Nature Chemistry Contents August 2011 Volume 3 Number 8 pp 571-648

TABLE OF CONTENTS August 2011 Volume 3, Issue 8 Editorial Research Highlights Correction News and Views Perspective Articles Corrigendum In Your Element Recommend to your library Web feed Subscribe Advertisement Nature Outlook: Biofuels To find out more about the potential and pitfalls of this sustainable technology, access the Outlook free online for six months. Produced with support from: Biotechnology and Biological Sciences Research Council, BP, Ceres, São Paulo Research Foundation, U.S. Department of Energy's BioEnergy Science Center   Editorial Top The art of abstracts p571 doi:10.1038/nchem.1109 Including pictorial summaries of each article on the table-of-contents pages of a journal makes it just that little bit easier to browse — rather than search — the scientific literature. Full Text | PDF Research Highlights Top Our choice from the recent literature pp572 - 573 doi:10.1038/nchem.1107 Full Text | PDF Blogroll: What's in a name? p573 doi:10.1038/nchem.1104 Full Text | PDF Correction Top Our choice from the recent literature p573 doi:10.1038/nchem.1101 Full Text | PDF News and Views Top Atom-molecule interactions: Beyond billiard-ball collisions pp574 - 575 David W. Chandler doi:10.1038/nchem.1098 The collision of an atom and a diatomic molecule may sound like a simple process but it has long been studied to understand the inherent intricacies of collisional energy transfer. Now, experiments carried out in unprecedented detail on the scattering of NO by Ar have revealed further complexity: parity-dependent quantum interference effects. Full Text | PDF See also: Article by Eyles et al. Bioactive natural products: Function first pp575 - 576 Andrew J. Phillips doi:10.1038/nchem.1105 The synthesis and biological investigation of a family of natural products and unnatural analogues illustrates the importance of considering both form and function in the planning of any synthesis. Full Text | PDF See also: Article by Wender et al. Ligand design: The two faces of carboranes pp577 - 578 Andrew Weller doi:10.1038/nchem.1102 Carborane substituents — rather than alkyl or aryl groups — have now been used to tune ligand properties. Attaching a carborane cluster to a ligand through either a carbon or a boron atom markedly changes its coordination behaviour without altering its steric profile. Full Text | PDF See also: Article by Spokoyny et al. Bifunctional catalysis: A bridge from CO2 to methanol pp578 - 579 Pierre H. Dixneuf doi:10.1038/nchem.1103 Methanol — an important potential fuel and synthetic building block — can be produced via the hydrogenation of carbonates and carbamates using a pincer ruthenium(II) catalyst. Full Text | PDF See also: Article by Balaraman et al. DNA nanotechnology: Geometrical self-assembly pp580 - 581 Andrew J. Turberfield doi:10.1038/nchem.1097 DNA origami tiles with complementary shapes have been designed and assembled into large nanostructures through the geometrically controlled stacking of their helices. Full Text | PDF See also: Article by Woo & Rothemund Chemistry JOBS of the week Postdoctoral Fellowship National Institutes of Health (NIH) Bethesda, MD Research Technician #VTTA01 IMB Mainz Mainz PhD fellowships in Plasmonic, University of technology of Troyes, France Université de technologie de Troyes Troyes, France Scientist – Preclinical Pharmacology / In Vivo Models Roche Switzerland Zurich, Switzerland Professor / Full Professor in (electro)chemistry / physics of materials for energy storage Hasselt University Belgium Diepenbeek More Science jobs from Chemistry EVENT VI Latinoamerican Congress on Biology, Physics and Chemistry of Environment 11.-15.10.11 Peru More science events from Perspective Top Exploring and exploiting chemistry at the cell surface pp582 - 589 Morgan D. Mager, Vanessa LaPointe and Molly M. Stevens doi:10.1038/nchem.1090 When cells interact with an artificial surface, the result is a rapidly evolving and complex interface. This Perspective discusses how expressing the properties of both the cell and the substrate in chemical terms can aid in future material design. We also explore the importance of using multifunctional surfaces with quantitative, dynamic capabilities. Abstract | Full Text | PDF Articles Top A coordination chemistry dichotomy for icosahedral carborane-based ligands pp590 - 596 Alexander M. Spokoyny, Charles W. Machan, Daniel J. Clingerman, Mari S. Rosen, Michael J. Wiester, Robert D. Kennedy, Charlotte L. Stern, Amy A. Sarjeant and Chad A. Mirkin doi:10.1038/nchem.1088 Rather than tuning metal-ligand interactions using carbon-based substituents, the effect of icosahedral carborane moieties — boron-rich clusters — on the coordination chemistry of phosphine-thioether ligands has been investigated. Depending on the positional attachment of the sulfur atom, the carboranes acted as either strong electron-withdrawing or strong electron-donating substituents. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by Weller Interference structures in the differential cross-sections for inelastic scattering of NO by Ar  pp597 - 602 C. J. Eyles, M. Brouard, C.-H. Yang, J. K?os, F. J. Aoiz, A. Gijsbertsen, A. E. Wiskerke and S. Stolte doi:10.1038/nchem.1071 Differential cross sections for the rotationally inelastic scattering of NO by Ar are reported with unprecedented quantum-state resolution. The experiments give important details about the mechanism of this fundamental collisional process, providing evidence for a parity-dependent quantum-mechanical interference effect. Abstract | Full Text | PDF See also: News and Views by Chandler Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA pp603 - 608 Christopher Deck, Mario Jauker and Clemens Richert doi:10.1038/nchem.1086 A long-standing problem with the RNA-world hypothesis is that enzyme-free replication of RNA strands has not been demonstrated. Here, immobilization of a template strand and periodic replacement of a solution containing activated nucleotides allows the copying of unmodified RNA sequences containing any of the four natural nucleobases in near-quantitative yield. Abstract | Full Text | PDF Efficient hydrogenation of organic carbonates, carbamates and formates indicates alternative routes to methanol based on CO2 and CO  pp609 - 614 Ekambaram Balaraman, Chidambaram Gunanathan, Jing Zhang, Linda J. W. Shimon and David Milstein doi:10.1038/nchem.1089 Producing methanol — useful as both a fuel and a synthetic building block — from carbon monoxide and carbon dioxide has been achieved using homogeneous catalytic hydrogenation of carbonates, carbamates and formates. The catalyst is a dearomatized ruthenium(II) pincer complex and the reaction proceeds efficiently under mild conditions. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by Dixneuf Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities pp615 - 619 Paul A. Wender, Nicole Buschmann, Nathan B. Cardin, Lisa R. Jones, Cindy Kan, Jung-Min Kee, John A. Kowalski and Kate E. Longcore doi:10.1038/nchem.1074 The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit remarkable and potent biological activities. A gateway strategy designed to provide general synthetic access to and biological evaluation of natural and non-natural daphnanes is described and used for yuanhuapin analogues. Abstract | Full Text | PDF | Chemical compounds See also: News and Views by Phillips Programmable molecular recognition based on the geometry of DNA nanostructures pp620 - 627 Sungwook Woo and Paul W. K. Rothemund doi:10.1038/nchem.1070 Multiple specific binding interactions have typically been created from DNA using Watson–Crick complementarity. Now, diverse bonds have also been obtained through the geometric arrangement of blunt-end stacking interactions. Two approaches to specific interactions — binary and shape coding — are demonstrated. The thermodynamics and binding rules of the resulting ‘stacking bonds’ are explored. Abstract | Full Text | PDF See also: News and Views by Turberfield Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes pp628 - 633 Jacob C. Carlson, Shengying Li, Shamila S. Gunatilleke, Yojiro Anzai, Douglas A. Burr, Larissa M. Podust and David H. Sherman doi:10.1038/nchem.1087 Enzymes are capable of modifying complex organic structures with exquisite selectivity. Understanding these processes could help in the development and production of new bioactive compounds. Here, a complete reconstitution of tailoring steps in tirandamycin biosynthesis shows that two enzymes repeatedly exchange substrates to achieve several different oxidations en route to this family of antibiotic compounds. Abstract | Full Text | PDF | Chemical compounds Single-atom catalysis of CO oxidation using Pt1/FeOx  pp634 - 641 Botao Qiao, Aiqin Wang, Xiaofeng Yang, Lawrence F. Allard, Zheng Jiang, Yitao Cui, Jingyue Liu, Jun Li and Tao Zhang doi:10.1038/nchem.1095 An important goal for the improvement of certain heterogeneous catalysts is to decrease the amount of platinum required while maintaining high catalytic activity. Now, the practical synthesis of a stable catalyst consisting of isolated single platinum atoms anchored onto iron oxide nanocrystallites has been developed that exhibits high activity for CO oxidation. Abstract | Full Text | PDF Generation and exploitation of acyclic azomethine imines in chiral Brønsted acid catalysis pp642 - 646 Takuya Hashimoto, Hidenori Kimura, Yu Kawamata and Keiji Maruoka doi:10.1038/nchem.1096 Acyclic azomethine imines would be useful prochiral electrophiles in catalytic asymmetric reactions, but their generation often requires harsh conditions. Here, they are generated under mild conditions in the presence of an axially chiral dicarboxylic acid, with the chiral counterion (the conjugate base) then directing an enantioselective reaction with a diazoacetate nucleophile. Abstract | Full Text | PDF | Chemical compounds Corrigendum Top Design principles for oxygen-reduction activity on perovskite oxide catalysts for fuel cells and metal-air batteries p647 Jin Suntivich, Hubert A. Gasteiger, Naoaki Yabuuchi, Haruyuki Nakanishi, John B. Goodenough and Yang Shao-Horn doi:10.1038/nchem.1093 Full Text | PDF In Your Element Top Under sulfur's spell p648 Thomas Rauchfuss doi:10.1038/nchem.1100 Thomas Rauchfuss marvels at the diversity of sulfur reactivity. Although it poisons most industrial catalysts, it adopts many forms in nature and takes on a variety of biological roles — including that of a biocatalyst. 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