12 August 2010 Volume 466 Number 7308, pp 797 - 896
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EDITORIALS
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Standard issue p797
The industry behind direct-to-consumer gene tests needs to
establish guidelines for its wares.
doi:10.1038/466797a
http://links.ealert.nature.com/ctt?kn=88&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Cheap shots p797
Republican criticism of stimulus-funded science projects is
ill-informed and wide of the mark.
doi:10.1038/466797b
http://links.ealert.nature.com/ctt?kn=97&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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RESEARCH HIGHLIGHTS
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Infectious disease: Bat blight p798
doi:10.1038/466798a
http://links.ealert.nature.com/ctt?kn=94&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Palaeontology: Small, soft, Silurian p798
doi:10.1038/466798b
http://links.ealert.nature.com/ctt?kn=61&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Spectroscopy: Ultraviolet combs p798
doi:10.1038/466798c
http://links.ealert.nature.com/ctt?kn=66&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Genetics: Where pain lives p798
doi:10.1038/466798d
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Ageing: Delayed damage pp798-799
doi:10.1038/466798e
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Nanobiotechnology: More light on algae p799
doi:10.1038/466799a
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Genetics: Long and the short of it p799
doi:10.1038/466799b
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Astronomy: Cosmic pattern p799
doi:10.1038/466799c
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Evolution: Sharing a birthday p799
doi:10.1038/466799d
http://links.ealert.nature.com/ctt?kn=99&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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JOURNAL CLUB
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Journal club p799
Ian Howat
doi:10.1038/466799e
http://links.ealert.nature.com/ctt?kn=118&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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NEWS
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News briefing: 6–12 August 2010 pp800-801
The week in science.
doi:10.1038/466800a
http://links.ealert.nature.com/ctt?kn=16&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Upbeat oil report questioned p802
Researchers see major uncertainties in Deepwater Horizon spill
assessment.
Mark Schrope
doi:10.1038/466802a
http://links.ealert.nature.com/ctt?kn=233&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Power struggle hits Swedish institute p803
Faculty members launch attack on president of Karolinska Institute.
Alison Abbott
doi:10.1038/466803a
http://links.ealert.nature.com/ctt?kn=231&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
France digs deep for nuclear waste pp804-805
Geological storage of long-lived radioactive material is moving
closer to reality in Europe,
says Declan Butler.
doi:10.1038/466804a
http://links.ealert.nature.com/ctt?kn=229&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Mountain mining damages streams p806
Study shows that stripping mountains for coal has a much greater
impact than urban growth.
Natasha Gilbert
doi:10.1038/466806a
http://links.ealert.nature.com/ctt?kn=20&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Supercomputing for the birds p807
Teragrid machine prepares to crunch ornithologists' data.
Emma Marris
doi:10.1038/466807a
http://links.ealert.nature.com/ctt?kn=224&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Correction p807
doi:10.1038/466807b
http://links.ealert.nature.com/ctt?kn=251&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
NEWS FEATURES
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Francis Collins: One year at the helm pp808-810
Having taken on the biggest job in biomedicine — leading the US
National Institutes of Health — Francis Collins must now help
his agency over a funding cliff. Meredith Wadman looks at his
record so far, and his plans to cushion the fall.
Meredith Wadman
doi:10.1038/466808a
http://links.ealert.nature.com/ctt?kn=249&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Oceanography: Dead in the water pp812-814
Every summer for the past nine years, water with lethally low
concentrations of oxygen has appeared off the Oregon coast.
The hypoxia may be a sign of things to come elsewhere,
finds Virginia Gewin.
doi:10.1038/466812a
http://links.ealert.nature.com/ctt?kn=246&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
Concerns regarding sinking of South Korean warship p815
Kwang Sup Kim
doi:10.1038/466815a
http://links.ealert.nature.com/ctt?kn=112&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Problems in Turkish science run deeper than petty disputes p815
Ferhat Kaya
doi:10.1038/466815b
http://links.ealert.nature.com/ctt?kn=38&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Press release and media distort complex message p815
Victor H. Marin, Luisa E. Delgado and Antonio Tironi
doi:10.1038/466815c
http://links.ealert.nature.com/ctt?kn=34&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Difference between interim and final acid-rain reports p815
Naomi Oreskes and Erik M. Conway
doi:10.1038/466815d
http://links.ealert.nature.com/ctt?kn=36&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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OPINIONS
----------------------
Which way for genetic-test regulation? Leave test interpretation to
specialists pp816-817
Although largely unregulated, genetic tests are increasingly used
to diagnose conditions, map ancestry or predict disease risk. In
this, the first of two related pieces, Arthur L. Beaudet advocates
the US Food and Drug Administration banning direct-to-consumer
medical tests but leaving the analysis of clinical diagnostics to
specialists. In the second, Gail Javitt argues that the agency
should implement a regulatory framework for all health-related tests.
Arthur L. Beaudet
doi:10.1038/466816a
http://links.ealert.nature.com/ctt?kn=30&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Which way for genetic-test regulation? Assign regulation appropriate
to the level of risk pp817-818
Although largely unregulated, genetic tests are increasingly used to
diagnose conditions, map ancestry or predict disease risk. In this,
the second of two related pieces, Gail Javitt argues that the US
Food and Drug Administration should implement a regulatory framework
for all health-related tests. In the first, Arthur L. Beaudet
advocates the agency banning direct-to-consumer medical tests but
leaving the analysis of clinical diagnostics to specialists.
Gail Javitt
doi:10.1038/466817a
http://links.ealert.nature.com/ctt?kn=32&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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BOOKS AND ARTS
----------------------
The makings of great leaders pp819-820
Leadership, Michael Bond learns from two new books, is not about
getting people to do things, it is about getting them to want to
do things — and it emerged on the African plains.
Michael Bond reviews The New Psychology of Leadership: Identity,
Influence and Power By S. Alexander Haslam, Stephen Reicher
& Michael J. Platow and Selected: Why Some People Lead, Why
Others Follow, and Why It Matters by Mark van Vugt & Anjana Ahuja
doi:10.1038/466819a
http://links.ealert.nature.com/ctt?kn=53&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Palestinians and Israelis talk water p820
Haim Watzman reviews Water Wisdom: Preparing the Groundwork for
Cooperative and Sustainable Water Management in the Middle East
by Alon Tal and Alfred Abed Rabbo
doi:10.1038/466820a
http://links.ealert.nature.com/ctt?kn=51&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Information theory: A signal take on speech pp821-822
Approaches that abandon traditional speech categories offer promise
for developing statistical descriptions that encapsulate how speech
conveys information. Grandparents would be among the beneficiaries.
Michael S. Lewicki
doi:10.1038/466821a
http://links.ealert.nature.com/ctt?kn=49&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Geochemistry: Relict mantle from Earth's birth pp822-823
Geochemical evidence for the existence of the mother of all
mantle-source reservoirs for volcanism has come to light. The new
results have provocative implications for our understanding of
Earth's interior.
David Graham
doi:10.1038/466822a
http://links.ealert.nature.com/ctt?kn=47&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Neuroscience: A mine of imprinted genes pp823-824
Some genes exclusively express only their maternal or paternal copy.
Studies of the brain extend the list of such imprinted genes by an
order of magnitude, highlighting their spatial and temporal regulation.
Eric B. Keverne
doi:10.1038/466823a
http://links.ealert.nature.com/ctt?kn=8&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Plant pathology: Sudden larch death pp824-825
An aggressive and unpredictable fungal pathogen is devastating larch
plantations in Britain. Its remarkably broad host range, and the
possibility of further geographical spread, give heightened cause
for concern.
Clive Brasier and Joan Webber
doi:10.1038/466824a
http://links.ealert.nature.com/ctt?kn=10&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
High-temperature superconductivity: The benefit of fractal dirt pp825-827
Measurements of X-ray diffraction on small patches of a copper oxide
superconductor reveal that oxygen crystal defects form fractal
structures that seem to promote high-temperature superconductivity.
Jan Zaanen
doi:10.1038/466825a
http://links.ealert.nature.com/ctt?kn=2&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
50 & 100 years ago p826
doi:10.1038/466826a
http://links.ealert.nature.com/ctt?kn=6&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Behavioural neuroscience: Genes and the anxious brain pp827-828
Some people are naturally more anxious than others. A brain-imaging
study in monkeys provides surprising insights into which brain
regions are under the influence of genes in this phenomenon and
which are not.
Andreas Meyer-Lindenberg
doi:10.1038/466827a
http://links.ealert.nature.com/ctt?kn=24&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Palaeoanthropology: Australopithecine butchers p828
How far back in the human lineage does tool use extend? Fossil bones
that bear evidence of butchery marks made by stone implements increase
the known range of that behaviour to at least 3.2 million years ago.
David R. Braun
doi:10.1038/466828a
http://links.ealert.nature.com/ctt?kn=26&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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BRIEF COMMUNICATIONS ARISING
----------------------
The prion protein as a receptor for amyloid-[bgr] ppE3-E4
Helmut W. Kessels, Louis N. Nguyen, Sadegh Nabavi and Roberto Malinow
doi:10.1038/nature09217
Abstract: http://links.ealert.nature.com/ctt?kn=183&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Lauren et al. reply ppE4-E5
Juha Lauren et al.
doi:10.1038/nature09218
Abstract: http://links.ealert.nature.com/ctt?kn=190&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=258&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Mesenchymal and haematopoietic stem cells form a unique bone marrow
niche pp829-834
The identity of the cells that form the haematopoietic stem cell
(HSC) niche in bone marrow has been unclear. These authors identify
nestin-expressing mesenchymal stem cells as niche-forming cells.
These nestin-expressing cells show a close physical association
with HSCs and express high levels of genes involved in HSC maintenance,
and their depletion reduces bone marrow homing of haematopoietic
progenitors.
Simon Mendez-Ferrer et al.
doi:10.1038/nature09262
Abstract: http://links.ealert.nature.com/ctt?kn=189&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=255&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Mammalian microRNAs predominantly act to decrease target mRNA levels
pp835-840
MicroRNAs are known to affect the levels of both messenger RNA (mRNA)
and protein. But as protein production is dependent on the presence
of mRNA, it was not clear what the relative contributions of
microRNA-mediated mRNA cleavage and translational repression were.
These authors have parsed out the two mechanisms, and unexpectedly
find that microRNAs function primarily by affecting mRNA levels
rather than their translation. This suggests a reassessment of many
previous conclusions is necessary.
Huili Guo, Nicholas T. Ingolia, Jonathan S. Weissman and David P. Bartel
doi:10.1038/nature09267
Abstract: http://links.ealert.nature.com/ctt?kn=188&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=259&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
LETTERS
----------------------
Scale-free structural organization of oxygen interstitials in La2CuO4+y
pp841-844
The oxygen interstitials in the layers separating the superconducting
CuO2 planes undergo ordering phenomena in La2CuO4+y that enhance the
transition temperature (Tc). It is also known that complex systems
often have a scale-invariant structural organization, but hitherto
none had been found in high-Tc materials. These authors report that
the ordering of oxygen interstitials in the La2O2+y spacer layers
of La2CuO4+y high-Tc superconductors is characterized by a fractal
distribution up to a maximum limiting size of 400 [micro]m.
Michela Fratini et al.
doi:10.1038/nature09260
Abstract: http://links.ealert.nature.com/ctt?kn=149&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Nanoscale scanning probe ferromagnetic resonance imaging using
localized modes pp845-848
Advances in nanomagnetics research have brought powerful applications
in magnetic sensing technology, but so far no high-resolution
magnetic-imaging tool is available to characterize complex, often
buried, nanoscale structures. These authors have developed a scanning
probe technique in which the intense, confined magnetic field of a
micromagnetic probe tip is used to localize the ferromagnetic
resonance mode immediately beneath the probe, and demonstrate that
they can image magnetic features at a resolution of 200 nm.
Inhee Lee et al.
doi:10.1038/nature09279
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=241&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Precipitation-generated oscillations in open cellular cloud fields
pp849-852
Cloud simulation is one of the most challenging tasks in regional
to global-scale modelling. In many cases, the physical mechanisms
responsible for observed cloud dynamics are unknown, making it
difficult to realistically simulate their structure and behaviour.
These authors show that open cellular clouds -- characterized by
low albedo -- can be created by precipitation-driven downdrafts
and that the resulting cloud structure forms an oscillating,
self-organizing cloud field.
Graham Feingold et al.
doi:10.1038/nature09314
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=244&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Evidence for the survival of the oldest terrestrial mantle reservoir
pp853-856
High 3He/4He ratios in some basalts have been interpreted as evidence
for ancient reservoirs preserved in the Earth's mantle; however, such
rocks have never been observed to host the primitive lead-isotopic
compositions required for an early formation age. These authors show
that Baffin Island and West Greenland lavas exhibit primitive
lead-isotope ratios consistent with a mantle source age of 4.55–4.45
billion years, and that their source may be the most ancient
accessible reservoir in the mantle.
Matthew G. Jackson et al.
doi:10.1038/nature09287
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Evidence for stone-tool-assisted consumption of animal tissues before
3.39 million years ago at Dikika, Ethiopia pp857-860
The earliest direct evidence for stone tools is between 2.6 and
2.5 million years old and comes from Gona, Ethiopia. These authors
report bones from Dikika, Ethiopia, dated to around 3.4 million
years ago and marked with cuts indicative of the use of stone tools
to remove flesh and extract bone marrow. This is the earliest known
evidence of stone tool use, and might be attributed to the
activities of Australopithecus afarensis.
Shannon P. McPherron et al.
doi:10.1038/nature09248
Abstract: http://links.ealert.nature.com/ctt?kn=145&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Social learning promotes institutions for governing the commons pp861-863
Cooperation in evolutionary games can be stabilized through punishment
of non-cooperators, at a cost to those who do the punishing.
Punishment can take different forms, in particular peer-punishment,
in which individuals punish free-riders after the event, and
pool-punishment, in which a fund for sanctioning is set up beforehand.
These authors show that pool-punishment is superior to peer-punishment
in dealing with second-order free-riders, who cooperate in the main
game but refuse to contribute to punishment.
Karl Sigmund, Hannelore De Silva, Arne Traulsen and Christoph Hauert
doi:10.1038/nature09203
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=206&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Amygdalar and hippocampal substrates of anxious temperament differ in
their heritability pp864-868
Anxious temperament in both humans and monkeys is an important early
predictor of psychopathology and is known to be heritable. These
authors characterize the neural circuitry associated with this trait
and the extent to which its function is heritable. A scan of related
monkeys after exposure to mild stress showed that activation in both
the amygdala and hippocampus was predictive of anxious temperament,
but that heritability of activity in hippocampus was greater than
that in amygdala.
Jonathan A. Oler et al.
doi:10.1038/nature09282
Abstract: http://links.ealert.nature.com/ctt?kn=147&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Diverse somatic mutation patterns and pathway alterations in human
cancers pp869-873
These authors performed a large-scale study in which they identified
2,576 somatic mutations across 1,507 coding genes from 441 breast,
lung, ovarian and prostate cancer types and subtypes. The study
provides an overview of the mutational spectra across major human
cancers, implies an expanded role for G[alpha] subunits in multiple cancer
types and identifies several potential therapeutic targets.
Zhengyan Kan et al.
doi:10.1038/nature09208
Abstract: http://links.ealert.nature.com/ctt?kn=146&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Wnt11 patterns a myocardial electrical gradient through regulation of
the L-type Ca2+ channel pp874-878
An electrical gradient is crucial for the normal functioning of the
heart. These authors show that Wnt11 signals are required to set up
this gradient in the developing zebrafish heart by regulating the
L-type calcium channel.
Daniela Panakova, Andreas A. Werdich and Calum A. MacRae
doi:10.1038/nature09249
Abstract: http://links.ealert.nature.com/ctt?kn=143&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=114&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Microtubule nucleating [gamma]-TuSC assembles structures with 13-fold
microtubule-like symmetry pp879-882
Microtubules are nucleated in vivo by [gamma]-tubulin complexes and comprise
13 protofilaments. How this precise geometry is controlled remains
unclear. These authors report the cryo-electron microscopic structure
of the universally conserved, core microtubule nucleating complex,
[gamma]-tubulin small complex. The structure provides insight into
how this complex establishes thirteen-fold tubulin symmetry.
Justin M. Kollman et al.
doi:10.1038/nature09207
Abstract: http://links.ealert.nature.com/ctt?kn=142&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Structure of the LexA-DNA complex and implications for SOS box measurement
pp883-886
Normally, expression of bacterial DNA damage repair genes is repressed
by the binding of LexA protein to SOS 'boxes' in their operators. DNA
damage activates the RecA protein, which promotes autocleavage of LexA
such that its repression is relieved and repair proteins are expressed.
These authors solve several structures of LexA dimer bound to SOS box
DNA, and find that the orientation of the DNA-binding wings can account
for the strict intersite spacing.
Adrianna P. P. Zhang, Ying Z. Pigli and Phoebe A. Rice
doi:10.1038/nature09200
Abstract: http://links.ealert.nature.com/ctt?kn=155&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Dynamics and mechanism of repair of ultraviolet-induced (6-4)
photoproduct by photolyase pp887–890
The repair enzyme (6-4) photolyase uses light energy to cleave the
ultraviolet-induced bond between pyrimidine dimers. These authors
use ultrafast spectroscopy to examine the detailed electron and
proton movements during the catalytic photocycle. Histidine 364 is
identified as the crucial residue involved in the rate-limiting step.
Jiang Li et al.
doi:10.1038/nature09192
Abstract: http://links.ealert.nature.com/ctt?kn=157&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=157&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Regions
Georgia by the numbers p892
Georgia looks to capitalize on its public-health and bioscience
strengths.
doi:10.1038/nj7308-892a
http://links.ealert.nature.com/ctt?kn=130&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Jeffrey Koplan p892
Jeffrey Koplan, vice-president for global health at Emory University
and former director of the Centers for Disease Control and Prevention
(CDC), both in Atlanta, discusses Georgia's life-sciences and
public-health sectors.
Karen Kaplan
doi:10.1038/nj7308-892b
http://links.ealert.nature.com/ctt?kn=134&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Prospects
Scientific career renewal p893
Finding time to explore new research areas can be beneficial for
science and scientists, says Peter Fiske.
Peter Fiske
doi:10.1038/nj7308-893a
http://links.ealert.nature.com/ctt?kn=131&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
FUTURES
----------------------
Killing time p896
An unexpected stay.
John Gilbey
doi:10.1038/466896a
http://links.ealert.nature.com/ctt?kn=159&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
11 August 2010
Statistical inference for noisy nonlinear ecological dynamic systems
Simon N. Wood
doi:10.1038/nature09319
Abstract: http://links.ealert.nature.com/ctt?kn=160&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=160&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Production of p53 gene knockout rats by homologous recombination in
embryonic stem cells
Chang Tong et al.
doi:10.1038/nature09368
Abstract: http://links.ealert.nature.com/ctt?kn=165&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
08 August 2010
OncomiR addiction in an in vivo model of microRNA-21-induced
pre-B-cell lymphoma
Pedro P. Medina, Mona Nolde and Frank J. Slack
doi:10.1038/nature09284
Abstract: http://links.ealert.nature.com/ctt?kn=193&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=193&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake
Fabiana Perocchi et al.
doi:10.1038/nature09358
Abstract: http://links.ealert.nature.com/ctt?kn=185&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=185&m=35685683&r=MjA1NzcwMjE4MQS2&b=2&j=Nzk0NjI2MTES1&mt=1&rt=0
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