The EDGE: Nature contents: 19 May 2011

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=========================== ADVERTISEMENT ===========================

---THIS WEEK'S HIGHLIGHTS:

--Physical Sciences
-Unbound or distant planetary mass population detected by gravitational
microlensing
Gravitational microlensing observations in the direction of the
Galactic Bulge have come up with a surprising result, the discovery
of 10 previously unknown extrasolar planets that are not bound to
host stars
http://links.ealert.nature.com/ctt?kn=105&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

--Physical Sciences
-Observation of the antimatter helium-4 nucleus
The [alpha]-particle - the helium nucleus consisting of two protons and two
neutrons - was identified a century ago by Ernest Rutherford. Its
antimatter counterpart, two antiprotons and two antineutrons, has now
been detected at Brookhaven National Laboratory.
http://links.ealert.nature.com/ctt?kn=108&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

--Earth & Environmental Sciences
-Species-area relationships always overestimate extinction rates from habitat loss
There is broad agreement that Earth is facing a biodiversity crisis,
but estimating extinction rates remains a challenge. Here Fangliang He
and Stephen Hubbell demonstrate that a widely used indirect method of
estimating extinction rates - based on backward extrapolation of
species-area relationship data - tends to overestimate the problem.
http://links.ealert.nature.com/ctt?kn=103&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

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--Podcast & Video
-This week, wandering planets, legless lizards and the growing pains
of artificially created stem cells. Plus, the best of the rest
from this week's Nature.
http://links.ealert.nature.com/ctt?kn=137&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0
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======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=139&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

EDITORIALS
** There's a time to be critical
An accusation that referees are too demanding and editors too supine
demands a response. Authors, editors and referees all have lessons
to learn.
http://links.ealert.nature.com/ctt?kn=104&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Getting personal
Targeted therapies work, but need help to fulfil their potential.
http://links.ealert.nature.com/ctt?kn=113&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** The human epoch
Official recognition for the Anthropocene would focus minds on the
challenges to come.
http://links.ealert.nature.com/ctt?kn=114&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

WORLD VIEWS
** Add coastal vegetation to the climate critical list
Forests are protected, but carbon sinks in mangroves, seagrasses and
marshes are ignored. Margareth da Silva Copertino wants Brazil to change that.
http://links.ealert.nature.com/ctt?kn=42&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

SEVEN DAYS
** Seven days: 13-19 May 2011
The week in science
http://links.ealert.nature.com/ctt?kn=25&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

NEWS IN FOCUS
** Major reform for climate body
Intergovernmental panel aims to become more responsive.
http://links.ealert.nature.com/ctt?kn=22&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Shuttle's end spells change at NASA
As the shuttle flies its penultimate mission, the US space agency
seeks to fill a looming gap in crew transport.
http://links.ealert.nature.com/ctt?kn=21&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Japan rethinks its energy policy
Renewables come to the fore as universities take the lead on
electricity conservation.
http://links.ealert.nature.com/ctt?kn=31&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** 'Soap opera' sours cancer chief hunt
Spain's scientists worried by fallout from high-profile spat.
http://links.ealert.nature.com/ctt?kn=30&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Geneticists bid to build a better bee
Honeybee genome offers clues for fighting diseases.
http://links.ealert.nature.com/ctt?kn=28&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Battle of Yucca Mountain rages on
Proposed interim storage unlikely to settle US debate.
http://links.ealert.nature.com/ctt?kn=26&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

FEATURES
** Energy: America's top climate cop
The United States has abandoned comprehensive greenhouse-gas curbs,
but California is pressing ahead. Mary Nichols is leading the fight
against emissions.
http://links.ealert.nature.com/ctt?kn=37&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Stem cells: The growing pains of pluripotency
The field of induced pluripotent stem cells has grown up fast. Now it
is entering the difficult stage.
http://links.ealert.nature.com/ctt?kn=35&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

COMMENT
** Nuclear winter is a real and present danger
Models show that even a 'small' nuclear war would cause catastrophic
climate change. Such findings must inform policy, says Alan Robock.
http://links.ealert.nature.com/ctt?kn=109&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Research beyond the recession
Nokia, Toyota and Roche explain how they are weathering the financial
crash, the technologies they are investing in and their innovation
strategies.
http://links.ealert.nature.com/ctt?kn=111&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

BOOKS AND ARTS
** Neuroscience: My brain made me do it
Adam Kepecs urges caution in considering the unconscious mind in the
justice system.
http://links.ealert.nature.com/ctt?kn=101&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=85&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Theatre: The chief designer
A clever play shows how engineer Sergei Korolyov drove the Soviet
space programme, finds Philip Ball.
http://links.ealert.nature.com/ctt?kn=83&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Q&A: Cosmic gardener
Charles Jencks designs landscapes and sculptures to convey concepts in
astronomy, biology and mathematics - notably at CERN, Europe's
particle-physics lab near Geneva, Switzerland, and in his Garden of
Cosmic Speculation near Dumfries in Scotland, UK. On the launch of his
new book, he discusses green architecture and metaphor.
http://links.ealert.nature.com/ctt?kn=90&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

CORRESPONDENCE
** Guidelines for HIV in court cases
Thomas Leitner
http://links.ealert.nature.com/ctt?kn=88&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** PhDs: what's left if science abdicates?
Kenneth S. Kosik
http://links.ealert.nature.com/ctt?kn=95&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** PhDs: Israel also trains plenty
Thomas Hays
http://links.ealert.nature.com/ctt?kn=93&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Crop failure signals biodiversity crisis
Kelvin S.-H. Peh
http://links.ealert.nature.com/ctt?kn=97&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** China must reduce fertilizer use too
Peng Gong, Lu Liang and Qiang Zhang
http://links.ealert.nature.com/ctt?kn=96&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Data archiving is a good investment
Heather A. Piwowar, Todd J. Vision and Michael C. Whitlock
http://links.ealert.nature.com/ctt?kn=128&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Noisy oil exploration disrupts marine life
Michael Stocker
http://links.ealert.nature.com/ctt?kn=130&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Address education inequality in India
Manas Kaushik and Subha Ramani
http://links.ealert.nature.com/ctt?kn=110&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Fund experiments on atmospheric hazards
Stefano Galmarini, Andreas Stohl and Gerhard Wotawa
http://links.ealert.nature.com/ctt?kn=119&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

OBITUARY
** William Nunn Lipscomb Jr (1919-2011)
Chemist who discovered a new kind of bonding.
http://links.ealert.nature.com/ctt?kn=117&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

CORRECTION
** Correction
http://links.ealert.nature.com/ctt?kn=116&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

========================
Specials - Insight: Cardiovascular Biology
========================

http://links.ealert.nature.com/ctt?kn=50&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Cardiovascular biology
Clare Thomas
http://links.ealert.nature.com/ctt?kn=115&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet and Rakesh K. Jain
http://links.ealert.nature.com/ctt?kn=125&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Lessons on the pathogenesis of aneurysm from heritable conditions
Mark E. Lindsay and Harry C. Dietz
http://links.ealert.nature.com/ctt?kn=123&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Progress and challenges in translating the biology of atherosclerosis
Peter Libby, Paul M Ridker and Goran K. Hansson
http://links.ealert.nature.com/ctt?kn=122&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Heart regeneration
Michael A. Laflamme and Charles E. Murry
http://links.ealert.nature.com/ctt?kn=121&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

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Scientific Reports - Call for papers
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Publishing made easy! Entirely open access with papers accepted on
technical merit, the community evaluates the importance of papers
post-peer review. Scientific Reports exists to facilitate the rapid
peer review and publication of research that is of interest to
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Submit now!
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======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Global quantification of mammalian gene expression control
Bjorn Schwanhausser, Dorothea Busse, Na Li, Gunnar Dittmar, Johannes Schuchhardt et al.
Gene expression is a multistep process that involves the transcription, transla...
http://links.ealert.nature.com/ctt?kn=44&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Kristine Williams, Jesper Christensen, Marianne Terndrup Pedersen, Jens V. Johansen, Paul A. C. Cloos et al.
Enzymes catalysing the methylation of the 5-position of cytosine (mC) have esse...
http://links.ealert.nature.com/ctt?kn=45&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Eocene lizard from Germany reveals amphisbaenian origins
Johannes Muller, Christy A. Hipsley, Jason J. Head, Nikolay Kardjilov, Andre Hilger et al.
Amphisbaenia is a speciose clade of fossorial lizards characterized by a snake-...
http://links.ealert.nature.com/ctt?kn=46&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Species-area relationships always overestimate extinction rates from habitat loss
Fangliang He and Stephen P. Hubbell
Extinction from habitat loss is the signature conservation problem of the twent...
http://links.ealert.nature.com/ctt?kn=103&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Neuropsin cleaves EphB2 in the amygdala to control anxiety
Benjamin K. Attwood, Julie-Myrtille Bourgognon, Satyam Patel, Mariusz Mucha, Emanuele Schiavon et al.
A minority of individuals experiencing traumatic events develop anxiety disorde...
http://links.ealert.nature.com/ctt?kn=75&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Stem-cell-triggered immunity through CLV3p-FLS2 signalling
Horim Lee, Ok-Kyong Chah and Jen Sheen
Stem cells in the shoot apical meristem (SAM) of plants are the self-renewable ...
http://links.ealert.nature.com/ctt?kn=72&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** A novel protein family mediates Casparian strip formation in the endodermis
Daniele Roppolo, Bert De Rybel, Valerie Denervaud Tendon, Alexandre Pfister, Julien Alassimone et al.
Polarized epithelia are fundamental to multicellular life. In animal epithelia,...
http://links.ealert.nature.com/ctt?kn=73&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition
Cihangir Duy, Christian Hurtz, Seyedmehdi Shojaee, Leandro Cerchietti, Huimin Geng et al.
Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukae...
http://links.ealert.nature.com/ctt?kn=70&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
Hao Wu, Ana C. D'Alessio, Shinsuke Ito, Kai Xia, Zhibin Wang et al.
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcyt...
http://links.ealert.nature.com/ctt?kn=71&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
William A. Pastor, Utz J. Pape, Yun Huang, Hope R. Henderson, Ryan Lister et al.
5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in dive...
http://links.ealert.nature.com/ctt?kn=68&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
Gabriella Ficz, Miguel R. Branco, Stefanie Seisenberger, Fatima Santos, Felix Krueger et al.
Methylation at the 5[prime] position of cytosine in DNA has important roles i...
http://links.ealert.nature.com/ctt?kn=69&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Non-adaptive origins of interactome complexity
Ariel Fernandez and Michael Lynch
The boundaries between prokaryotes, unicellular eukaryotes and multicellular eu...
http://links.ealert.nature.com/ctt?kn=62&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
Guillaume Lebon, Tony Warne, Patricia C. Edwards, Kirstie Bennett, Christopher J. Langmead et al.
Adenosine receptors and [bgr]-adrenoceptors are G-protein-coupled receptors (...
http://links.ealert.nature.com/ctt?kn=53&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Principles of activation and permeation in an anion-selective Cys-loop receptor
Ryan E. Hibbs and Eric Gouaux
Fast inhibitory neurotransmission is essential for nervous system function and ...
http://links.ealert.nature.com/ctt?kn=55&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Neural crest regulates myogenesis through the transient activation of NOTCH
Anne C. Rios, Olivier Serralbo, David Salgado and Christophe Marcelle
How dynamic signalling and extensive tissue rearrangements interact to generate...
http://links.ealert.nature.com/ctt?kn=47&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Control of visual cortical signals by prefrontal dopamine
Behrad Noudoost and Tirin Moore
The prefrontal cortex is thought to modulate sensory signals in posterior corti...
http://links.ealert.nature.com/ctt?kn=49&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** COP1 is a tumour suppressor that causes degradation of ETS transcription factors
Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen O'Rourke et al.
The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors in the E26...
http://links.ealert.nature.com/ctt?kn=51&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Reprogramming transcription by distinct classes of enhancers functionally
defined by eRNA
Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su et al.
Mammalian genomes are populated with thousands of transcriptional enhancers tha...
http://links.ealert.nature.com/ctt?kn=52&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Immunogenicity of induced pluripotent stem cells
Tongbiao Zhao, Zhen-Ning Zhang, Zhili Rong and Yang Xu
Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with de...
http://links.ealert.nature.com/ctt?kn=146&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Biodiversity: Species loss revisited
Carsten Rahbek and Robert K. Colwell
Conservationists predict massive extinctions as a result of habitat
loss. Habitat loss undoubtedly does drive extinctions, but dealing with
an unmet assumption that underlies these predictions yields much lower
estimates.
http://links.ealert.nature.com/ctt?kn=66&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Epigenetics: Tet proteins in the limelight
Nathalie Veron and Antoine H. F. M. Peters
Tet proteins mediate the hydroxymethylation of DNA. New work reveals
their function in gene regulation and the extent of their activity
throughout the genome of embryonic stem cells.
http://links.ealert.nature.com/ctt?kn=67&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Plant biology: Unveiling the Casparian strip
Markus Grebe
The Casparian strip in plant roots is a diffusion barrier that directs
water and solutes from the soil to the water-conducting tissues.
Proteins involved in making the strip have at long last been identified.
http://links.ealert.nature.com/ctt?kn=63&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

NEWS & COMMENT
** Zoology: Warblers of the underwater world
http://links.ealert.nature.com/ctt?kn=9&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Microbiology: Starved cells turn on themselves
http://links.ealert.nature.com/ctt?kn=10&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Animal behaviour: Strike a pose and hide
http://links.ealert.nature.com/ctt?kn=11&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Drug design: Designer proteins target flu
http://links.ealert.nature.com/ctt?kn=12&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Immunology: Blocking brain inflammation
http://links.ealert.nature.com/ctt?kn=1&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Autoimmunity: Taming psoriasis with vitamin D
http://links.ealert.nature.com/ctt?kn=2&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Neuroscience: A search for depression genes
http://links.ealert.nature.com/ctt?kn=4&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Getting personal
Targeted therapies work, but need help to fulfil their potential.
http://links.ealert.nature.com/ctt?kn=113&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Research beyond the recession
Nokia, Toyota and Roche explain how they are weathering the financial
crash, the technologies they are investing in and their innovation strategies.
http://links.ealert.nature.com/ctt?kn=111&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Neuroscience: My brain made me do it
Adam Kepecs urges caution in considering the unconscious mind in the justice system.
http://links.ealert.nature.com/ctt?kn=101&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=85&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Guidelines for HIV in court cases
Thomas Leitner
http://links.ealert.nature.com/ctt?kn=88&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Crop failure signals biodiversity crisis
Kelvin S.-H. Peh
http://links.ealert.nature.com/ctt?kn=97&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=78&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

CAREERS
** Forensics: The call of the crime lab
http://links.ealert.nature.com/ctt?kn=6&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Turning point: Jill Venton
http://links.ealert.nature.com/ctt?kn=7&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

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=====================================================================

======================== CHEMICAL SCIENCES ========================
RESEARCH
** Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
William A. Pastor, Utz J. Pape, Yun Huang, Hope R. Henderson, Ryan Lister et al.
5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in dive...
http://links.ealert.nature.com/ctt?kn=68&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Agonist-bound adenosine A2A receptor structures reveal common
features of GPCR activation
Guillaume Lebon, Tony Warne, Patricia C. Edwards, Kirstie Bennett, Christopher J. Langmead et al.
Adenosine receptors and [bgr]-adrenoceptors are G-protein-coupled receptors (...
http://links.ealert.nature.com/ctt?kn=53&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Principles of activation and permeation in an anion-selective
Cys-loop receptor
Ryan E. Hibbs and Eric Gouaux
Fast inhibitory neurotransmission is essential for nervous system
function and ...
http://links.ealert.nature.com/ctt?kn=55&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** COP1 is a tumour suppressor that causes degradation of ETS
transcription factors
Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen
O'Rourke et al.
The proto-oncogenes ETV1, ETV4 and
ETV5 encode transcription factors in the E26...
http://links.ealert.nature.com/ctt?kn=51&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Reprogramming transcription by distinct classes of enhancers
functionally defined by eRNA
Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su et al.
Mammalian genomes are populated with
thousands of transcriptional enhancers tha...
http://links.ealert.nature.com/ctt?kn=52&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

NEWS & COMMENT
** Drug design: Designer proteins target flu
http://links.ealert.nature.com/ctt?kn=12&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** William Nunn Lipscomb Jr (1919-2011)
Chemist who discovered a new kind of bonding.
http://links.ealert.nature.com/ctt?kn=117&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=78&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

CAREERS
** Forensics: The call of the crime lab
http://links.ealert.nature.com/ctt?kn=6&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Turning point: Jill Venton
http://links.ealert.nature.com/ctt?kn=7&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

========================
PHYSICAL SCIENCES
========================
RESEARCH
** Unbound or distant planetary mass population detected by
gravitational microlensing
T. Sumi, K. Kamiya, D. P. Bennett, I. A. Bond, F. Abe et al.
Since 1995, more than 500 exoplanets have been detected using
different techniq...
http://links.ealert.nature.com/ctt?kn=105&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Observation of the antimatter helium-4 nucleus
H. Agakishiev, M. M. Aggarwal, Z. Ahammed, A. V. Alakhverdyants, I.
Alekseev et al.
High-energy nuclear collisions create an energy density
similar to that of the ...
http://links.ealert.nature.com/ctt?kn=108&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Sharply increased mass loss from glaciers and ice caps in the
Canadian Arctic Archipelago
Alex S. Gardner, Geir Moholdt, Bert Wouters, Gabriel J. Wolken,
David O. Burgess et al.
Mountain glaciers and ice caps are contributing significantly to
present rates ...
http://links.ealert.nature.com/ctt?kn=34&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Melting of the Earth's inner core
David Gubbins, Binod Sreenivasan, Jon Mound and Sebastian Rost
The Earth's magnetic field is generated by a dynamo in the liquid iron ...
http://links.ealert.nature.com/ctt?kn=36&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Interannual atmospheric variability forced by the deep equatorial
Atlantic Ocean
Peter Brandt, Andreas Funk, Verena Hormann, Marcus Dengler, Richard
J. Greatbatch et al.
Climate variability in the tropical Atlantic Ocean is determined by
large-scale...
http://links.ealert.nature.com/ctt?kn=27&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Astronomy: Bound and unbound planets abound
Joachim Wambsganss
Two teams searching for extrasolar planets have jointly discovered
a new population of objects: ten Jupiter-mass planets far from their
host stars, or perhaps even floating freely through the Milky Way.
http://links.ealert.nature.com/ctt?kn=32&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Earth science: A deep foundry
Bruce Buffett
Melting and solidification of iron alloys in Earth's core may explain
structural complexity in the solid inner core, and alter the way we
think about the dynamics of the deep interior.
http://links.ealert.nature.com/ctt?kn=33&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

NEWS & COMMENT
** Physics: : Achieving spin control
http://links.ealert.nature.com/ctt?kn=19&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Materials science: Diamond lighter than a feather
http://links.ealert.nature.com/ctt?kn=20&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Nuclear winter is a real and present danger
Models show that even a 'small' nuclear war would cause catastrophic
climate change. Such findings must inform policy, says Alan Robock.
http://links.ealert.nature.com/ctt?kn=109&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=85&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Q&A: Cosmic gardener
Charles Jencks designs landscapes and sculptures to convey concepts
in astronomy, biology and mathematics [mdash] notably at CERN, Europe's
particle-physics lab near Geneva, Switzerland, and in his Garden of
Cosmic Speculation near Dumfries in Scotland, UK. On the launch of
his new book, he discusses green architecture and metaphor.
http://links.ealert.nature.com/ctt?kn=90&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=78&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Unbound or distant planetary mass population detected by
gravitational microlensing
T. Sumi, K. Kamiya, D. P. Bennett, I. A. Bond, F. Abe et al.
Since 1995, more than 500 exoplanets have been detected using different
techniq...
http://links.ealert.nature.com/ctt?kn=105&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Astronomy: Bound and unbound planets abound
Joachim Wambsganss
Two teams searching for extrasolar planets have jointly discovered a
new population of objects: ten Jupiter-mass planets far from their host
stars, or perhaps even floating freely through the Milky Way.
http://links.ealert.nature.com/ctt?kn=32&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

NEWS & COMMENT
** Seismology: : Awakening a fault line within
http://links.ealert.nature.com/ctt?kn=18&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=85&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** China must reduce fertilizer use too
Peng Gong, Lu Liang and Qiang Zhang
http://links.ealert.nature.com/ctt?kn=96&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Noisy oil exploration disrupts marine life
Michael Stocker
http://links.ealert.nature.com/ctt?kn=130&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Fund experiments on atmospheric hazards
Stefano Galmarini, Andreas Stohl and Gerhard Wotawa
http://links.ealert.nature.com/ctt?kn=119&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=78&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

========================
Specials - Technology Feature
========================
** Synthetic genomes: The next step for the synthetic genome
Monya Baker
http://links.ealert.nature.com/ctt?kn=5&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

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=====================================================================

======================== CAREERS & JOBS ========================
** Forensics: The call of the crime lab
Forensic scientists can work in academia, government and the private
sector, but the field is competitive.
http://links.ealert.nature.com/ctt?kn=145&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Turning point: Jill Venton
An analytical chemist turned neuroscientist probes fruitfly brain
function.
http://links.ealert.nature.com/ctt?kn=100&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** There's a time to be critical
An accusation that referees are too demanding and editors too supine
demands a response. Authors, editors and referees all have lessons to learn.
http://links.ealert.nature.com/ctt?kn=104&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Energy: America's top climate cop
The United States has abandoned comprehensive greenhouse-gas curbs, but
California is pressing ahead. Mary Nichols is leading the fight against
emissions.
http://links.ealert.nature.com/ctt?kn=37&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Research beyond the recession
Nokia, Toyota and Roche explain how they are weathering the financial
crash, the technologies they are investing in and their innovation strategies.
http://links.ealert.nature.com/ctt?kn=111&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** PhDs: what's left if science abdicates?
Kenneth S. Kosik
http://links.ealert.nature.com/ctt?kn=95&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** PhDs: Israel also trains plenty
Thomas Hays
http://links.ealert.nature.com/ctt?kn=93&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Noisy oil exploration disrupts marine life
Michael Stocker
http://links.ealert.nature.com/ctt?kn=130&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Address education inequality in India
Manas Kaushik and Subha Ramani
http://links.ealert.nature.com/ctt?kn=110&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

** Fund experiments on atmospheric hazards
Stefano Galmarini, Andreas Stohl and Gerhard Wotawa
http://links.ealert.nature.com/ctt?kn=119&m=36629689&r=MjA1NzcwMjE4MQS2&b=2&j=MTAxNzIzMTc4S0&mt=1&rt=0

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The EDGE

Wednesday, May 18, 2011

Nature contents: 19 May 2011

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