The EDGE: Nature contents: 26 May 2011

Nature Alert
The science that matters. Every week.

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View Table of Contents http://links.ealert.nature.com/ctt?kn=58&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

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=========================== ADVERTISEMENT ===========================

---THIS WEEK'S HIGHLIGHTS:

--Biological Sciences
-A 2020 vision for vaccines against HIV, tuberculosis and malaria
Virologists Rino Rappuoli and Alan Aderem anticipate significant
advances in the science of rational design. By 2020, they say,
vaccination should be capable of reversing the spread of HIV/AIDS,
malaria and tuberculosis.
http://links.ealert.nature.com/ctt?kn=111&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

--Earth & Environmental Sciences
-Hf-W-Th evidence for rapid growth of Mars and its status as a planetary embryo
Hafnium-tungsten-thorium isotope data suggest that Mars accreted very
rapidly to reach about half of its present size in two million years or
less, and subsequently avoided colliding and merging with other planets.
This may explain why Mars is much smaller than Venus and Earth.
http://links.ealert.nature.com/ctt?kn=113&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

--Physical Sciences
-Improved measurement of the shape of the electron
The standard model of particle physics predicts that the electron is
not quite a perfect sphere. But new experiments, at the highest
resolution yet, fail to reveal any deviation from the spherical.
http://links.ealert.nature.com/ctt?kn=108&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

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RIKEN RESEARCH - The latest in news and research from RIKEN, Japan's
flagship research organization http://links.ealert.nature.com/ctt?kn=25&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

Research highlights:
New tool for proton spin | Sugar synthesis hits the sweet spot | Following directions

News, research highlights and in-depth interviews with RIKEN's leading
researchers, updated weekly and all completely free.
Keep up to date by registering for the weekly email alert!
http://links.ealert.nature.com/ctt?kn=13&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

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--Podcast & Video
-On the show this week, we go diving with giant shrimp, have a stab at
making people say yes to vaccines, measure the roundness of the electron
and go to a science fiction exhibition. Plus, the best of the rest
from this week's Nature.
http://links.ealert.nature.com/ctt?kn=77&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

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======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=141&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

EDITORIALS
** The long game
Graphene is not a miracle material, just a very promising one. It will
take restraint and sustained interest to deliver its potential.
http://links.ealert.nature.com/ctt?kn=109&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Copy and paste
A slow university investigation into serious accusations of misconduct
benefits no one.
http://links.ealert.nature.com/ctt?kn=118&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Modern heroes
The great achievements of vaccines are not consigned to the past.
http://links.ealert.nature.com/ctt?kn=119&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

WORLD VIEW
** Can Europe build a framework for success?
The European Framework programme, one of the world's largest science
funders, has improved its reputation. Not by enough, says Colin
Macilwain
http://links.ealert.nature.com/ctt?kn=40&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

SEVEN DAYS
** Seven days: 20-26 May 2011
The week in science
http://links.ealert.nature.com/ctt?kn=24&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

NEWS
** Polio clings on in Pakistan
Fears grow that health-service reforms may let virus flourish, just as
the global eradication effort reaches its endgame.
http://links.ealert.nature.com/ctt?kn=23&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Russia revitalizes science
Researchers drawn by 'mega-grants' find rewards and frustrations in
equal measure.
http://links.ealert.nature.com/ctt?kn=22&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Global health funding: Revamp for WHO
Critics call for restructuring of world health body, together with
greater focus on fewer issues.
http://links.ealert.nature.com/ctt?kn=31&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Change rattles the world's biggest dish
After nearly half a century, Cornell University loses stewardship of
the renowned Arecibo radio telescope.
http://links.ealert.nature.com/ctt?kn=30&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Evidence of altered RNA stirs debate
Sceptics question find that upends biology's 'central dogma'.
http://links.ealert.nature.com/ctt?kn=28&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Therapeutic success stifles medical progress
Drug development loses momentum as patients shun clinical trials for
tried and tested treatments. Could payment for participation be the
answer?
http://links.ealert.nature.com/ctt?kn=26&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

FEATURES
** Vaccines: The case of measles
Great advances in the development and distribution of vaccines mean
that some diseases can be eradicated. Measles is an important case
study: efforts to stem the disease have been successful, but uneven
political commitment, lack of funds and public fear threaten to
undermine the progress.
http://links.ealert.nature.com/ctt?kn=37&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Vaccines: The real issues in vaccine safety
Hysteria about false vaccine risks often overshadows the challenges
of detecting the real ones.
http://links.ealert.nature.com/ctt?kn=35&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Vaccines: His best shot
Can Bruce Walker transform HIV vaccine research?
http://links.ealert.nature.com/ctt?kn=14&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

COMMENT
** Target the fence-sitters
Past waves of vaccine rejection in industrialized nations have a lot
to teach us about preventing future ones, argues Julie Leask.
http://links.ealert.nature.com/ctt?kn=114&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Lessons from polio eradication
Ridding the world of polio requires a global initiative that tailors
strategies to communities, say Heidi J. Larson and Isaac Ghinai.
http://links.ealert.nature.com/ctt?kn=116&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

BOOKS AND ARTS
** Technology: Charging towards the superbattery
Lithium-ion technology is bringing us closer to solving energy and
transport problems, finds Bruno Scrosati.
http://links.ealert.nature.com/ctt?kn=106&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Neuroscience: What makes us laugh
Humour is the brain's reward for discovering unexpected errors, says
Appletree Rodden.
http://links.ealert.nature.com/ctt?kn=86&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Art: Body work
Genetics and artificial intelligence figure prominently in an
unsettling Dublin exhibition, discovers Anthony King.
http://links.ealert.nature.com/ctt?kn=93&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

CORRESPONDENCE
** Peer reviews: in praise of referees
Eric L. Altschuler
http://links.ealert.nature.com/ctt?kn=91&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Peer reviews: make them public
Daniel Mietchen
http://links.ealert.nature.com/ctt?kn=97&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Cooperation is key to Asian hydropower
Lishan Ran and X. X. Lu
http://links.ealert.nature.com/ctt?kn=95&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Seeking out Earth's warning signals
Friedemann Freund
http://links.ealert.nature.com/ctt?kn=100&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Can Facebook influence funding?
Paolo Zamboni
http://links.ealert.nature.com/ctt?kn=99&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

CORRIGENDA
** Senescence and tumour clearance is triggered by p53 restoration in
murine liver carcinomas
http://links.ealert.nature.com/ctt?kn=74&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** A map of human genome variation from population-scale sequencing
http://links.ealert.nature.com/ctt?kn=71&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Diphthamide biosynthesis requires an organic radical generated by
an iron-sulphur enzyme
http://links.ealert.nature.com/ctt?kn=72&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

========================
Specials - Outlook: Hepatitis C
========================
** Perspective: Test and treat this silent killer
Brian R. Edlin
The scourge of the hepatitis C virus in the United States is woefully
underestimated. Brian R. Edlin reckons it's time the infection is
given the priority it demands in this early release article for the
upcoming Outlook on Hepatitis C.
http://links.ealert.nature.com/ctt?kn=32&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

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essay competition. We invite aspiring science writers to submit an
'In Your Element'-style essay on any one of the following elements
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Further details are available here:
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======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Royalactin induces queen differentiation in honeybees
Masaki Kamakura
The honeybee (Apis mellifera) forms two female castes: the queen and
the worker...
http://links.ealert.nature.com/ctt?kn=127&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Probing cellular protein complexes using single-molecule pull-down
Ankur Jain, Ruijie Liu, Biswarathan Ramani, Edwin Arauz,
Yuji Ishitsuka et al.
Proteins perform most cellular functions in macromolecular complexes.
The same ...
http://links.ealert.nature.com/ctt?kn=126&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Earth's earliest non-marine eukaryotes
Paul K. Strother, Leila Battison, Martin D. Brasier and Charles H. Wellman
The existence of a terrestrial Precambrian (more than 542Myr ago) bio...
http://links.ealert.nature.com/ctt?kn=63&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** A giant Ordovician anomalocaridid
Peter Van Roy and Derek E. G. Briggs
Anomalocaridids, giant lightly sclerotized invertebrate predators,
occur in a n...
http://links.ealert.nature.com/ctt?kn=51&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Learning-related feedforward inhibitory connectivity growth required
for memory precision
Sarah Ruediger, Claudia Vittori, Ewa Bednarek, Christel Genoud,
Piergiorgio Strata et al.
In the adult brain, new synapses are formed and pre-existing ones
are lost, but...
http://links.ealert.nature.com/ctt?kn=52&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Long-term evolution and transmission dynamics of swine
influenza A virus
Dhanasekaran Vijaykrishna, Gavin J. D. Smith, Oliver G. Pybus,
Huachen Zhu, Samir Bhatt et al.
Swine influenza A viruses (SwIV) cause significant economic losses
in animal hu...
http://links.ealert.nature.com/ctt?kn=45&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Profound early control of highly pathogenic SIV by an effector
memory T-cell vaccine
Scott G. Hansen, Julia C. Ford, Matthew S. Lewis, Abigail B. Ventura,
Colette M. Hughes et al.
The acquired immunodeficiency syndrome (AIDS)-causing lentiviruses
human immuno...
http://links.ealert.nature.com/ctt?kn=47&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Aberrant lipid metabolism disrupts calcium homeostasis causing liver
endoplasmic reticulum stress in obesity
Suneng Fu, Ling Yang, Ping Li, Oliver Hofmann, Lee Dicker et al.
The endoplasmic reticulum (ER) is the main site of protein and lipid
synthesis,...
http://links.ealert.nature.com/ctt?kn=48&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Neural crest regulates myogenesis through the transient activation
of NOTCH
Anne C. Rios, Olivier Serralbo, David Salgado and Christophe Marcelle
How dynamic signalling and extensive tissue rearrangements interact
to generate...
http://links.ealert.nature.com/ctt?kn=50&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Structure of the spliceosomal U4 snRNP core domain and its
implication for snRNP biogenesis
Adelaine K. W. Leung, Kiyoshi Nagai and Jade Li
The spliceosome is a dynamic macromolecular machine that assembles
on pre-messe...
http://links.ealert.nature.com/ctt?kn=41&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Improved molecular replacement by density- and energy-guided protein
structure optimization
Frank DiMaio, Thomas C. Terwilliger, Randy J. Read, Alexander Wlodawer,
Gustav Oberdorfer et al.
Molecular replacement procedures, which search for placements of a
starting mod...
http://links.ealert.nature.com/ctt?kn=42&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Role of the ubiquitin-like protein Hub1 in splice-site usage and
alternative splicing
Shravan Kumar Mishra, Tim Ammon, Grzegorz M. Popowicz, Marcin Krajewski,
Roland J. Nagel et al.
Alternative splicing of pre-messenger RNAs diversifies gene products
in eukaryo...
http://links.ealert.nature.com/ctt?kn=133&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Transcriptomic analysis of autistic brain reveals convergent
molecular pathology
Irina Voineagu, Xinchen Wang, Patrick Johnston, Jennifer K. Lowe,
Yuan Tian et al.
Autism spectrum disorder (ASD) is a common, highly heritable
neurodevelopmental...
http://links.ealert.nature.com/ctt?kn=134&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** A nuclear-receptor-dependent phosphatidylcholine pathway with
antidiabetic effects
Jae Man Lee, Yoon Kwang Lee, Jennifer L. Mamrosh, Scott A. Busby,
Patrick R. Griffin et al.
Nuclear hormone receptors regulate diverse metabolic pathways and
the orphan nu...
http://links.ealert.nature.com/ctt?kn=115&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction
factor counteracted by Vpx
Nadine Laguette, Bijan Sobhian, Nicoletta Casartelli, Mathieu Ringeard,
Christine Chable-Bessia et al.
The primate lentivirus auxiliary protein Vpx counteracts an unknown
restriction...
http://links.ealert.nature.com/ctt?kn=125&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Determinants of nucleosome organization in primary human cells
Anton Valouev, Steven M. Johnson, Scott D. Boyd, Cheryl L. Smith,
Andrew Z. Fire et al.
Nucleosomes are the basic packaging units of chromatin, modulating a
ccessibilit...
http://links.ealert.nature.com/ctt?kn=122&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Tunable pKa values and the basis of opposite charge selectivities
in nicotinic-type receptors
Gisela D. Cymes and Claudio Grosman
Among ion channels, only the nicotinic-receptor superfamily has evolved
to gene...
http://links.ealert.nature.com/ctt?kn=121&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Detection of prokaryotic mRNA signifies microbial viability and
promotes immunity
Leif E. Sander, Michael J. Davis, Mark V. Boekschoten, Derk Amsen,
Christopher C. Dascher et al.
Live vaccines have long been known to trigger far more vigorous
immune response...
http://links.ealert.nature.com/ctt?kn=120&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Forces between clustered stereocilia minimize friction in the ear
on a subnanometre scale
Andrei S. Kozlov, Johannes Baumgart, Thomas Risler, Corstiaen P. C.
Versteegh and A. J. Hudspeth
The detection of sound begins when energy derived from an acoustic
stimulus def...
http://links.ealert.nature.com/ctt?kn=130&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Telomere shortening and loss of self-renewal in dyskeratosis
congenita induced pluripotent stem cells
Luis F. Z. Batista, Matthew F. Pech, Franklin L. Zhong, Ha Nam Nguyen,
Kathleen T. Xie et al.
The differentiation of patient-derived induced pluripotent stem cells
(iPSCs) t...
http://links.ealert.nature.com/ctt?kn=128&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Entomology: Royal aspirations
Gene E. Robinson
What makes a queen honeybee? The proposal of a definitive answer to
this long-standing question offers much royal food for thought for
those studying the evolution of social traits and insect genomes.
http://links.ealert.nature.com/ctt?kn=43&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Vaccinology: Persistence pays off
R. Paul Johnson
Developing AIDS vaccines has been a frustrating business. A vaccine
that triggers immune responses that effectively control early infection
by the simian counterpart of HIV in macaques seems promising.
http://links.ealert.nature.com/ctt?kn=44&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Medicinal chemistry: New lead for pain treatment
Sarah E. Reisman
The synthesis of conolidine, a scarce, naturally occurring compound,
has enabled the first studies of its pharmacological properties to be
carried out. Excitingly, conolidine is a painkiller that seems to have
an unusual mechanism of action.
http://links.ealert.nature.com/ctt?kn=75&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Protein-protein interactions: Pull-down for single molecules
Philip Tinnefeld
An innovative marriage of techniques, combining the principles of common
protein pull-down assays with single-molecule fluorescence microscopy,
opens up new ways of visualizing cellular protein complexes.
http://links.ealert.nature.com/ctt?kn=73&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** A 2020 vision for vaccines against HIV, tuberculosis and malaria
Rino Rappuoli and Alan Aderem
Acquired immune deficiency syndrome (AIDS), malaria and tuberculosis
collective...
http://links.ealert.nature.com/ctt?kn=111&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

NEWS & COMMENT
** Palaeontology: Stronger smell, bigger brain
http://links.ealert.nature.com/ctt?kn=69&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Cognitive neuroscience: Scenes deciphered from spaces
http://links.ealert.nature.com/ctt?kn=70&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Ecology: Parasites make their hosts hide
http://links.ealert.nature.com/ctt?kn=67&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Metabolic engineering: Bacterial chemical factories
http://links.ealert.nature.com/ctt?kn=68&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Neuroscience: Rapid recovery from stroke
http://links.ealert.nature.com/ctt?kn=64&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Genetics: Genetics of malaria severity
http://links.ealert.nature.com/ctt?kn=9&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Cancer: Radiation's double whammy
http://links.ealert.nature.com/ctt?kn=10&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Modern heroes
The great achievements of vaccines are not consigned to the past.
http://links.ealert.nature.com/ctt?kn=119&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Target the fence-sitters
Past waves of vaccine rejection in industrialized nations have a lot
to teach us about preventing future ones, argues Julie Leask.
http://links.ealert.nature.com/ctt?kn=114&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Can Facebook influence funding?
Paolo Zamboni
http://links.ealert.nature.com/ctt?kn=99&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=81&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Reviews Key Advances in Medicine 2010

A new eBook of 44 essays highlighting the key advances in medical
research last year, written by leading international clinical
researchers.

Covering: cardiology, clinical oncology, endocrinology,
gastroenterology and hepatology, nephrology, neurology,
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Available now:
http://links.ealert.nature.com/ctt?kn=104&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

=====================================================================

======================== CHEMICAL SCIENCES ========================
RESEARCH
** Probing cellular protein complexes using single-molecule pull-down
Ankur Jain, Ruijie Liu, Biswarathan Ramani, Edwin Arauz, Yuji Ishitsuka
et al.
Proteins perform most cellular functions in macromolecular complexes.
The same ...
http://links.ealert.nature.com/ctt?kn=126&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Structure of the spliceosomal U4 snRNP core domain and its implication
for snRNP biogenesis
Adelaine K. W. Leung, Kiyoshi Nagai and Jade Li
The spliceosome is a dynamic macromolecular machine that assembles on
pre-messe...
http://links.ealert.nature.com/ctt?kn=41&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Medicinal chemistry: New lead for pain treatment
Sarah E. Reisman
The synthesis of conolidine, a scarce, naturally occurring compound,
has enabled the first studies of its pharmacological properties to be
carried out. Excitingly, conolidine is a painkiller that seems to
have an unusual mechanism of action.
http://links.ealert.nature.com/ctt?kn=75&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Protein-protein interactions: Pull-down for single molecules
Philip Tinnefeld
An innovative marriage of techniques, combining the principles of
common protein pull-down assays with single-molecule fluorescence
microscopy, opens up new ways of visualizing cellular protein complexes.
http://links.ealert.nature.com/ctt?kn=73&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Catalysis for fluorination and trifluoromethylation
Takeru Furuya, Adam S. Kamlet and Tobias Ritter
Recent advances in catalysis have made the incorporation of fluorine
into compl...
http://links.ealert.nature.com/ctt?kn=11&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

NEWS & COMMENT
** Metabolic engineering: Bacterial chemical factories
http://links.ealert.nature.com/ctt?kn=68&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=49&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

========================
PHYSICAL SCIENCES
========================
RESEARCH
** Improved measurement of the shape of the electron
J. J. Hudson, D. M. Kara, I. J. Smallman, B. E. Sauer, M. R. Tarbutt
et al.
The electron is predicted to be slightly aspheric, with a distortion
characteri...
http://links.ealert.nature.com/ctt?kn=108&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Interannual atmospheric variability forced by the deep equatorial
Atlantic Ocean
Peter Brandt, Andreas Funk, Verena Hormann, Marcus Dengler, Richard
J. Greatbatch et al.
Climate variability in the tropical Atlantic Ocean is determined by
large-scale...
http://links.ealert.nature.com/ctt?kn=1&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** A hydrothermal origin for isotopically anomalous cap dolostone
cements from south China
Thomas F. Bristow, Magali Bonifacie, Arkadiusz Derkowski, John M.
Eiler and John P. Grotzinger
The release of methane into the atmosphere through destabilization
of clathrate...
http://links.ealert.nature.com/ctt?kn=12&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Applied physics: A stroke of X-ray
Stefan Kneip
X-rays were discovered more than 100 years ago. They have since become
a staple tool for medicine and science, so researchers are continuing
their efforts to find innovative ways to produce them.
http://links.ealert.nature.com/ctt?kn=2&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Precision measurement: A search for electrons that do the twist
Aaron E. Leanhardt
One might think that physicists know everything about the electron. But
the latest measurement of its shape could alter expectations for results
at high-energy particle accelerators.
http://links.ealert.nature.com/ctt?kn=4&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

NEWS & COMMENT
** Planetary science: Carbon monoxide on Pluto
http://links.ealert.nature.com/ctt?kn=5&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Engineering: See-through solar cells
http://links.ealert.nature.com/ctt?kn=6&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** The long game
Graphene is not a miracle material, just a very promising one. It will
take restraint and sustained interest to deliver its potential.
http://links.ealert.nature.com/ctt?kn=109&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Technology: Charging towards the superbattery
Lithium-ion technology is bringing us closer to solving energy and
transport problems, finds Bruno Scrosati.
http://links.ealert.nature.com/ctt?kn=106&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=88&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Cooperation is key to Asian hydropower
Lishan Ran and X. X. Lu
http://links.ealert.nature.com/ctt?kn=95&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

CAREERS
** Gender divide in physics spans globe
http://links.ealert.nature.com/ctt?kn=7&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=61&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Hf-W-Th evidence for rapid growth of Mars and its status as a
planetary embryo
N. Dauphas and A. Pourmand
Terrestrial planets are thought to have formed through collisions
between large...
http://links.ealert.nature.com/ctt?kn=113&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Inferring nonlinear mantle rheology from the shape of the Hawaiian
swell
N. Asaadi, N. M. Ribe and F. Sobouti
The convective circulation generated within the Earth's mantle by
buoya...
http://links.ealert.nature.com/ctt?kn=27&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Earth's earliest non-marine eukaryotes
Paul K. Strother, Leila Battison, Martin D. Brasier and Charles H.
Wellman
The existence of a terrestrial Precambrian (more than 542Myr ago) bio...
http://links.ealert.nature.com/ctt?kn=63&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Planetary science: Building a planet in record time
Alan Brandon
It seems that Mars had grown to near its present size by 2 million to
4 million years after the Solar System began to form. Such rapid growth
explains why the planet is much smaller than Earth and Venus.
http://links.ealert.nature.com/ctt?kn=34&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

NEWS & COMMENT
** Geophysics: Glacial biography of Greenland
http://links.ealert.nature.com/ctt?kn=36&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Cooperation is key to Asian hydropower
Lishan Ran and X. X. Lu
http://links.ealert.nature.com/ctt?kn=95&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Seeking out Earth's warning signals
Friedemann Freund
http://links.ealert.nature.com/ctt?kn=100&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=60&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

========================
Specials - Outlook: Hepatitis C
========================
** Perspective: Test and treat this silent killer
Brian R. Edlin
http://links.ealert.nature.com/ctt?kn=32&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Special: Vaccines

Vaccines are responsible for some of the world�s greatest public health
triumphs. In the past decade, vaccines against leading killer diseases
have been introduced, and more are on the way. But funding is tight,
and unfounded doubts about the safety of vaccines persist. Nature
explores the social and scientific challenges facing this key weapon
in the twenty-first century�s medical armoury.

Access the Special online.
http://links.ealert.nature.com/ctt?kn=57&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

=====================================================================

======================== CAREERS & JOBS ========================
** Lab personnel: Technically gifted
A good technician can be vital to a successful lab. But how to become
one, and how to select the best in a diverse market?
http://links.ealert.nature.com/ctt?kn=147&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Gender divide in physics spans globe
Report reveals inequality in opportunities and expectations.
http://links.ealert.nature.com/ctt?kn=102&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Student visas extended
United States updates visa process for science students.
http://links.ealert.nature.com/ctt?kn=103&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Recruits lack skills
UK employers support extra STEM training.
http://links.ealert.nature.com/ctt?kn=105&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Boost for networks
European Union increases research-network budget.
http://links.ealert.nature.com/ctt?kn=123&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Peer reviews: in praise of referees
Eric L. Altschuler
http://links.ealert.nature.com/ctt?kn=91&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Peer reviews: make them public
Daniel Mietchen
http://links.ealert.nature.com/ctt?kn=97&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

** Can Facebook influence funding?
Paolo Zamboni
http://links.ealert.nature.com/ctt?kn=99&ms=MzY2NTE0MzMS1&r=MjA1NzcwMjE4MQS2&b=2&j=MTAyMzczODY2S0&mt=1&rt=0

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The EDGE

Wednesday, May 25, 2011

Nature contents: 26 May 2011

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