Nature Reviews Cancer contents August 2011 Volume 11 Number 8 pp 533-618

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TABLE OF CONTENTS
August 2011 Volume 11 Number 8		Advertisement
Impact Factor 37.178 * Subscribe to Nature Reviews Cancer Recommend to your library	In this issue Research Highlights Reviews Correspondence Also this month Article series: Epigenetics and genetics Featured article: Advances in sarcoma genomics and new therapeutic targets Barry S. Taylor, Jordi Barretina, Robert G. Maki, Cristina R. Antonescu, Samuel Singer & Marc Ladanyi	BD Matrigel Matrix. Cited in more than 6000 papers. BD Matrigel Matrix is certified LDEV-free, and is the most trusted and extensively published basement membrane matrix for good reason: Reliability. Try BD Matrigel Matrix or other BD recommended materials for 3D culture and save 15% on your order. BD Extracellular Matrices give you reliability, confidence and consistency. bdbiosciences.com/cellculture/ecm
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From the editors p533 | doi:10.1038/nrc3118 PDF
RESEARCH HIGHLIGHTS Top Leukaemia and lymphoma: The expansive reach of TET2 p535 | doi:10.1038/nrc3115 Two papers report the effects of TET2 deficiency on haematopoiesis in mice and show that TET2 is a pleiotropic regulator of lineage development. PDF Cachexia: Putting the brakes on lipid loss p536 | doi:10.1038/nrc3113 Cancer-associated cachexia is reduced in mice lacking enzymes that are crucial for triglyceride lipolysis, and a similar mechanism may operate in humans. PDF Disease mechanisms: Out with the old, in with the new p536 | doi:10.1038/nrc3116 A new study reveals that the oesophageal to intestinal metaplasia observed in Barrett's oesophagus may be caused by oesophageal colonization by a residual embryonic cell population PDF Nanotechnology: Tag teams p537 | doi:10.1038/nrc3111 Two papers have examined how modifying nanoparticles can increase the specificity of tumour cell killing in vivo. PDF Systems biology: Lethal weaknesses p538 | doi:10.1038/nrc3109 A new genomic-scale computer model of the cancer metabolome indicates synthetic lethal interactions. PDF Ovarian cancer: Driving force p538 | doi:10.1038/nrc3112 In vitro imaging reveals a possible mechanism for clearance of the mesothelial barrier by ovarian cancer cells during metastasis. PDF Immunotherapy: A vaccine for prostate cancer? p539 | doi:10.1038/nrc3117 The expression of prostate-specific antigens using viral vectors shows promise for the treatment of prostate cancer. PDF Cancer JOBS of the week Postdoctoral / Research Scientist Zymo Research Corp. Irvine, CA Director of Surgical Pathology University of Wisconsin-Madison Madison, Wisconsin Postdoc: Computational Cancer Biology The Netherlands Cancer Institute & Astra Zeneca Amsterdam, The Netherlands IARC-Australia Postdoctoral Fellowship for Training in Cancer Research 2012 - 2013 International Agency for Research on Cancer (IARC/WHO) Lyon, France Group Leader, PCMP Brigham and Women's Hospital & Dana-Farber Cancer Institute Boston, MA More Science jobs from Cancer EVENT Frontiers in Cancer Prevention Research 22.-25.10.11 MA, US More science events from
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REVIEWS		Top
Advances in sarcoma genomics and new therapeutic targets Barry S. Taylor, Jordi Barretina, Robert G. Maki, Cristina R. Antonescu, Samuel Singer & Marc Ladanyi p541 | doi:10.1038/nrc3087 Sarcomas are increasingly classified according to the genetic abnormalities associated with their pathogenesis. What are the mechanisms of sarcomagenesis and how might these genetic abnormalities lead to improved therapy for patients? Abstract | Full Text | PDF
Cyclin D as a therapeutic target in cancer Elizabeth A. Musgrove, C. Elizabeth Caldon, Jane Barraclough, Andrew Stone & Robert L. Sutherland p558 | doi:10.1038/nrc3090 Is the ability of D-type cyclins to activate cyclin-dependent kinases an effective means of targeting these oncogenes, and how might the patient subgroups that are most likely to benefit be identified? Abstract | Full Text | PDF
Chemotaxis in cancer Evanthia T. Roussos, John S. Condeelis & Antonia Patsialou p573 | doi:10.1038/nrc3078 Chemotaxis confers directionality to migrating tumour cells away from the tumour and recruits various cells to the tumour. This Review discusses the mechanisms of chemotaxis and how this process contributes to tumour progression. Abstract | Full Text | PDF | Supplementary information
Article series: Epigenetics and genetics Cancer biology and NuRD: a multifaceted chromatin remodelling complex Anne Y. Lai & Paul A. Wade p588 | doi:10.1038/nrc3091 The nucleosome remodelling and histone deacetylase (NuRD) complex has been implicated in the regulation of transcriptional events that are integral to oncogenesis and cancer progression. This Review discusses how inappropriate localization of the complex could contribute to tumour biology. Abstract | Full Text | PDF
The different roles of ER subtypes in cancer biology and therapy Christoforos Thomas & Jan-Åke Gustafsson p597 | doi:10.1038/nrc3093 Perturbation of oestrogen receptor (ER) subtype-specific expression has been detected in various types of cancer, and these differences correlate with the clinical outcome. The selective restoration or ablation of their activity is one of the major therapeutic approaches for hormone-dependent cancers. Abstract | Full Text | PDF
Calcium in tumour metastasis: new roles for known actors Natalia Prevarskaya, Roman Skryma & Yaroslav Shuba p609 | doi:10.1038/nrc3105 The ubiquitous second messenger Ca2+ is a crucial regulator of cell migration. This Review discusses recent data on ORAI1, STIM1 and TRP, which have been implicated in tumour cell migration and the metastatic cell phenotype. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: The two faces of autophagy and the pathological underestimation of DCIS Ke-Da Yu & Zhi-Ming Shao p618 | doi:10.1038/nrc2950-c1 Full Text | PDF
Correspondence: A response to the two faces of autophagy in DCIS Virginia Espina & Lance A. Liotta p618 | doi:10.1038/nrc2950-c2 Full Text | PDF
Erratum: Otto Warburg's contributions to current concepts of cancer metabolism Willem H. Koppenol, Patricia L. Bounds & Chi V. Dang p618 | doi:10.1038/nrc3108 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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