Laboratory Investigation - Table of Contents alert Volume 91 Issue 12

TABLE OF CONTENTS Volume 91, Issue 12 (December 2011) In this issue Inside LI Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Announcing Open Laboratory Investigation now offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited on PubMed Central at the time of publication and will be freely available immediately. Find out more from the FAQs page.   Inside LI Top Inside Lab Invest 2011 91: 1682-1683; 10.1038/labinvest.2011.166 Full Text Research Articles Top ORAL AND GASTROINTESTINAL SYSTEMS Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms Dimethyloxalylglycine (DMOG) inhibits prolyl-4-hydroxylase domain enzymes, including hypoxia inducible factor. In vivo and in vitro gut injury models show that DMOG works in a VEGF-dependent manner, stimulating cell migration and proliferation, decreasing indomethacin- and restraint-induced injury. DMOG may therefore be useful in stabilizing or repairing gut mucosa. Tania Marchbank, Asif Mahmood, Sarah Harten, Patrick H Maxwell and Raymond J Playford 2011 91: 1684-1694; advance online publication, August 29, 2011; 10.1038/labinvest.2011.129 Abstract | Full Text FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer Four and a half LIM domain protein-2 expression in myofibroblasts is associated with enhanced migratory capacity and lymphatic metastasis in sporadic colon cancer, but not in peritumoural myofibroblasts of sporadic and hereditary nonpolyposis colorectal cancer. These findings may explain the less invasive and more protruding tumor margin of microsatellite-instable carcinomas. Lucia Gullotti, Jacqueline Czerwitzki, Jutta Kirfel, Peter Propping, Nils Rahner, Verena Steinke, Philip Kahl, Christoph Engel, Roland Schüle, Reinhard Buettner and Nicolaus Friedrichs 2011 91: 1695-1705; advance online publication, August 8, 2011; 10.1038/labinvest.2011.109 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS Norcantharidin inhibits the expression of extracellular matrix and TGF-β1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway Norcantharidin, an inhibitor of calcineurin, attenuates renal tubulointerstitial fibrosis in rat models of diabetic nephropathy through inhibition of the expression of extracellular matrix and of TGF-β1 in tubules. However, the anti-fibrogenic effect of norcantharidin on tubular interstitium is independent of the calcineurin signaling pathway, so the mechanism is not known. Ying Li, Qiong Chen, Fu-You Liu, You-Ming Peng, Shuai Wang, Ji Li, Jun Li, Shao-Bin Duan, Lin Sun, Guang-Hui Ling and Jun-Hui Luo 2011 91: 1706-1716; advance online publication, September 19, 2011; 10.1038/labinvest.2011.119 Abstract | Full Text Netrin-1 overexpression in kidney proximal tubular epithelium ameliorates cisplatin nephrotoxicity Currently there are no treatments available for cisplatin-induced acute kidney injury. Overexpression of netrin-1, a laminin-related protein, reduces cisplatininduced kidney injury by suppressing inflammation and apoptosis in renal tubular epitheliam both in vivo and in vitro. Therefore, netrin-1 may be a useful therapeutic agent for treating cisplatin nephrotoxicity. Amala Rajasundari, Laurent Pays, Patrick Mehlen and Ganesan Ramesh 2011 91: 1717-1726; advance online publication, August 29, 2011; 10.1038/labinvest.2011.126 Abstract | Full Text Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis Spleen tyrosine kinase (Syk) is activated in glomerular neutrophils in human and experimental acute antibody-dependent glomerular injury. Administration of a Syk inhibitor reduces JNK and p38 MAPK signaling, with suppression of glomerular thrombosis and neutrophil recruitment, resulting in abrogation of proteinuria in rat nephrotoxic serum nephritis. Jessica Ryan, Frank Y Ma, John Kanellis, Mercedes Delgado, Kate Blease and David J Nikolic-Paterson 2011 91: 1727-1738; advance online publication, September 5, 2011; 10.1038/labinvest.2011.137 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells The mechanisms regulating maintenance of articular cartilage remain unclear, but the superficial zone of articular cartilage is known to be involved. In vivo and in vitro mouse systems are used to demonstrate that β-catenin signaling is required for proliferative activity and differentiation of superficial zone articular cartilage cells. Rika Yasuhara, Yoichi Ohta, Takahito Yuasa, Naoki Kondo, Tai Hoang, Sankar Addya, Paolo Fortina, Maurizio Pacifici, Masahiro Iwamoto and Motomi Enomoto-Iwamoto 2011 91: 1739-1752; advance online publication, October 3, 2011; 10.1038/labinvest.2011.144 Abstract | Full Text Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway Erythropoietin (EPO) accelerates skin wound healing in mice by activating the TGF-β signaling pathway. EPO treatment enhances phosphorylation of Smad2 and Smad3 in fibroblasts and in wound tissue. Blockade of TGF-β attenuates EPO-induced acceleration of wound epithelialization and markedly reverses EPO effects on expression of TGF-β1 and α-smooth muscle actin. Nikolai Siebert, Weiguo Xu, Eberhard Grambow, Dietmar Zechner and Brigitte Vollmar 2011 91: 1753-1765; advance online publication, September 5, 2011; 10.1038/labinvest.2011.125 Abstract | Full Text PERIPHERAL AND CENTRAL NERVOUS SYSTEM Dual role of the mitochondrial protein frataxin in astrocytic tumors Although the mitochondrial protein frataxin acts as a tumor suppressor in carcinomas, frataxin expression in glioma cells accelerates tumor growth in nude mice. At the same time, chemosensitivity of glioma cells is increased. Both effects may be the result of changes in reactive oxygen species levels and antioxidative defenses. Elmar Kirches, Nadine Andrae, Aline Hoefer, Barbara Kehler, Kim Zarse, Martin Leverkus, Gerburg Keilhoff, Peter Schonfeld, Thomas Schneider, Annette Wilisch-Neumann and Christian Mawrin 2011 91: 1766-1776; advance online publication, August 22, 2011; 10.1038/labinvest.2011.130 Abstract | Full Text A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules As a marker for stress granules, the phosphorylated ribosomal protein S6 (pS6) localizes to granulovacuolar degeneration in Alzheimer's disease. Further, pS6-positive granules are never associated with apoptotic neurons, and contain less RNA oxidation. These results suggest that granulovacuolar degeneration parallels stress granules and are a neuroprotective response to chronic oxidative stress in Alzheimer's disease brain. Rudy J Castellani, Yashi Gupta, Baiyang Sheng, Sandra L Siedlak, Peggy LR Harris, Jeff M Coller, George Perry, Hyoung-gon Lee, Massimo Tabaton, Mark A Smith, Xinglong Wang and Xiongwei Zhu 2011 91: 1777-1786; advance online publication, October 3, 2011; 10.1038/labinvest.2011.149 Abstract | Full Text BLOOD, LYMPHATICS, IMMUNE SYSTEM, STEM CELLS Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage A novel microfluidic cassette procedure for rapid isolation of neutrophils is compared to the traditional laborious method. The new procedure appears equivalent to the standard method of neutrophil isolation for genomic analysis, and identifies differences in gene expression secondary to the source of the cells or in vivo or ex vivo stimuli. Elizabeth A Warner, Kenneth T Kotz, Ricardo F Ungaro, Amer S Abouhamze, M Cecilia Lopez, Alex G Cuenca, Kindra M Kelly-Scumpia, Claudia Moreno, Kerri A O'Malley, Jennifer D Lanz, Henry V Baker, Larry C Martin, Mehmet Toner, Ronald G Tompkins, Philip A Efron and Lyle L Moldawer 2011 91: 1787-1795; advance online publication, September 19, 2011; 10.1038/labinvest.2011.94 Abstract | Full Text SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity The stem cell transcription factor SOX2 is ectopically overexpressed in lung adenocarcinomas. It is preferentially expressed in cancer-stem cells isolated from lung adenocarcinoma cells, and enhances tumorigenicity of lung cancer cell lines. Therefore, SOX2 may have a role in tumorigenicity of lung adenocarcinoma and is a potential target for treatment. Munehide Nakatsugawa, Akari Takahashi, Yoshihiko Hirohashi, Toshihiko Torigoe, Satoko Inoda, Masaki Murase, Hiroko Asanuma, Yasuaki Tamura, Rena Morita, Yoshitaka Michifuri, Toru Kondo, Tadashi Hasegawa, Hiroki Takahashi and Noriyuki Sato 2011 91: 1796-1804; advance online publication, September 19, 2011; 10.1038/labinvest.2011.140 Abstract | Full Text   Advertisement Ensure your access If you are unable to access the articles in this alert, your library may not subscribe to this journal. Our online recommendation form is a simple way to make your librarian aware that this journal is valuable to your research. Recommend now!   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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