The science that matters. Every week.
Visit www.nature.com/nature?WT.ec_id=NATURE-20110317
Subscribe to Nature http://links.ealert.nature.com/ctt?kn=117&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
View Table of Contents http://links.ealert.nature.com/ctt?kn=52&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
4th Annual BioPharma Asia Convention 2011
http://links.ealert.nature.com/ctt?kn=37&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
28-31 March 2011
Marina Bay Sands, Singapore
BioPharma Asia Convention 2011 is uniquely positioned as Asia's only
exhibition that showcases leading technocrats, solution and service
suppliers across the entire value chain of the biopharma industry
in Asia!
Contact Debby Lim at +65 6322 2710 to save up to SGD1680 when you
register!
mailto:debby.lim@terrapinn.com
=====================================================================
---THIS WEEK'S HIGHLIGHTS:
--Biological Sciences
-The CatSper channel mediates progesterone-induced Ca2+ influx in
human sperm
The finding that the female steroid hormone progesterone activates
the CatSper calcium channel in the sperm flagellum at conception could
lead to the development of new classes of non-hormonal contraceptives.
[ http://links.ealert.nature.com/ctt?kn=97&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0 ]
--Physical Sciences
-Single-spin addressing in an atomic Mott Insulator
A new technique achieves coherent spin-manipulation in a strongly
correlated quantum system consisting of an optical lattice of ultracold
atoms, making it possible to control the spins of individual atoms for
the first time,
[ http://links.ealert.nature.com/ctt?kn=99&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0 ]
--Earth & Environmental Sciences
-The role of crustal quartz in controlling Cordilleran deformation
A long-standing mystery in the field of plate tectonics can be summarized
with the question, why are mountain ranges where they are? Anthony Lowry
and Marta Perez-Gussinye show that the local abundance of crustal quartz,
the weakest mineral in continental rocks, may be a major factor.
[ http://links.ealert.nature.com/ctt?kn=94&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0 ]
=========================== ADVERTISEMENT ===========================
JOHNS HOPKINS UNIVERSITY - MS in Bioscience Regulatory Affairs
Attend an online info session for the MS in Bioscience Regulatory
Affairs on April 6th. Learn how you can earn your degree ONLINE, the
admission requirements, course structure, and how online education works.
Learn more and RSVP online, biotechnology.jhu.edu.
http://links.ealert.nature.com/ctt?kn=13&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
=====================================================================
--Podcast & Video
-This week, how sperm find the egg, controversial chronic fatigue
research and physicist James Clerk Maxwell. Plus, an update on the
nuclear power plant rocked by the Japanese earthquake.
[ http://links.ealert.nature.com/ctt?kn=123&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0 ]
=====================================================================
======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=124&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
EDITORIALS
** A bold unifying leap
How James Clerk Maxwell made a difference 150 years ago.
http://links.ealert.nature.com/ctt?kn=96&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Into ignorance
Vote to overturn an aspect of climate science marks a worrying trend
in US Congress.
http://links.ealert.nature.com/ctt?kn=103&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Cause for concern
Scientists studying diseases should be motivated by patients, but not
led by them.
http://links.ealert.nature.com/ctt?kn=104&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
WORLD VIEW
** Cash alone will not slow forest carbon emissions
To succeed, the REDD initiative needs a dose of 'GREEN' to restore
degraded forests and help boost economic development,
argues Andy White.
http://links.ealert.nature.com/ctt?kn=72&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
SEVEN DAYS
** Seven days: 17 March 2011
The week in science
http://links.ealert.nature.com/ctt?kn=21&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
NEWS
** Quake sparks nuclear crisis
Explosions at a tsunami-hit plant will knock public confidence and
the industry worldwide.
http://links.ealert.nature.com/ctt?kn=20&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Giant shock rattles ideas about quake behaviour
Few experts thought the seismic zone off Sendai, Japan, was capable of such violence
http://links.ealert.nature.com/ctt?kn=19&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** US free-speech law offers protection — at a price
Some fear that law to aid whistle-blowers will expose researchers
to smear campaigns.
http://links.ealert.nature.com/ctt?kn=28&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** US physics feels the squeeze
Obama's pro-science 2012 budget hides some bitter pills for physical
scientists.
http://links.ealert.nature.com/ctt?kn=27&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Hidden toll of embryo ethics war
Federal funds continue to be withheld for stem cells derived without
destroying embryos.
http://links.ealert.nature.com/ctt?kn=25&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Europe rules against stem-cell patents
Work with human embryonic stem cells is 'contrary to ethics'.
http://links.ealert.nature.com/ctt?kn=23&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
FEATURES
** Virology: Fighting for a cause
When Judy Mikovits found links between chronic fatigue syndrome and
a virus, the world took notice. Now, she's caught between the
patients who believe her work and the researchers who don't.
http://links.ealert.nature.com/ctt?kn=34&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Physics: Unification + 150
In 1861, James Clerk Maxwell unified electricity, magnetism and light.
Experiments under way today could inch physicists closer to combining
everything else.
http://links.ealert.nature.com/ctt?kn=32&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
COMMENT
** The laird of physics
James Clerk Maxwell's 1861 work on electromagnetism, which unified
scientific fields, was driven as much by technology as by abstract
theorizing, argues Simon Schaffer.
http://links.ealert.nature.com/ctt?kn=100&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** To invisibility and beyond
Combining Maxwell's equations with Einstein's general relativity
promises perfect images and cloaking devices, explains Ulf Leonhardt.
http://links.ealert.nature.com/ctt?kn=102&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
SPRING BOOKS
** Exhibition: Size Matters
http://links.ealert.nature.com/ctt?kn=92&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Biology: A revolution in evolution
Manfred Milinski enjoys Martin Nowak's paean to the power of
cooperation to shape animal and human societies.
http://links.ealert.nature.com/ctt?kn=80&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Physics: Fundamental Feynman
An account of the physicist's work reminds Leonard Mlodinow of the
gulf between theory and experiment.
http://links.ealert.nature.com/ctt?kn=79&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** New in paperback
Highlights of this season's releases
http://links.ealert.nature.com/ctt?kn=83&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Biotechnology: Making people
Today's wariness of reproductive technologies stems from myths,
legends and Hollywood, finds Chris Mason.
http://links.ealert.nature.com/ctt?kn=82&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Anatomy: How to get ahead
A thorough review of how the human head evolved shows how hominins
outpaced apes, finds Henry Gee.
http://links.ealert.nature.com/ctt?kn=85&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Technology: The medium is the message
Thomas J. Misa enjoys a history of communication tools, from talking
drums to Twitter.
http://links.ealert.nature.com/ctt?kn=84&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Psychology: Holding on to happiness
Sonja Lyubomirsky welcomes a call for society to encourage people to
'flourish'.
http://links.ealert.nature.com/ctt?kn=87&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Earth systems: The biosphere rebooted
Michael J. Benton finds hope for the future in a study of humanity's
cooperation with the environment.
http://links.ealert.nature.com/ctt?kn=86&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
CORRESPONDENCE
** Intolerance: retain healthy scepticism
Andy Stirling
http://links.ealert.nature.com/ctt?kn=118&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Intolerance: science informs, not defines
Brian Wynne
http://links.ealert.nature.com/ctt?kn=119&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** More protection for China's wetlands
Zhenguo Niu, Haiying Zhang and Peng Gong
http://links.ealert.nature.com/ctt?kn=101&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** The social impact of innovation
Timothy Roper
http://links.ealert.nature.com/ctt?kn=110&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
OBITUARY
** Marshall Stoneham (1940-2011)
Theoretician who contributed widely to condensed-matter physics.
http://links.ealert.nature.com/ctt?kn=107&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Don't miss out on $3 million in research funding
Proposals due by 4/29/11 for projects focused on modulation of:
•B cells
•Glial cells (microglia, macrophages, astrocytes)
•CNS ion channels, exchangers, transporters
Apply TODAY at www.FastForward.org
http://links.ealert.nature.com/ctt?kn=126&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
=====================================================================
======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** DICER1 deficit induces Alu RNA toxicity in age-related macular
degeneration
Hiroki Kaneko, Sami Dridi, Valeria Tarallo, Bradley D. Gelfand,
Benjamin J. Fowler et al.
Geographic atrophy (GA), an untreatable advanced form of age-related
macular de...
http://links.ealert.nature.com/ctt?kn=106&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Structure and mechanism of the hexameric MecA-ClpC molecular machine
Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Qi Hu et al.
Regulated proteolysis by ATP-dependent proteases is universal in all
living cel...
http://links.ealert.nature.com/ctt?kn=105&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Crystal structure of a potassium ion transporter, TrkH
Yu Cao, Xiangshu Jin, Hua Huang, Mehabaw Getahun Derebe,
Elena J. Levin et al.
The TrkH/TrkG/KtrB proteins mediate K+ uptake in bacteria and probably
evolved ...
http://links.ealert.nature.com/ctt?kn=115&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Eocene global warming events driven by ventilation of oceanic
dissolved organic carbon
Philip F. Sexton, Richard D. Norris, Paul A. Wilson, Heiko Palike,
Thomas Westerhold et al.
'Hyperthermals' are intervals of rapid, pronounced global warmi...
http://links.ealert.nature.com/ctt?kn=113&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Amygdala circuitry mediating reversible and bidirectional control
of anxiety
Kay M. Tye, Rohit Prakash, Sung-Yon Kim, Lief E. Fenno,
Logan Grosenick et al.
Anxiety--a sustained state of heightened apprehension in the
absence of ...
http://links.ealert.nature.com/ctt?kn=112&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Catalytic activity of the caspase-8-FLIPL complex inhibits
RIPK3-dependent necrosis
Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich,
Laura L. McCormick, Patrick Fitzgerald et al.
Caspase-8 has two opposing biological functions--it promotes cell
death ...
http://links.ealert.nature.com/ctt?kn=111&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** RIP3 mediates the embryonic lethality of caspase-8-deficient mice
William J. Kaiser, Jason W. Upton, Alyssa B. Long,
Devon Livingston-Rosanoff, Lisa P. Daley-Bauer et al.
Apoptosis and necroptosis are complementary pathways controlled by
common signa...
http://links.ealert.nature.com/ctt?kn=58&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Functional complementation between FADD and RIP1 in embryos and
lymphocytes
Haibing Zhang, Xiaohui Zhou, Thomas McQuade, Jinghe Li,
Francis Ka-Ming Chan et al.
FADD is a common adaptor shared by several death receptors for
signalling apopt...
http://links.ealert.nature.com/ctt?kn=48&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** MHC class II transactivator CIITA is a recurrent gene fusion
partner in lymphoid cancers
Christian Steidl, Sohrab P. Shah, Bruce W. Woolcock, Lixin Rui,
Masahiro Kawahara et al.
Chromosomal translocations are critically involved in the molecular
pathogenesi...
http://links.ealert.nature.com/ctt?kn=49&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** The CatSper channel mediates progesterone-induced Ca2+ influx in
human sperm
Timo Strunker, Normann Goodwin, Christoph Brenker, Nachiket D. Kashikar,
Ingo Weyand et al.
In the oviduct, cumulus cells that surround the oocyte release
progesterone. In...
http://links.ealert.nature.com/ctt?kn=97&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Progesterone activates the principal Ca2+ channel of human sperm
Polina V. Lishko, Inna L. Botchkina and Yuriy Kirichok
Steroid hormone progesterone released by cumulus cells surrounding
the egg is a...
http://links.ealert.nature.com/ctt?kn=42&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Chromosome length influences replication-induced topological stress
Andreas Kegel, Hanna Betts-Lindroos, Takaharu Kanno, Kristian Jeppsson,
Lena Strom et al.
During chromosome duplication the parental DNA molecule becomes
overwound, or p...
http://links.ealert.nature.com/ctt?kn=44&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Catecholamine receptor polymorphisms affect decision-making in
C. elegans
Andres Bendesky, Makoto Tsunozaki, Matthew V. Rockman, Leonid Kruglyak
and Cornelia I. Bargmann
Innate behaviours are flexible: they change rapidly in response to
transient en...
http://links.ealert.nature.com/ctt?kn=45&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Structural basis for recognition of centromere histone variant
CenH3 by the chaperone Scm3
Zheng Zhou, Hanqiao Feng, Bing-Rui Zhou, Rodolfo Ghirlando,
Kaifeng Hu et al.
The centromere is a unique chromosomal locus that ensures accurate
segregation ...
http://links.ealert.nature.com/ctt?kn=47&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric
single-stranded DNA
Rachel Litman Flynn, Richard C. Centore, Roderick J. O'Sullivan,
Rekha Rai, Alice Tse et al.
Maintenance of telomeres requires both DNA replication and telomere
'ca...
http://links.ealert.nature.com/ctt?kn=38&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Aberrant chromosome morphology in human cells defective for Holliday
junction resolution
Thomas Wechsler, Scott Newman and Stephen C. West
In somatic cells, Holliday junctions can be formed between sister
chromatids du...
http://links.ealert.nature.com/ctt?kn=39&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Tumour evolution inferred by single-cell sequencing
Nicholas Navin, Jude Kendall, Jennifer Troge, Peter Andrews,
Linda Rodgers et al.
Genomic analysis provides insights into the role of copy number
variation in di...
http://links.ealert.nature.com/ctt?kn=40&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** An siRNA pathway prevents transgenerational retrotransposition in
plants subjected to stress
Hidetaka Ito, Herve Gaubert, Etienne Bucher, Marie Mirouze,
Isabelle Vaillant et al.
Eukaryotic genomes consist to a significant extent of retrotransposons
that are...
http://links.ealert.nature.com/ctt?kn=41&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Structure of mammalian AMPK and its regulation by ADP
Bing Xiao, Matthew J. Sanders, Elizabeth Underwood, Richard Heath,
Faith V. Mayer et al.
The heterotrimeric AMP-activated protein kinase (AMPK) has a key role
in regula...
http://links.ealert.nature.com/ctt?kn=70&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Vision: Dicer leaps into view
Gunter Meister
An enzyme called Dicer is known for its central role in RNA-controlled
gene silencing. Mammalian Dicer1, however, also seems to have another
function: it maintains visual health by degrading toxic RNA molecules.
http://links.ealert.nature.com/ctt?kn=68&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Programmed cell death: Apoptosis meets necrosis
Marcus E. Peter
Apoptotic cell death is essential for the development of multicellular
organisms. Paradoxically, three proteins instrumental in apoptosis
also collaborate to preserve life by preventing necrotic cell death.
http://links.ealert.nature.com/ctt?kn=69&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Reproductive biology: Progesterone's gateway into sperm
Steve Publicover and Christopher Barratt
The hormone progesterone rapidly activates intracellular signalling
in human sperm, regulating key aspects of their physiology. An ion
channel unique to the sperm tail seems to relay progesterone's signal.
http://links.ealert.nature.com/ctt?kn=66&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Translational medicine: Cancer lessons from mice to humans
David Tuveson and Douglas Hanahan
New clinical trials report the efficacy of two mechanism-based
therapies for treating human pancreatic neuroendocrine tumours.
Studies in mouse models have contributed to these success stories,
and continue to do so.
http://links.ealert.nature.com/ctt?kn=67&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
NEWS & COMMENT
** Cell biology: Seeing cells with sheets of light
http://links.ealert.nature.com/ctt?kn=64&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Animal behaviour: Chickens feel for each other
http://links.ealert.nature.com/ctt?kn=65&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Neuroscience: Cell support for memory
http://links.ealert.nature.com/ctt?kn=62&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Microbiology: Stopping the cellular pump
http://links.ealert.nature.com/ctt?kn=63&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Neuroscience: Brain fluid spurs stem cells
http://links.ealert.nature.com/ctt?kn=59&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Immunology: Feedback loop in lupus
http://links.ealert.nature.com/ctt?kn=9&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Genetics: New proteins from neighbours
http://links.ealert.nature.com/ctt?kn=10&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Cause for concern
Scientists studying diseases should be motivated by patients, but not
led by them.
http://links.ealert.nature.com/ctt?kn=104&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Biology: A revolution in evolution
Manfred Milinski enjoys Martin Nowak's paean to the power of
cooperation to shape animal and human societies.
http://links.ealert.nature.com/ctt?kn=80&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** New in paperback
Highlights of this season's releases
http://links.ealert.nature.com/ctt?kn=83&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Biotechnology: Making people
Today's wariness of reproductive technologies stems from myths,
legends and Hollywood, finds Chris Mason.
http://links.ealert.nature.com/ctt?kn=82&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Anatomy: How to get ahead
A thorough review of how the human head evolved shows how hominins
outpaced apes, finds Henry Gee.
http://links.ealert.nature.com/ctt?kn=85&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Psychology: Holding on to happiness
Sonja Lyubomirsky welcomes a call for society to encourage people
to 'flourish'.
http://links.ealert.nature.com/ctt?kn=87&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Marshall Stoneham (1940-2011)
Theoretician who contributed widely to condensed-matter physics.
http://links.ealert.nature.com/ctt?kn=107&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Chemistry: Enzyme expertise
Biocatalysis specialists are in high demand in industry.
http://links.ealert.nature.com/ctt?kn=11&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=75&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
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=====================================================================
======================== CHEMICAL SCIENCES ========================
RESEARCH
** Structure and mechanism of the hexameric MecA-ClpC molecular machine
Feng Wang, Ziqing Mei, Yutao Qi, Chuangye Yan, Qi Hu et al.
Regulated proteolysis by ATP-dependent proteases is universal in all
living cel...
http://links.ealert.nature.com/ctt?kn=105&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Structural basis for recognition of centromere histone variant
CenH3 by the chaperone Scm3
Zheng Zhou, Hanqiao Feng, Bing-Rui Zhou, Rodolfo Ghirlando,
Kaifeng Hu et al.
The centromere is a unique chromosomal locus that ensures accurate
segregation ...
http://links.ealert.nature.com/ctt?kn=47&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric
single-stranded DNA
Rachel Litman Flynn, Richard C. Centore, Roderick J. O'Sullivan,
Rekha Rai, Alice Tse et al.
Maintenance of telomeres requires both DNA replication and telomere
'ca...
http://links.ealert.nature.com/ctt?kn=38&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Aberrant chromosome morphology in human cells defective for Holliday
junction resolution
Thomas Wechsler, Scott Newman and Stephen C. West
In somatic cells, Holliday junctions can be formed between sister
chromatids du...
http://links.ealert.nature.com/ctt?kn=39&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Structure of mammalian AMPK and its regulation by ADP
Bing Xiao, Matthew J. Sanders, Elizabeth Underwood, Richard Heath,
Faith V. Mayer et al.
The heterotrimeric AMP-activated protein kinase (AMPK) has a key role
in regula...
http://links.ealert.nature.com/ctt?kn=70&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Materials science: Complex order in soft matter
Sharon C. Glotzer and Michael Engel
Spherical micelles can aggregate into highly organized structures.
New micelle arrangements mimic known atomic crystals, both periodic
and aperiodic, and provide evidence for a material with 18-fold
rotational symmetry.
http://links.ealert.nature.com/ctt?kn=12&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Chemistry: Enzyme expertise
Biocatalysis specialists are in high demand in industry.
http://links.ealert.nature.com/ctt?kn=11&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
NEWS & COMMENT
** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=46&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
======================== PHYSICAL SCIENCES ========================
RESEARCH
** Single-spin addressing in an atomic Mott insulator
Christof Weitenberg, Manuel Endres, Jacob F. Sherson, Marc Cheneau,
Peter Schausz et al.
Ultracold atoms in optical lattices provide a versatile tool with
which to inve...
http://links.ealert.nature.com/ctt?kn=99&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** An hour-glass magnetic spectrum in an insulating, hole-doped
antiferromagnet
A. T. Boothroyd, P. Babkevich, D. Prabhakaran and P. G. Freeman
Superconductivity in layered copper oxide compounds emerges when
charge carrier...
http://links.ealert.nature.com/ctt?kn=1&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Transport through modes in random media
Jing Wang and Azriel Z. Genack
Excitations in complex media are superpositions of eigenstates that
are referre...
http://links.ealert.nature.com/ctt?kn=2&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Eocene global warming events driven by ventilation of oceanic
dissolved organic carbon
Philip F. Sexton, Richard D. Norris, Paul A. Wilson, Heiko Palike,
Thomas Westerhold et al.
'Hyperthermals' are intervals of rapid, pronounced global warmi...
http://links.ealert.nature.com/ctt?kn=113&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Controlling inelastic light scattering quantum pathways in graphene
Chi-Fan Chen, Cheol-Hwan Park, Bryan W. Boudouris, Jason Horng,
Baisong Geng et al.
Inelastic light scattering spectroscopy has, since its first discovery,
been an...
http://links.ealert.nature.com/ctt?kn=4&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Electromagnetically induced transparency and slow light with
optomechanics
A. H. Safavi-Naeini, T. P. Mayer Alegre, J. Chan, M. Eichenfield,
M. Winger et al.
Controlling the interaction between localized optical and mechanical
excitation...
http://links.ealert.nature.com/ctt?kn=5&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Materials science: Complex order in soft matter
Sharon C. Glotzer and Michael Engel
Spherical micelles can aggregate into highly organized structures.
New micelle arrangements mimic known atomic crystals, both periodic
and aperiodic, and provide evidence for a material with 18-fold
rotational symmetry.
http://links.ealert.nature.com/ctt?kn=12&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** High-temperature superconductivity: The secret of the hourglass
Jan Zaanen
The finding that a cobalt oxide insulator's magnetism is similar to
that of cuprate superconductors lends support to the popular but
contentious idea that stripe-like electronic order is present in the
latter materials.
http://links.ealert.nature.com/ctt?kn=6&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
NEWS & COMMENT
** Astronomy: New-looking old galaxies
http://links.ealert.nature.com/ctt?kn=7&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Materials: Fine-tuning optical fibres
http://links.ealert.nature.com/ctt?kn=24&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** A bold unifying leap
How James Clerk Maxwell made a difference 150 years ago.
http://links.ealert.nature.com/ctt?kn=96&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** The laird of physics
James Clerk Maxwell's 1861 work on electromagnetism, which unified
scientific fields, was driven as much by technology as by abstract
theorizing, argues Simon Schaffer.
http://links.ealert.nature.com/ctt?kn=100&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** To invisibility and beyond
Combining Maxwell's equations with Einstein's general relativity
promises perfect images and cloaking devices, explains Ulf Leonhardt.
http://links.ealert.nature.com/ctt?kn=102&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Physics: Fundamental Feynman
An account of the physicist's work reminds Leonard Mlodinow of the
gulf between theory and experiment.
http://links.ealert.nature.com/ctt?kn=79&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Technology: The medium is the message
Thomas J. Misa enjoys a history of communication tools, from talking
drums to Twitter.
http://links.ealert.nature.com/ctt?kn=84&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Marshall Stoneham (1940-2011)
Theoretician who contributed widely to condensed-matter physics.
http://links.ealert.nature.com/ctt?kn=107&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=55&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Eocene global warming events driven by ventilation of oceanic
dissolved organic carbon
Philip F. Sexton, Richard D. Norris, Paul A. Wilson, Heiko Palike,
Thomas Westerhold et al.
'Hyperthermals' are intervals of rapid, pronounced global warmi...
http://links.ealert.nature.com/ctt?kn=113&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** The role of crustal quartz in controlling Cordilleran deformation
Anthony R. Lowry and Marta Perez-Gussinye
Large-scale deformation of continents remains poorly understood more
than 40|[t...
http://links.ealert.nature.com/ctt?kn=94&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Earth science: Continental jelly
Roland Burgmann and Pascal Audet
An approach integrating different data sets has been used to map out
seismic-velocity ratios in the crust of western North America. High
inferred quartz content correlates with tectonic deformation zones.
http://links.ealert.nature.com/ctt?kn=31&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
NEWS & COMMENT
** Geophysics: Faster ice melt, higher sea levels
http://links.ealert.nature.com/ctt?kn=33&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Into ignorance
Vote to overturn an aspect of climate science marks a worrying trend
in US Congress.
http://links.ealert.nature.com/ctt?kn=103&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** New in paperback
Highlights of this season's releases
http://links.ealert.nature.com/ctt?kn=83&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Earth systems: The biosphere rebooted
Michael J. Benton finds hope for the future in a study of humanity's
cooperation with the environment.
http://links.ealert.nature.com/ctt?kn=86&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** More protection for China's wetlands
Zhenguo Niu, Haiying Zhang and Peng Gong
http://links.ealert.nature.com/ctt?kn=101&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=54&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
Nature Special: Maxwell's Equation
150 years ago this month a 30 year old James Clerk Maxwell wrote
down the equations that laid the foundations for modern physics.
Four pieces in this week's Nature discuss the origin and legacies
of Maxwell's insight.
Access the Special online.
http://links.ealert.nature.com/ctt?kn=56&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
Listen to this week's Nature Podcast.
http://links.ealert.nature.com/ctt?kn=22&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
=====================================================================
======================== CAREERS & JOBS ========================
** Chemistry: Enzyme expertise
Biocatalysis specialists are in high demand in industry.
http://links.ealert.nature.com/ctt?kn=130&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Mid-career crunch
Some senior scientists feel neglected by the National Institutes of
Health's grant formula.
http://links.ealert.nature.com/ctt?kn=108&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
** Cash alone will not slow forest carbon emissions
To succeed, the REDD initiative needs a dose of 'GREEN' to restore degraded forests and help boost economic development, argues Andy White.
http://links.ealert.nature.com/ctt?kn=14&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
ATURE-20110317
** Europe rules against stem-cell patents
Work with human embryonic stem cells is 'contrary to ethics'.
http://links.ealert.nature.com/ctt?kn=30&m=36390638&r=MjA1NzcwMjE4MQS2&b=2&j=OTY4MDUxMTMS1&mt=1&rt=0
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