Nature Reviews Cancer contents December Volume 11 Number 12 pp 825-895

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TABLE OF CONTENTS
December 2011 Volume 11 Number 12
Impact Factor 31.694 * Subscribe to Nature Reviews Cancer Recommend to your library	In this issue Comment Research Highlights Reviews Perspectives Correspondence Also this month Article series: Epigenetics and genetics Poster: Proteasome inhibition in cancer therapy  Featured article: MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy Andrea L. Kasinski & Frank J. Slack
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Nature Reviews Molecular Cell Biology Poster - From teratomas to embryonic stem cells: discovering pluripotency This Poster provides a timeline overview of the history of pluripotency, starting from early studies of teratocarcinomas in 1954, which preceded the isolation of mouse and human ES cells, and ending with the generation of iPS cells. In doing so, it highlights how our understanding of the pluripotent state has evolved over almost 60 years. Access the Poster FREE online! www.nature.com/nrm/posters/discoveringpluripotency Produced with support from: Abcam Plc
From the editors p825 | doi:10.1038/nrc3182 PDF
Comment: Risks of online advertisement of direct-to-consumer thermography for breast cancer screening Kimberly M. Lovett & Bryan A. Liang p827 | doi:10.1038/nrc3170 The controversy surrounding thermography as a stand alone screening method for breast cancer. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Lymphoma: Suppressive EPH-ect p829 | doi:10.1038/nrc3178 Genomic analysis combined with functional screening has identified an extracellular non-membrane bound form of the ephrin receptor EPHA7 as a tumour suppressor in follicular lymphoma that could be exploited therapeutically. PDF Epigenetics: Layer by layer p830 | doi:10.1038/nrc3172 Protein-coding and non-coding RNAs influence the interaction of microRNAs with their target RNAs. PDF Cancer stem cells: VEGF promotes stemness p831 | doi:10.1038/nrc3176 Using a mouse model of chemically induced skin tumours, Cédric Blanpain and colleagues have uncovered an autocrine role for vascular endothelial growth factor signalling in cancer stem cells. PDF Genetics: BRCA inequality p831 | doi:10.1038/nrc3177 A new study compares the effects of BRCA1 and BRCA2 lesions on clinical treatment responses in ovarian cancer. PDF Senescence: NF-κB shows its beneficial side p832 | doi:10.1038/nrc3168 Two new studies describe a tumour suppressive role for NF-κB as a master regulator of a secretory phenotype during senescence in vivo. PDF Therapeutics: Another tool in the BCR–ABL kit? p832 | doi:10.1038/nrc3173 This Cell paper shows that an interaction between the SH2 and kinase domains of BCR–ABL is necessary for kinase activation; inhibition of this interface prevents leukaemogenesis in mice and can restore sensitivity to tyrosine kinase inhibitors. PDF Kidney tumours: 'NRF said p833 | doi:10.1038/nrc3175 Two papers have identified a new pathway through which the loss of the tumour suppressor fumarate hydratase might promote tumour development. PDF Cancer JOBS of the week Regulatory Affairs - Pharm Chemicals Solution 1900 Millipore Corp. Wissenschaftliche / r Mitarbeiter / in Karlsruhe Institute of Technology (KIT) - Helmholtz Association Java Developer Michigan State University Senior Scientist, Computational Biology Sage Bionetworks Postdoctoral fellow - Stem Cell and Developmental Biology University of Michigan Medical School More Science jobs from Cancer EVENT Active Surveillance for Low Risk Prostate Cancer 12.-13.01.12 Rotterdam, Netherlands More science events from
REVIEWS		Top
Choline metabolism in malignant transformation Kristine Glunde, Zaver M. Bhujwalla & Sabrina M. Ronen p835 | doi:10.1038/nrc3162 Choline metabolism is commonly deregulated in cancer, leading to increased levels of choline metabolites. This Review discusses the deregulation of choline metabolism in cancer, its reciprocal interaction with oncogenic signalling and the possible clinical applications in diagnostics and therapy. Abstract | Full Text | PDF
Article series: Epigenetics and genetics MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy Andrea L. Kasinski & Frank J. Slack p849 | doi:10.1038/nrc3166 Many different microRNAs (miRNAs) have now been linked to cancer, but our understanding of the pathways that are regulated by these miRNAs in vivo is still limited. This Review discusses progress in using mouse models to understand the roles of miRNAs in cancer and the therapeutic potential of these molecules. Abstract | Full Text | PDF
Gastrointestinal stromal tumours: origin and molecular oncology Christopher L. Corless, Christine M. Barnett & Michael C. Heinrich p865 | doi:10.1038/nrc3143 Although gastrointestinal stromal tumours (GISTs) are genetically heterogeneous, the identification of receptor tyrosine kinase mutations has led to improved treatments using targeted therapy. This Review discusses how the underlying genetics influences GIST disease progression and therapeutic responses, new insights into the cellular origins of GISTs and strategies for overcoming therapeutic resistance. Abstract | Full Text | PDF
PERSPECTIVES		Top
An intermittent approach for cancer chemoprevention Xiangwei Wu & Scott M. Lippman p879 | doi:10.1038/nrc3167 Cancer chemoprevention approaches generally use long-term, continuous treatment, which can lead to adverse events. This Opinion article discusses whether short-term, intermittent therapy that exploits synthetic lethal interactions in premalignant cells might reduce the toxicity of chemoprevention while retaining its benefits. Abstract | Full Text | PDF
Molecular mechanisms of cancer development in obesity Melin J. Khandekar, Paul Cohen & Bruce M. Spiegelman p886 | doi:10.1038/nrc3174 Obesity is increasing in the developed world, and epidemiological studies indicate that this is accompanied by an increased risk of cancer. This Opinion article discusses the possible mechanisms by which obesity might promote tumorigenesis. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: The BIO-PIN paradigm: 'access to' or 'return of' results? Eric Vermeulen, Paul van der Valk, José J. M. Koevoets, Martina C. Cornel & Marjanka K. Schmidt p895 | doi:10.1038/nrc3022-c1 Full Text | PDF
Correspondence: The flexibility of biobanking with the Bio-PIN system J.J. Nietfeld, Jeremy Sugarman & Jan-Eric Litton p895 | doi:10.1038/nrc3022-c2 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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