9 September 2010 Volume 467 Number 7312, pp 133 - 244
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Nature Web Focus Biological noise
Biological processes, such as protein synthesis or trafficking,
undergo random fluctuations - 'noise' - that are often detrimental
to reliable information transfer, but can also constitute opportunitie
s
for more efficient cellular computations. This web focus highlights
the most vibrant research on the biological systems that have
evolved to harness or exploit cellular noise, with direct implications
for cancer, stem cells, ageing and evolution, as published in
Nature over the past ten years.
Access selected content free online.
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EDITORIALS
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Science scorned p133
The anti-science strain pervading the right wing in the United States
is the last thing the country needs in a time of economic challenge.
doi:10.1038/467133a
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A destabilizing force p133
Public allegations threaten the impartiality of misconduct inquiries.
doi:10.1038/467133b
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RESEARCH HIGHLIGHTS
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Palaeontology: Leaf-like history of lacewings p134
doi:10.1038/467134a
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Astrophysics: The nuances of a fireball p134
doi:10.1038/467134b
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Marine ecology: Crab fights p134
doi:10.1038/467134c
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Networks: Contagious behaviour p134
doi:10.1038/467134d
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Astrophysics: How the galaxy lost its stars p134
doi:10.1038/467134e
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Primatology: Thanks mum! pp134-135
doi:10.1038/467134f
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Atmospheric chemistry: A wandering ozone hole p135
doi:10.1038/467135a
http://links.ealert.nature.com/ctt?kn=92&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Evolutionary biology: Ginormous genomes p135
doi:10.1038/467135b
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Marine biology: Charismatic carbon p135
doi:10.1038/467135c
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Planetary science: Weighing the planets p135
doi:10.1038/467135d
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JOURNAL CLUB
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Journal club p135
Martha Merrow
doi:10.1038/467135e
http://links.ealert.nature.com/ctt?kn=112&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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NEWS
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News briefing: 3–9 September 2010 pp136-137
The week in science.
doi:10.1038/467136a
http://links.ealert.nature.com/ctt?kn=1&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
US stem-cell chaos felt abroad pp138-139
Court ruling endangers international partnerships.
Meredith Wadman
doi:10.1038/467138a
http://links.ealert.nature.com/ctt?kn=233&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
NASA panel weighs asteroid danger pp140-141
Telescopes in space could help pin down the risk of a deadly impact.
Eugenie Samuel Reich
doi:10.1038/467140a
http://links.ealert.nature.com/ctt?kn=231&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Rare victory in fight against melanoma pp140-141
Genetically tailored approach could slow disease progress.
Heidi Ledford
doi:10.1038/467140b
http://links.ealert.nature.com/ctt?kn=229&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Teams battle for neuron prize p143
Contest spurs progress for programs that can map a brain cell's
myriad branches.
Adam Mann
doi:10.1038/467143a
http://links.ealert.nature.com/ctt?kn=227&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Big emitters team up p144
US–China clean-energy collaboration targets coal and cars.
David Cyranoski
doi:10.1038/467144a
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'Climate wars' claims disputed p145
New research challenges idea that global warming will drive civil
unrest.
Quirin Schiermeier
doi:10.1038/467145a
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Correction p145
doi:10.1038/467145b
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NEWS FEATURES
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Neuroscience: In their nurture pp146-148
Can epigenetics underlie the enduring effects of a mother's love?
Lizzie Buchen investigates the criticisms of a landmark study and
the controversial field to which it gave birth.
Lizzie Buchen
doi:10.1038/467146a
http://links.ealert.nature.com/ctt?kn=240&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Geology: A trip to dinosaur time pp150-151
A project to drill a 10-kilometre-deep hole in China will provide the
best view yet of the turbulent Cretaceous period. Jane Qiu reports.
Jane Qiu
doi:10.1038/467150a
http://links.ealert.nature.com/ctt?kn=244&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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CORRESPONDENCE
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Big projects would be shooting in the dark without team effort p153
Burton Richter
doi:10.1038/467153a
http://links.ealert.nature.com/ctt?kn=39&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Urban ecosystems research joins mainstream ecology p153
Paul Mayer
doi:10.1038/467153b
http://links.ealert.nature.com/ctt?kn=35&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
A call for action to curb invasive species in South America p153
Karina Speziale and Sergio Lambertucci
doi:10.1038/467153c
http://links.ealert.nature.com/ctt?kn=37&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Chinese journal finds 31% of submissions plagiarized p153
Yuehong Zhang
doi:10.1038/467153d
http://links.ealert.nature.com/ctt?kn=31&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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OPINION
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Time to automate identification pp154-155
Taxonomists should work with specialists in pattern recognition,
machine learning and artificial intelligence, say Norman MacLeod,
Mark Benfield and Phil Culverhouse -- more accuracy and less drudgery
will result.
Norman MacLeod, Mark Benfield and Phil Culverhouse
doi:10.1038/467154a
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BOOKS AND ARTS
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Chronicle of cybernetics pioneers pp156-157
Rodney Brooks enjoys an account of the freewheeling group of post-war
British researchers that sowed the seeds of robotics through a desire
to imitate animal brains and behaviour.
Rodney Brooks reviews The Cybernetic Brain: Sketches of Another
Future by Andrew Pickering
doi:10.1038/467156a
http://links.ealert.nature.com/ctt?kn=54&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Lessons from Climategate p157
Dave S. Reay reviews The Climate Files: The Battle for the Truth
About Global Warming by Fred Pearce
doi:10.1038/467157a
http://links.ealert.nature.com/ctt?kn=52&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Monkey business p158
Walton Ford's painting of a historical primate banquet belongs to a
rich tradition of exploring the 'human animal', explains Martin Kemp.
Martin Kemp
doi:10.1038/467158a
http://links.ealert.nature.com/ctt?kn=50&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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NEWS AND VIEWS
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Evolutionary biology: Communication and speciation pp159-160
An electrifying evolutionary radiation has evidently occurred among
elephant fish in Africa's Ivindo basin. An implication is that open
niches for communication can result in species diversification.
Manuel Leal and Jonathan B. Losos
doi:10.1038/467159a
http://links.ealert.nature.com/ctt?kn=48&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Climate change: A glacial test of timing pp160-161
Meticulous reconstruction of the former extent of a glacier high in
the mountains of New Zealand will help in interpreting global-scale
climatic adjustments that occurred at the end of the last glaciation.
Martin P. Kirkbride
doi:10.1038/467160a
http://links.ealert.nature.com/ctt?kn=46&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Gene targeting: Enter the rat pp161-163
Advances in stem-cell technology have broken the barrier to gene
targeting in mammals other than mice. A wide array of research
opportunities now opens up, especially in studies involving the
laboratory rat.
F. Kent Hamra
doi:10.1038/467161a
http://links.ealert.nature.com/ctt?kn=12&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
50 & 100 years ago p163
doi:10.1038/467163b
http://links.ealert.nature.com/ctt?kn=5&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Systems biology: The cost of feedback control pp163-164
Noise in biochemical processes can compromise precision in cellular
functions. An analysis involving information theory suggests that
there is a strict limit to how far noise can be suppressed by
feedback.
Li Sun and Attila Becskei
doi:10.1038/467163a
http://links.ealert.nature.com/ctt?kn=7&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Nanotechnology: Holes with an edge pp164-165
Tiny holes have been drilled through individual layers of graphene
-- atomically thin sheets of carbon -- using an electron beam. These
nanopores might be useful for the ultrarapid sequencing of single
DNA molecules.
Hagan Bayley
doi:10.1038/467164a
http://links.ealert.nature.com/ctt?kn=26&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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REVIEW
----------------------
Functional roles for noise in genetic circuits pp167-173
Avigdor Eldar and Michael B. Elowitz
doi:10.1038/nature09326
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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ARTICLES
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Fundamental limits on the suppression of molecular fluctuations
pp174-178
Biological systems avoid molecular noise using feedback loops
controlling RNA or protein synthesis, but these reactions rely on
the stochastic birth and death of molecules. These authors use
control and information theory to show that making a genetic network
twice as accurate takes 16 times more signalling steps. Nature must
therefore call on brute-force solutions to maintain accuracy, and
hence does so only when noise suppression is absolutely vital.
Ioannis Lestas, Glenn Vinnicombe and Johan Paulsson
doi:10.1038/nature09333
Abstract: http://links.ealert.nature.com/ctt?kn=183&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Enhancement of proteasome activity by a small-molecule inhibitor of
USP14 pp179-184
In the ubiquitin-proteasome system, substrates destined for
destruction are modified with ubiquitin chains and then degraded by
the proteasome. These authors reveal a regulatory mechanism in which
proteasomal activity is modulated by the length of ubiquitin chains
in human cells. They find that deubiquitinating enzyme USP14 can
inhibit the degradation of ubiquitin-conjugated substrates by
trimming ubiquitin chains, and that stimulation of proteasome
activity may be used to reduce the levels of toxic proteins in cells.
Byung-Hoon Lee et al.
doi:10.1038/nature09299
Abstract: http://links.ealert.nature.com/ctt?kn=182&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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LETTERS
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High-resolution tunnelling spectroscopy of a graphene quartet
pp185-189
In graphene, two particular sets of electrons exist that have a
fourfold energy degeneracy. To study the corresponding four quantum
states comprising a Landau level, these authors perform measurements
on epitaxial graphene at 10 millikelvin. They take spectral
'fingerprints' of the Landau levels, showing in detail how they
evolve with magnetic field and how they split into the four separate
quantum states. They also observe states with Landau level filling
factors of 7/2, 9/2 and 11/2.
Young Jae Song et al.
doi:10.1038/nature09330
Abstract: http://links.ealert.nature.com/ctt?kn=189&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=266&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Graphene as a subnanometre trans-electrode membrane pp190-193
Graphene is highly electronically conducting across the plane of the
material. These authors show that a graphene membrane separating two
ionic solutions in electrical contact is strongly ionically
insulating despite being atomically thin and has in-plane electronic
properties dependent on the interfacial environment. Numerical
modelling reveals that very high spatial resolution is possible
using this system, and the researchers propose that drilled membranes
could form the basis of DNA sequencing devices.
S. Garaj et al.
doi:10.1038/nature09379
Abstract: http://links.ealert.nature.com/ctt?kn=188&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Glacier retreat in New Zealand during the Younger Dryas stadial
pp194-197
The Younger Dryas -- during which Northern Hemisphere temperatures
cooled drastically in just a few years -- is perhaps the best-known
example of abrupt climate change, but its global extent is under
debate, particularly in the record of glacial behaviour in New
Zealand. These authors present evidence for glacial retreat in New
Zealand during the Younger Dryas, supporting the hypothesis that
Northern Hemisphere climate changes caused Southern Hemisphere
warming through a series of climate feedbacks.
Michael R. Kaplan et al.
doi:10.1038/nature09313
Abstract: http://links.ealert.nature.com/ctt?kn=187&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
2010 Maule earthquake slip correlates with pre-seismic locking of
Andean subduction zone pp198-202
These authors show evidence for a high coherence between the slip
distribution inferred from the 2010 Maule earthquake, Chile, and the
patchwork of interseismic locking distribution derived from global
positioning system observations during the previous decade. Their
work suggests that coseismic slip heterogeneity at the scale of
single asperities should indicate the seismic potential of future
earthquakes, which thus might be anticipated by geodetic
observations.
Marcos Moreno, Matthias Rosenau and Onno Oncken
doi:10.1038/nature09349
Abstract: http://links.ealert.nature.com/ctt?kn=153&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=245&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
A bizarre, humped Carcharodontosauria (Theropoda) from the Lower
Cretaceous of Spain pp203-206
The almost complete and remarkably conserved skeleton of a
medium-sized dinosaur was discovered in Las Hoyas, Spain.
Phylogenetic analysis places this specimen at the evolutionary base
of the Carcharodontosauridae.
Francisco Ortega, Fernando Escaso and Jose L. Sanz
doi:10.1038/nature09181
Abstract: http://links.ealert.nature.com/ctt?kn=152&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=248&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Whole-exome sequencing identifies recessive WDR62 mutations in severe
brain malformations pp207-210
Mapping disease loci that underlie putative Mendelian forms of
malformations of cortical development is complicated by genetic
heterogeneity, small family sizes and diagnostic classifications that
may not reflect molecular pathogenesis. These authors use whole-exome
sequencing to identify recessive mutations in WDR62 as the cause of a
wide spectrum of severe cerebral cortical malformations. WDR62's
nuclear localization to germinal neuroepithelia indicates that
cortical malformations can be caused by events during progenitor
proliferation and neurogenesis.
Kaya Bilguvar et al.
doi:10.1038/nature09327
Abstract: http://links.ealert.nature.com/ctt?kn=155&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=211&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Production of p53 gene knockout rats by homologous recombination in
embryonic stem cells pp211-213
The rat is a animal model widely used for studying human physiology
and disease, but functional genomics and genetic research have been
stifled by the limited availability of gene targeting tools. These
authors have established gene targeting by homologous recombination
in rat embryonic stem cells, and have generated p53 gene knockout
rats for the first time.
Chang Tong et al.
doi:10.1038/nature09368
Abstract: http://links.ealert.nature.com/ctt?kn=154&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=4&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
A cryptic sensor for HIV-1 activates antiviral innate immunity in
dendritic cells pp214-217
Human immunodeficiency virus (HIV) fails to induce interferon in the
cells that it infects, but the underlying mechanisms are not known.
These authors show that the virus can in fact activate the interferon
pathway in dendritic cells when the usual block to infection is
bypassed. Dendritic cell activation depends on the HIV-1
capsid/cyclophilin A interaction, which is known to have a role in
HIV-1 infectivity.
Nicolas Manel et al.
doi:10.1038/nature09337
Abstract: http://links.ealert.nature.com/ctt?kn=149&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=222&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
MEC-17 is an [agr]-tubulin acetyltransferase pp218-222
In eukaryotic cells, a subset of microtubules undergo
post-translational modifications such as acetylation, which alters
microtubule dynamics and trafficking of motors. These authors
identify MEC-17 as the enzyme that directly acetylates
[alpha]-tubulin in vitro and in vivo and in both invertebrates and
vertebrates. This is the identification of the long-sought enzyme
that acetylates microtubules.
Jyothi S. Akella et al.
doi:10.1038/nature09324
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=103&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
HAATI survivors replace canonical telomeres with blocks of generic
heterochromatin pp223-227
The ends of eukaryotic chromosomes are composed of repeat sequences
known as telomeres. Various proteins bind telomeres to protect them
from degradation or inappropriate DNA repair responses, and their
length is maintained by a specialized reverse transcriptase,
telomerase. These authors show that in the absence of telomerase,
telomeres can be maintained by amplifying and recombining
heterochromatin sequences there. This process requires histone
methylation and two telomere-binding proteins, Pot1 and Ccq1.
Devanshi Jain et al.
doi:10.1038/nature09374
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Telomeres avoid end detection by severing the checkpoint signal
transduction pathway pp228-232
The ends of chromosomes, known as telomeres, look like ends generated
by double-strand breaks, but if treated as such the DNA damage repair
system would initiate a checkpoint response and cause
telomere-telomere fusions. These authors show that telomeres lack two
types of histone modification that are required for recruitment of
Crb2b53BP1, without which the checkpoint cannot be activated even if
other DNA damage response proteins are recruited to a Taz1-deficient
telomere.
Tiago Carneiro et al.
doi:10.1038/nature09353
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Structural basis of Na+-independent and cooperative substrate/product
antiport in CaiT pp233-236
Transport of solutes across biological membranes is carried out by
specialized secondary transport proteins in the lipid bilayer. These
authors report structures of the sodium-independent
carnitine/butyrobetaine antiporter CaiT from two microorganisms. The
three-dimensional architecture of CaiT resembles that of the
Na+-dependent transporters LeuT and BetP, but in CaiT a methionine
sulphur takes the place of the Na+ ion to coordinate the substrate
in the central transport site, enabling Na+-independent transport to
occur.
Sabrina Schulze et al.
doi:10.1038/nature09310
Abstract: http://links.ealert.nature.com/ctt?kn=147&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Careers Q&A
Stephen Morris p239
Stephen Morris, a postdoc at the Centre of Molecular Materials for
Photonics and Electronics at the University of Cambridge, UK, is the
winner of the 2010 Young Scientist award from the British Liquid
Crystal Society.
Virginia Gewin
doi:10.1038/nj7312-239a
http://links.ealert.nature.com/ctt?kn=130&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
In Brief
Teamwork helps careers p239
Female scientists benefit from social networking sites.
doi:10.1038/nj7312-239b
http://links.ealert.nature.com/ctt?kn=133&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
In Brief
Women failed by mentors p239
'Sponsorship' mentoring needed to advance female scientists' careers.
doi:10.1038/nj7312-239c
http://links.ealert.nature.com/ctt?kn=131&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
In Brief
Site bridges science divide p239
New website helps to link North and Latin American researchers.
doi:10.1038/nj7312-239d
http://links.ealert.nature.com/ctt?kn=141&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Careers and Recruitment
Running the show p240
Project management requires a subtle set of skills that many
researchers find hard to master. Kelly Rae Chi provides a guide.
Kelly Rae Chi
doi:10.1038/nj7312-240a
http://links.ealert.nature.com/ctt?kn=138&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
----------------------
FUTURES
----------------------
Dark they were, and strange inside p244
A very blind date.
Vaughan Stanger
doi:10.1038/467244a
http://links.ealert.nature.com/ctt?kn=77&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
07 September 2010
Clinical efficacy of a RAF inhibitor needs broad target blockade in
BRAF-mutant melanoma near-final version
Gideon Bollag et al.
doi:10.1038/nature09454
First paragraph: http://links.ealert.nature.com/ctt?kn=146&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=158&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
08 September 2010
A trans-acting locus regulates an anti-viral expression network and
type 1 diabetes risk
Matthias Heinig et al.
doi:10.1038/nature09386
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=161&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Early warning signals of extinction in deteriorating environments
John M. Drake and Blaine D. Griffen
doi:10.1038/nature09389
Abstract: http://links.ealert.nature.com/ctt?kn=166&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=166&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
05 September 2010
Phosphorylation of MLL by ATR is required for execution of mammalian
S-phase checkpoint
Han Liu et al.
doi:10.1038/nature09350
Abstract: http://links.ealert.nature.com/ctt?kn=167&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=167&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Oligomeric organization of the B-cell antigen receptor on resting
cells
Jianying Yang and Michael Reth
doi:10.1038/nature09357
Abstract: http://links.ealert.nature.com/ctt?kn=191&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=191&m=35773183&r=MjA1NzcwMjE4MQS2&b=2&j=ODE0MTc3MTES1&mt=1&rt=0
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