22 July 2010 Volume 466 Number 7305, pp 413 - 522
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----------------------
EDITORIALS
----------------------
NASA under the spotlight p413
The decade-late, over-budget arrival of SOFIA shows that NASA's
practices need to change.
doi:10.1038/466413a
http://links.ealert.nature.com/ctt?kn=207&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Effective approach pp413-414
The controversy surrounding diabetes drugs highlights the importance
of comparative studies.
doi:10.1038/466413b
http://links.ealert.nature.com/ctt?kn=215&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
An act of distinction p414
Researchers and activists alike benefit from dialogue -- and a clear
line between legal and illegal acts.
doi:10.1038/466414a
http://links.ealert.nature.com/ctt?kn=214&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
RESEARCH HIGHLIGHTS
----------------------
Sexual selection: Networking for mates p416
doi:10.1038/466416a
http://links.ealert.nature.com/ctt?kn=212&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Cancer biology: Leukaemia lockdown p416
doi:10.1038/466416b
http://links.ealert.nature.com/ctt?kn=168&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Physics: Detection from a distance p416
doi:10.1038/466416c
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Virology: HIV spread in 3D p416
doi:10.1038/466416d
http://links.ealert.nature.com/ctt?kn=170&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Neuroscience: Versatile vision p416
doi:10.1038/466416e
http://links.ealert.nature.com/ctt?kn=169&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Ecology: Hunt for pathogen's home p417
doi:10.1038/466417a
http://links.ealert.nature.com/ctt?kn=164&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Molecular evolution: Sperm-making origins p417
doi:10.1038/466417b
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Physics: Sticky balls p417
doi:10.1038/466417c
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Neuroscience: Brain breathing p417
doi:10.1038/466417d
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Particle physics: Arctic antimatter p417
doi:10.1038/466417e
http://links.ealert.nature.com/ctt?kn=162&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
JOURNAL CLUB
----------------------
Journal club p417
Francois Fuks
doi:10.1038/466417f
http://links.ealert.nature.com/ctt?kn=160&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
NEWS
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News briefing: 22 July 2010 pp418-419
The week in science
doi:10.1038/466418a
http://links.ealert.nature.com/ctt?kn=289&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Diabetes drugs offered fresh start pp420-421
As FDA advisers vote for restrictions on Avandia, researchers reveal
a way to make such drugs safer.
Heidi Ledford
doi:10.1038/466420a
http://links.ealert.nature.com/ctt?kn=290&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
UK government warned over 'catastrophic' cuts pp420-421
Royal Society predicts 'game over' for British science.
Richard Van Noorden
doi:10.1038/466420b
http://links.ealert.nature.com/ctt?kn=291&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Audit picks a bone with US relics office p422
Congressional watchdog unearths shortcomings at agency in charge of
repatriating ancient tribal remains.
Rex Dalton
doi:10.1038/466422a
http://links.ealert.nature.com/ctt?kn=283&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Amazon drought raises research doubts p423
Studies highlight uncertainties over effects of climate change.
Jeff Tollefson
doi:10.1038/466423a
http://links.ealert.nature.com/ctt?kn=285&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Animal rights 'terror' law challenged p424
Targeted researchers support the legislation, despite free-speech
concerns.
Emma Marris
doi:10.1038/466424a
http://links.ealert.nature.com/ctt?kn=287&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Report maps perils of warming p425
Degree-by-degree breakdown of climate effects published.
Hannah Hoag
doi:10.1038/466425a
http://links.ealert.nature.com/ctt?kn=288&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Collider gets yet more exotic 'to-do' list p426
The Large Hadron Collider could throw up evidence of new physics
earlier than expected.
Zeeya Merali
doi:10.1038/466426a
http://links.ealert.nature.com/ctt?kn=254&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
NEWS FEATURES
----------------------
Astronomy: Ready for boarding — finally pp428-431
NASA and Germany have spent 15 years and billions of dollars on SOFIA,
an airborne telescope that is about to produce its first results.
Eric Hand asks whether the science will justify the cost.
Eric Hand
doi:10.1038/466428a
http://links.ealert.nature.com/ctt?kn=251&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Ecology: A world without mosquitoes pp432-434
Eradicating any organism would have serious consequences for
ecosystems — wouldn't it? Not when it comes to mosquitoes,
finds Janet Fang.
doi:10.1038/466432a
http://links.ealert.nature.com/ctt?kn=248&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
CORRESPONDENCE
----------------------
They come for the fiction and stay for the science p435
James Kakalios
doi:10.1038/466435a
http://links.ealert.nature.com/ctt?kn=184&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Businesses and biodiversity: they would say that p435
Gail Whiteman, Michael Dorsey and Bettina Wittneben
doi:10.1038/466435b
http://links.ealert.nature.com/ctt?kn=183&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
An independent thinker, willing to say what he thought p435
Nicolas Nierenberg, Walter R. Tschinkel and Victoria J. Tschinkel
doi:10.1038/466435c
http://links.ealert.nature.com/ctt?kn=182&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
OPINIONS
----------------------
Tie funding to research integrity pp436-437
A change in institutional culture is needed to promote responsible
scientific behaviour and prevent misconduct. That's unlikely to
happen unless money is involved,
say Sandra Titus and Xavier Bosch.
doi:10.1038/466436a
http://links.ealert.nature.com/ctt?kn=181&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Peers nip misconduct in the bud pp438-440
A new survey shows that informal intervention can often avert much
irresponsible scientific behaviour, and is not as risky as people
might fear,
say Gerald Koocher and Patricia Keith-Spiegel.
doi:10.1038/466438a
http://links.ealert.nature.com/ctt?kn=180&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
BOOKS AND ARTS
----------------------
When doubt becomes a weapon pp441-442
Brian Wynne wishes that a book on the vulnerability of scientific
evidence to attack by ideologists had grappled more with the larger
question of why science is such an easy target.
Brian Wynne reviews Merchants of Doubt: How a Handful of Scientists
Obscured the Truth on Issues from Tobacco Smoke to Global Warming
by Naomi Oreskes and Erik M. Conway
doi:10.1038/466441a
http://links.ealert.nature.com/ctt?kn=178&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Behind the periodic table p442
Philip Ball reviews The Disappearing Spoon: And Other True Tales of
Madness, Love, and the History of the World from the Periodic Table
of the Elements by Sam Kean
doi:10.1038/466442a
http://links.ealert.nature.com/ctt?kn=177&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
NEWS AND VIEWS
----------------------
Obesity: New life for antidiabetic drugs pp443-444
Antidiabetic drugs that activate the protein PPAR[gamma] had a bright
start but soon lost their appeal because of undesirable side effects.
Subtle modifications may once again make them suitable for treating
diabetes.
Riekelt H. Houtkooper and Johan Auwerx
doi:10.1038/466443a
http://links.ealert.nature.com/ctt?kn=176&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Astrophysics: Broad-brush cosmos pp444-445
An innovative way of mapping the large-scale structure in the Universe
sidesteps the need to observe millions of galaxies individually. The
approach holds promise for both astrophysical and cosmological studies.
Chris L. Carilli
doi:10.1038/466444a
http://links.ealert.nature.com/ctt?kn=175&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Climate change: Fatter marmots on the rise pp445-447
Demonstrations of coupled phenotypic and demographic responses to
climate change are rare. But they are much needed in formulating
predictions of the effects of climate change on natural populations.
Marcel E. Visser
doi:10.1038/466445a
http://links.ealert.nature.com/ctt?kn=174&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Catalysis: Fluorination made easier pp447-448
By putting the pieces of a chemical puzzle into the right order, a
thorny problem in catalysis has been solved. This opens the door to
syntheses of molecules that contain the useful trifluoromethyl group.
Tobias Ritter
doi:10.1038/466447a
http://links.ealert.nature.com/ctt?kn=293&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Conservation science: Hunting the cause of a population crash p448
Tamas Szekely and William J. Sutherland
doi:10.1038/466448a
http://links.ealert.nature.com/ctt?kn=295&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Neuroscience: Brain's traffic lights p449
The organization of behaviour as sequences of actions requires proper
initiation and termination of each action sequence. The neural circuit
that signals instructions to start and stop is now revealed.
Paolo Calabresi and Massimiliano Di Filippo
doi:10.1038/466449a
http://links.ealert.nature.com/ctt?kn=298&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
BRIEF COMMUNICATION ARISING
----------------------
Segregation of yeast nuclear pores pE1
Anton Khmelinskii et al.
doi:10.1038/nature09255
Abstract: http://links.ealert.nature.com/ctt?kn=301&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=304&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
ARTICLES
----------------------
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR[gamma]
by Cdk5 pp451-456
PPAR[gamma] ligands are used to control diabetes, but their anti-diabetic
actions are puzzling. Here the authors show that phosphorylation of
PPAR[gamma] by cyclin-dependent kinase 5 (Cdk5) in mice is linked to
obesity induced by high-fat feeding, and that inhibition of the effect
in humans by the drug rosiglitazone is closely associated with its
anti-diabetic effects. Several anti-diabetic PPAR[gamma] ligands directly
inhibit the effect, and thus support a more normal non-diabetic pattern
of gene expression.
Jang Hyun Choi et al.
doi:10.1038/nature09291
Abstract: http://links.ealert.nature.com/ctt?kn=307&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=310&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Start/stop signals emerge in nigrostriatal circuits during sequence
learning pp457-462
The appropriate initiation and termination of behavioural action
sequences is imperative, but the neural mechanisms underlying the
learning and execution of fixed behavioural patterns are poorly
understood. Here the authors reveal start/stop neuronal activity in
basal ganglia circuits that emerge during task training in mice.
Genetically altering these circuits disrupted the activity and
impaired performance, providing evidence for a causal relationship
between the specific neuronal activity and task learning.
Xin Jin and Rui M. Costa
doi:10.1038/nature09263
Abstract: http://links.ealert.nature.com/ctt?kn=312&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=314&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
LETTERS
----------------------
An intensity map of hydrogen 21-cm emission at redshift z[ap]0.8
pp463-465
Hitherto, 21-cm emission has been detected in galaxies only to redshift
0.24, although it is possible to measure the aggregate emission from
many more distant, unresolved sources in the 'cosmic web'. Here the
authors report a three-dimensional 21-cm intensity field at redshift
0.53-1.12. They co-add neutral-hydrogen emission from the volumes
surrounding about 10,000 galaxies to detect the aggregate 21-cm glow
at a significance of approximately four standard deviations.
Tzu-Ching Chang, Ue-Li Pen, Kevin Bandura and Jeffrey B. Peterson
doi:10.1038/nature09187
Abstract: http://links.ealert.nature.com/ctt?kn=315&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=329&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Lunar apatite with terrestrial volatile abundances pp466-469
These authors report the concentrations of hydrogen, chlorine and
sulphur in the mineral apatite from a lunar basalt, and show that
the concentrations are indistinguishable from apatites in common
terrestrial igneous rocks. They conclude that both metamorphic and
igneous models of apatite formation suggest a volatile inventory
for at least some lunar materials that is similar to comparable
materials within the Earth.
Jeremy W. Boyce et al.
doi:10.1038/nature09274
Abstract: http://links.ealert.nature.com/ctt?kn=324&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=326&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Atomically precise bottom-up fabrication of graphene nanoribbons
pp470-473
Graphene nanoribbons (GNRs) have structure-dependent electronic
properties that make them attractive for the fabrication of nanoscale
electronic devices, but exploiting this potential has been hindered
by the lack of precise production methods. Here the authors demonstrate
how to reliably produce different GNRs, using precursor monomers that
encode the structure of the targeted nanoribbon and are converted into
GNRs by means of surface-assisted coupling.
Jinming Cai et al.
doi:10.1038/nature09211
Abstract: http://links.ealert.nature.com/ctt?kn=335&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=337&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Binary nanocrystal superlattice membranes self-assembled at the
liquid-air interface pp474-477
The spontaneous assembly of two different types of nanoparticle into
ordered superlattices offers a route to designing materials with
precisely controlled properties, but available synthesis strategies
have many practical limitations. These authors report a fabrication
process which overcomes these limitations. They generate large-scale
(square-millimetre) binary superlattice structures at a liquid-air
interface, allowing the material to be free standing or transferred
to any substrate ready for fabrication into useful devices.
Angang Dong et al.
doi:10.1038/nature09188
Abstract: http://links.ealert.nature.com/ctt?kn=330&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=333&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Temperature-controlled organic carbon mineralization in lake sediments
pp478-481
The annual burial of organic carbon in lakes and reservoirs exceeds
that of ocean sediments, but inland waters are components of the
global carbon cycle that receive only limited attention. Here the
authors find that the mineralization of organic carbon in lake
sediments exhibits a strong positive relationship with temperature,
suggesting that warmer water temperatures lead to more mineralization
and less organic carbon burial.
Cristian Gudasz et al.
doi:10.1038/nature09186
Abstract: http://links.ealert.nature.com/ctt?kn=342&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=344&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Coupled dynamics of body mass and population growth in response to
environmental change pp482-485
Climate change can affect the phenology, population dynamics and
morphology of species, but it is difficult to study all these factors
and their interactions at once. Using long-term data for individual
yellow-bellied marmots, these authors show that climate change has
increased the length of the marmot growing season, leading to a gradual
increase in individual size. It has simultaneously increased the
fitness of large individuals, leading to a rapid increase in population
size.
Arpat Ozgul et al.
doi:10.1038/nature09210
Abstract: http://links.ealert.nature.com/ctt?kn=339&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=233&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Allelic variation in a fatty-acyl reductase gene causes divergence in
moth sex pheromones pp486-489
The European corn borer consists of two sex pheromone races, leading
to strong reproductive isolation which could represent a first step
in speciation. Female sex pheromone production and male behavioural
response are under the control of different genes, but the identity
of these genes is unknown. These authors show that allelic variation
in a gene essential for pheromone biosynthesis accounts for the
phenotypic variation in female pheromone production, leading to
race-specific signals.
Jean-Marc Lassance et al.
doi:10.1038/nature09058
Abstract: http://links.ealert.nature.com/ctt?kn=234&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=235&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Phenotypic robustness conferred by apparently redundant transcriptional
enhancers pp490-493
Transcriptional enhancers are segments of regulatory DNA located some
distance from the coding region of a gene, and several of them may
sometimes serve apparently redundant functions. These authors demonstrate
in Drosophila that such 'redundant' enhancers, by contributing higher
overall levels of transcription, ensure robustness of phenotypes against
both genetic and environmental perturbations, for example mutations in
other genes or temperature changes that would otherwise lead to aberrant
development.
Nicolas Frankel et al.
doi:10.1038/nature09158
Abstract: http://links.ealert.nature.com/ctt?kn=236&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=227&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Co-option of the hormone-signalling module dafachronic acid-DAF-12 in
nematode evolution pp494-497
Plants or animals with identical genomes in a given species can develop
into wildly differing forms, depending on environmental conditions, a
phenomenon that is widespread in nature yet rarely described in genetic
and molecular terms. These authors show that the formation of additional
teeth-like structures in the mouth of the nematode Pristionchus pacificus
in response to overcrowding is mediated by the same endocrine system that
controls dauer larva formation.
Gilberto Bento, Akira Ogawa and Ralf J. Sommer
doi:10.1038/nature09164
Abstract: http://links.ealert.nature.com/ctt?kn=228&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=229&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
A new DAF-16 isoform regulates longevity pp498-502
The insulin/IGF-1 signalling (IIS) pathway is involved in various
biological processes, including regulation of longevity. In the worm
Caenorhabditis elegans, the transcription factor DAF-16a, one of two
isoforms, has a major role in this pathway, regulating longevity,
stress response and dauer diapause. These authors describe a new
isoform, DAF-16d/f, which is also important in the regulation of
lifespan. The DAF-16 isoforms functionally cooperate to fine-tune
IIS-mediated processes in the context of a whole organism.
Eun-Soo Kwon, Sri Devi Narasimhan, Kelvin Yen and Heidi A. Tissenbaum
doi:10.1038/nature09184
Abstract: http://links.ealert.nature.com/ctt?kn=231&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=238&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and
craniofacial development pp503-507
PHF8 is a JmjC domain-containing protein, the gene for which has been
linked to X-linked mental retardation (XLMR). These authors demonstrate
PHF8 to be a histone demethylase with activity against H4K20me1. It has
a role in regulating gene expression as well as in neuronal cell
survival and craniofacial development in zebrafish. The results suggest
there may be a link between histone methylation dynamics and XLMR.
Hank H. Qi et al.
doi:10.1038/nature09261
Abstract: http://links.ealert.nature.com/ctt?kn=239&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=241&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
PHF8 mediates histone H4 lysine 20 demethylation events involved in
cell cycle progression pp508-512
These authors show that the JmjC domain-containing protein PHF8 has
histone demethylase activity against H4K20me1 and is linked to two
distinct events during cell cycle progression. PHF8 is recruited to
the promoters of genes involved in the G1-S phase transition, where
it removes H4K20me1 and contributes to gene activation, whereas
dissociation of PHF8 from chromatin in prophase allows H4K20me1 to
accumulate during mitosis.
Wen Liu et al.
doi:10.1038/nature09272
Abstract: http://links.ealert.nature.com/ctt?kn=261&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=263&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
LRRC26 auxiliary protein allows BK channel activation at resting
voltage without calcium pp513-516
Here the authors show that in non-excitable LNCaP prostate cancer
cells, the large-conductance, voltage- and calcium-activated potassium
(BK) channel can be activated at negative voltages without rises in
intracellular Ca2+ concentration, by interacting with an auxiliary
protein, the leucine-rich repeat containing protein 26. This auxiliary
protein modulates BK channel gating by enhancing the allosteric coupling
between voltage-sensor activation and the channel's closed-open
transition.
Jiusheng Yan and Richard W. Aldrich
doi:10.1038/nature09162
Abstract: http://links.ealert.nature.com/ctt?kn=256&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=258&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
NATUREJOBS
----------------------
Region
Shanghai by the numbers p518
Life sciences play a major role in Shanghai's growing business
community.
doi:10.1038/nj7305-518a
http://links.ealert.nature.com/ctt?kn=153&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Careers Q&A
Kewen Jin p518
Kewen Jin, general manager of Charles River Laboratories China,
a contract research organization for preclinical services, discusses
the opportunities and challenges for Shanghai.
David Cyranoski
doi:10.1038/nj7305-518b
http://links.ealert.nature.com/ctt?kn=152&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
News
Argentina smooths the path for returnees p519
Federal agreement aims to cut through red tape.
Ana Belluscio
doi:10.1038/nj7305-519a
http://links.ealert.nature.com/ctt?kn=172&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Prospects
Finding a 'real' job p519
'Alternative' careers may be commonplace, but that doesn't mitigate
a sense of failure, says Katherine Sixt.
Katherine Sixt
doi:10.1038/nj7305-519b
http://links.ealert.nature.com/ctt?kn=173&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
FUTURES
----------------------
Little Dutch boy p522
A delicate balancing act.
Jeff Crook
doi:10.1038/466522a
http://links.ealert.nature.com/ctt?kn=250&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
----------------------
Advance Online Publication
----------------------
18 July 2010
Regulation of myeloid leukaemia by the cell-fate determinant Musashi
Takahiro Ito et al.
doi:10.1038/nature09171
Abstract: http://links.ealert.nature.com/ctt?kn=253&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=245&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Cross-species genomics matches driver mutations and cell compartments
to model ependymoma
Robert A. Johnson et al.
doi:10.1038/nature09173
Abstract: http://links.ealert.nature.com/ctt?kn=247&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=271&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Microbial metalloproteomes are largely uncharacterized
Aleksandar Cvetkovic et al.
doi:10.1038/nature09265
Abstract: http://links.ealert.nature.com/ctt?kn=110&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=104&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal
and inner cell mass specification
Shinsuke Ito et al.
doi:10.1038/nature09303
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=99&m=35619053&r=MjA1NzcwMjE4MQS2&b=2&j=NzgxMjgxMjIS1&mt=1&rt=0
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UCSD Clinical and Translational Research Institute and
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Frontiers of Clinical Investigation Symposium
Pain 2010: From Bench to Bedside
October 14-16, 2010
La Jolla, CA, USA
This symposium will explore innovative approaches to bridge laboratory
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