The science that matters. Every week.
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RIKEN RESEARCH - The latest in news and research from RIKEN, Japan's
flagship research organization
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=========================== ADVERTISEMENT ===========================
---THIS WEEK'S HIGHLIGHTS:
--Biological Sciences
-A conditional knockout resource for the genome-wide study of mouse
gene function
Knockout mice in which a specific gene is inactivated are central to
the analysis of gene function and now a new resource that has already
produced thousands of conditional mutations in the C57BL/6 embryonic
stem cells is available for the creation of mutant mice for large-scale
phenotyping programmes.
http://links.ealert.nature.com/ctt?kn=104&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
--Physical Sciences
-Zero outward flow velocity for plasma in a heliosheath transition
layer
Voyager 1, launched in September 1977, has almost left the Solar System
behind. But not quite, as these latest messages from the distant probe
demonstrate.
http://links.ealert.nature.com/ctt?kn=107&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
--Biological Sciences
-Transcriptomic analysis of autistic brain reveals convergent
molecular pathology
Are there many different pathologies presenting as autistic spectrum
disorder (ASD), or do the myriad genetic causes converge on a few
biological pathways affected in most individuals, which could be
therapeutically targeted? A transcriptome and gene co-expression network
analysis suggests that the latter, convergent model, is the case.
http://links.ealert.nature.com/ctt?kn=101&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Liquidator 96 - The Manual Multi-Task Master
Rainin's manual 96-well benchtop liquid handling system delivers
precise, accurate and reproducible results well-to-well, plate-to-plate.
The Liquidator 96 offers flexibility and high-throughput for genomics,
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Fill or transfer between 96 and 384-well plates.
Learn more at www.mt.com/liq96
=====================================================================
--Podcast & Video
-In this week's podcast: cyber warfare, species xenophobia and the
chemistry of water. Plus, the best of the rest from this week's Nature.
http://links.ealert.nature.com/ctt?kn=137&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
--Specials - Insight
-Intestinal networks in health and disease
Four reviews in this issue focus on the dual role of the digestive
tract, as the supplier of nutrients and as a barrier against the
outside world.
http://links.ealert.nature.com/ctt?kn=48&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
=====================================================================
======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=138&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
EDITORIALS
** Contaminated food for thought
If it is to deal effectively with outbreaks of infectious diseases,
Germany must streamline its convoluted systems for reporting and
communication.
http://links.ealert.nature.com/ctt?kn=102&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Full transparency
Nations should release global nuclear-monitoring data to academics
and the public.
http://links.ealert.nature.com/ctt?kn=113&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Great ape debate
Researchers should contribute to a US analysis of the case for
chimpanzee research.
http://links.ealert.nature.com/ctt?kn=114&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
WORLD VIEW
** Poison in party pills is too much to swallow
The harm caused by designer drugs justifies the law's attempts to
keep pace with underground chemists, says Mike Cole.
http://links.ealert.nature.com/ctt?kn=14&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
SEVEN DAYS
** Seven days: 10-16 June 2011
The week in science
http://links.ealert.nature.com/ctt?kn=22&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
NEWS IN FOCUS
** Studies spy on a river's rage
Investigation into this year's Mississippi floods could shape coastal
restoration plans.
http://links.ealert.nature.com/ctt?kn=21&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Life hackers seek new tools
Field aims to enlist techniques from molecular biology to attack
fundamental challenges.
http://links.ealert.nature.com/ctt?kn=20&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Mouse library set to be knockout
Global effort to disable every mouse gene nears completion.
http://links.ealert.nature.com/ctt?kn=29&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Species spellchecker fixes plant glitches
Online tool should weed out misspellings and duplications.
http://links.ealert.nature.com/ctt?kn=28&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Europe tackles huge fraud
Regulators scramble to recover millions of euros awarded to fake
research projects.
http://links.ealert.nature.com/ctt?kn=26&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Egypt invests in its science
Latest budget establishes research as a national priority.
http://links.ealert.nature.com/ctt?kn=24&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
FEATURES
** Animal rights: Chimpanzee research on trial
As pressure from activists builds, the United States is considering
whether it should end invasive experiments in chimpanzees.
http://links.ealert.nature.com/ctt?kn=35&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Physics of life: The dawn of quantum biology
The key to practical quantum computing and high-efficiency solar cells
may lie in the messy green world outside the physics lab.
http://links.ealert.nature.com/ctt?kn=33&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
COMMENT
** Buried by bad decisions
Our brains are hard-wired to make poor choices about harm prevention
in today's world. But we can fight it, says Daniel Gilbert.
http://links.ealert.nature.com/ctt?kn=109&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Democratizing clinical research
Keith Lloyd and Jo White commend a way for patients, clinicians and
scientists to set priorities jointly.
http://links.ealert.nature.com/ctt?kn=111&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
BOOKS AND ARTS
** Virology: Potent tiny packages
Carl Zimmer's primer on viruses entertains, but reveals little about
their basic traits, says Robin Weiss.
http://links.ealert.nature.com/ctt?kn=99&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Techniques: Records in the field
Good notebook skills are vital for documenting observations of the
natural world, finds Sandra Knapp.
http://links.ealert.nature.com/ctt?kn=82&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Books in brief
http://links.ealert.nature.com/ctt?kn=80&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Q&A: The adaptive lyricist
Baba Brinkman is a Canadian rap artist whose award-winning show The
Rap Guide to Evolution wowed UK crowds at the Edinburgh Fringe Festival
during Charles Darwin's bicentenary year. As the show opens next week
for a long summer run off Broadway in New York, Brinkman discusses
rhyme, improvisation and scientific certainty.
http://links.ealert.nature.com/ctt?kn=86&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
CORRESPONDENCE
** Extinctions: conserve not collate
Megan Evans, Hugh Possingham and Kerrie Wilson
http://links.ealert.nature.com/ctt?kn=85&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Extinctions: consider all species
T. M. Brooks
http://links.ealert.nature.com/ctt?kn=90&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Making society more resilient
Akira S. Mori
http://links.ealert.nature.com/ctt?kn=88&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Population decline is a long way off
Robert Wyman
http://links.ealert.nature.com/ctt?kn=94&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Brazilian soya: the argument for
Rachael Garrett
http://links.ealert.nature.com/ctt?kn=92&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Brazilian soya: the argument against
Brenda Baletti
http://links.ealert.nature.com/ctt?kn=129&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Peer reviews: some are already public
Bernd Pulverer
http://links.ealert.nature.com/ctt?kn=130&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Change Chinese returnee rules
Jun Li
http://links.ealert.nature.com/ctt?kn=110&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Worm scientist's identity revealed
Mark J. F. Brown
http://links.ealert.nature.com/ctt?kn=121&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
========================
Specials - Insight: Intestinal Networks in Health and Disease
========================
** Intestinal networks in health and disease
Ulla Weiss
http://links.ealert.nature.com/ctt?kn=118&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Intestinal homeostasis and its breakdown in inflammatory bowel disease
Kevin J. Maloy and Fiona Powrie
http://links.ealert.nature.com/ctt?kn=116&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Genetics and pathogenesis of inflammatory bowel disease
Bernard Khor, Agnes Gardet and Ramnik J. Xavier
http://links.ealert.nature.com/ctt?kn=115&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Microenvironmental regulation of stem cells in intestinal
homeostasis and cancer
Jan Paul Medema and Louis Vermeulen
http://links.ealert.nature.com/ctt?kn=126&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Human nutrition, the gut microbiome and the immune system
Andrew L. Kau, Philip P. Ahern, Nicholas W. Griffin, Andrew L. Goodman and Jeffrey I. Gordon
http://links.ealert.nature.com/ctt?kn=124&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Vilcek Prize For Creative Promise 2012
Biomedical Science
$25,000 Prize
Now Seeking Applications - Deadline August 14th 2011
Vilcek.org
http://links.ealert.nature.com/ctt?kn=136&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
=====================================================================
======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** A conditional knockout resource for the genome-wide study of mouse
gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis,
Wendy Bushell et al.
Gene targeting in embryonic stem cells has become the principal
technology for ...
http://links.ealert.nature.com/ctt?kn=104&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Latent TGF-[bgr] structure and activation
Minlong Shi, Jianghai Zhu, Rui Wang, Xing Chen, Lizhi Mi et al.
Transforming growth factor (TGF)-[bgr] is stored in the extracellular
matrix ...
http://links.ealert.nature.com/ctt?kn=42&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** X-ray structure of a bacterial oligosaccharyltransferase
Christian Lizak, Sabina Gerber, Shin Numao, Markus Aebi and Kaspar
P. Locher
Asparagine-linked glycosylation is a post-translational modification
of protein...
http://links.ealert.nature.com/ctt?kn=44&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Control of visual cortical signals by prefrontal dopamine
Behrad Noudoost and Tirin Moore
The prefrontal cortex is thought to modulate sensory signals in
posterior corti...
http://links.ealert.nature.com/ctt?kn=46&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Forces between clustered stereocilia minimize friction in the ear
on a subnanometre scale
Andrei S. Kozlov, Johannes Baumgart, Thomas Risler, Corstiaen P. C.
Versteegh and A. J. Hudspeth
The detection of sound begins when energy derived from an acoustic
stimulus def...
http://links.ealert.nature.com/ctt?kn=49&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Transcriptomic analysis of autistic brain reveals convergent
molecular pathology
Irina Voineagu, Xinchen Wang, Patrick Johnston, Jennifer K. Lowe,
Yuan Tian et al.
Autism spectrum disorder (ASD) is a common, highly heritable
neurodevelopmental...
http://links.ealert.nature.com/ctt?kn=101&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Detection of prokaryotic mRNA signifies microbial viability and
promotes immunity
Leif E. Sander, Michael J. Davis, Mark V. Boekschoten, Derk Amsen,
Christopher C. Dascher et al.
Live vaccines have long been known to trigger far more vigorous
immune response...
http://links.ealert.nature.com/ctt?kn=38&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Reprogramming transcription by distinct classes of enhancers
functionally defined by eRNA
Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su et al.
Mammalian genomes are populated with thousands of transcriptional
enhancers tha...
http://links.ealert.nature.com/ctt?kn=39&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Converting nonsense codons into sense codons by targeted
pseudouridylation
John Karijolich and Yi-Tao Yu
All three translation termination codons, or nonsense codons, contain
a uridine...
http://links.ealert.nature.com/ctt?kn=40&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Telomere shortening and loss of self-renewal in dyskeratosis
congenita induced pluripotent stem cells
Luis F. Z. Batista, Matthew F. Pech, Franklin L. Zhong, Ha Nam Nguyen,
Kathleen T. Xie et al.
The differentiation of patient-derived induced pluripotent stem cells
(iPSCs) t...
http://links.ealert.nature.com/ctt?kn=41&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** COP1 is a tumour suppressor that causes degradation of ETS
transcription factors
Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen
O'Rourke et al.
The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors
in the E26...
http://links.ealert.nature.com/ctt?kn=71&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** NMDA receptor blockade at rest triggers rapid behavioural
antidepressant responses
Anita E. Autry, Megumi Adachi, Elena Nosyreva, Elisa S. Na, Maarten
F. Los et al.
Clinical studies consistently demonstrate that a single sub-psychomimetic
dose ...
http://links.ealert.nature.com/ctt?kn=123&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Structure-based design of non-natural amino-acid inhibitors of
amyloid fibril formation
Stuart A. Sievers, John Karanicolas, Howard W. Chang, Anni Zhao,
Lin Jiang et al.
Many globular and natively disordered proteins can convert into
amyloid fibrils...
http://links.ealert.nature.com/ctt?kn=122&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors
Erkan Karakas, Noriko Simorowski and Hiro Furukawa
Since it was discovered that the anti-hypertensive agent ifenprodil has neuropr...
http://links.ealert.nature.com/ctt?kn=59&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Structural basis of steroid hormone perception by the receptor
kinase BRI1
Michael Hothorn, Youssef Belkhadir, Marlene Dreux, Tsegaye Dabi,
Joseph. P. Noel et al.
Polyhydroxylated steroids are regulators of body shape and size in
higher organ...
http://links.ealert.nature.com/ctt?kn=51&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Structural insight into brassinosteroid perception by BRI1
Ji She, Zhifu Han, Tae-Wuk Kim, Jinjing Wang, Wei Cheng et al.
Brassinosteroids are essential phytohormones that have crucial roles
in plant g...
http://links.ealert.nature.com/ctt?kn=52&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Animal behaviour: Born leaders
Franz J. Weissing
In animals that live in groups, some individuals are leaders and others
are followers. A modelling study shows that variation in leadership
evolves spontaneously and need not be related to differences in knowledge
or power.
http://links.ealert.nature.com/ctt?kn=69&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Protein synthesis: Stop the nonsense
Adrian R. Ferre-D'Amare
A subtle biochemical alteration can reprogram signals that herald the
termination of protein translation into signals encoding amino acids
at the level of messenger RNA [mdash] and without altering the
corresponding DNA.
http://links.ealert.nature.com/ctt?kn=70&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Structural biology: Porthole to catalysis
Reid Gilmore
The crystal structure of a sugar-transferring enzyme offers insight
into the mechanism of a ubiquitous protein-modification reaction, and
solves the mystery of how the enzyme recognizes certain sequences in
proteins.
http://links.ealert.nature.com/ctt?kn=67&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Gene expression: The autism disconnect
Zeljka Korade and Karoly Mirnics
Separating primary from secondary changes in the autistic brain has
long been a research goal. With knowledge of wide-ranging molecular
deficits, identification of the best therapeutic targets becomes a
priority.
http://links.ealert.nature.com/ctt?kn=68&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
NEWS & COMMENT
** Animal behaviour: Fitter fish lead the pack
http://links.ealert.nature.com/ctt?kn=65&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Cancer therapeutics: Targeted drug fights melanoma
http://links.ealert.nature.com/ctt?kn=66&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Neurogenetics: Extended hunt for autism genes
http://links.ealert.nature.com/ctt?kn=63&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Neuroscience: How nicotine curbs weight gain
http://links.ealert.nature.com/ctt?kn=64&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Biophysics: Fluorescent cells turned into lasers
http://links.ealert.nature.com/ctt?kn=60&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Metagenomics: Movies of the body's bacteria
http://links.ealert.nature.com/ctt?kn=9&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Contaminated food for thought
If it is to deal effectively with outbreaks of infectious diseases,
Germany must streamline its convoluted systems for reporting and
communication.
http://links.ealert.nature.com/ctt?kn=102&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Great ape debate
Researchers should contribute to a US analysis of the case for
chimpanzee research.
http://links.ealert.nature.com/ctt?kn=114&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Democratizing clinical research
Keith Lloyd and Jo White commend a way for patients, clinicians and
scientists to set priorities jointly.
http://links.ealert.nature.com/ctt?kn=111&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Virology: Potent tiny packages
Carl Zimmer's primer on viruses entertains, but reveals little about
their basic traits, says Robin Weiss.
http://links.ealert.nature.com/ctt?kn=99&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Books in brief
http://links.ealert.nature.com/ctt?kn=80&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Q&A: The adaptive lyricist
Baba Brinkman is a Canadian rap artist whose award-winning show The
Rap Guide to Evolution wowed UK crowds at the Edinburgh Fringe Festival
during Charles Darwin's bicentenary year. As the show opens next week
for a long summer run off Broadway in New York, Brinkman discusses
rhyme, improvisation and scientific certainty.
http://links.ealert.nature.com/ctt?kn=86&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Extinctions: conserve not collate
Megan Evans, Hugh Possingham and Kerrie Wilson
http://links.ealert.nature.com/ctt?kn=85&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Extinctions: consider all species
T. M. Brooks
http://links.ealert.nature.com/ctt?kn=90&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Making society more resilient
Akira S. Mori
http://links.ealert.nature.com/ctt?kn=88&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Population decline is a long way off
Robert Wyman
http://links.ealert.nature.com/ctt?kn=94&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Brazilian soya: the argument for
Rachael Garrett
http://links.ealert.nature.com/ctt?kn=92&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Brazilian soya: the argument against
Brenda Baletti
http://links.ealert.nature.com/ctt?kn=129&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Worm scientist's identity revealed
Mark J. F. Brown
http://links.ealert.nature.com/ctt?kn=121&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=75&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
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=====================================================================
======================== CHEMICAL SCIENCES ========================
RESEARCH
** X-ray structure of a bacterial oligosaccharyltransferase
Christian Lizak, Sabina Gerber, Shin Numao, Markus Aebi and Kaspar
P. Locher
Asparagine-linked glycosylation is a post-translational modification
of protein...
http://links.ealert.nature.com/ctt?kn=44&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Modular and predictable assembly of porous organic molecular
crystals
James T. A. Jones, Tom Hasell, Xiaofeng Wu, John Bacsa, Kim E.
Jelfs et al.
Nanoporous molecular frameworks are important in applications
such as separatio...
http://links.ealert.nature.com/ctt?kn=10&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Reprogramming transcription by distinct classes of enhancers
functionally defined by eRNA
Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su et al.
Mammalian genomes are populated with thousands of transcriptional
enhancers tha...
http://links.ealert.nature.com/ctt?kn=39&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Converting nonsense codons into sense codons by targeted
pseudouridylation
John Karijolich and Yi-Tao Yu
All three translation termination codons, or nonsense codons,
contain a uridine...
http://links.ealert.nature.com/ctt?kn=40&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** COP1 is a tumour suppressor that causes degradation of ETS
transcription factors
Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen
O'Rourke et al.
The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription
factors in the E26...
http://links.ealert.nature.com/ctt?kn=71&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
Stuart A. Sievers, John Karanicolas, Howard W. Chang, Anni Zhao, Lin Jiang et al.
Many globular and natively disordered proteins can convert into amyloid fibrils...
http://links.ealert.nature.com/ctt?kn=122&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B
NMDA receptors
Erkan Karakas, Noriko Simorowski and Hiro Furukawa
Since it was discovered that the anti-hypertensive agent ifenprodil
has neuropr...
http://links.ealert.nature.com/ctt?kn=59&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Protein synthesis: Stop the nonsense
Adrian R. Ferre-D'Amare
A subtle biochemical alteration can reprogram signals that herald
the termination of protein translation into signals encoding amino
acids at the level of messenger RNA [mdash] and without altering the
corresponding DNA.
http://links.ealert.nature.com/ctt?kn=70&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Structural biology: Porthole to catalysis
Reid Gilmore
The crystal structure of a sugar-transferring enzyme offers insight
into the mechanism of a ubiquitous protein-modification reaction, and
solves the mystery of how the enzyme recognizes certain sequences in
proteins.
http://links.ealert.nature.com/ctt?kn=67&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
NEWS & COMMENT
** Chemistry: Recipe for a good catalyst
http://links.ealert.nature.com/ctt?kn=11&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=47&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
======================== PHYSICAL SCIENCES ========================
RESEARCH
** Black hole growth in the early Universe is self-regulated and
largely hidden from view
Ezequiel Treister, Kevin Schawinski, Marta Volonteri, Priyamvada
Natarajan and Eric Gawiser
The formation of the first massive objects in the infant Universe
remains impos...
http://links.ealert.nature.com/ctt?kn=12&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Zero outward flow velocity for plasma in a heliosheath transition
layer
Stamatios M. Krimigis, Edmond C. Roelof, Robert B. Decker and Matthew
E. Hill
Voyager 1 has been in the reservoir of energetic ions and electrons
that consti...
http://links.ealert.nature.com/ctt?kn=107&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Emerging local Kondo screening and spatial coherence in the
heavy-fermion metal YbRh2Si2
S. Ernst, S. Kirchner, C. Krellner, C. Geibel, G. Zwicknagl et al.
The entanglement of quantum states is both a central concept in
fundamental phy...
http://links.ealert.nature.com/ctt?kn=1&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Forces between clustered stereocilia minimize friction in the ear
on a subnanometre scale
Andrei S. Kozlov, Johannes Baumgart, Thomas Risler, Corstiaen P. C.
Versteegh and A. J. Hudspeth
The detection of sound begins when energy derived from an acoustic
stimulus def...
http://links.ealert.nature.com/ctt?kn=49&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Condensed-matter physics: Microscopy of the macroscopic
Piers Coleman
The presence of magnetic moments in materials known as Kondo lattices
can lead to an exotic transformation in their properties. The first
successful endeavour into imaging such a transformation has now been
made.
http://links.ealert.nature.com/ctt?kn=2&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Astrophysics: Early black holes uncovered
Alexey Vikhlinin
Collective X-ray emission from distant galaxies reveals a hidden
population of supermassive black holes. This finding suggests that
galaxies and their central black holes have been coevolving since early
cosmic times.
http://links.ealert.nature.com/ctt?kn=4&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
NEWS & COMMENT
** Photonics: Rainbow from a single LED
http://links.ealert.nature.com/ctt?kn=5&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Books in brief
http://links.ealert.nature.com/ctt?kn=80&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=58&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Earthquakes: The lessons of Tohoku-Oki
Jean-Philippe Avouac
An exceptional data set documents surface deformation before, during and
after the earthquake that struck northeastern Japan in March 2011. But
models for assessing seismic and tsunami hazard remain inadequate.
http://links.ealert.nature.com/ctt?kn=6&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Coseismic and postseismic slip of the 2011 magnitude-9 Tohoku-Oki
earthquake
Shinzaburo Ozawa, Takuya Nishimura, Hisashi Suito, Tomokazu Kobayashi,
Mikio Tobita et al.
Most large earthquakes occur along an oceanic trench, where an oceanic
plate su...
http://links.ealert.nature.com/ctt?kn=7&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
NEWS & COMMENT
** Geochemistry: Mercury on the decline
http://links.ealert.nature.com/ctt?kn=25&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Full transparency
Nations should release global nuclear-monitoring data to academics
and the public.
http://links.ealert.nature.com/ctt?kn=113&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Books in brief
http://links.ealert.nature.com/ctt?kn=80&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=57&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
CAREERS
** Fieldwork: Close quarters
http://links.ealert.nature.com/ctt?kn=32&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
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Produced with support from: YAKULT HONSHA CO., LTD
=====================================================================
======================== CAREERS & JOBS ========================
** Fieldwork: Close quarters
Cramped living conditions, unruly colleagues or crowded schedules can
be challenging for the most intrepid scientist.
http://links.ealert.nature.com/ctt?kn=144&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Postdocs with promise
UK university offers fellowships leading to academic posts.
http://links.ealert.nature.com/ctt?kn=98&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Research centres open
Early-career scientists sought to join collaborative institutions in
Germany.
http://links.ealert.nature.com/ctt?kn=119&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Women feel isolated
Isolation and lack of confidence hold back careers of female postdocs,
says US association.
http://links.ealert.nature.com/ctt?kn=117&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Democratizing clinical research
Keith Lloyd and Jo White commend a way for patients, clinicians and
scientists to set priorities jointly.
http://links.ealert.nature.com/ctt?kn=111&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Making society more resilient
Akira S. Mori
http://links.ealert.nature.com/ctt?kn=88&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Population decline is a long way off
Robert Wyman
http://links.ealert.nature.com/ctt?kn=94&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Brazilian soya: the argument for
Rachael Garrett
http://links.ealert.nature.com/ctt?kn=92&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Brazilian soya: the argument against
Brenda Baletti
http://links.ealert.nature.com/ctt?kn=129&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Peer reviews: some are already public
Bernd Pulverer
http://links.ealert.nature.com/ctt?kn=130&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
** Change Chinese returnee rules
Jun Li
http://links.ealert.nature.com/ctt?kn=110&ms=MzY3MTc2ODES1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAzOTIzNTg3S0&mt=1&rt=0
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