The EDGE: Nature contents: 14 July 2011

Nature Alert
The science that matters. Every week.

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View Table of Contents http://links.ealert.nature.com/ctt?kn=60&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

RIKEN RESEARCH - The latest in news and research from RIKEN, Japan's
flagship research organization
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Research highlights: A diamond ring sparks a paradigm shift | Making
holograms look more real | Awaiting orders to retaliate

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Keep up to date by registering for the weekly email alert!
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====================== THIS WEEK'S HIGHLIGHTS =======================

--Biological Sciences
-Low-energy control of electrical turbulence in the heart
Tests in a dog model show that a new technique called low-energy
antifibrillation pacing or LEAP, can resuscitate the heart using much
less energy than conventional cardiac defibrillation - and with fewer
side effects.
http://links.ealert.nature.com/ctt?kn=109&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

--Earth & Environmental Sciences
-Increased soil emissions of potent greenhouse gases under increased
atmospheric CO2
Analysis of the published evidence confirms that increased atmospheric
carbon dioxide levels stimulate soil emissions of nitrous oxide from
terrestrial ecosystems and of methane from rice paddies and natural
wetlands. These are both powerful greenhouse gases, and this phenomenon
could negate at least 17% of the mitigation effect of the increase in
the terrestrial carbon sink expected from a rise in carbon dioxide alone.
http://links.ealert.nature.com/ctt?kn=112&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

--Biological Sciences
-Genome sequence and analysis of the tuber crop potato
The genome of the potato, a staple crop vital to food security and
becoming increasingly important in the developing world, has been
sequenced. This achievement will facilitate genetic improvements in
the potato that could boost crop yields.
http://links.ealert.nature.com/ctt?kn=106&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

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=====================================================================

--Podcast & Video
-This week, we learn how old mathematical theories apply to the modern
world, hear of a gentle way to mend a broken heart and find out how
tiny ancestors gave rise to the biggest creatures ever to have walked
the Earth.
http://links.ealert.nature.com/ctt?kn=137&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

--Specials - Outlook
-Alzheimer's disease
From dancing to drugs, research on Alzheimer's disease is moving
apace. Our improved understanding of the role that amyloid-[beta] plays
is uncovering new ways to treat and perhaps prevent the disease.
Imaging the brain is improving diagnosis, and better biomarkers to
track disease progression are sought. Could we soon lift the spectre
of Alzheimer's disease?
http://links.ealert.nature.com/ctt?kn=20&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

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======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=139&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

EDITORIALS
** There will be blood
Screening of newborns for genetic disorders is important, but so is
educating parents to ensure that they give the proper consent.
http://links.ealert.nature.com/ctt?kn=107&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** REACH further
Europe's plan for a comprehensive chemical register needs more effort from all involved.
http://links.ealert.nature.com/ctt?kn=117&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Sunday best
Good news - Australia's politicians have rediscovered climate change.
http://links.ealert.nature.com/ctt?kn=118&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

WORLD VIEW
** The dubious benefits of broader impact
Assessments of the wider value of research are unpopular. Proposed
changes will only produce more hype and hypocrisy, says Daniel Sarewitz.
http://links.ealert.nature.com/ctt?kn=150&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

SEVEN DAYS
** Seven days: 8-14 July 2011
The week in science
http://links.ealert.nature.com/ctt?kn=28&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

NEWS IN FOCUS
** Dawn nears Vesta
Mission poised to explore the Solar System's largest asteroids in detail.
http://links.ealert.nature.com/ctt?kn=26&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** African outbreak stumps experts
With few leads to go on, researchers pursue the childhood malady nodding syndrome.
http://links.ealert.nature.com/ctt?kn=25&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Data gaps threaten chemical safety law
European companies are not providing robust information to regulators
or alternatives to animal experiments.
http://links.ealert.nature.com/ctt?kn=36&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Paxil study under fire
Trial researcher alleges paper exaggerated antidepressant benefits.
http://links.ealert.nature.com/ctt?kn=35&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** No fallout legacy for Japan's farms
But the most contaminated soils need urgent clean-up.
http://links.ealert.nature.com/ctt?kn=33&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

FEATURES
** Newborn screening: A spot of trouble
By raising hell about newborn blood-spot screening, Twila Brase could
jeopardize public-health programmes and derail research. The problem
is, she has a point.
http://links.ealert.nature.com/ctt?kn=30&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Dinosaurs: Rise of the titans
The sauropods were the biggest creatures ever to walk the planet. But
the keys to their success emerged in their tiny ancestors.
http://links.ealert.nature.com/ctt?kn=41&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

COMMENT
** Genomics for the world
Medical genomics has focused almost entirely on those of European
descent. Other ethnic groups must be studied to ensure that more people
benefit, say Carlos D. Bustamante, Esteban Gonzalez Burchard and
Francisco M. De La Vega.
http://links.ealert.nature.com/ctt?kn=113&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** The unplanned impact of mathematics
Peter Rowlett introduces seven little-known tales illustrating that
theoretical work may lead to practical applications, but it can't be
forced and it can take centuries.
http://links.ealert.nature.com/ctt?kn=115&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

BOOKS AND ARTS
** Evolution: A tale of feathers
Alan Brush enjoys a compelling narrative on the discoveries that have
illuminated the complexities and evolution of plumage.
http://links.ealert.nature.com/ctt?kn=104&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Palaeontology: Living it large
Brian Switek swoons over a New York exhibition that brings giant
sauropods back to life.
http://links.ealert.nature.com/ctt?kn=86&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Q&A: The interpreter
In 1973, Herbert Terrace, a psychologist at Columbia University in
New York, embarked on an experiment to teach sign language to an infant
chimpanzee named Nim Chimpsky, after linguist Noam Chomsky. On the
release of the documentary Project Nim, Terrace talks about research
ethics, chimp cognition and the origins of language.
http://links.ealert.nature.com/ctt?kn=92&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

CORRESPONDENCE
** Time to end US chimp studies
John J. Pippin
http://links.ealert.nature.com/ctt?kn=90&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** E. coli outbreak exposed tech gaps
Rainer Fislage
http://links.ealert.nature.com/ctt?kn=96&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Dam not sole cause of Chinese drought
X. X. Lu, Xiankun Yang and Siyue Li
http://links.ealert.nature.com/ctt?kn=94&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Green labelling being misused
David P. Edwards, Brendan Fisher and David S. Wilcove
http://links.ealert.nature.com/ctt?kn=99&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

CORRECTIONS
** Corrections
http://links.ealert.nature.com/ctt?kn=98&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Correction
http://links.ealert.nature.com/ctt?kn=130&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

*6th Conference on Advances in Stem Cell Research - *23rd -26th January
2012 Slovenia.

A four day conference, part of the highly-successful series exploring
developments in stem cell science.

Plenary speakers: Hans Clevers and Huck-Hui Ng.

For more details, a full programme and to register, visit our website.
http://links.ealert.nature.com/ctt?kn=138&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

Places will be allocated on a first come first served basis.

http://links.ealert.nature.com/ctt?kn=19&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

=====================================================================

======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Genome sequence and analysis of the tuber crop potato
The Potato Genome Consortium (Participants are listed alphabetically
by institution.)The Potato Genome Sequencing Consortium
Potato (Solanum tuberosum L.) is the world's most important non-grain f...
http://links.ealert.nature.com/ctt?kn=106&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Functional regeneration of respiratory pathways after spinal cord
injury
Warren J. Alilain, Kevin P. Horn, Hongmei Hu, Thomas E. Dick and Jerry
Silver
Spinal cord injuries often occur at the cervical level above the phrenic
motor ...
http://links.ealert.nature.com/ctt?kn=126&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Dicer recognizes the 5[prime] end of RNA for efficient and accurate
processing
Jong-Eun Park, Inha Heo, Yuan Tian, Dhirendra K. Simanshu, Hyeshik
Chang et al.
A hallmark of RNA silencing is a class of approximately 22-nucleotide
RNAs that...
http://links.ealert.nature.com/ctt?kn=125&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Increased soil emissions of potent greenhouse gases under increased
atmospheric CO2
Kees Jan van Groenigen, Craig W. Osenberg and Bruce A. Hungate
Increasing concentrations of atmospheric carbon dioxide (CO2) can affect
biotic...
http://links.ealert.nature.com/ctt?kn=112&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** In vivo genome editing restores haemostasis in a mouse model of
haemophilia
Hojun Li, Virginia Haurigot, Yannick Doyon, Tianjian Li, Sunnie Y.
Wong et al.
Editing of the human genome to correct disease-causing mutations is
a promising...
http://links.ealert.nature.com/ctt?kn=124&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** CCL2 recruits inflammatory monocytes to facilitate breast-tumour
metastasis
Bin-Zhi Qian, Jiufeng Li, Hui Zhang, Takanori Kitamura, Jinghang Zhang
et al.
Macrophages, which are abundant in the tumour microenvironment, enhance
maligna...
http://links.ealert.nature.com/ctt?kn=65&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and
Treg cells
Andrea Facciabene, Xiaohui Peng, Ian S. Hagemann, Klara Balint,
Andrea Barchetti et al.
Although immune mechanisms can suppress tumour growth, tumours
establish potent...
http://links.ealert.nature.com/ctt?kn=54&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Selective killing of cancer cells by a small molecule targeting
the stress response to ROS
Lakshmi Raj, Takao Ide, Aditi U. Gurkar, Michael Foley, Monica Schenone
et al.
Malignant transformation, driven by gain-of-function mutations in
oncogenes and...
http://links.ealert.nature.com/ctt?kn=55&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Low-energy control of electrical turbulence in the heart
Stefan Luther, Flavio H. Fenton, Bruce G. Kornreich, Amgad Squires,
Philip Bittihn et al.
Controlling the complex spatio-temporal dynamics underlying life-
threatening ca...
http://links.ealert.nature.com/ctt?kn=109&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Architecture of the Mediator head module
Tsuyoshi Imasaki, Guillermo Calero, Gang Cai, Kuang-Lei Tsai, Kentaro
Yamada et al.
Mediator is a key regulator of eukaryotic transcription, connecting
activators ...
http://links.ealert.nature.com/ctt?kn=48&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Coordination of DNA replication and histone modification by the
Rik1-Dos2 complex
Fei Li, Rob Martienssen and W. Zacheus Cande
Histone modification marks have an important role in many chromatin
processes. ...
http://links.ealert.nature.com/ctt?kn=50&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B
NMDA receptors
Erkan Karakas, Noriko Simorowski and Hiro Furukawa
Since it was discovered that the anti-hypertensive agent ifenprodil
has neuropr...
http://links.ealert.nature.com/ctt?kn=51&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Multi-domain conformational selection underlies pre-mRNA splicing
regulation by U2AF
Cameron D. Mackereth, Tobias Madl, Sophie Bonnal, Bernd Simon, Katia
Zanier et al.
Many cellular functions involve multi-domain proteins, which are
composed of st...
http://links.ealert.nature.com/ctt?kn=131&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** The ELF4-ELF3-LUX complex links the circadian clock to diurnal
control of hypocotyl growth
Dmitri A. Nusinow, Anne Helfer, Elizabeth E. Hamilton, Jasmine J.
King, Takato Imaizumi et al.
The circadian clock is required for adaptive responses to daily and
seasonal ch...
http://links.ealert.nature.com/ctt?kn=114&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Inference of human population history from individual whole-genome
sequences
Heng Li and Richard Durbin
The history of human population size is important for understanding
human evolu...
http://links.ealert.nature.com/ctt?kn=123&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** MicroRNA-mediated conversion of human fibroblasts to neurons
Andrew S. Yoo, Alfred X. Sun, Li Li, Aleksandr Shcheglovitov, Thomas
Portmann et al.
Neurogenic transcription factors and evolutionarily conserved
signalling pathwa...
http://links.ealert.nature.com/ctt?kn=121&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** The crystal structure of a voltage-gated sodium channel
Jian Payandeh, Todd Scheuer, Ning Zheng and William A. Catterall
Voltage-gated sodium (NaV) channels initiate electrical signalling
in excitable...
http://links.ealert.nature.com/ctt?kn=120&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Protein targeting and degradation are coupled for elimination
of mislocalized proteins
Tara Hessa, Ajay Sharma, Malaiyalam Mariappan, Heather D. Eshleman,
Erik Gutierrez et al.
A substantial proportion of the genome encodes membrane proteins
that are deliv...
http://links.ealert.nature.com/ctt?kn=119&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Crystal structure of the human centromeric nucleosome containing
CENP-A
Hiroaki Tachiwana, Wataru Kagawa, Tatsuya Shiga, Akihisa Osakabe,
Yuta Miya et al.
In eukaryotes, accurate chromosome segregation during mitosis and
meiosis is co...
http://links.ealert.nature.com/ctt?kn=128&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Competition, predation and natural selection in island lizards
Jonathan B. Losos and Robert M. Pringle
Arising from R. Calsbeek & R. M. Cox Nature 465, 613-616 (2010);
Calsbe...
Discerning the relative influence of competition and predation as
selective for...
http://links.ealert.nature.com/ctt?kn=47&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Calsbeek & Cox reply
Ryan Calsbeek and Robert M. Cox
Replying to J. B. Losos & R. M. Pringle...
http://links.ealert.nature.com/ctt?kn=77&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** CD95 promotes tumour growth
Lina Chen, Sun-Mi Park, Alexei V. Tumanov, Annika Hau, Kenjiro Sawada
et al.
http://links.ealert.nature.com/ctt?kn=75&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Telomere dysfunction induces metabolic and mitochondrial compromise
Ergun Sahin, Simona Colla, Marc Liesa, Javid Moslehi, Florian L.
Muller et al.
http://links.ealert.nature.com/ctt?kn=76&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Neuroscience: Weight loss through smoking
Randy J. Seeley and Darleen A. Sandoval
Many people smoke to keep their weight down. The identification of
the molecular target in the brain for the appetite-suppressant effects
of nicotine is a first step towards finding healthy alternatives to
smoking for weight management.
http://links.ealert.nature.com/ctt?kn=53&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Global change: Indirect feedbacks to rising CO2
Alexander Knohl and Edzo Veldkamp
There have been many studies on the effects of enriched levels of
atmospheric carbon dioxide on soils. A meta-analysis shows that
emissions of other greenhouse gases increase under high-CO2 conditions.
http://links.ealert.nature.com/ctt?kn=44&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Regenerative medicine: Drawing breath after spinal injury
Katherine Zukor and Zhigang He
New work on a rat model suggests that, after spinal-cord injury,
restoration of sustained and robust respiratory function is possible
using strategies that promote both neuronal plasticity and regeneration.
http://links.ealert.nature.com/ctt?kn=45&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Cardiovascular disease: Several small shocks beat one big one
Richard A. Gray and John P. Wikswo
Life-threatening abnormalities in the electrical rhythm of the heart
are usually treated with the application of a large electric shock.
An approach involving a significantly smaller shock energy may be
equally effective.
http://links.ealert.nature.com/ctt?kn=46&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

CORRIGENDA
** CD95 promotes tumour growth
http://links.ealert.nature.com/ctt?kn=75&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Telomere dysfunction induces metabolic and mitochondrial compromise
http://links.ealert.nature.com/ctt?kn=76&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

NEWS & COMMENT
** Immunology: Crystal ball for flu vaccines
http://links.ealert.nature.com/ctt?kn=73&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Developmental biology: How the mole got its 'thumb'
http://links.ealert.nature.com/ctt?kn=74&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Neurodevelopment: Defects from stunted neurites
http://links.ealert.nature.com/ctt?kn=71&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Cancer: Pushing back on drug resistance
http://links.ealert.nature.com/ctt?kn=72&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Immunology: Virus detected upon entry
http://links.ealert.nature.com/ctt?kn=69&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Metabolism: Bad fat makes good
http://links.ealert.nature.com/ctt?kn=70&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Plant biology: New light shed on leaf growth
http://links.ealert.nature.com/ctt?kn=66&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** There will be blood
Screening of newborns for genetic disorders is important, but so is
educating parents to ensure that they give the proper consent.
http://links.ealert.nature.com/ctt?kn=107&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Genomics for the world
Medical genomics has focused almost entirely on those of European
descent. Other ethnic groups must be studied to ensure that more
people benefit, say Carlos D. Bustamante, Esteban Gonzalez Burchard
and Francisco M. De La Vega.
http://links.ealert.nature.com/ctt?kn=113&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Evolution: A tale of feathers
Alan Brush enjoys a compelling narrative on the discoveries that have
illuminated the complexities and evolution of plumage.
http://links.ealert.nature.com/ctt?kn=104&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Q&A: The interpreter
In 1973, Herbert Terrace, a psychologist at Columbia University in New
York, embarked on an experiment to teach sign language to an infant
chimpanzee named Nim Chimpsky, after linguist Noam Chomsky. On the
release of the documentary Project Nim, Terrace talks about research
ethics, chimp cognition and the origins of language.
http://links.ealert.nature.com/ctt?kn=92&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Time to end US chimp studies
John J. Pippin
http://links.ealert.nature.com/ctt?kn=90&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** E. coli outbreak exposed tech gaps
Rainer Fislage
http://links.ealert.nature.com/ctt?kn=96&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Green labelling being misused
David P. Edwards, Brendan Fisher and David S. Wilcove
http://links.ealert.nature.com/ctt?kn=99&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=81&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Outlook: Alzheimer's Disease

From dancing to drugs, research on Alzheimer's disease is moving apace.
Our improved understanding of the role that amyloid-[beta] plays is
uncovering new ways to treat and perhaps prevent the disease.

Access the Outlook free online for six months.
http://links.ealert.nature.com/ctt?kn=149&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

Produced with support from:
Eli Lilly and Company

=====================================================================

======================== CHEMICAL SCIENCES ========================
RESEARCH
** Collective synthesis of natural products by means of organocascade
catalysis
Spencer B. Jones, Bryon Simmons, Anthony Mastracchio and David W. C.
MacMillan
Organic chemists are now able to synthesize small quantities of
almost any know...
http://links.ealert.nature.com/ctt?kn=10&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Selective killing of cancer cells by a small molecule targeting
the stress response to ROS
Lakshmi Raj, Takao Ide, Aditi U. Gurkar, Michael Foley, Monica
Schenone et al.
Malignant transformation, driven by gain-of-function mutations in
oncogenes and...
http://links.ealert.nature.com/ctt?kn=55&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Inkjet printing of single-crystal films
Hiromi Minemawari, Toshikazu Yamada, Hiroyuki Matsui, Jun'ya Tsutsumi,
Simon Haas et al.
The use of single crystals has been fundamental to the development of
semicondu...
http://links.ealert.nature.com/ctt?kn=9&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

NEWS & COMMENT
** REACH further
Europe's plan for a comprehensive chemical register needs more effort
from all involved.
http://links.ealert.nature.com/ctt?kn=117&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=52&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

======================== PHYSICAL SCIENCES ========================
RESEARCH
** A low mass for Mars from Jupiter's early gas-driven migration
Kevin J. Walsh, Alessandro Morbidelli, Sean N. Raymond, David P.
O'Brien and Avi M. Mandell
Jupiter and Saturn formed in a few million years (ref. 1) from a
gas-dominated ...
http://links.ealert.nature.com/ctt?kn=11&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Measurement of the internal state of a single atom without energy
exchange
Jurgen Volz, Roger Gehr, Guilhem Dubois, Jerome Esteve and Jakob Reichel
A measurement necessarily changes the quantum state being measured,
a phenomeno...
http://links.ealert.nature.com/ctt?kn=13&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Increased soil emissions of potent greenhouse gases under increased
atmospheric CO2
Kees Jan van Groenigen, Craig W. Osenberg and Bruce A. Hungate
Increasing concentrations of atmospheric carbon dioxide (CO2) can
affect biotic...
http://links.ealert.nature.com/ctt?kn=112&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Inkjet printing of single-crystal films
Hiromi Minemawari, Toshikazu Yamada, Hiroyuki Matsui, Jun'ya Tsutsumi, Simon Haas et al.
The use of single crystals has been fundamental to the development of semicondu...
http://links.ealert.nature.com/ctt?kn=9&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Global change: Indirect feedbacks to rising CO2
Alexander Knohl and Edzo Veldkamp
There have been many studies on the effects of enriched levels of
atmospheric carbon dioxide on soils. A meta-analysis shows that emissions
of other greenhouse gases increase under high-CO2 conditions.
http://links.ealert.nature.com/ctt?kn=44&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Quantum physics: Gentle measurement
Peter Maunz
Ideally, measurement of the energy state of a single atom would set
the atom to the measured state without affecting any of its other
properties. This goal has now been achieved with the assistance of a
small optical cavity.
http://links.ealert.nature.com/ctt?kn=1&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

NEWS & COMMENT
** Astronomy: Galactic dust from exploding stars
http://links.ealert.nature.com/ctt?kn=2&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Materials science: Phase-shifters magnified
http://links.ealert.nature.com/ctt?kn=4&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Climate change: The cooling effects of haze
http://links.ealert.nature.com/ctt?kn=5&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Dam not sole cause of Chinese drought
X. X. Lu, Xiankun Yang and Siyue Li
http://links.ealert.nature.com/ctt?kn=94&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=64&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** A low mass for Mars from Jupiter's early gas-driven migration
Kevin J. Walsh, Alessandro Morbidelli, Sean N. Raymond, David P.
O'Brien and Avi M. Mandell
Jupiter and Saturn formed in a few million years (ref. 1) from a
gas-dominated ...
http://links.ealert.nature.com/ctt?kn=11&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Increased soil emissions of potent greenhouse gases under increased
atmospheric CO2
Kees Jan van Groenigen, Craig W. Osenberg and Bruce A. Hungate
Increasing concentrations of atmospheric carbon dioxide (CO2) can
affect biotic...
http://links.ealert.nature.com/ctt?kn=112&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Thermal history of Mars inferred from orbital geochemistry of
volcanic provinces
David Baratoux, Michael J. Toplis, Marc Monnereau and Olivier Gasnault
http://links.ealert.nature.com/ctt?kn=6&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Global change: Indirect feedbacks to rising CO2
Alexander Knohl and Edzo Veldkamp
There have been many studies on the effects of enriched levels of
atmospheric carbon dioxide on soils. A meta-analysis shows that emissions
of other greenhouse gases increase under high-CO2 conditions.
http://links.ealert.nature.com/ctt?kn=44&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

CORRIGENDUM
** Thermal history of Mars inferred from orbital geochemistry of
volcanic provinces
http://links.ealert.nature.com/ctt?kn=6&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

NEWS & COMMENT
** Climate change: The cooling effects of haze
http://links.ealert.nature.com/ctt?kn=5&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Dam not sole cause of Chinese drought
X. X. Lu, Xiankun Yang and Siyue Li
http://links.ealert.nature.com/ctt?kn=94&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Green labelling being misused
David P. Edwards, Brendan Fisher and David S. Wilcove
http://links.ealert.nature.com/ctt?kn=99&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=63&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

======================== Specials - Outlook: Alzheimers ========================
http://links.ealert.nature.com/ctt?kn=14&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Alzheimer's disease
Herb Brody
http://links.ealert.nature.com/ctt?kn=32&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Dementia: A problem for our age
Alison Abbott
As the number of Alzheimer's cases rises rapidly in an ageing global
population...
http://links.ealert.nature.com/ctt?kn=39&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Biomarkers: Warning signs
Ruth Williams
The hunt is on for biomarkers that signal the descent into Alzheimer's
disease....
http://links.ealert.nature.com/ctt?kn=40&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Perspective: In search of biomarkers
Neil S. Buckholtz
New methods to follow changes in the brain or blood associated with
Alzheimer's...
http://links.ealert.nature.com/ctt?kn=37&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Drugs: A tangled web of targets
Lauren Gravitz
Drugs in development for Alzheimer's disease take aim at a variety
of neural me...
http://links.ealert.nature.com/ctt?kn=38&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Amyloid: Little proteins, big clues
Jim Schnabel
After a quarter of a century, the amyloid hypothesis for Alzheimer's
disease is...
http://links.ealert.nature.com/ctt?kn=23&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Perspective: Prevention is better than cure
Sam Gandy
Attempts to reduce amyloid-[beta] in the brain have yet to show
clinical bene...
http://links.ealert.nature.com/ctt?kn=24&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Prevention: Activity is the best medicine
Sarah DeWeerdt
Can exercise, social interaction and the Mediterranean diet really
help to keep...
http://links.ealert.nature.com/ctt?kn=21&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Vaccines: Chasing the dream
Jim Schnabel
After a decade of disappointments, hopes for a successful Alzheimer's
vaccine t...
http://links.ealert.nature.com/ctt?kn=22&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

** Genetics: Finding risk factors
Michael Eisenstein
Uncovering genes that are linked with Alzheimer's disease can help
researchers ...
http://links.ealert.nature.com/ctt?kn=27&ms=MzY4MTQxNDcS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA2MTc4OTk5S0&mt=1&rt=0

The EDGE

Wednesday, July 13, 2011

Nature contents: 14 July 2011

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