Molecular Systems Biology - New articles published 2 August 2011

Latest Articles 2 August 2011   Featured Article News and Views Research Articles   Web feeds About Open access Advertisement NEW!Agilent CytoGenomics 1.5 Software for LOH and UPD detection! An automated analysis path has been created for CGH+SNP microarray data analysis, providing greater efficiency and throughput in the cytogenetic research lab. CytoGenomics 1.5 Software helps put biological data into context, with internal database comparisons and links to external databases Visit www.agilent.com/genomics/cyto_software   Advertisement Gordon Research Conferences is pleased to announce the following upcoming meetings for the 2012 calendar year: Ligand Recognition & Molecular Gating Jan 15-20, 2012 Pineal Cell Biology Jan 29 - February 3, 2012 Protons & Membrane Reactions Feb 19-24, 2012 Reprogramming Cell Fate NEW! Feb 26 - Mar 2, 2012 Antibody Biology & Engineering Mar 25-30, 2012 For more information, please visit us on the web at www.grc.org   Featured Article AlleleSeq: analysis of allele-specific expression and binding in a network framework A computational pipeline for constructing a personal diploid genome and determining sites of allele-specific activity is developed. Using a regulatory network framework, allele-specific binding and expression are found to be significantly coordinated across the genome. Joel Rozowsky, Alexej Abyzov, Jing Wang, Pedro Alves, Debasish Raha, Arif Harmanci, Jing Leng, Robert Bjornson, Yong Kong, Naoki Kitabayashi, Nitin Bhardwaj, Mark Rubin, Michael Snyder & Mark Gerstein Molecular Systems Biology 7:522; doi:10.1038/msb.2011.54; published 2 August 2011 Full Text | PDF | Supp. Inf. | Review Process News and Views Suppressing variation in synthetic circuits Eric Batchelor & Galit Lahav Molecular Systems Biology 7:520; doi:10.1038/msb.2011.53; published 2 August 2011 Full Text | PDF Research Articles Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism A comprehensive genome-scale metabolic network of Chlamydomonas reinhardtii, including a detailed account of light-driven metabolism, is reconstructed and validated. The model provides a new resource for research of C. reinhardtii metabolism and in algal biotechnology. Roger L Chang, Lila Ghamsari, Ani Manichaikul, Erik F Y Hom, Santhanam Balaji, Weiqi Fu, Yun Shen, Tong Hao, Bernhard Ø Palsson, Kourosh Salehi-Ashtiani & Jason A Papin Molecular Systems Biology 7:518; doi:10.1038/msb.2011.52; published 2 August 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template Variable gene dosage is a major source of fluctuations in gene expression in both endogenous and synthetic circuits. Synthetic incoherent feedforward regulatory motifs using RNA interference are shown to robustly adapt to changes in DNA template amounts in mammalian cells. Leonidas Bleris, Zhen Xie, David Glass, Asa Adadey, Eduardo Sontag & Yaakov Benenson Molecular Systems Biology 7:519; doi:10.1038/msb.2011.49; published 2 August 2011 Synopsis | Full Text | PDF | Supp. Inf. | Review Process

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