The science that matters. Every week.
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View Table of Contents http://links.ealert.nature.com/ctt?kn=52&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
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======================= THIS WEEK'S HIGHLIGHTS =======================
--Physical Sciences
-Deep winds beneath Saturn's upper clouds from a seasonal long-lived
planetary-scale storm
Six Great White Spot (GWS) events have been observed in the atmosphere
of Saturn since 1876. The latest erupted in December 2010 and has
been the subject of intense observation.
http://links.ealert.nature.com/ctt?kn=100&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
--Earth & Environmental Sciences
-Tracking apex marine predator movements in a dynamic ocean
Electronic tracking data on 23 species has revealed the predator
hotspots, foraging patterns and migration corridors of large
marine predators in the Pacific Ocean. A major finding is the
discovery that retentive oceanographic conditions on the west coast
of North America have created an ocean wilderness where large
predators are relatively undisturbed.
http://links.ealert.nature.com/ctt?kn=102&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
--Biological Sciences
-Structure-based design of non-natural amino-acid inhibitors of
amyloid fibril formation
Inhibitors of pathological amyloid fibril formation may be useful as
therapeutics in amyloid diseases such as Alzheimer's if they are
sufficiently specific. The use of computer-aided design has produced
a promising new class of anti-amyloid.
http://links.ealert.nature.com/ctt?kn=97&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Now Live - a new multidisciplinary research journal from the
publishers of Nature
Online and open access, Scientific Reports provides rapid publication
and high visibility of research - for all areas of science. All papers
accepted for publication are technically sound, without any
requirement for impact.
Submit your next paper to Scientific Reports
http://links.ealert.nature.com/ctt?kn=34&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
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--Podcast & Video
-This week, Saturn's storm, the link between alcohol and DNA damage,
and the vitamin D debate. Plus, the best of the rest from this week's
Nature.
http://links.ealert.nature.com/ctt?kn=134&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
--Specials - Technology Feature
-Animal models: Inside the minds of mice and men
Monitoring technologies and genetic engineering are producing a growing
array of animal models for psychiatric disorders, but researchers are
still learning how best to use them.
http://links.ealert.nature.com/ctt?kn=103&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
=====================================================================
======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=135&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
EDITORIALS
** Taken for a ride
Underhand attempts by the US Congress to bypass regulatory decisions
made by federal agencies erode science-based policy.
http://links.ealert.nature.com/ctt?kn=98&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Activation energy
The US Department of Energy must learn from its shoddy response to
misconduct allegations.
http://links.ealert.nature.com/ctt?kn=108&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Up and away
The final mission of the space shuttle heralds difficult days for
space science.
http://links.ealert.nature.com/ctt?kn=109&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
WORLD VIEW
** Fishery reform slips through the net
Upcoming change fails to tackle the pernicious relationship between
government advisers and the fishing lobby, says Rainer Froese.
http://links.ealert.nature.com/ctt?kn=144&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
SEVEN DAYS
** Seven days: 1-7 July 2011
The week in science
http://links.ealert.nature.com/ctt?kn=21&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
NEWS IN FOCUS
** Greek crisis spurs research reforms
Economic meltdown adds fresh vigour to science shake-up.
http://links.ealert.nature.com/ctt?kn=20&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Europe lines up hefty science-funding hike
Farm subsidies trimmed to enable a 45% rise for research.
http://links.ealert.nature.com/ctt?kn=19&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** NASA faces dearth of mission leaders
Experience gap looms large in next generation of principal investigators
for Discovery programme.
http://links.ealert.nature.com/ctt?kn=27&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Spain's ship comes in
Globe-trotting expedition hopes to prove the value of old-fashioned
scientific seafaring.
http://links.ealert.nature.com/ctt?kn=26&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** NIH cancer chief wants more with less
Harold Varmus discusses his first year at the National Cancer Institute.
http://links.ealert.nature.com/ctt?kn=24&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Mosquitoes score in chemical war
Growing resistance is threatening global malaria-control efforts.
http://links.ealert.nature.com/ctt?kn=22&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
FEATURES
** Misconduct at the DOE: Investigation closed
A legal case about public access to documents is raising questions
about the US Department of Energy's scrutiny of alleged scientific
misconduct.
http://links.ealert.nature.com/ctt?kn=33&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Nutrition advice: The vitamin D-lemma
A vociferous debate about vitamin-D supplementation reveals the
difficulty of distilling strong advice from weak evidence.
http://links.ealert.nature.com/ctt?kn=31&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
COMMENT
** Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here
research priorities for improving the lives of people with mental illness
around the world, and calls for urgent action and investment.
http://links.ealert.nature.com/ctt?kn=104&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Don't define nanomaterials
Basing regulations on a term with no scientific justification will do
more harm than good, argues Andrew D. Maynard.
http://links.ealert.nature.com/ctt?kn=106&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
SUMMER BOOKS
** Summer books
As holidays beckon, Nature's reviewers and editors offer a selection
of reading for researchers away from the bench and lecture hall.
http://links.ealert.nature.com/ctt?kn=95&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
CORRESPONDENCE
** Non-natives: 141 scientists object
Daniel Simberloff
http://links.ealert.nature.com/ctt?kn=79&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: put biodiversity at risk
Andrei Alyokhin
http://links.ealert.nature.com/ctt?kn=77&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: plusses of invasion ecology
Julie L. Lockwood, Martha F. Hoopes and Michael P. Marchetti
http://links.ealert.nature.com/ctt?kn=83&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: four risk factors
Manuel Lerdau and Jacob D. Wickham
http://links.ealert.nature.com/ctt?kn=81&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** UK cancer genetics gets personal
David Wiseman, Alice Tuff and James Peach
http://links.ealert.nature.com/ctt?kn=87&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Nuclear winter was and is debatable
Russell Seitz
http://links.ealert.nature.com/ctt?kn=85&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** All-male line-up yet again
Virginia Valian
http://links.ealert.nature.com/ctt?kn=90&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
CORRECTIONS
** Corrections
http://links.ealert.nature.com/ctt?kn=89&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Corrections
http://links.ealert.nature.com/ctt?kn=127&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Fancd2 counteracts the toxic effects of naturally produced aldehydes
in mice
Frederic Langevin, Gerry P. Crossan, Ivan V. Rosado, Mark J. Arends
and Ketan J. Patel
Reactive aldehydes are common carcinogens. They are also by-products
of several...
http://links.ealert.nature.com/ctt?kn=120&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Crystal structure of a copper-transporting PIB-type ATPase
Pontus Gourdon, Xiang-Yu Liu, Tina Skjorringe, J. Preben Morth, Lisbeth
Birk Moller et al.
Heavy-metal homeostasis and detoxification is crucial for cell
viability. P-typ...
http://links.ealert.nature.com/ctt?kn=119&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structure of the human histamine H1 receptor complex with doxepin
Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto,
Graeme Winter et al.
The biogenic amine histamine is an important pharmacological mediator
involved ...
http://links.ealert.nature.com/ctt?kn=56&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Tracking apex marine predator movements in a dynamic ocean
B. A. Block, I. D. Jonsen, S. J. Jorgensen, A. J. Winship, S. A.
Shaffer et al.
Pelagic marine predators face unprecedented challenges and uncertain
futures. O...
http://links.ealert.nature.com/ctt?kn=102&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** NMDA receptor blockade at rest triggers rapid behavioural
antidepressant responses
Anita E. Autry, Megumi Adachi, Elena Nosyreva, Elisa S. Na, Maarten
F. Los et al.
Clinical studies consistently demonstrate that a single
sub-psychomimetic dose ...
http://links.ealert.nature.com/ctt?kn=47&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structure-based design of non-natural amino-acid inhibitors of
amyloid fibril formation
Stuart A. Sievers, John Karanicolas, Howard W. Chang, Anni Zhao, Lin
Jiang et al.
Many globular and natively disordered proteins can convert into amyloid
fibrils...
http://links.ealert.nature.com/ctt?kn=97&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Whole-genome sequencing identifies recurrent mutations in chronic
lymphocytic leukaemia
Xose S. Puente, Magda Pinyol, Victor Quesada, Laura Conde, Gonzalo R.
Ordonez et al.
Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in
adults in W...
http://links.ealert.nature.com/ctt?kn=48&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Oncogene-induced Nrf2 transcription promotes ROS detoxification and
tumorigenesis
Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton, Aarthi
Gopinathan, Cong Wei et al.
Reactive oxygen species (ROS) are mutagenic and may thereby promote
cancer. Nor...
http://links.ealert.nature.com/ctt?kn=41&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Intravenous gammaglobulin suppresses inflammation through a novel
TH2 pathway
Robert M. Anthony, Toshihiko Kobayashi, Fredrik Wermeling and Jeffrey
V. Ravetch
High-dose intravenous immunoglobulin is a widely used therapeutic
preparation o...
http://links.ealert.nature.com/ctt?kn=43&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** XUTs are a class of Xrn1-sensitive antisense regulatory non-coding
RNA in yeast
E. L. van Dijk, C. L. Chen, Y. d'Aubenton-Carafa, S. Gourvennec, M.
Kwapisz et al.
Non-coding (nc)RNAs are key players in numerous biological processes
such as ge...
http://links.ealert.nature.com/ctt?kn=44&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** The ribosome uses two active mechanisms to unwind messenger RNA
during translation
Xiaohui Qu, Jin-Der Wen, Laura Lancaster, Harry F. Noller, Carlos
Bustamante et al.
The ribosome translates the genetic information encoded in messenger
RNA into p...
http://links.ealert.nature.com/ctt?kn=46&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Initial radiation of jaws demonstrated stability despite faunal and
environmental change
Philip S. L. Anderson, Matt Friedman, Martin D. Brazeau and Emily J.
Rayfield
More than 99 per cent of the roughly 58,000 living vertebrate species
have jaws...
http://links.ealert.nature.com/ctt?kn=128&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex
with its substrate TBP
Petra Wollmann, Sheng Cui, Ramya Viswanathan, Otto Berninghausen,
Melissa N. Wells et al.
Swi2/Snf2-type ATPases regulate genome-associated processes such as
transcripti...
http://links.ealert.nature.com/ctt?kn=105&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Excess digestive capacity in predators reflects a life of feast
and famine
Jonathan B. Armstrong and Daniel E. Schindler
A central challenge for predators is achieving positive energy balance
when pre...
http://links.ealert.nature.com/ctt?kn=118&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Legionella pneumophila SidD is a deAMPylase that modifies Rab1
Yunhao Tan and Zhao-Qing Luo
Legionella pneumophila actively modulates host vesicle trafficking
pathways to ...
http://links.ealert.nature.com/ctt?kn=115&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Sushma Gurumurthy, Stephanie Z. Xie, Brinda Alagesan, Judith Kim,
Rushdia Z. Yusuf et al.
http://links.ealert.nature.com/ctt?kn=18&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Lgr5 homologues associate with Wnt receptors and mediate R-spondin
signalling
Wim de Lau, Nick Barker, Teck Y. Low, Bon-Kyoung Koo, Vivian S. W.
Li et al.
The adult stem cell marker Lgr5 and its relative Lgr4 are often
co-expressed in...
http://links.ealert.nature.com/ctt?kn=16&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Coordination of DNA replication and histone modification by the
Rik1-Dos2 complex
Fei Li, Rob Martienssen and W. Zacheus Cande
Histone modification marks have an important role in many chromatin
processes. ...
http://links.ealert.nature.com/ctt?kn=111&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Architecture of the Mediator head module
Tsuyoshi Imasaki, Guillermo Calero, Gang Cai, Kuang-Lei Tsai, Kentaro
Yamada et al.
Mediator is a key regulator of eukaryotic transcription, connecting
activators ...
http://links.ealert.nature.com/ctt?kn=123&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Direct generation of functional dopaminergic neurons from mouse
and human fibroblasts
Massimiliano Caiazzo, Maria Teresa Dell'Anno, Elena Dvoretskova,
Dejan Lazarevic, Stefano Taverna et al.
Transplantation of dopaminergic neurons can potentially improve the
clinical ou...
http://links.ealert.nature.com/ctt?kn=121&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structural biology: A platform for copper pumps
Nigel J. Robinson
Copper is vital to most cells, but too much is lethal. The structure
of a protein that pumps copper ions out of the cytosol provides insight
into both the pumping mechanism and how certain mutations in the
protein cause disease.
http://links.ealert.nature.com/ctt?kn=37&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Cancer: When antioxidants are bad
Rushika M. Perera and Nabeel Bardeesy
Reactive oxygen species (ROS) get a bad press, as evidenced by the
notable trend in the use of dietary and cosmetic antioxidants. New work
suggests, however, that ROS might have a role in mitigating certain cancers.
http://links.ealert.nature.com/ctt?kn=38&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Metabolism: Alcohol, DNA and disease
Hans Joenje
Acetaldehyde, a reactive metabolite of ethanol, can damage DNA unless
properly processed. A biochemical pathway involved in Fanconi anaemia
seems to be essential for protection against such damage.
http://links.ealert.nature.com/ctt?kn=39&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
CORRIGENDA
** Sensitivity to antitubulin chemotherapeutics is regulated by MCL1
and FBW7
http://links.ealert.nature.com/ctt?kn=40&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** A role for mitochondria in NLRP3 inflammasome activation
http://links.ealert.nature.com/ctt?kn=68&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
NEWS & COMMENT
** Ecology: An ecological boost from climate change
http://links.ealert.nature.com/ctt?kn=66&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Palaeontology: Ancient tooth tells of migration
http://links.ealert.nature.com/ctt?kn=67&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Animal behaviour: Birds eavesdrop to skirt chipmunks
http://links.ealert.nature.com/ctt?kn=64&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Epigenetics: Stressed genes are inherited
http://links.ealert.nature.com/ctt?kn=65&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Cancer: Low carb, low tumour growth
http://links.ealert.nature.com/ctt?kn=62&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Microbiology: A key for bacterial entry
http://links.ealert.nature.com/ctt?kn=63&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Neuroscience: Protein brings death to myelin
http://links.ealert.nature.com/ctt?kn=60&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here
research priorities for improving the lives of people with mental
illness around the world, and calls for urgent action and investment.
http://links.ealert.nature.com/ctt?kn=104&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: 141 scientists object
Daniel Simberloff
http://links.ealert.nature.com/ctt?kn=79&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: put biodiversity at risk
Andrei Alyokhin
http://links.ealert.nature.com/ctt?kn=77&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: plusses of invasion ecology
Julie L. Lockwood, Martha F. Hoopes and Michael P. Marchetti
http://links.ealert.nature.com/ctt?kn=83&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: four risk factors
Manuel Lerdau and Jacob D. Wickham
http://links.ealert.nature.com/ctt?kn=81&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** UK cancer genetics gets personal
David Wiseman, Alice Tuff and James Peach
http://links.ealert.nature.com/ctt?kn=87&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** All-male line-up yet again
Virginia Valian
http://links.ealert.nature.com/ctt?kn=90&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Summer books
As holidays beckon, Nature's reviewers and editors offer a selection
of reading for researchers away from the bench and lecture hall.
http://links.ealert.nature.com/ctt?kn=95&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
CAREERS
**Inside information
http://links.ealert.nature.com/ctt?kn=57&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
**Turning point: Job Dekker
http://links.ealert.nature.com/ctt?kn=9&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=72&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Naturejobs Career Expo - London - UK's largest fair and conference
focused exclusively on the scientific world.
22 September 2011
Exhibition is FREE
REGISTER TODAY: http://links.ealert.nature.com/ctt?kn=143&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
=====================================================================
======================== CHEMICAL SCIENCES ========================
RESEARCH
** Crystal structure of a copper-transporting PIB-type ATPase
Pontus Gourdon, Xiang-Yu Liu, Tina Skjorringe, J. Preben Morth, Lisbeth
Birk Moller et al.
Heavy-metal homeostasis and detoxification is crucial for cell viability.
P-typ...
http://links.ealert.nature.com/ctt?kn=119&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structure of the human histamine H1 receptor complex with doxepin
Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto,
Graeme Winter et al.
The biogenic amine histamine is an important pharmacological mediator
involved ...
http://links.ealert.nature.com/ctt?kn=56&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structure-based design of non-natural amino-acid inhibitors of
amyloid fibril formation
Stuart A. Sievers, John Karanicolas, Howard W. Chang, Anni Zhao, Lin
Jiang et al.
Many globular and natively disordered proteins can convert into amyloid
fibrils...
http://links.ealert.nature.com/ctt?kn=97&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** The ribosome uses two active mechanisms to unwind messenger RNA
during translation
Xiaohui Qu, Jin-Der Wen, Laura Lancaster, Harry F. Noller, Carlos
Bustamante et al.
The ribosome translates the genetic information encoded in messenger
RNA into p...
http://links.ealert.nature.com/ctt?kn=46&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex
with its substrate TBP
Petra Wollmann, Sheng Cui, Ramya Viswanathan, Otto Berninghausen,
Melissa N. Wells et al.
Swi2/Snf2-type ATPases regulate genome-associated processes such as
transcripti...
http://links.ealert.nature.com/ctt?kn=105&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Legionella pneumophila SidD is a deAMPylase that modifies Rab1
Yunhao Tan and Zhao-Qing Luo
Legionella pneumophila actively modulates host vesicle trafficking
pathways to ...
http://links.ealert.nature.com/ctt?kn=115&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Coordination of DNA replication and histone modification by the
Rik1-Dos2 complex
Fei Li, Rob Martienssen and W. Zacheus Cande
Histone modification marks have an important role in many chromatin
processes. ...
http://links.ealert.nature.com/ctt?kn=111&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Architecture of the Mediator head module
Tsuyoshi Imasaki, Guillermo Calero, Gang Cai, Kuang-Lei Tsai, Kentaro
Yamada et al.
Mediator is a key regulator of eukaryotic transcription, connecting
activators ...
http://links.ealert.nature.com/ctt?kn=123&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Structural biology: A platform for copper pumps
Nigel J. Robinson
Copper is vital to most cells, but too much is lethal. The structure
of a protein that pumps copper ions out of the cytosol provides insight
into both the pumping mechanism and how certain mutations in the
protein cause disease.
http://links.ealert.nature.com/ctt?kn=37&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
CORRIGENDUM
** A role for mitochondria in NLRP3 inflammasome activation
http://links.ealert.nature.com/ctt?kn=68&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
CAREERS
**Turning point: Job Dekker
http://links.ealert.nature.com/ctt?kn=9&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=45&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
======================== PHYSICAL SCIENCES ========================
RESEARCH
** Deep winds beneath Saturn's upper clouds from a seasonal long-lived
planetary-scale storm
A. Sanchez-Lavega, T. del Rio-Gaztelurrutia, R. Hueso, J. M.
Gomez-Forrellad, J. F. Sanz-Requena et al.
Convective storms occur regularly in Saturn's atmosphere. Huge storms k...
http://links.ealert.nature.com/ctt?kn=100&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** A giant thunderstorm on Saturn
G. Fischer, W. S. Kurth, D. A. Gurnett, P. Zarka, U. A. Dyudina et al.
Lightning discharges in Saturn's atmosphere emit radio waves with inten...
http://links.ealert.nature.com/ctt?kn=11&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Attosecond control of electrons emitted from a nanoscale metal tip
Michael Kruger, Markus Schenk and Peter Hommelhoff
Attosecond science is based on steering electrons with the electric
field of we...
http://links.ealert.nature.com/ctt?kn=12&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Thermal spin current from a ferromagnet to silicon by Seebeck spin tunnelling
Jean-Christophe Le Breton, Sandeep Sharma, Hidekazu Saito, Shinji Yuasa and Ron Jansen
Heat generation by electric current, which is ubiquitous in electronic devices ...
http://links.ealert.nature.com/ctt?kn=1&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Sideband cooling of micromechanical motion to the quantum ground
state
J. D. Teufel, T. Donner, Dale Li, J. W. Harlow, M. S. Allman et al.
The advent of laser cooling techniques revolutionized the study of
many atomic-...
http://links.ealert.nature.com/ctt?kn=10&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Saturn: Storm-clouds brooding on towering heights
Peter Read
Springtime on Saturn came in with a bang last December, when a massive
storm erupted in its north temperate zone. This rare event has been observed in unprecedented detail from the ground and from space.
CORRIGENDUM
** Observation of the fractional quantum Hall effect in graphene
http://links.ealert.nature.com/ctt?kn=6&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=2&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
NEWS & COMMENT
** Astronomy: Nuclear network detects fireball
http://links.ealert.nature.com/ctt?kn=4&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Biomaterials: Barnacles help battle biofilms
http://links.ealert.nature.com/ctt?kn=5&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Don't define nanomaterials
Basing regulations on a term with no scientific justification will do
more harm than good, argues Andrew D. Maynard.
http://links.ealert.nature.com/ctt?kn=106&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Nuclear winter was and is debatable
Russell Seitz
http://links.ealert.nature.com/ctt?kn=85&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** All-male line-up yet again
Virginia Valian
http://links.ealert.nature.com/ctt?kn=90&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Summer books
As holidays beckon, Nature's reviewers and editors offer a selection
of reading for researchers away from the bench and lecture hall.
http://links.ealert.nature.com/ctt?kn=95&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=55&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Indian and African plate motions driven by the push force of the Reunion plume head
Steven C. Cande and Dave R. Stegman
Mantle plumes are thought to play an important part in the Earth's tect...
http://links.ealert.nature.com/ctt?kn=7&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Deep winds beneath Saturn's upper clouds from a seasonal long-lived
planetary-scale storm
A. Sanchez-Lavega, T. del Rio-Gaztelurrutia, R. Hueso, J. M.
Gomez-Forrellad, J. F. Sanz-Requena et al.
Convective storms occur regularly in Saturn's atmosphere. Huge storms k...
http://links.ealert.nature.com/ctt?kn=100&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** A giant thunderstorm on Saturn
G. Fischer, W. S. Kurth, D. A. Gurnett, P. Zarka, U. A. Dyudina et al.
Lightning discharges in Saturn's atmosphere emit radio waves with
inten...
http://links.ealert.nature.com/ctt?kn=11&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Tracking apex marine predator movements in a dynamic ocean
B. A. Block, I. D. Jonsen, S. J. Jorgensen, A. J. Winship, S. A.
Shaffer et al.
Pelagic marine predators face unprecedented challenges and uncertain
futures. O...
http://links.ealert.nature.com/ctt?kn=102&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Initial radiation of jaws demonstrated stability despite faunal and
environmental change
Philip S. L. Anderson, Matt Friedman, Martin D. Brazeau and Emily J.
Rayfield
More than 99 per cent of the roughly 58,000 living vertebrate species
have jaws...
http://links.ealert.nature.com/ctt?kn=128&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Earth science: Plate motion and mantle plumes
R. Dietmar Muller
A model based on geophysical data from the Indian Ocean suggests that
a mantle-plume head may once have coupled the motions of the African
and Indian tectonic plates, and determined their respective speeds.
http://links.ealert.nature.com/ctt?kn=23&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Saturn: Storm-clouds brooding on towering heights
Peter Read
Springtime on Saturn came in with a bang last December, when a massive
storm erupted in its north temperate zone. This rare event has been
observed in unprecedented detail from the ground and from space.
http://links.ealert.nature.com/ctt?kn=2&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
NEWS & COMMENT
** Climate change: Extra warming near Greenland
http://links.ealert.nature.com/ctt?kn=30&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Up and away
The final mission of the space shuttle heralds difficult days for
space science.
http://links.ealert.nature.com/ctt?kn=109&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: 141 scientists object
Daniel Simberloff
http://links.ealert.nature.com/ctt?kn=79&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: put biodiversity at risk
Andrei Alyokhin
http://links.ealert.nature.com/ctt?kn=77&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: plusses of invasion ecology
Julie L. Lockwood, Martha F. Hoopes and Michael P. Marchetti
http://links.ealert.nature.com/ctt?kn=83&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: four risk factors
Manuel Lerdau and Jacob D. Wickham
http://links.ealert.nature.com/ctt?kn=81&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Nuclear winter was and is debatable
Russell Seitz
http://links.ealert.nature.com/ctt?kn=85&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=54&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
========================
Specials - Technology Feature
========================
** Animal models: Inside the minds of mice and men
Monya Baker
http://links.ealert.nature.com/ctt?kn=61&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
======================== CAREERS & JOBS ========================
** Turbocharge your writing today
Before you can tackle the overwhelming task of huge writing projects,
you must first put aside some widely held myths, say Maria Gardiner
and Hugh Kearns
http://links.ealert.nature.com/ctt?kn=142&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Better teaching needed
Stronger science education is needed to build interest in related
careers.
http://links.ealert.nature.com/ctt?kn=116&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Inside information
Online forum matches queries about employers with answers from current
employees.
http://links.ealert.nature.com/ctt?kn=114&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Women want flexibility
Control of their work schedules helps women to stay in jobs after
childbirth, study finds.
http://links.ealert.nature.com/ctt?kn=112&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Turning point: Job Dekker
Risky research direction pays off for biochemist and award-winning
young investigator Job Dekker.
http://links.ealert.nature.com/ctt?kn=110&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Activation energy
The US Department of Energy must learn from its shoddy response to misconduct allegations.
http://links.ealert.nature.com/ctt?kn=108&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: 141 scientists object
Daniel Simberloff
http://links.ealert.nature.com/ctt?kn=79&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Non-natives: four risk factors
Manuel Lerdau and Jacob D. Wickham
http://links.ealert.nature.com/ctt?kn=81&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** Nuclear winter was and is debatable
Russell Seitz
http://links.ealert.nature.com/ctt?kn=85&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
** All-male line-up yet again
Virginia Valian
http://links.ealert.nature.com/ctt?kn=90&ms=MzY3OTA0NDkS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTA1NjQyMDQ4S0&mt=1&rt=0
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