The EDGE: Nature contents: 23 March 2011

Nature Alert
The science that matters. Every week.

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---THIS WEEK'S HIGHLIGHTS:

--Biological Sciences
-The histone methyltransferase SETDB1 is recurrently amplified in
melanoma and accelerates its onset
Experiments in a transgenic zebrafish model of melanoma identify
SETDB1 as an important oncogene.
[ http://links.ealert.nature.com/ctt?kn=98&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0 ]

--Physical Sciences
-Catalytic Z-selective olefin cross-metathesis for natural product
synthesis
A new chemical method for synthesizing the Z-alkene bond, one of the
most important chemical bonds in nature, opens up new routes to
industrially useful compounds.
[ http://links.ealert.nature.com/ctt?kn=101&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0 ]

--Biological Sciences
-Duplications of the neuropeptide receptor gene VIPR2 confer
significant risk for schizophrenia
Genome-wide analysis in two large schizophrenia cohorts reveals a
significant association between duplications within a region of
chromosome 7 and schizophrenia, and points to the VIPR2 receptor as a
potential target for antipsychotic drugs.
[ http://links.ealert.nature.com/ctt?kn=95&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0 ]

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http://links.ealert.nature.com/ctt?kn=125&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

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--Podcast & Video
-This week, we drill into the Earth's mantle, make some mouse sperm in
the lab and try to find early warning signals of cancer. Plus, our top
pick from the rest of this week's Nature

[ http://links.ealert.nature.com/ctt?kn=130&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0 ]

=========================== ADVERTISEMENT ===========================

Microbiota and mucosal immunology: the interface in health and disease
April 14-16, 2011 * San Francisco, CA, USA
This conference will bring together scientists and clinicians from
various backgrounds to provide a comprehensive view of the interaction
of the microbiome and the host immune responses at mucosal surfaces.
Register today: http://links.ealert.nature.com/ctt?kn=74&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

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======================== NEWS AND COMMENT ===========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=132&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

EDITORIALS
** The long road back
For now, Japan's scientists have higher priorities than rebuilding
their research infrastructure, but when they do get to it, they will
need help from the international scientific community.
http://links.ealert.nature.com/ctt?kn=97&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Contact your MP!
British readers should help to change libel laws that suppress global
scientific discussion.
http://links.ealert.nature.com/ctt?kn=105&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** A unifying cause
Conference of science journalists can strengthen ties between the Arab
world and the West.
http://links.ealert.nature.com/ctt?kn=106&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

WORLD VIEW
** Do not phase out nuclear power — yet
Fission power must remain a crucial part of the energy mix until
renewable energy technologies can be scaled up, argues Charles D.
Ferguson.
http://links.ealert.nature.com/ctt?kn=75&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

SEVEN DAYS
** Seven days: 24 March 2011
The week in science
http://links.ealert.nature.com/ctt?kn=24&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

NEWS
** The meltdown that wasn't
How a handful of operators at a crippled reactor averted a greater
catastrophe at the Fukushima plant.
http://links.ealert.nature.com/ctt?kn=22&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Radiation risks unknown
Scientists struggle to calculate long-term effects of low-dose
exposures in Fukushima.
http://links.ealert.nature.com/ctt?kn=21&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Quake shakes Japan's science
Natural disaster leaves researchers struggling with broken equipment
and a crippled infrastructure.
http://links.ealert.nature.com/ctt?kn=30&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Europe makes do without NASA
US budget crisis forces European Space Agency to abandon plans for
joint mission.
http://links.ealert.nature.com/ctt?kn=29&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Australian grazing trial ignites debate
Researchers question science behind controversial effort to examine
cattle's role in controlling bushfires.
http://links.ealert.nature.com/ctt?kn=27&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** US government scientists test limits of conflict rules
Policy change has made it easier to serve on boards of scientific
societies.
http://links.ealert.nature.com/ctt?kn=25&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Genome builders face the competition
Three independent projects seek to contrast approaches in preparation
for routine analysis of genetic data.
http://links.ealert.nature.com/ctt?kn=36&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

FEATURES
** Cancer: Missing the mark
Why is it so hard to find a test to predict cancer?
http://links.ealert.nature.com/ctt?kn=34&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Cosmology: The hunting of the dark
The race to detect dark matter has yielded mostly confusion. But the
larger, more sensitive detectors being built could change that picture
soon.
http://links.ealert.nature.com/ctt?kn=13&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

COMMENT
** Journey to the mantle of the Earth
On the 50th anniversary of the first attempt to drill into Earth's
mantle, Damon Teagle and Benoit Ildefonse say that what was once
science fiction is now possible.
http://links.ealert.nature.com/ctt?kn=102&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Africa needs climate data to fight disease
Madeleine C. Thomson and colleagues call on climate and health
researchers, policy-makers and practitioners to work together to tackle infectious diseases.
http://links.ealert.nature.com/ctt?kn=104&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

BOOKS AND ARTS
** Health: A long, diligent life
A 90-year cohort study hints that personality plays a unexpected part
in lifespan, finds Marten Lagergren.
http://links.ealert.nature.com/ctt?kn=93&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Conservation: After the auroch
Emma Marris is gripped by an account of our love-hate relationship
with extinct megafauna.
http://links.ealert.nature.com/ctt?kn=81&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=80&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Medicine: Clinical precision
W. F. Bynum enjoys a history of three revolutionary moments in health
care.
http://links.ealert.nature.com/ctt?kn=84&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Theatre: A monstrous tale
A new staging of Frankenstein plays up the monster but draws no morals
about science, finds Philip Ball.
http://links.ealert.nature.com/ctt?kn=83&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

CORRESPONDENCE
** Scientists should cut waste too
Matthew Kumar
http://links.ealert.nature.com/ctt?kn=86&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Anthropology: it can be interdisciplinary
Eric Alden Smith, Michael Gurven and Monique Borgerhoff Mulder
http://links.ealert.nature.com/ctt?kn=85&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Anthropology: follow field primatologists
K. Anne-Isola Nekaris, Vincent Nijman and Laurie R. Godfrey
http://links.ealert.nature.com/ctt?kn=88&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Intolerance: UK chief scientist responds
John Beddington
http://links.ealert.nature.com/ctt?kn=87&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Negative results are published
Bob O'Hara
http://links.ealert.nature.com/ctt?kn=123&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Animal research: a personal lesson
John P. Gluck
http://links.ealert.nature.com/ctt?kn=124&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Animal research: the peaceful approach
Crystal Miller-Spiegel
http://links.ealert.nature.com/ctt?kn=103&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Animal research: replacing the lab rat
Martin Stephens
http://links.ealert.nature.com/ctt?kn=115&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Community choice: Skeleton boosts stud quotient
http://links.ealert.nature.com/ctt?kn=112&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Special: Japan earthquake and nuclear crisis

Nature brings you regular updates on the crisis, as well as analysis
of why this earthquake was so destructive, the Japanese government's
struggle to respond to the nuclear disaster, and the effects on Japan's
research community.

Access the Special free online.
http://links.ealert.nature.com/ctt?kn=58&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

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======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Initial genome sequencing and analysis of multiple myeloma
Michael A. Chapman, Michael S. Lawrence, Jonathan J. Keats,
Kristian Cibulskis, Carrie Sougnez et al.
Multiple myeloma is an incurable malignancy of plasma cells, and its
pathogenes...
http://links.ealert.nature.com/ctt?kn=110&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** The developmental transcriptome of Drosophila melanogaster
Brenton R. Graveley, Angela N. Brooks, Joseph W. Carlson,
Michael O. Duff, Jane M. Landolin et al.
Drosophila melanogaster is one of the most well studied genetic model
organisms...
http://links.ealert.nature.com/ctt?kn=108&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Comprehensive analysis of the chromatin landscape in Drosophila
melanogaster
Peter V. Kharchenko, Artyom A. Alekseyenko, Yuri B. Schwartz,
Aki Minoda, Nicole C. Riddle et al.
Chromatin is composed of DNA and a variety of modified histones and
non-histone...
http://links.ealert.nature.com/ctt?kn=120&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Duplications of the neuropeptide receptor gene VIPR2 confer
significant risk for schizophrenia
Vladimir Vacic, Shane McCarthy, Dheeraj Malhotra, Fiona Murray,
Hsun-Hua Chou et al.
Rare copy number variants (CNVs) have a prominent role in the
aetiology of schi...
http://links.ealert.nature.com/ctt?kn=95&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** In vitro production of functional sperm in cultured neonatal mouse
testes
Takuya Sato, Kumiko Katagiri, Ayako Gohbara, Kimiko Inoue,
Narumi Ogonuki et al.
Spermatogenesis is one of the most complex and longest processes of
sequential ...
http://links.ealert.nature.com/ctt?kn=118&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Fat cells reactivate quiescent neuroblasts via TOR and glial
insulin relays in Drosophila
Rita Sousa-Nunes, Lih Ling Yee and Alex P. Gould
Many stem, progenitor and cancer cells undergo periods of mitotic
quiescence from...
http://links.ealert.nature.com/ctt?kn=117&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** The histone methyltransferase SETDB1 is recurrently amplified in
melanoma and accelerates its onset
Craig J. Ceol, Yariv Houvras, Judit Jane-Valbuena, Steve Bilodeau,
David A. Orlando et al.
The most common mutation in human melanoma, BRAF(V600E), activates the
serine...
http://links.ealert.nature.com/ctt?kn=98&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** DHODH modulates transcriptional elongation in the neural crest and
melanoma
Richard Mark White, Jennifer Cech, Sutheera Ratanasirintrawoot,
Charles Y. Lin, Peter B. Rahl et al.
Melanoma is a tumour of transformed melanocytes, which are originally
derived f...
http://links.ealert.nature.com/ctt?kn=116&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** FAS and NF-[kgr]B signalling modulate dependence of lung cancers on
mutant EGFR
Trever G. Bivona, Haley Hieronymus, Joel Parker, Kenneth Chang,
Miquel Taron et al.
Human lung adenocarcinomas with activating mutations in EGFR
(epidermal growth ...
http://links.ealert.nature.com/ctt?kn=57&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** A cis-regulatory map of the Drosophila genome
Nicolas Negre, Christopher D. Brown, Lijia Ma,
Christopher Aaron Bristow, Steven W. Miller et al.
Systematic annotation of gene regulatory elements is a major
challenge in genom...
http://links.ealert.nature.com/ctt?kn=49&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric
single-stranded DNA
Rachel Litman Flynn, Richard C. Centore, Roderick J. O'Sullivan,
Rekha Rai, Alice Tse et al.
Maintenance of telomeres requires both DNA replication and telomere
'ca...
http://links.ealert.nature.com/ctt?kn=50&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Mapping and analysis of chromatin state dynamics in nine human cell
types
Jason Ernst, Pouya Kheradpour, Tarjei S. Mikkelsen, Noam Shoresh,
Lucas D. Ward et al.
Chromatin profiling has emerged as a powerful means of genome
annotation and de...
http://links.ealert.nature.com/ctt?kn=43&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Loss-of-function mutations in sodium channel Nav1.7 cause anosmia
Jan Weiss, Martina Pyrski, Eric Jacobi, Bernd Bufe, Vivienne Willnecker
et al.
Loss of function of the gene SCN9A, encoding the voltage-gated sodium
channel N...
http://links.ealert.nature.com/ctt?kn=45&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Molecular regulation of sexual preference revealed by genetic
studies of 5-HT in the brains of male mice
Yan Liu, Yun'ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen et al.
Although the question of to whom a male directs his mating attempts is
a critic...
http://links.ealert.nature.com/ctt?kn=46&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Crystal structure of inhibitor of [kgr]B kinase [bgr]
Guozhou Xu, Yu-Chih Lo, Qiubai Li, Gennaro Napolitano, Xuefeng Wu
et al.
Inhibitor of [kgr]B (I[kgr]B) kinase (IKK) phosphorylates I[kgr]B
protein...
http://links.ealert.nature.com/ctt?kn=48&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Shank3 mutant mice display autistic-like behaviours and striatal
dysfunction
Joao Peca, Catia Feliciano, Jonathan T. Ting, Wenting Wang,
Michael F. Wells et al.
Autism spectrum disorders (ASDs) comprise a range of disorders that
share a cor...
http://links.ealert.nature.com/ctt?kn=39&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** A long noncoding RNA maintains active chromatin to coordinate
homeotic gene expression
Kevin C. Wang, Yul W. Yang, Bo Liu, Amartya Sanyal,
Ryan Corces-Zimmerman et al.
The genome is extensively transcribed into long intergenic noncoding
RNAs (linc...
http://links.ealert.nature.com/ctt?kn=40&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Local, persistent activation of Rho GTPases during plasticity of
single dendritic spines
Hideji Murakoshi, Hong Wang and Ryohei Yasuda
The Rho family of GTPases have important roles in the morphogenesis of
the dend...
http://links.ealert.nature.com/ctt?kn=41&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Structure and mechanism of the uracil transporter UraA
Feiran Lu, Shuo Li, Yang Jiang, Jing Jiang, He Fan et al.
The nucleobase/ascorbate transporter (NAT) proteins, also known as
nucleobase/c...
http://links.ealert.nature.com/ctt?kn=42&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Inclusive fitness theory and eusociality
Patrick Abbot, Jun Abe, John Alcock, Samuel Alizon,
Joao A. C. Alpedrinha et al.
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson
Nature 466, 1057-...
Nowak et al. argue that inclusive fitness theory has been of little
value in ex...
http://links.ealert.nature.com/ctt?kn=70&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Only full-sibling families evolved eusociality
Jacobus J. Boomsma, Madeleine Beekman, Charlie K. Cornwallis,
Ashleigh S. Griffin, Luke Holman et al.
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson
Nature 466, 1057-...
The paper by Nowak et al. has the evolution of eusociality as its
title, but it...
http://links.ealert.nature.com/ctt?kn=68&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Kin selection and eusociality
Joan E. Strassmann, Robert E. Page, Jr., Gene E. Robinson and
Thomas D. Seeley
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson
Nature 466, 1057-...
Hamilton described a selective process in which individuals affect kin
(kin sel...
http://links.ealert.nature.com/ctt?kn=69&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Inclusive fitness in evolution
Regis Ferriere and Richard E. Michod
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson
Nature 466, 1057-...
For over fifty years, the evolution of social behaviour has been
guided by the ...
http://links.ealert.nature.com/ctt?kn=66&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** In defence of inclusive fitness theory
Edward Allen Herre and William T. Wcislo
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson
Nature 466, 1057-...
Arguably the defining characteristic of the scientific process is its
capacity ...
http://links.ealert.nature.com/ctt?kn=67&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Nowak et al. reply
Martin A. Nowak, Corina E. Tarnita and Edward O. Wilson
Replying to: P. Abbot et al....
http://links.ealert.nature.com/ctt?kn=64&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Reproductive biology: In vitro sperm maturation
Marco Seandel and Shahin Rafii
Anticancer therapies can impair male fertility. Whereas men can opt to
freeze their sperm before treatment, young boys don't produce mature
sperm and so lack this choice. Work in mice offers hope for such
patients.
http://links.ealert.nature.com/ctt?kn=65&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Schizophrenia: Zooming in on a gene
Hugh D. Piggins
Genome-wide association studies are often criticized for providing
little insight of immediate physiological relevance. The finding of
one such study, which implicates a signalling molecule in
schizophrenia, is welcome news.
http://links.ealert.nature.com/ctt?kn=62&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Developmental biology: A mouse is not a cow
Janet Rossant
Early cell-lineage decisions during embryonic development differ
between mice and cows. This finding calls for a re-examination of
developmental variations across mammals, but does not undermine use of
the mouse as a model organism.
http://links.ealert.nature.com/ctt?kn=63&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Molecular biology: A fly in the face of genomics
Eileen E. M. Furlong
The modENCODE project uses integrative analysis to annotate genomic
elements in the fruitfly and a nematode worm. The first fly data have
now been published.
http://links.ealert.nature.com/ctt?kn=59&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

NEWS & COMMENT
** Ecology: Better fragmented than lost
http://links.ealert.nature.com/ctt?kn=9&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Cancer: Liver cancer lifeline found
http://links.ealert.nature.com/ctt?kn=10&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Cell biology: Plot twist for proteins
http://links.ealert.nature.com/ctt?kn=11&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Development: How the chicken's neck got naked
http://links.ealert.nature.com/ctt?kn=12&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Microbiology: Sugary coat of armour
http://links.ealert.nature.com/ctt?kn=1&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Africa needs climate data to fight disease
Madeleine C. Thomson and colleagues call on climate and health
researchers, policy-makers and practitioners to work together to
tackle infectious diseases.
http://links.ealert.nature.com/ctt?kn=104&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Health: A long, diligent life
A 90-year cohort study hints that personality plays a unexpected part
in lifespan, finds Marten Lagergren.
http://links.ealert.nature.com/ctt?kn=93&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=80&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Medicine: Clinical precision
W. F. Bynum enjoys a history of three revolutionary moments in
health care.
http://links.ealert.nature.com/ctt?kn=84&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Animal research: a personal lesson
John P. Gluck
http://links.ealert.nature.com/ctt?kn=124&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Animal research: the peaceful approach
Crystal Miller-Spiegel
http://links.ealert.nature.com/ctt?kn=103&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Animal research: replacing the lab rat
Martin Stephens
http://links.ealert.nature.com/ctt?kn=115&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Cancer research: Promise of protection
Kelly Rae Chi
http://links.ealert.nature.com/ctt?kn=138&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Turning Point: Richard Green
Virginia Gewin
http://links.ealert.nature.com/ctt?kn=141&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=76&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Outlook Cancer Prevention

Are we entering the era of cancer as an avoidable disease?
New vaccines and chemopreventive drugs, along with healthier
diets and lifestyles, could shift the emphasis in cancer medicine
towards thwarting the disease before it afflicts us.
Access the Outlook free online for six months and find out more.
http://links.ealert.nature.com/ctt?kn=149&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

Produced with support by Janssen Global Services, LLC

=====================================================================

======================== CHEMICAL SCIENCES ==========================
RESEARCH
** Catalytic Z-selective olefin cross-metathesis for natural product
synthesis
Simon J. Meek, Robert V. O'Brien, Josep Llaveria, Richard R. Schrock
and Amir H. Hoveyda
Alkenes are found in many biologically active molecules, and there are
a large ...
http://links.ealert.nature.com/ctt?kn=101&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Organic chemistry: Overcoming catalytic bias
Daesung Lee
Metathesis reactions can be used to make carbon-carbon double bonds
-- bar one isomeric class. By using new catalysts and balancing out the
stabilities of intermediates in the reaction, the elusive isomers can
be made.
http://links.ealert.nature.com/ctt?kn=5&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

NEWS & COMMENT
** Chemistry: Copper makes for selectivity
http://links.ealert.nature.com/ctt?kn=6&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=47&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

======================== PHYSICAL SCIENCES ==========================
RESEARCH
** Interaction-based quantum metrology showing scaling beyond the
Heisenberg limit
M. Napolitano, M. Koschorreck, B. Dubost, N. Behbood, R. J. Sewell
et al.
Quantum metrology aims to use entanglement and other quantum resources
to impro...
http://links.ealert.nature.com/ctt?kn=7&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Collapse of long-range charge order tracked by time-resolved
photoemission at high momenta
Timm Rohwer, Stefan Hellmann, Martin Wiesenmayer, Christian Sohrt,
Ankatrin Stange et al.
Intense femtosecond (10-15[thinsp]s) light pulses can be used to
tran...
http://links.ealert.nature.com/ctt?kn=26&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Fault lubrication during earthquakes
G. Di Toro, R. Han, T. Hirose, N. De Paola, S. Nielsen et al.
The determination of rock friction at seismic slip rates
(about 1[thinsp]m|[t...
http://links.ealert.nature.com/ctt?kn=33&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Global warming: The soot factor
Johannes Quaas
The surface warming due to emissions of black-carbon aerosols over the
second half of the twentieth century has been identified in
observations. These findings will inform debate over the climatic
effects of controlling such emissions.
http://links.ealert.nature.com/ctt?kn=35&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Cosmology: Lenses under the lens
Ana Lopes
http://links.ealert.nature.com/ctt?kn=31&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

NEWS & COMMENT
** Physics: An 'electric' force for neutral atoms
http://links.ealert.nature.com/ctt?kn=32&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Africa needs climate data to fight disease
Madeleine C. Thomson and colleagues call on climate and health
researchers, policy-makers and practitioners to work together to
tackle infectious diseases.
http://links.ealert.nature.com/ctt?kn=104&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Agency woos women
NASA launches website to draw female interest.
http://links.ealert.nature.com/ctt?kn=140&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=56&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

================== EARTH AND ENVIRONMENTAL SCIENCES =================
RESEARCH
** Fault lubrication during earthquakes
G. Di Toro, R. Han, T. Hirose, N. De Paola, S. Nielsen et al.
The determination of rock friction at seismic slip rates
(about 1[thinsp]m|[t...
http://links.ealert.nature.com/ctt?kn=33&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Redox freezing and melting in the Earth's deep mantle resulting
from carbon-iron redox coupling
Arno Rohrbach and Max W. Schmidt
Very low seismic velocity anomalies in the Earth's mantle may reflect s...
http://links.ealert.nature.com/ctt?kn=20&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Low strength of deep San Andreas fault gouge from SAFOD core
David A. Lockner, Carolyn Morrow, Diane Moore and Stephen Hickman
The San Andreas fault accommodates 28-34[thinsp]mm[thinsp]yr|[minus...
http://links.ealert.nature.com/ctt?kn=17&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Global warming: The soot factor
Johannes Quaas
The surface warming due to emissions of black-carbon aerosols over
the second half of the twentieth century has been identified in
observations. These findings will inform debate over the climatic
effects of controlling such emissions.
http://links.ealert.nature.com/ctt?kn=35&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

NEWS & COMMENT
** Planetary science: Methane rain falls on Titan
http://links.ealert.nature.com/ctt?kn=18&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Journey to the mantle of the Earth
On the 50th anniversary of the first attempt to drill into Earth's
mantle, Damon Teagle and Benoit Ildefonse say that what was once
science fiction is now possible.
http://links.ealert.nature.com/ctt?kn=102&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Africa needs climate data to fight disease
Madeleine C. Thomson and colleagues call on climate and health
researchers, policy-makers and practitioners to work together to
tackle infectious diseases.
http://links.ealert.nature.com/ctt?kn=104&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Climate modelling: Melting of the third pole
http://links.ealert.nature.com/ctt?kn=23&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=55&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

=============== Specials - Outlook: Cancer Prevention ===============
http://links.ealert.nature.com/ctt?kn=149&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Cancer Prevention
Herb Brody
http://links.ealert.nature.com/ctt?kn=148&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Introduction: The prevention agenda
Tiffany O'Callaghan
http://links.ealert.nature.com/ctt?kn=147&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Chemoprevention: First line of defence
Lauren Gravitz
http://links.ealert.nature.com/ctt?kn=153&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Vaccines: Know your enemy
Michael Eisenstein
http://links.ealert.nature.com/ctt?kn=152&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Perspective: The big C — for Chemoprevention
Michael B. Sporn
http://links.ealert.nature.com/ctt?kn=151&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Epigenetics: Unravelling the cancer code
Vicki Brower
http://links.ealert.nature.com/ctt?kn=150&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Early detection: Spotting the first signs
Neil Savage.
http://links.ealert.nature.com/ctt?kn=157&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Lifestyle: Breaking the cancer habit
Cassandra Willyard
http://links.ealert.nature.com/ctt?kn=156&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0

** Perspective: Tackling the real issues
Stephen S. Hecht
http://links.ealert.nature.com/ctt?kn=155&m=36412923&r=MjA1NzcwMjE4MQS2&b=2&j=OTczNzE3MDcS1&mt=1&rt=0