Laboratory Investigation - Table of Contents alert Volume 91 Issue 8

TABLE OF CONTENTS Volume 91, Issue 8 (August 2011) In this issue Inside LI Mini Review Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Announcing Open Laboratory Investigation now offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited on PubMed Central at the time of publication and will be freely available immediately. Find out more from the FAQs page.   Inside LI Top Inside Lab Invest 2011 91: 1120-1121; 10.1038/labinvest.2011.106 Abstract | Full Text Mini Review Top The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics This review explores the relationship between mitochondrial genetics and function in cardiovascular disease susceptibility with respect to the evolutionary pressures that likely influenced mitochondrial-nuclear relationships. Moving forward, researchers should consider these factors with respect to experimental design and data interpretation when exploring the basis for individual disease susceptibility. David M Krzywanski, Douglas R Moellering, Jessica L Fetterman, Kimberly J Dunham-Snary, Melissa J Sammy and Scott W Ballinger 2011 91: 1122-1135; advance online publication, June 6, 2011; 10.1038/labinvest.2011.95 Abstract | Full Text Research Articles Top HEPATIC AND PANCREATIC SYSTEMS The nuclear receptor CAR modulates alcohol-induced liver injury The constitutive androstane receptor (CAR) is essential in xenobiotic detoxification. While CAR−/− mice are highly susceptible to alcohol-induced liver injury, pre-activation of CAR enhances the hepatic toxicity of alcohol in wild type but not CAR−/− mice. Drug-induced CAR activation thus enhances alcohol-induced liver injury by suppressing expression of enzymes that metabolize alcohol. Xiaosong Chen, Zhipeng Meng, Xiaoqiong Wang, Samuel Zeng and Wendong Huang 2011 91: 1136-1145; advance online publication, April 25, 2011; 10.1038/labinvest.2011.68 Abstract | Full Text Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma Autophagy is activated in cholangiocarcinoma cells that are resistant to chemotherapeutic agents. Inhibition of autophagy suppresses tumor growth, induces apoptosis and sensitizes cholangiocarcinoma cells to chemotherapy-induced cell death. Thus, regulation of autophagy may influence tumor progression and enhance the therapeutic activity of anti-tumor drugs. Yu-Jie Hou, Li-Wei Dong, Ye-Xiong Tan, Guang-Zhen Yang, Yu-Fei Pan, Zhong Li, Liang Tang, Min Wang, Qing Wang and Hong-Yang Wang 2011 91: 1146-1157; advance online publication, June 6, 2011; 10.1038/labinvest.2011.97 Abstract | Full Text Post liver transplantation acute kidney injury in a rat model of syngeneic orthotopic liver transplantation Acute kidney injury is a frequent complication after liver transplantation. A rat model of syngeneic orthotopic liver transplantation shows that the systemic inflammatory response induced by transplantation is the initiating factor for such kidney damage. Consequently, protection of the liver graft and inhibition of the systemic inflammatory response are vital in reducing the risk of post-liver transplantation acute kidney injury. Jun Wang, Zhiyong Du, Wen Zhang, Baosan Han, Chenghong Peng and Nan Chen 2011 91: 1158-1169; advance online publication, May 23, 2011; 10.1038/labinvest.2011.59 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE Loss of VOPP1 overexpression in squamous carcinoma cells induces apoptosis through oxidative cellular injury VOPP1 is a recently discovered protein that is over-expressed in a variety of cancers and its over-expression exerts a pro-survival effect . Reducing VOPP1 protein levels in carcinoma-derived cell lines results in oxidative stress, which eventually induces the execution of the apoptotic program. Alexander S Baras, Alex Solomon, Robert Davidson and Christopher A Moskaluk 2011 91: 1170-1180; advance online publication, April 25, 2011; 10.1038/labinvest.2011.70 Abstract | Full Text Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis The role of maspin localization in tumor growth and metastasis is revealed by expressing maspin or nuclear-excluded maspin in cells that lack endogenous maspin. Exclusion of maspin from the nucleus abolishes metastasis suppression; only the nuclear form is associated with diminished levels of colony-stimulating factor-1, a cytokine involved in tumor growth and invasion. Brigitte Goulet, Wendy Kennette, Amber Ablack, Carl O Postenka, M Nicole Hague, Joe S Mymryk, Alan B Tuck, Vincent Giguère, Ann F Chambers and John D Lewis 2011 91: 1181-1187; advance online publication, April 18, 2011; 10.1038/labinvest.2011.66 Abstract | Full Text Hydrogen sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling Hydrogen sulfide reduces the basal expression of IL-8, and interferes with IL-17 and IL-22-induced IL-8 production in human keratinocytes. These new observations, taken together with the known anti-inflammatory activity of H2S, are relevant to understanding previously unexplained effects of sulfur-rich balneotherapy in the treatment of psoriasis. Prisco Mirandola, Giuliana Gobbi, Cristina Micheloni, Mauro Vaccarezza, Daniela Di Marcantonio, Francesca Ruscitti, Giuseppe de Panfilis and Marco Vitale 2011 91: 1188-1194; advance online publication, May 9, 2011; 10.1038/labinvest.2011.76 Abstract | Full Text Functional characterization of osteosarcoma cell lines provides representative models to study the human disease Commonly used osteosarcoma cell lines are characterized functionally and phenotypically in vitro and in vivo to determine their usefulness as model systems for the study of osteosarcoma. Upon subcutaneous xenotransplantation, only a subset of the lines displays characteristics of human osteosarcoma, such as extra cellular matrix production, angiogenesis and metastasis. Alexander B Mohseny, Isidro Machado, Yongping Cai, Karl-Ludwig Schaefer, Massimo Serra, Pancras C W Hogendoorn, Antonio Llombart-Bosch and Anne-Marie Cleton-Jansen 2011 91: 1195-1205; advance online publication, April 25, 2011; 10.1038/labinvest.2011.72 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts Fibroblasts from fibroblastic foci in idiopathic pulmonary fibrosis are Thy-1-negative, while most fibroblasts from normal lungs are Thy-1-positive. Loss of Thy-1 induces a fibrogenic phenotype, including increased proliferative and migratory capacity and contraction of collagen. On a molecular level, the Thy-1-negative cells exhibit TGF-β-induced MMP-9 expression, creating a fibrogenic positive feedback loop. Gustavo Ramírez, James S Hagood, Yan Sanders, Remedios Ramírez, Carina Becerril, Lourdes Segura, Lourdes Barrera, Moisés Selman and Annie Pardo 2011 91: 1206-1218; advance online publication, May 16, 2011; 10.1038/labinvest.2011.80 Abstract | Full Text PERIPHERAL AND CENTRAL NERVOUS SYSTEM Loss of functional albumin triggers acceleration of transthyretin amyloid fibril formation in familial amyloidotic polyneuropathy Transthyretin (TTR)-related familial amyloidotic polyneuropathy is characterized by systemic accumulation of TTR amyloid fibrils. The first evidence is presented that albumin, the most abundant protein in plasma, acts as an antioxidant and plays an inhibitory role in the TTR amyloid formation process. Tomoe Kugimiya, Hirofumi Jono, Shiori Saito, Toru Maruyama, Daisuke Kadowaki, Yohei Misumi, Yoshinobu Hoshii, Masayoshi Tasaki, Yu Su, Mitsuharu Ueda, Konen Obayashi, Makoto Shono, Masaki Otagiri and Yukio Ando 2011 91: 1219-1228; advance online publication, May 2, 2011; 10.1038/labinvest.2011.71 Abstract | Full Text MODELS AND TECHNIQUES Bone marrow cell-mediated production of transgenic chickens The successful production of chickens using cells trans-differentiated from adult chicken bone marrow cells transplanted into the testes is demonstrated. This is a novel approach to the production of transgenic poultry, and is a promising advance in stem cell and developmental biology. Young Tae Heo, Sung Ho Lee, Ji Hoon Yang, Teoan Kim and Hoon Taek Lee 2011 91: 1229-1240; advance online publication, April 25, 2011; 10.1038/labinvest.2011.53 Abstract | Full Text Development of an in vitro model of myotube ischemia A model for the study of potential therapeutic agents for critical limb ischemia is described. Monolayers of C2C12 myoblasts can be differentiated into mature myotubes and used to simulate parameters that occur in skeletal muscle ischemia. As proof-of-concept, erythropoietin exhibits tissue protective effects in the model. Dhiraj Joshi, Hemanshu Patel, Daryll M Baker, Xu Shiwen, David J Abraham and Janice C Tsui 2011 91: 1241-1252; advance online publication, May 23, 2011; 10.1038/labinvest.2011.79 Abstract | Full Text Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables Quantitative assessment of the effect of delayed formalin fixation on surgical resections, using biopsies as controls, suggests that measurement of phosphoproteins by immunological methods is dramatically affected by pre-analytic variables. Core needle biopsies suffer less pre-analytic variation and appear to be more valuable for assessment of biomarkers. Yalai Bai, Juliana Tolles, Huan Cheng, Summar Siddiqui, Arun Gopinath, Eirini Pectasides, Robert L Camp, David L Rimm and Annette M Molinaro 2011 91: 1253-1261; advance online publication, April 25, 2011; 10.1038/labinvest.2011.75 Abstract | Full Text Advertisement Ensure your access If you are unable to access the articles in this alert, your library may not subscribe to this journal. Our online recommendation form is a simple way to make your librarian aware that this journal is valuable to your research. Recommend now!   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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