Nature Reviews Immunology Contents August 2011 Volume 11 Number 8 pp 497-565

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TABLE OF CONTENTS
August 2011 Volume 11 Number 8
Impact Factor 35.196 * Subscribe to Nature Reviews Immunology Recommend to your library	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis Mark M. Davis, John D. Altman & Evan W. Newell
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From the editors p497 | doi:10.1038/nri3038 PDF
RESEARCH HIGHLIGHTS Top Innate immunity: Neutrophil U-turn fans the flames p498 | doi:10.1038/nri3032 Backtracking neutrophils can promote dissemination of inflammatory responses. PDF Immunotherapy: Pieces of the IVIG anti-inflammatory response p499 | doi:10.1038/nri3026 IVIG-mediated immunosuppression occurs through IL-33-induced expansion of IL-4-secreting basophil populations. PDF IN BRIEF Cell death and immunity | Innate immunity | Viral immunity p499 | doi:10.1038/nri3033 PDF Tolerance: Both natural and induced TReg talents needed p500 | doi:10.1038/nri3030 Induced CD4+ TReg cells are essential for tolerance even in the presence of natural TReg cells. PDF Asthma: The secret face of H. pylori p500 | doi:10.1038/nri3034 Early infection with H. pylori prevents asthma in a TReg cell-dependent manner. PDF In the news p500 | doi:10.1038/nri3040 PDF B cells: The B boyz of sepsis p501 | doi:10.1038/nri3036 B cells help protect against sepsis-induced lethality. PDF Innate immunity: SHP regulates TLR signalling p502 | doi:10.1038/nri3031 SHP is a negative regulator of TLR signalling pathways. PDF Immune regulation: Lysosomes at the heart of inflammation p502 | doi:10.1038/nri3035 Lysosomes promote inflammation by degrading cytosolic glucocorticoid receptors. PDF T cells: A metabolic sHIFt to turn 17 p503 | doi:10.1038/nri3037 A HIF1α-dependent metabolic switch influences the balance between TH17 and induced TReg cell differentiation. PDF Antiviral immunity: Rapid response team p504 | doi:10.1038/nri3025 A helicase–TRIF complex functions as a 'first responder' to viral dsRNA that triggers initial interferon production. PDF IN BRIEF Innate immunity | Immunodeficiency | Parasite immunity p504 | doi:10.1038/nri3039 PDF Immunology JOBS of the week W3-Professor (f / m) for Experimental Neurophysiology DZNE Koln, Germany Director The Luc Hoffmann Institute Gland, Switzerland Chair in Environmental Change Biology Imperial College London London, United Kingdom Lecturer in Earth Observation and Climate Physics Imperial College London London, United Kingdom Professor (W3) of Electrochemistry Karlsruhe Institute of Technology (KIT) Karlsruhe, Germany More Science jobs from Immunology EVENT Summer Academy in Immunology 03.-18.09.11 Hannover, Germany More science events from
REVIEWS		Top
Immunity against Staphylococcus aureus cutaneous infections Lloyd S. Miller & John S. Cho p505 | doi:10.1038/nri3010 This article looks at recent developments in our understanding of protective immune mechanisms against Staphylococcus aureus skin infections, with a focus on IL-1- and IL-17-mediated responses, and the impact of these new discoveries on future immunotherapy and vaccination strategies. Abstract | Full Text | PDF
Neutrophils in the activation and regulation of innate and adaptive immunity Alberto Mantovani, Marco A. Cassatella, Claudio Costantini & Sébastien Jaillon p519 | doi:10.1038/nri3024 This Review provides an overview of the multiple functions of neutrophils in the immune system. Although classically considered simply as 'first responders', it is now clear that neutrophils contribute to the activation and polarization of numerous cells of both the innate and adaptive immune systems and are important players in the pathogenesis of many diseases. Abstract | Full Text | PDF
Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms Alan L. Rothman p532 | doi:10.1038/nri3014 Alan Rothman describes the types of immune response that are associated with protection and pathology during dengue virus infection. Although virus-specific antibodies provide protective neutralizing immunity, they can also facilitate infection of other host cells; the author discusses the implications of this for vaccine development. Abstract | Full Text | PDF
Post-thymic maturation: young T cells assert their individuality Pamela J. Fink & Deborah W. Hendricks p544 | doi:10.1038/nri3028 Recent thymic emigrants (RTEs) are a population of T cells that undergo maturation in the periphery and are functionally distinct from mature naive T cells. These cells constitute a major proportion of the T cell pool in neonates and in adults recovering from lymphoablation. This article describes what is known, and what remains to be discovered, about RTEs. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis Mark M. Davis, John D. Altman & Evan W. Newell p551 | doi:10.1038/nri3020 The detection of multiple and often rare T cell specificities is crucial for understanding and therapeutically manipulating T cell responses. In this Perspective article, Davis et al. summarize the latest advances in peptide–MHC multimer technology that have rendered peptide–MHC multimers a valuable tool in both basic and clinical T cell research. Abstract | Full Text | PDF
VIEWPOINT Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Boris Reizis, Marco Colonna, Giorgio Trinchieri, Franck Barrat & Michel Gilliet p558 | doi:10.1038/nri3027 In this Viewpoint article, Nature Reviews Immunology asks five experts in the field to share their thoughts on the development and immune functions of plasmacytoid dendritic cells. Importantly, will these cells be a useful clinical target? Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Heat shock proteins are no DAMPs, rather 'DAMPERs' Femke Broere, Ruurd van der Zee & Willem van Eden p565 | doi:10.1038/nri2873-c1 Full Text | PDF
Correspondence: Are heat shock proteins DAMPs? Grace Y. Chen & Gabriel Nuñez p565 | doi:10.1038/nri2873-c2 Full Text | PDF
Corrigendum: TH17 cells in tumour immunity and immunotherapy Weiping Zou & Nicholas P. Restifo p565 | doi:10.1038/nri3029 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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