The EDGE: Nature contents: 10 March 2011

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=========================== ADVERTISEMENT ===========================
NPG Asia Materials - Weekly research highlights and field reviews by
top materials researchers from the Asia-Pacific region
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Research highlights: Fullerenes: Shaken cubes shine bright |
Smart fluids: Switchable viscosity | Solar cells: In the fast lane

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Reviews: Nanostructured metal oxide-based biosensors | Self-assembled
colloidal photonics | Silicon photonics device engineering
=====================================================================

=========================== ADVERTISEMENT ===========================
---THIS WEEK'S HIGHLIGHTS:

--Earth & Environmental Sciences
-Permanent El Nino during the Pliocene warm period not supported by
coral evidence
Indirect evidence that the Pliocene warm period 3.5 million years ago
was a time of permanent El Nino - with the equatorial Pacific uniformly
warm - is contradicted by new data from fossil corals. El Nino climate
variations were much the same as today, it seems.
[ http://links.ealert.nature.com/ctt?kn=109&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0 ]

--Biological Sciences
-Human-specific loss of regulatory DNA and the evolution of
human-specific traits
Over 500 deletions in the human genome remove sequences found in
between chimpanzees and widely conserved in other animals. These
genomic changes are enriched near genes involved in neural development
and steroid hormone signalling.
[ http://links.ealert.nature.com/ctt?kn=100&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0 ]

--Biological Sciences
-Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory
immunity to dietary antigens mechanism
The vitamin A metabolite retinoic acid acts synergistically with the
cytokine interleukin-15 to induce interleukin-12p70 production and
promoting an inflammatory T-cell response to dietary antigens. This
work points to a previously unknown mechanism of possible relevance
to gluten intolerance.
[ http://links.ealert.nature.com/ctt?kn=94&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0 ]

--Podcast & Video
-This week, shape-shifting proteins, scaling up quantum mechanics and
how the human penis lost its spines. Plus, the best of the rest of
this week's Nature.
[ http://links.ealert.nature.com/ctt?kn=125&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0 ]
=====================================================================

======================== NEWS AND COMMENT ========================
Read daily news coverage http://links.ealert.nature.com/ctt?kn=126&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

EDITORIALS
** Embrace change
US biomedical scientists should support bold plans to transform the
process of drug development. Now is not the time for disunity.
http://links.ealert.nature.com/ctt?kn=96&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Notes on a scandal
Events this month have shown that government stances on academic
misbehaviour differ wildly.
http://links.ealert.nature.com/ctt?kn=104&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Over the limit
Evidence should be considered when setting policy, but not to the
exclusion of other factors.
http://links.ealert.nature.com/ctt?kn=105&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

WORLD VIEW
** Science agencies must bite innovation bullet
Before research can rebuild the US economy it must learn from the
prosperous heyday of the military–industrial complex,
says Daniel Sarewitz.
http://links.ealert.nature.com/ctt?kn=69&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

SEVEN DAYS
** Seven days: 10 March 2011
The week in science
http://links.ealert.nature.com/ctt?kn=30&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

NEWS
** Mourning Glory
NASA satellite crash will hamper solar monitoring and aerosol
measurements vital to improving climate models.
http://links.ealert.nature.com/ctt?kn=22&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** US scientists in budget limbo
Researchers face anxious wait as negotiations continue in Congress
over 2011 budget.
http://links.ealert.nature.com/ctt?kn=20&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Risky energy research faces uncertain future
ARPA-E's aggressive approach to managing research wins support — but
perhaps not federal dollars.
http://links.ealert.nature.com/ctt?kn=28&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** US Mars mission takes pole position
Sample-return trip to go ahead, but only if costs can be cut.
http://links.ealert.nature.com/ctt?kn=26&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** China unveils green targets
Premier vows to improve energy efficiency and curb pollution and
carbon emissions.
http://links.ealert.nature.com/ctt?kn=24&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Cable test raises fears at fusion project
Degradation of superconducting cables for the heart of the ITER
fusion machine threatens to cause further delays.
http://links.ealert.nature.com/ctt?kn=31&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

FEATURES
** Protein structure: Breaking the protein rules
If dogma dictates that proteins need a structure to function, then why
do so many of them live in a state of disorder?
http://links.ealert.nature.com/ctt?kn=16&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Oceanography: Earth's acid test
As the oceans rapidly grow more acidic, scientists are scrambling to
discover how marine life is likely to react.
http://links.ealert.nature.com/ctt?kn=15&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

COMMENT
** Vaccinate for the next H2N2 pandemic now
An old influenza strain still circulating in birds and swine could
easily jump back to humans now that immunity to it has dropped,
warn Gary J. Nabel and his colleagues.
http://links.ealert.nature.com/ctt?kn=101&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Biobanks need publicity
Most Europeans haven't heard of their nation's repositories of human
blood and tissue samples. Promote them, say George Gaskell and
Herbert Gottweis, or they could fail.
http://links.ealert.nature.com/ctt?kn=103&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

BOOKS AND ARTS
** Biography: Canonical prophet
Pedro Ferreira is inspired by a treasury of recollections of physicist
Bryce DeWitt by his widow Cecile.
http://links.ealert.nature.com/ctt?kn=92&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Geography: Islamic views of Earth
A magisterial series revolutionizes our understanding of Arabic
geography, finds Celal Sengor.
http://links.ealert.nature.com/ctt?kn=79&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Fiction: Attack of the killer fungi
Philip Ball applauds physicist Paul McEuen's debut thriller about a
madness-inducing mould.
http://links.ealert.nature.com/ctt?kn=77&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Museums: Campus treasures
Sally MacDonald and Jack Ashby explain how best to air the gems hidden
within university science collections.
http://links.ealert.nature.com/ctt?kn=83&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=82&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

CORRESPONDENCE
** Complexity clouds finance-risk models
Didier Sornette and Susanne von der Becke
http://links.ealert.nature.com/ctt?kn=85&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Science and religion are wise to talk
Denis Alexander and Bob White
http://links.ealert.nature.com/ctt?kn=84&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Infrastructure vital to genome success
Martin Yuille
http://links.ealert.nature.com/ctt?kn=87&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

CORRECTION
** Correction
http://links.ealert.nature.com/ctt?kn=14&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

CORRIGENDA
** Reliability of flipper-banded penguins as indicators of climate change
http://links.ealert.nature.com/ctt?kn=86&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
http://links.ealert.nature.com/ctt?kn=120&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** CD95 promotes tumour growth
http://links.ealert.nature.com/ctt?kn=121&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
Don't miss out on $3 million in research funding

Proposals due by 4/29/11 for projects focused on modulation of:

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http://links.ealert.nature.com/ctt?kn=128&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0
=====================================================================

======================== BIOLOGICAL SCIENCES ========================
RESEARCH
** Network anatomy and in vivo physiology of visual cortical neurons
Davi D. Bock, Wei-Chung Allen Lee, Aaron M. Kerlin, Mark L. Andermann,
Greg Hood et al.
In the cerebral cortex, local circuits consist of tens of thousands
of neurons,...
http://links.ealert.nature.com/ctt?kn=102&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Wiring specificity in the direction-selectivity circuit of the retina
Kevin L. Briggman, Moritz Helmstaedter and Winfried Denk
The proper connectivity between neurons is essential for the implementation
of ...
http://links.ealert.nature.com/ctt?kn=114&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Laura Pasqualucci, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri,
Adina Grunn et al.
B-cell non-Hodgkin's lymphoma comprises biologically and clinically dis...
http://links.ealert.nature.com/ctt?kn=111&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Permanent El Nino during the Pliocene warm period not supported by
coral evidence
Tsuyoshi Watanabe, Atsushi Suzuki, Shoshiro Minobe, Tatsunori Kawashima,
Koji Kameo et al.
The El Nino/Southern Oscillation (ENSO) system during the Pliocene war...
http://links.ealert.nature.com/ctt?kn=109&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Human-specific loss of regulatory DNA and the evolution of
human-specific traits
Cory Y. McLean, Philip L. Reno, Alex A. Pollen, Abraham I. Bassan,
Terence D. Capellini et al.
Humans differ from other animals in many aspects of anatomy,
physiology, and be...
http://links.ealert.nature.com/ctt?kn=100&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory
immunity to dietary antigens
R. W. DePaolo, V. Abadie, F. Tang, H. Fehlner-Peach, J. A. Hall et al.
Under physiological conditions the gut-associated lymphoid tissues
not only pre...
http://links.ealert.nature.com/ctt?kn=94&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Modelling the long QT syndrome with induced pluripotent stem cells
Ilanit Itzhaki, Leonid Maizels, Irit Huber, Limor Zwi-Dantsis,
Oren Caspi et al.
The ability to generate patient-specific human induced pluripotent
stem cells (...
http://links.ealert.nature.com/ctt?kn=107&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Using induced pluripotent stem cells to investigate cardiac phenotypes
in Timothy syndrome
Masayuki Yazawa, Brian Hsueh, Xiaolin Jia, Anca M. Pasca,
Jonathan A. Bernstein et al.
Individuals with congenital or acquired prolongation of the QT interval,
or lon...
http://links.ealert.nature.com/ctt?kn=119&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** CREBBP mutations in relapsed acute lymphoblastic leukaemia
Charles G. Mullighan, Jinghui Zhang, Lawryn H. Kasper, Stephanie Lerach,
Debbie Payne-Turner et al.
Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of
death due to...
http://links.ealert.nature.com/ctt?kn=117&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated
nuclear DNA repair
Yankun Gao, Sachin Katyal, Youngsoo Lee, Jingfeng Zhao,
Jerold E. Rehg et al.
DNA replication and repair in mammalian cells involves three distinct
DNA ligas...
http://links.ealert.nature.com/ctt?kn=116&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Crucial role for DNA ligase III in mitochondria but not in
Xrcc1-dependent repair
Deniz Simsek, Amy Furda, Yankun Gao, Jerome Artus, Erika Brunet et al.
Mammalian cells have three ATP-dependent DNA ligases, which are
required for DN...
http://links.ealert.nature.com/ctt?kn=115&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Structural basis of RNA polymerase II backtracking, arrest and
reactivation
Alan C. M. Cheung and Patrick Cramer
During gene transcription, RNA polymerase (Pol) II moves forwards
along DNA and...
http://links.ealert.nature.com/ctt?kn=55&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Caspase signalling controls microglia activation and neurotoxicity
Miguel A. Burguillos, Tomas Deierborg, Edel Kavanagh, Annette Persson,
Nabil Hajji et al.
Activation of microglia and inflammation-mediated neurotoxicity are
suggested t...
http://links.ealert.nature.com/ctt?kn=47&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Crystal structure of metarhodopsin II
Hui-Woog Choe, Yong Ju Kim, Jung Hee Park, Takefumi Morizumi,
Emil F. Pai et al.
G-protein-coupled receptors (GPCRs) are seven transmembrane helix
(TM) proteins...
http://links.ealert.nature.com/ctt?kn=48&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** The structural basis of agonist-induced activation in constitutively
active rhodopsin
Jorg Standfuss, Patricia C. Edwards, Aaron D'Antona, Maikel Fransen,
Guifu Xie et al.
G-protein-coupled receptors (GPCRs) comprise the largest family of
membrane pro...
http://links.ealert.nature.com/ctt?kn=41&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Amygdala circuitry mediating reversible and bidirectional control
of anxiety
Kay M. Tye, Rohit Prakash, Sung-Yon Kim, Lief E. Fenno,
Logan Grosenick et al.
Anxiety--a sustained state of heightened apprehension in the
absence of ...
http://links.ealert.nature.com/ctt?kn=43&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Hedgehog/Wnt feedback supports regenerative proliferation of
epithelial stem cells in bladder
Kunyoo Shin, John Lee, Nini Guo, James Kim, Agnes Lim et al.
Epithelial integrity in metazoan organs is maintained through the
regulated pro...
http://links.ealert.nature.com/ctt?kn=44&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Reliability of flipper-banded penguins as indicators of climate change
Claire Saraux, Celine Le Bohec, Joel M. Durant, Vincent A. Viblanc,
Michel Gauthier-Clerc et al.
http://links.ealert.nature.com/ctt?kn=86&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
Faiyaz Notta, Charles G. Mullighan, Jean C. Y.Wang, Armando Poeppl,
Sergei Doulatov et al.
http://links.ealert.nature.com/ctt?kn=120&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** CD95 promotes tumour growth
Lina Chen, Sun-Mi Park, Alexei V. Tumanov, Annika Hau,
Kenjiro Sawada et al.
http://links.ealert.nature.com/ctt?kn=121&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Immunology: Context is key in the gut
Craig L. Maynard and Casey T. Weaver
The vitamin-A metabolite retinoic acid normally favours immune
tolerance in the gut. But in coeliac disease -- an intestinal
inflammatory disorder due to adverse reactivity to a dietary protein
-- it may do just the opposite.
http://links.ealert.nature.com/ctt?kn=46&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Neuroscience: Towards functional connectomics
H. Sebastian Seung
To understand the brain, the thousands of synaptic connections made
by each of billions of neurons should be mapped and related to
neuronal function. First steps towards this formidable goal are now
reported.
http://links.ealert.nature.com/ctt?kn=37&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Host-pathogen interaction: Culprit within a culprit
Martin Olivier
The parasitic infection mucocutaneous leishmaniasis can vary in
severity. It emerges that the levels of an RNA virus within the
parasite affect both the host's immune response and the parasite's
persistence.
http://links.ealert.nature.com/ctt?kn=38&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

NEWS & COMMENT
** Genetics: Prenatal test for Down's syndrome
http://links.ealert.nature.com/ctt?kn=39&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Zoology: Fish that feed through their skin
http://links.ealert.nature.com/ctt?kn=40&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Animal behaviour: Sharks swim with direction
http://links.ealert.nature.com/ctt?kn=67&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Evolution: A changing eye on the world
http://links.ealert.nature.com/ctt?kn=65&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Microbiology: Tagging the TB bacterium
http://links.ealert.nature.com/ctt?kn=66&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Archaeology: Stone Age home by the sea
http://links.ealert.nature.com/ctt?kn=63&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Cancer: Stressing out cancer cells
http://links.ealert.nature.com/ctt?kn=64&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Embrace change
US biomedical scientists should support bold plans to transform the
process of drug development. Now is not the time for disunity.
http://links.ealert.nature.com/ctt?kn=96&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Vaccinate for the next H2N2 pandemic now
An old influenza strain still circulating in birds and swine could
easily jump back to humans now that immunity to it has dropped,
warn Gary J. Nabel and his colleagues.
http://links.ealert.nature.com/ctt?kn=101&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Fiction: Attack of the killer fungi
Philip Ball applauds physicist Paul McEuen's debut thriller about
a madness-inducing mould.
http://links.ealert.nature.com/ctt?kn=77&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Museums: Campus treasures
Sally MacDonald and Jack Ashby explain how best to air the gems
hidden within university science collections.
http://links.ealert.nature.com/ctt?kn=83&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=82&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Infrastructure vital to genome success
Martin Yuille
http://links.ealert.nature.com/ctt?kn=87&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Opportunities in wheat
UK-based project looking for geneticists and bioinformaticians.
http://links.ealert.nature.com/ctt?kn=61&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** More News & Comment on BIOLOGICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=73&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
Dicer knockout mice with diabetes... Take a look at this recent study
in the EMBO Journal:

miRNA control insulin content in pancreatic beta cells via
downregulation of transcriptional repressors
Melkman-Zehavi, E. Hornstein and colleagues.

A pancreatic beta cell-specific knockout of Dicer with a diabetic
phenotype reveals critical roles for specific miRNAs in the regulation
of insulin expression.
http://links.ealert.nature.com/ctt?kn=21&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0
=====================================================================

======================== CHEMICAL SCIENCES ========================
RESEARCH
** Crystal structure of metarhodopsin II
Hui-Woog Choe, Yong Ju Kim, Jung Hee Park, Takefumi Morizumi,
Emil F. Pai et al.
G-protein-coupled receptors (GPCRs) are seven transmembrane helix
(TM) proteins...
http://links.ealert.nature.com/ctt?kn=48&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** The structural basis of agonist-induced activation in constitutively
active rhodopsin
Jorg Standfuss, Patricia C. Edwards, Aaron D'Antona, Maikel Fransen, G
uifu Xie et al.
G-protein-coupled receptors (GPCRs) comprise the largest family of
membrane pro...
http://links.ealert.nature.com/ctt?kn=41&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Materials science: Bubble wrap of cell-like aggregates
Takamasa Harada and Dennis E. Discher
Using a microfluidic device, tiny polymeric capsules have been made in
which different compounds can be isolated in separate, membrane-bound
compartments -- a prerequisite for the development of artificial cell
aggregates.
http://links.ealert.nature.com/ctt?kn=62&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

NEWS & COMMENT
** Chemistry: Where did the xenon go?
http://links.ealert.nature.com/ctt?kn=59&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** More News & Comment on CHEMICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=45&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

======================== PHYSICAL SCIENCES ========================
RESEARCH
** Coupled quantized mechanical oscillators
K. R. Brown, C. Ospelkaus, Y. Colombe, A. C. Wilson, D. Leibfried et al.
The harmonic oscillator is one of the simplest physical systems but
also one of...
http://links.ealert.nature.com/ctt?kn=60&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Trapped-ion antennae for the transmission of quantum information
M. Harlander, R. Lechner, M. Brownnutt, R. Blatt and W. Hansel
More than 100 years ago, Hertz succeeded in transmitting signals over
a few met...
http://links.ealert.nature.com/ctt?kn=56&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Circuit cavity electromechanics in the strong-coupling regime
J. D. Teufel, Dale Li, M. S. Allman, K. Cicak, A. J. Sirois et al.
Demonstrating and exploiting the quantum nature of macroscopic
mechanical objec...
http://links.ealert.nature.com/ctt?kn=9&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Permanent El Nino during the Pliocene warm period not supported
by coral evidence
Tsuyoshi Watanabe, Atsushi Suzuki, Shoshiro Minobe, Tatsunori Kawashima,
Koji Kameo et al.
The El Nino/Southern Oscillation (ENSO) system during the Pliocene war...
http://links.ealert.nature.com/ctt?kn=109&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Collapse of long-range charge order tracked by time-resolved
photoemission at high momenta
Timm Rohwer, Stefan Hellmann, Martin Wiesenmayer, Christian Sohrt,
Ankatrin Stange et al.
Intense femtosecond (10-15 s) light pulses can be used to tran...
http://links.ealert.nature.com/ctt?kn=10&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Quantum mechanics: A light sounding drum
Miles Blencowe
In the effort to demonstrate quantum behaviour in the motion of
macroscopic mechanical objects, strong coupling between the objects
and an electromagnetic oscillator is advantageous. Such coupling
has now been achieved.
http://links.ealert.nature.com/ctt?kn=11&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Materials science: Bubble wrap of cell-like aggregates
Takamasa Harada and Dennis E. Discher
Using a microfluidic device, tiny polymeric capsules have been made
in which different compounds can be isolated in separate,
membrane-bound compartments -- a prerequisite for the development of
artificial cell aggregates.
http://links.ealert.nature.com/ctt?kn=62&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

NEWS & COMMENT
** Materials: Solar cells take a stretch
http://links.ealert.nature.com/ctt?kn=12&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Biography: Canonical prophet
Pedro Ferreira is inspired by a treasury of recollections of physicist
Bryce DeWitt by his widow Cecile.
http://links.ealert.nature.com/ctt?kn=92&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=82&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Finance: Quantifiable prospects
Despite market gyrations, banks can offer mathematicians and physicists
a way to put their acumen to lucrative use.
http://links.ealert.nature.com/ctt?kn=1&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Turning point: Andrew Dessler
A Google fellowship will help atmospheric scientist Andrew Dessler
spread the word about climate change.
http://links.ealert.nature.com/ctt?kn=2&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** More News & Comment on PHYSICAL SCIENCES
http://links.ealert.nature.com/ctt?kn=54&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

======================== EARTH AND ENVIRONMENTAL SCIENCES ========================
RESEARCH
** Permanent El Nino during the Pliocene warm period not supported
by coral evidence
Tsuyoshi Watanabe, Atsushi Suzuki, Shoshiro Minobe, Tatsunori Kawashima,
Koji Kameo et al.
The El Nino/Southern Oscillation (ENSO) system during the Pliocene war...
http://links.ealert.nature.com/ctt?kn=109&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** A rapid mechanism to remobilize and homogenize highly crystalline
magma bodies
Alain Burgisser and George W. Bergantz
The largest products of magmatic activity on Earth, the great bodies
of granite...
http://links.ealert.nature.com/ctt?kn=4&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Reliability of flipper-banded penguins as indicators of climate change
Claire Saraux, Celine Le Bohec, Joel M. Durant, Vincent A. Viblanc, M
ichel Gauthier-Clerc et al.
http://links.ealert.nature.com/ctt?kn=86&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Earthquakes: A Chilean surprise
Thorne Lay
Initiation of the great 2010 Chile earthquake occurred within the
rupture zone of the 1835 event experienced by Charles Darwin. However,
the peak fault slip was to the north of the epicentre -- not where it
was expected to occur.
http://links.ealert.nature.com/ctt?kn=5&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

NEWS & COMMENT
** Glaciology: Glacier grows from below
http://links.ealert.nature.com/ctt?kn=6&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Geography: Islamic views of Earth
A magisterial series revolutionizes our understanding of Arabic geography,
finds Celal Sengor.
http://links.ealert.nature.com/ctt?kn=79&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Books in brief
http://links.ealert.nature.com/ctt?kn=82&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** More News & Comment on EARTH AND ENVIRONMENTAL SCIENCES
http://links.ealert.nature.com/ctt?kn=53&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
Graphene: The Road to Applications
May 11-13, 2011 • Cambridge, MA, USA
This meeting will focus on those applications of graphene that are
most likely to reach the market within the next 5-10 years or
sooner, and strategies to overcome the roadblocks along the way.
For more information and to register visit:
http://links.ealert.nature.com/ctt?kn=70&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0
=====================================================================

======================== CAREERS & JOBS ========================
** Finance: Quantifiable prospects
Despite market gyrations, banks can offer mathematicians and physicists
a way to put their acumen to lucrative use.
http://links.ealert.nature.com/ctt?kn=132&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Turning point: Andrew Dessler
A Google fellowship will help atmospheric scientist Andrew Dessler
spread the word about climate change.
http://links.ealert.nature.com/ctt?kn=112&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Research role play
Online game offers glimpse into the daily life of a scientist.
http://links.ealert.nature.com/ctt?kn=110&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Rise in female scientists
Women are taking a growing number of US academic life-science positions.
http://links.ealert.nature.com/ctt?kn=108&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Opportunities in wheat
UK-based project looking for geneticists and bioinformaticians.
http://links.ealert.nature.com/ctt?kn=106&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Risky energy research faces uncertain future
ARPA-E's aggressive approach to managing research wins support — but
perhaps not federal dollars.
http://links.ealert.nature.com/ctt?kn=32&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

** Science and religion are wise to talk
Denis Alexander and Bob White
http://links.ealert.nature.com/ctt?kn=84&m=36364875&r=MjA1NzcwMjE4MQS2&b=2&j=OTYyNjYzMjkS1&mt=1&rt=0

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The EDGE

Wednesday, March 9, 2011

Nature contents: 10 March 2011

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