5 August 2010 Volume 466 Number 7307, pp 667 - 788
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EDITORIALS
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Domestic science p667
Although China is a world leader in renewable-energy technology, it
is missing the chance to deploy this equipment on a suitably grand
scale at home.
doi:10.1038/466667a
http://links.ealert.nature.com/ctt?kn=90&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Slow progress p667
US cap-and-trade legislation has fallen victim to politics. But all
is not lost.
doi:10.1038/466667b
http://links.ealert.nature.com/ctt?kn=100&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Ecology: Life after logging p668
doi:10.1038/466668a
http://links.ealert.nature.com/ctt?kn=96&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Biotechnology: Fuel from microbes p668
doi:10.1038/466668b
http://links.ealert.nature.com/ctt?kn=64&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Neuroscience: Tunnelling brain cells p668
doi:10.1038/466668c
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Evolution: Ear roots p668
doi:10.1038/466668d
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Astronomy: Powerful space lens p668
doi:10.1038/466668e
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Chemistry: Splitting with sunlight p669
doi:10.1038/466669a
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Cancer biology: Blood vessel regulator p669
doi:10.1038/466669b
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Climate science: Hotter heatwaves p669
doi:10.1038/466669c
http://links.ealert.nature.com/ctt?kn=108&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Developmental biology: New hearts need jolts p669
doi:10.1038/466669d
http://links.ealert.nature.com/ctt?kn=102&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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JOURNAL CLUB
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Journal club p669
Dov Sax
doi:10.1038/466669e
http://links.ealert.nature.com/ctt?kn=121&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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NEWS
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News briefing: 30 July–5 August 2010 pp670-671
The week in science.
doi:10.1038/466670a
http://links.ealert.nature.com/ctt?kn=19&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Demand for malaria drug soars pp672-673
Farmers and scientists struggle to keep up with needs of ambitious
medicine-subsidy programme.
Richard Van Noorden
doi:10.1038/466672a
http://links.ealert.nature.com/ctt?kn=226&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Sponge genome goes deep p673
Researchers wring evolutionary clues from gene sequence.
Adam Mann
doi:10.1038/466673a
http://links.ealert.nature.com/ctt?kn=224&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
UK embryo agency faces the axe p674
Coalition government promises to abolish respected regulator in
effort to cut back on quangos.
Daniel Cressey
doi:10.1038/466674a
http://links.ealert.nature.com/ctt?kn=222&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Salamander's egg surprise p675
Algae enjoy symbiotic relationship with embryos.
Anna Petherick
doi:10.1038/466675a
http://links.ealert.nature.com/ctt?kn=220&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
'Tough' chief to defend MRC p675
John Savill will helm the UK Medical Research Council.
Daniel Cressey
doi:10.1038/466675b
http://links.ealert.nature.com/ctt?kn=249&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Drug safety crackdown revs up p677
FDA's strengthened powers to assess drugs already on the market
will soon be put to the test.
Heidi Ledford
doi:10.1038/466677a
http://links.ealert.nature.com/ctt?kn=245&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
US report pins down future biosecurity p678
Committee recommends a sequence-based system for identifying
pathogens.
Meredith Wadman
doi:10.1038/466678a
http://links.ealert.nature.com/ctt?kn=243&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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NEWS FEATURES
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Deepwater Horizon: A scientist at the centre of the spill pp680-684
Vernon Asper was one of the first researchers in the Gulf of Mexico
to study the oil gushing out from the BP well. But it has not all
been smooth sailing, reports Mark Schrope.
Mark Schrope
doi:10.1038/466680a
http://links.ealert.nature.com/ctt?kn=234&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Citizen science: People power pp685-687
Networks of human minds are taking citizen science to a new level,
reports Eric Hand.
Eric Hand
doi:10.1038/466685a
http://links.ealert.nature.com/ctt?kn=238&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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COLUMN
----------------------
World view: Not by experts alone p688
More and earlier public involvement is required to steer powerful
new technologies wisely, says Daniel Sarewitz.
Daniel Sarewitz
doi:10.1038/466688a
http://links.ealert.nature.com/ctt?kn=227&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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CORRESPONDENCE
----------------------
UK coalition's funding plan accelerates trends Labour started p689
William Cullerne Bown
doi:10.1038/466689a
http://links.ealert.nature.com/ctt?kn=115&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
The long story of how the boson got only Higgs's name p689
Ian Sample
doi:10.1038/466689b
http://links.ealert.nature.com/ctt?kn=38&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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OPINION
----------------------
Harnessing telecoms cables for science pp690-691
Telecommunications companies and oceanographers should work together
to plug old and new submarine cables into research projects, says
Yuzhu You. A global network could monitor climate change.
Yuzhu You
doi:10.1038/466690a
http://links.ealert.nature.com/ctt?kn=34&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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BOOKS AND ARTS
----------------------
Overcoming agony pp692-693
A broad account of the science of pain offers hope to patients but
highlights how the culture of medicine needs to change, explains Lucy
Odling-Smee.
Lucy Odling-Smee reviews The Pain Chronicles: Cures, Myths,
Mysteries, Prayers, Diaries, Brain Scans, Healing, and the Science
of Suffering by Melanie Thernstrom
doi:10.1038/466692a
http://links.ealert.nature.com/ctt?kn=36&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
An embellished tale of Pluto's discovery pp693-694
Caleb Scharf reviews Percival's Planet: A Novel by Michael Byers
doi:10.1038/466693a
http://links.ealert.nature.com/ctt?kn=30&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Behind the Mona Lisa's smile p694
X-ray scans reveal Leonardo's remarkable control of glaze thickness,
explains Philip Ball.
Philip Ball
doi:10.1038/466694a
http://links.ealert.nature.com/ctt?kn=32&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Serious fun with computer games p695
Sophisticated multimedia experiments offer platforms for learning
about science through play, Aleks Krotoski finds.
Aleks Krotoski
doi:10.1038/466695a
http://links.ealert.nature.com/ctt?kn=53&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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NEWS AND VIEWS
----------------------
Earth science: An inner core slip-sliding away pp697-698
An ingenious proposal holds that Earth's inner core is solidifying
in the western hemisphere and melting in the east. The process is
consequent on, and reinforces, its easterly slippage -- or
translation.
Michael I. Bergman
doi:10.1038/466697a
http://links.ealert.nature.com/ctt?kn=51&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Ecology: Close relatives are bad news pp698-699
In tropical rainforests, tree seedlings growing close to their parent
are more likely to die. This mortality, caused by soil organisms,
helps to explain the coexistence and relative abundance of species.
Owen T. Lewis
doi:10.1038/466698a
http://links.ealert.nature.com/ctt?kn=47&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Crohn's disease: Genes, viruses and microbes pp699-700
Variations in several genes can increase an individual's
susceptibility to complex disorders. But what tips the balance to
cause the full-blown disease? For Crohn's disease, viruses could
provide part of the answer.
Alison Simmons
doi:10.1038/466699a
http://links.ealert.nature.com/ctt?kn=8&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Spectroscopy: Attosecond prints of electrons pp700-702
Attosecond spectroscopy has been used to track the real-time motion
of electrons in a krypton ion, and to probe the entanglement between
an electron removed from the atom and the ion left behind.
Olga Smirnova
doi:10.1038/466700a
http://links.ealert.nature.com/ctt?kn=10&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Neuroanatomy: From fin to forelimb p701
Katie Ridd
doi:10.1038/466701a
http://links.ealert.nature.com/ctt?kn=4&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Metabolism: Malaria parasite stands out pp702-703
One of the hallmarks of cellular biochemistry is the ability to
extract energy efficiently from available substrates. The malaria
parasite, however, deviates from the norm, and has come up with its
own solution.
Hagai Ginsburg
doi:10.1038/466702a
http://links.ealert.nature.com/ctt?kn=6&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Genomics: Variations in blood lipids pp703-704
What is the new gold standard for genome-wide association studies? As
exemplified by analyses of blood lipids, it is collaboration to amass
huge sample sizes and functional studies of the genes identified.
Alan R. Shuldiner and Toni I. Pollin
doi:10.1038/466703a
http://links.ealert.nature.com/ctt?kn=27&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Inorganic chemistry: Cation o' nine tails pp704-705
The field of actinide chemistry is still young, not least because the
radioactivity of these elements makes them difficult to work with. A
study now reveals details of how actinide compounds might behave in
water.
Polly L. Arnold
doi:10.1038/466704a
http://links.ealert.nature.com/ctt?kn=16&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Obituary: Harry Whittington (1916-2010) p706
Palaeontologist who revealed the extraordinary animals of the
Burgess Shale.
Derek E. G. Briggs
doi:10.1038/466706a
http://links.ealert.nature.com/ctt?kn=21&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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ARTICLES
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Biological, clinical and population relevance of 95 loci for blood
lipids pp707-713
Lipid concentration in the serum is one of the most important risk
factors for coronary artery disease and can be targeted for
therapeutic intervention. A genome-wide association study in >100,000
individuals of European ancestry now finds 95 significantly
associated loci that also affect lipid traits in non-European
populations. Among associated loci are those involved in cholesterol
metabolism, known targets of cholesterol-lowering drugs and those
that contribute to normal variation in lipid traits and to extreme
lipid phenotypes.
Tanya M. Teslovich et al.
doi:10.1038/nature09270
Abstract: http://links.ealert.nature.com/ctt?kn=182&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol
locus pp714-719
A non-coding polymorphism at a locus associated with myocardial
infarction in humans creates a CCAAT/enhancer binding protein
transcription factor binding site and alters the hepatic expression
of the SORT1 gene. These authors show that modulating Sort1 levels
in mouse liver alters levels of plasma low-density lipoprotein
cholesterol and very low-density lipoprotein, potentially explaining
why polymorphisms at this locus are associated with heart disease.
Kiran Musunuru et al.
doi:10.1038/nature09266
Abstract: http://links.ealert.nature.com/ctt?kn=181&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
The Amphimedon queenslandica genome and the evolution of animal
complexity pp720-726
These authors report and analyse the draft genome sequence of the
demosponge Amphimedon queenslandica. Sponges lie on the earliest
branching lineage in the animal kingdom and thus have been important
in studies of the origins of multicellularity. Comparative genomic
analyses presented here provide significant insights into
evolutionary origins of genes and pathways related to the hallmarks
of metazoan multicellularity and to cancer biology.
Mansi Srivastava et al.
doi:10.1038/nature09201
Abstract: http://links.ealert.nature.com/ctt?kn=180&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=261&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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LETTERS
----------------------
A ground-layer adaptive optics system with multiple laser guide
stars pp727-729
Ground-based telescopes can in principle make high-resolution,
wide-field observations when fitted with ground-layer adaptive optics
(GLAO). These authors report observations of the core of the globular
cluster M3 after a recent upgrade to their GLAO system. In natural
seeing of 0.7[Prime], the point spread function at 2.2-[micro]m
wavelength was sharpened to 0.3[Prime] over a field of at least
2[prime]. The wide-field resolution was enhanced by a factor of two
to three over previous work, and extends to a wavelength of
1.2 [prime]m.
M. Hart et al.
doi:10.1038/nature09311
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=229&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Quantum entanglement between an optical photon and a solid-state spin
qubit pp730-734
Quantum entanglement is widely used in fundamental tests of quantum
mechanics and applications such as quantum cryptography. Previous
experiments have demonstrated entanglement of optical photons with
trapped atoms, ions and atomic ensembles. These authors realize
quantum entanglement between the polarization of a single optical
photon and a solid-state qubit associated with a single electronic
spin. This may provide a key building block for the solid-state
realization of quantum optical networks.
E. Togan et al.
doi:10.1038/nature09256
Abstract: http://links.ealert.nature.com/ctt?kn=143&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=233&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Loss-free and active optical negative-index metamaterials pp735-738
Metamaterials have the counterintuitive optical property of negative
refraction index. They have a wide range of possible applications,
including 'invisibility cloaks' and perfect lenses, but their
performance is severely limited by absorption losses. These authors
have incorporated an optical gain medium within a metamaterial as a
way to compensate the intrinsic loss, and show that optical pumping
leads to a significantly improved negative refraction index and
figure of merit within the 722-738-nm visible wavelength range.
Shumin Xiao et al.
doi:10.1038/nature09278
Abstract: http://links.ealert.nature.com/ctt?kn=146&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=240&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Real-time observation of valence electron motion pp739-743
Attosecond technology (1 as = 10-18 S) promises the tools needed to
directly probe electron motion in real time. These authors report
attosecond pump-probe measurements that track the movement of
valence electrons in krypton ions. This first proof-of-principle
demonstration uses a simple system, but the expectation is that
attosecond transient absorption spectroscopy will ultimately also
reveal the elementary electron motions that underlie the properties
of molecules and solid-state materials.
Eleftherios Goulielmakis et al.
doi:10.1038/nature09212
Abstract: http://links.ealert.nature.com/ctt?kn=145&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Melting-induced stratification above the Earth's inner core due to
convective translation pp744-747
These authors show that simultaneous crystallization and melting at
the surface of the Earth's inner core can result in a translational
mode of thermal convection within the inner core, producing the
observed stratified layer of reduced seismic velocity at the base of
the outer core. The dynamical model they propose also introduces an
asymmetry between hemispheres that may explain the enigmatic East-West
asymmetry in seismic properties of the inner core.
Thierry Alboussiere, Renaud Deguen and Mickael Melzani
doi:10.1038/nature09257
Abstract: http://links.ealert.nature.com/ctt?kn=140&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
The evolution of mammal-like crocodyliforms in the Cretaceous Period
of Gondwana pp748-751
A spectacular adaptive radiation among notosuchian crocodyliforms in
the southern continents of Gondwana led to all manner of strange
forms; in particular, their teeth, rather than being undifferentiated
conical fangs, were often differentiated into biting and crushing
types, as seen in mammals. These authors describe a new form from the
Cretaceous period of Tanzania in which upper and lower dentitions
were capable of occlusion, a feature otherwise known only from
mammals.
Patrick M. O'Connor et al.
doi:10.1038/nature09061
Abstract: http://links.ealert.nature.com/ctt?kn=139&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=201&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Negative plant-soil feedback predicts tree-species relative abundance
in a tropical forest pp752-755
One potential mechanism for maintaining biodiversity is negative
feedback between a species and its specific enemies, meaning that
other species can grow in its vicinity better than further
individuals of the species in question. These authors show that in a
tropical forest it is the soil biota that is the main cause of this
feedback, and that this effect can explain the diversity.
Scott A. Mangan et al.
doi:10.1038/nature09273
Abstract: http://links.ealert.nature.com/ctt?kn=142&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Predicting protein structures with a multiplayer online game
pp756-760
Predicting the structure of a folded protein from first principles
for any given amino-acid sequence remains a formidable computational
challenge. To recruit human abilities to the task, these authors
turned their Rosetta structure prediction algorithm into an online
multiplayer game in which thousands of non-scientists competed and
collaborated to produce new algorithms and search strategies for
protein structure refinement. This shows that computationally complex
problems can be effectively 'crowd-sourced' through interactive
multiplayer games.
Seth Cooper et al.
doi:10.1038/nature09304
Abstract: http://links.ealert.nature.com/ctt?kn=141&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=103&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Link communities reveal multiscale complexity in networks pp761-764
Network theory has become pervasive in all sectors of biology, from
biochemical signalling to human societies, but identification of
relevant functional communities has been impaired by many nodes
belonging to several overlapping groups at once, and by hierarchical
structures. These authors offer a radically different viewpoint,
focusing on links rather than nodes, which allows them to demonstrate
that overlapping communities and network hierarchies are two faces of
the same issue.
Yong-Yeol Ahn, James P. Bagrow and Sune Lehmann
doi:10.1038/nature09182
Abstract: http://links.ealert.nature.com/ctt?kn=138&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Regulation of myeloid leukaemia by the cell-fate determinant Musashi
pp765-768
Chronic myelogenous leukaemia (CML) can progress from a chronic to
an acute phase. These authors show in mouse models that leukaemia
progression is controlled by the cell-fate regulator Musashi2, which
in turn regulates Numb, Notch and p53 to block cellular
differentiation. Musashi2 expression can be increased by aberrant
transcription factors found in leukaemia, is observed during cancer
progression in human CML patients and is associated with poorer
prognosis.
Takahiro Ito et al.
doi:10.1038/nature09171
Abstract: http://links.ealert.nature.com/ctt?kn=137&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Epigenetic silencing of engineered L1 retrotransposition events in
human embryonic carcinoma cells pp769-773
The ability of retrotransposons to mobilize and insert into genes
presents a challenge to a cell needing to maintain its genomic
integrity. These authors have studied retrotransposition in embryonic
carcinoma-derived cells. On insertion into DNA, the retrotransposon
is quickly silenced, but the retrotransposon-specificity of this
process implies that multiple silencing mechanisms may exist. Once
cells differentiate, the ability to silence newly introduced
retrotransposons is lost but previously inactivated retrotransposons
remain inactive.
Jose L. Garcia-Perez et al.
doi:10.1038/nature09209
Abstract: http://links.ealert.nature.com/ctt?kn=152&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Branched tricarboxylic acid metabolism in Plasmodium falciparum
pp774-778
A central hub of carbon metabolism is the tricarboxylic acid (TCA)
cycle, which serves to connect the processes of glycolysis,
gluconeogenesis, respiration, amino acid synthesis and other
biosynthetic pathways. These authors show that TCA metabolism in the
human malaria parasite Plasmodium falciparum is largely disconnected
from glycolysis and is organized along a fundamentally different
architecture -- not cyclic, but branched -- from the canonical
textbook pathway.
Kellen L. Olszewski et al.
doi:10.1038/nature09301
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Microbial metalloproteomes are largely uncharacterized pp779-782
Metalloproteins are important in many biological processes, including
respiration, photosynthesis and drug metabolism. Using genome
sequences to predict the numbers and types of metal an organism uses
is currently very challenging. These authors used a proteomics
approach to identify and characterize a large number of a
microorganism's metalloproteins on a genome-wide scale, and
successfully separated and identified its cytoplasmic metalloproteins.
Aleksandar Cvetkovic et al.
doi:10.1038/nature09265
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Researchers on a mission p784
Marine biologists are developing an appreciation for conservation, a
change that is creating new jobs. Emma Marris reports.
Emma Marris
doi:10.1038/nj7307-784a
http://links.ealert.nature.com/ctt?kn=131&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
----------------------
FUTURES
----------------------
The silver bullet and the golden goose p788
A healthy profit.
Norman Spinrad
doi:10.1038/466788a
http://links.ealert.nature.com/ctt?kn=155&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
04 August 2010
Type IIA topoisomerase inhibition by a new class of antibacterial
agents
Benjamin D. Bax et al.
doi:10.1038/nature09197
Abstract: http://links.ealert.nature.com/ctt?kn=160&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=160&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Rb regulates fate choice and lineage commitment in vivo
Eliezer Calo et al.
doi:10.1038/nature09264
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=161&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
01 August 2010
A ribosome-associating factor chaperones tail-anchored membrane
proteins
Malaiyalam Mariappan et al.
doi:10.1038/nature09296
Abstract: http://links.ealert.nature.com/ctt?kn=184&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=184&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Structure of the torque ring of the flagellar motor and the molecular
basis for rotational switching
Lawrence K. Lee et al.
doi:10.1038/nature09300
Abstract: http://links.ealert.nature.com/ctt?kn=176&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=176&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
=========================== ADVERTISEMENT ===========================
British Journal of Cancer presents:
Guidelines for the Welfare of Animals in Cancer Research, 2010
http://links.ealert.nature.com/ctt?kn=13&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
Updated, enhanced, and providing practical advice on animal
welfare specifically for today's cancer researchers, these
guidelines define and encourage sharing of best practice in
laboratory work. Already endorsed by leading scientists
worldwide, they should also be read by those making decisions
about licensing, funding and publication.
Read the guidelines at
http://links.ealert.nature.com/ctt?kn=13&m=35666326&r=MjA1NzcwMjE4MQS2&b=2&j=NzkwNTYxNjMS1&mt=1&rt=0
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