Nature Reviews Neuroscience contents August 2011 Volume 12 Number 8 pp 427-484

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TABLE OF CONTENTS
August 2011 Volume 12 Number 8
Impact Factor 29.51 * Subscribe to Nature Reviews Neuroscience Recommend to your library	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Fighting neurodegeneration with rapamycin: mechanistic insights Jordi Bové, Marta Martínez-Vicente & Miquel Vila
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Nature Outlook: Alzheimer's Disease From dancing to drugs, research on Alzheimer's disease is moving apace. Our improved understanding of the role that amyloid-β plays is uncovering new ways to treat and perhaps prevent the disease. Access the Outlook free online for six months. Produced with support from: Eli Lilly and Company
From the editors p427 | doi:10.1038/nrn3080 PDF
RESEARCH HIGHLIGHTS Top Autism: The importance of getting the dose right p429 | doi:10.1038/nrn3083 Rare copy number variations explain a relatively large proportion of sporadic cases of autism spectrum disorders. PDF Psychiatric disorders: The stress of city life p430 | doi:10.1038/nrn3079 Social stress processing in healthy individuals is affected by city living and an urban upbringing PDF IN BRIEF Dendrites | Neurological disorders | Glia | Sensory systems p430 | doi:10.1038/nrn3081 PDF Pain: Blocking painful interactions p431 | doi:10.1038/nrn3069 Blocking interactions between CRMP2 and the calcium channel CaV2.2 suppresses imflammatory and neuropathic pain. PDF Sensory systems: A promising line of defence p431 | doi:10.1038/nrn3070 Odorants that cause prolonged activation of CO2-sensing neurons in mosquitoes interfere with their host-seeking behaviour, and might lead to the development of a new class of insect repellents. PDF Learning and memory: Flies know their way p432 | doi:10.1038/nrn3074 Flies use visual cues to guide their navigation and require neurons in the ellipsoid body to do so. PDF Stem cells: Experiences direct fate p432 | doi:10.1038/nrn3077 Adult hippocampal neural stem cells can give rise to persisting populations of stem cells and neurons, with cell fate being affected by an animal's experiences. PDF IN BRIEF Autism | Psychiatric disorders | Synaptic homeostasis | Behavioural neuroscience p433 | doi:10.1038/nrn3082 PDF Circadian rhythms: Calcium sets the tempo p434 | doi:10.1038/nrn3073 Calcium signalling mediates circadian regulation of extracellular ATP accumulation by astrocytes. PDF Behavioural neuroscience: Fly fisticuffs p434 | doi:10.1038/nrn3078 Loneliness increases aggressiveness, even in flies PDF Psychiatric disorders: The dark side of depression p435 | doi:10.1038/nrn3072 Immune factors mediate the effect of circadian disruption on depression-like behaviour PDF Neuroscience JOBS of the week W3-Professor (f / m) for Experimental Neurophysiology DZNE Koln, Germany Director The Luc Hoffmann Institute London, United Kingdom Postdoctoral Fellow Mount Sinai School of Medicine New York City Research Biomedicine Centro de Investigacion y de Estudios Avanzados del IPN Mexico, City Technology Platform Managers Regional Centre for Biotechnology Gurgaon, India More Science jobs from Neuroscience EVENT Champalimaud Neuroscience Symposium 18.-21.09.11 Lisbon, Portugal More science events from
REVIEWS		Top
Fighting neurodegeneration with rapamycin: mechanistic insights Jordi Bové, Marta Martínez-Vicente & Miquel Vila p437 | doi:10.1038/nrn3068 Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), has neuroprotective effects in models of several neurodegenerative diseases. In this Review, Vila and colleagues discuss the mechanisms by which rapamycin exerts neuroprotection, including effects on autophagy and apoptosis, and on the translation of pro-death and pro-survival proteins. Abstract | Full Text | PDF | Supplementary information
Gut feelings: the emerging biology of gut–brain communication Emeran A. Mayer p453 | doi:10.1038/nrn3071 The importance of interactions between the brain and the digestive system in health and disease has been recognized for centuries. Mayer reviews the neuroanatomy and signalling mechanisms that underlie this bidirectional communication system in health and disease, as well as possible consequences for higher-level executive functions and emotional states. Abstract | Full Text | PDF
Neural mechanisms of the cognitive model of depression Seth G. Disner, Christopher G. Beevers, Emily A. P. Haigh & Aaron T. Beck p467 | doi:10.1038/nrn3027 Aaron Beck's influential cognitive model of depression posits that cognitive biases lead to depressive symptoms. In this Review, Beck and colleagues discuss neuroimaging findings suggesting that both top-down and bottom-up neural mechanisms underlie these biases, and propose a neurobiological architecture of the cognitive model of depression. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Differentiating the rapid actions of cocaine Roy A. Wise & Eugene A. Kiyatkin p479 | doi:10.1038/nrn3043 The immediate subjective effects of cocaine are central to its rewarding properties and addictive qualities; however, the mechanisms by which the drug causes these rapid effects were unclear. Wise and Kayatkin describe recent findings that show that cocaine-predictive cues can activate the dopaminergic reward system in less time than it takes for cocaine to reach and block dopamine transporters in the brain. Abstract | Full Text | PDF
Erratum: Linking lipids to Alzheimer's disease: cholesterol and beyond Gilbert Di Paolo & Tae-Wan Kim 484 | doi:10.1038/nrn3075 Full Text | PDF
Corrigendum: Using theoretical models to analyse neural development Arjen van Ooyen p484 | doi:10.1038/nrn3076 Full Text | PDF
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