Nature Reviews Molecular Cell Biology contents August 2011 Volume 12 Number 8 pp461-541

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TABLE OF CONTENTS
August 2011 Volume 12 Number 8		Advertisement
Impact Factor 38.65 * Subscribe to Nature Reviews Molecular Cell Biology Recommend to your library	In this issue Research Highlights Reviews Correspondence Perspectives Also this month  Featured article: The 'invisible hand': regulation of RHO GTPases by RHOGDIs Rafael Garcia-Mata, Etienne Boulter & Keith Burridge	Speed through PCR assays with the Bio-Rad C1000 Touch™ thermal cycler. Spend less time programming with the remarkably easy-to-use touch screen. The C1000 Touch thermal cycler's revolutionary features give you shorter time to better results. Learn more at www.bio-rad.com/ad/PCRevolutionary
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From the editors p461 | doi:10.1038/nrm3162 PDF
RESEARCH HIGHLIGHTS Top Chromatin: The inheritance of stress p462 | doi:10.1038/nrm3164 Phosphorylation of ATF2 leads to heritable disruption of heterochromatin. PDF JOURNAL CLUB To Cut or NoCut in mitosis p463 | doi:10.1038/nrm3148 Describes the discovery of the NoCut checkpoint. PDF Calcium: Mitochondria channel calcium p463 | doi:10.1038/nrm3156 Identifies the long sought-after mitochondrial calcium uniporter. PDF Ubiquitin: Timing is everything p464 | doi:10.1038/nrm3157 A chain initiation motif in APC/C substrates regulates the timing of degradation. PDF Membrane dynamics: MIEF1 mingles with mitochondria p464 | doi:10.1038/nrm3161 MIEF1 is identified as a novel regulator of mitochondrial membrane dynamics. PDF Cell migration: Many (converging) pathways, one destination p465 | doi:10.1038/nrm3163 SH3BP1 interacts with the exocyst to inactivate RAC1 at the leading edge. PDF Cell cycle: Keeping centrosome numbers in check p466 | doi:10.1038/nrm3158 FBXW5 regulates centrosome duplication and is itself controlled by APC/C and PLK4. PDF Ageing: Recapturing youth p466 | doi:10.1038/nrm3160 Replicative lifespan is reset during gametogenesis in budding yeast. PDF IN BRIEF Organelle biogenesis | Small RNAs | Gene expression p466 | doi:10.1038/nrm3165 PDF IN BRIEF Metabolism | Epigenetics | Development p467 | doi:10.1038/nrm3166 PDF Molecular Cell Biology JOBS of the week Postdoc: Computational Cancer Biology The Netherlands Cancer Institute & Astra Zeneca Amsterdam, The Netherlands PhD Scholarship: Biogeochemical heterogeneity Denmark, Technical University of Denmark, Denmark Professor in immunology or cancer biology University of Southern Denmark, Faculty of Health Sciences Denmark Computational Biologist Cleveland Clinic Lerner Research Institute Cleveland, Ohio, USA Research Assistant in immuno / molecular diagnosis / detection of Cestode Zoonoses University of Salford Salford, UK More Science jobs from Molecular Cell Biology EVENT Cellular Biology of Addiction 09.-15.08.11 NY, US More science events from
REVIEWS		Top
Phosphatases: providing safe passage through mitotic exit Claudia Wurzenberger & Daniel W. Gerlich p469 | doi:10.1038/nrm3149 The regulation of mitotic exit requires the rapid reversal of mitotic phosphorylation on a broad range of substrates. This requires not only inactivation of mitotic kinases but also activation of protein phosphatases, which work in regulatory networks to ensure that an interphase cell is correctly established. Abstract | Full Text | PDF
Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing Jeremy R. Haag & Craig S. Pikaard p483 | doi:10.1038/nrm3152 In eukaryotes, RNA polymerases I, II and III synthesize RNAs, which are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, to orchestrate non-coding RNA-mediated gene silencing processes. Their subunit compositions reveal that they evolved as specialized forms of RNA polymerase II. Abstract | Full Text | PDF
The 'invisible hand': regulation of RHO GTPases by RHOGDIs Rafael Garcia-Mata, Etienne Boulter & Keith Burridge p493 | doi:10.1038/nrm3153 RHO-specific guanine nucleotide dissociation inhibitors (RHOGDIs) had long been considered to be passive inhibitors of RHO GTPases, 'locking' them in an inactive state. However, recent findings suggest that they have integral roles in regulating RHO GTPases, controlling aspects such as stability, expression, activity and membrane localization. Abstract | Full Text | PDF
From unwinding to clamping — the DEAD box RNA helicase family Patrick Linder & Eckhard Jankowsky p505 | doi:10.1038/nrm3154 RNA helicases of the DEAD box family are highly conserved enzymes with many roles in gene expression. Structural and mechanistic studies are uncovering the basis of their actions and have revealed roles not only in RNA unwinding but also in the remodelling of RNA–protein complexes and in the clamping of RNA to allow nucleation of larger complexes. Abstract | Full Text | PDF
Molecular mechanism and physiological functions of clathrin-mediated endocytosis Harvey T. McMahon & Emmanuel Boucrot p517 | doi:10.1038/nrm3151 Clathrin-mediated endocytosis is a modular process that involves core and accessory adaptor proteins that package cargoes into vesicles, ultimately leading to their uptake. It is essential for many physiological processes in higher eukaryotes, including signal termination and exocytosis, so its components are rarely associated with disease. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Correspondence: Mutually reinforcing patterning mechanisms Elena R. Alvarez-Buylla, Mariana Benítez & Carlos Espinosa-Soto p533 | doi:10.1038/nrm3079-c1 Full Text | PDF
Correspondence: Mutually reinforcing patterning mechanisms: authors' reply Adrienne H. K. Roeder, Paul T. Tarr, Cory Tobin, Xiaolan Zhang, Vijay Chickarmane, Alexandre Cunha & Elliot M. Meyerowitz p533 | doi:10.1038/nrm3079-c2 Full Text | PDF
Corrigendum: Cubism and the cell cycle: the many faces of the APC/C Jonathon Pines p533 | doi:10.1038/nrm3155 Full Text | PDF
Corrigendum: ARF family G proteins and their regulators: roles in membrane transport, development and disease Julie G. Donaldson & Catherine L. Jackson p533 | doi:10.1038/nrm3159 Full Text | PDF
PERSPECTIVES		Top
TIMELINE Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity Ana Maria Cuervo p535 | doi:10.1038/nrm3150 This Timeline article pays tribute to the late James Fred 'Paulo' Dice, whose vision of selective protein degradation in lysosomes led to the discovery of chaperone-mediated autophagy. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011

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