038/nri3110 Vitamin D is necessary for the IFNγ-induced antimicrobial response to M. tuberculosis. PDF Autoimmunity: Linking commensals with autoimmunity p802 | doi:10.1038/nri3114 Both the intestinal microbiota and self-antigen recognition drive autoimmune responses. PDF Dendritic cells: Choosing the right presentation p804 | doi:10.1038/nri3119 Virus-infected lymph node macrophages are 'ignored' by naive T cells to ensure optimal T cell priming on infected DCs. PDF Immune responses: Platelets drive shuttle buggy p804 | doi:10.1038/nri3121 Platelets associate with Gram-positive bacteria to promote targeting to DCs. PDF Cytokines: IL-17C joins the family firm p805 | doi:10.1038/nri3118 IL-17C promotes innate epithelial cell responses and TH17 cell functions. PDF Mucosal immunology: The 'AHR diet' for mucosal homeostasis p806 | doi:10.1038/nri3115 AHR ligands derived from cruciferous vegetables promote intestinal immune function. PDF IN BRIEF Tumour immunology: How does IL-12 enhance antitumour responses? | Vaccines: An effective PRR-targeting adjuvant in humans | Innate immunity: STAT6 activation in response to viral nucleic acids | T cell memory: Identifying memory CD4+ T cell precursors | T cell memory: The ID of memory CD8+ T cells PDF Immunology JOBS of the week PhD positions in applied computer science / media technology Gjøvik University College PhD Position in Cellular Biomechanics (Ref. CB-DN) Institute for Bioengineering of Catalonia Assistant Professor in Business Studies (1.0 FTE) Vesalius College Assistant Professor in European Union Policy (1.0 FTE) Vesalius College Postdoctoral position in Practical Secure Multi-Party Computation KTH Royal Institute of Technology More Science jobs from Immunology EVENT Vaccines for Chronic Diseases Symposium 07.-09.02.12 TX, US More science events from
REVIEWS		Top
TLR-dependent T cell activation in autoimmunity Kingston H. G. Mills p807 | doi:10.1038/nri3095 Infection, tissue injury and alterations in the composition of the microbiota have been implicated in the initiation of autoimmune diseases. In this Review article, Kingston Mills discusses how Toll-like receptor (TLR) signalling downstream of all these events can regulate the function of autoreactive T cells both directly and indirectly (through the activation of innate immune cells), and comments on the therapeutic implications of TLR targeting. Abstract | Full Text | PDF
Towards a systems understanding of MHC class I and MHC class II antigen presentation Jacques Neefjes, Marlieke L. M. Jongsma, Petra Paul & Oddmund Bakke p823 | doi:10.1038/nri3084 This article provides a broad, timely review of our current understanding of MHC class I and class II antigen presentation and presents a survey of 43 experts in the field on the most important outstanding issues. Abstract | Full Text | PDF
Peptidoglycan recognition proteins: modulators of the microbiome and inflammation Julien Royet, Dipika Gupta & Roman Dziarski p837 | doi:10.1038/nri3089 This Review discusses how invertebrate and vertebrate members of the PGRP family have developed an amazing variety of mechanisms to coordinate the host response to mutualistic, commensal and parasitic microorganisms. Abstract | Full Text | PDF
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses Lucy S. K. Walker & David M. Sansom p852 | doi:10.1038/nri3108 Cytotoxic T lymphocyte antigen 4 (CTLA4) has long been known to have an important regulatory role in the immune system; however, its mechanisms of action have been the subject of considerable debate. This article reviews the strengths and limitations of the cell-intrinsic and cell-extrinsic models that have been proposed to explain the function of CTLA4. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY Vaccines for the twenty-first century society Rino Rappuoli, Christian W. Mandl, Steven Black & Ennio De Gregorio p865 | doi:10.1038/nri3085 The childhood vaccination campaigns of the twentieth century represent one of the great success stories of modern medicine. But are we yet to realize the full potential of vaccines? This article discusses the medical needs of the twenty-first century society and proposes that new vaccines will play a major part in addressing these needs. Abstract | Full Text | PDF
INNOVATION Strategies to discover regulatory circuits of the mammalian immune system Ido Amit, Aviv Regev & Nir Hacohen p873 | doi:10.1038/nri3109 Using global profiling of gene and protein expression to derive models of regulatory networks in mammals poses many challenges. Here, the authors describe a systematic functional strategy to tackle these issues with a focus on its use in the immune system. Abstract | Full Text | PDF
Corrigendum: Organ-specific features of natural killer cells Fu-Dong Shi, Hans-Gustaf Ljunggren, Antonio La Cava & Luc Van Kaer p880 | doi:10.1038/nri3116 Full Text | PDF
Corrigendum: The golden anniversary of the thymus Jacques F. A. P. Miller p880 | doi:10.1038/nri3117 Full Text | PDF
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Nature Reviews Immunology turns 10 Nature Reviews Immunology celebrates 10 years of outstanding Reviews with a special anniversary issue in October, featuring a Viewpoint by our most highly cited authors. In addition, we bring you an immunology-themed crossword puzzle in the October anniversary issue. CLICK HERE for the online version. The answers will be published in the November issue. Good luck!
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