 | EMBO reports Volume 21, Issue 1 07 January 2020 |
Editorial
Registered animal studies and null data
EMBO Rep (2020) 21: e49868 | First Published: 23 December 2019
EMBO Press encourages to document or pre‐register animal experiments on the new Animal Study Registry to increase reproducibility and efficacy of animal research.
Opinion
Open Access Why (and how) we should publish negative data
EMBO Rep (2020) 21: e49775 | First Published: 20 December 2019
Negative data and refutations are a crucial element of the scientific process. But it needs solid arguments to convince editors and reviewers to publish negative results.
Open Access Collaborating by courier, imaging by mail
EMBO Rep (2020) 21: e49755 | First Published: 16 December 2019
Core facilities offer visiting scientists access to equipment and expertise to generate and analyze data. For some projects, it might however be more efficient to collaborate remotely by sending in samples.
How to preserve the original mission of research in the omics era?
EMBO Rep (2020) 21: e49649 | First Published: 10 December 2019
The current focus on biomedical research has led to dearth of funding for basic research in evolution or ecology with the aim to better understand life.
Correspondence
USP26 regulates TGF‐β signalling by deubiquitinating and stabilizing SMAD7; not applicable in glioblastoma
EMBO Rep (2020) 21: e47030 | First Published: 20 December 2019
Comment on "USP26 regulates TGF‐β signaling by deubiquitinating and stabilizing SMAD7" by Kit Leng Lui et al.
Response to: USP26 regulates TGF‐β signalling by deubiquitinating and stabilizing SMAD7; not applicable in glioblastoma
EMBO Rep (2020) 21: e47269 | First Published: 20 December 2019
The response by the authors.
X‐linked miR‐506 family miRNAs promote FMRP expression in mouse spermatogonia
EMBO Rep (2020) 21: e49024 | First Published: 06 December 2019
Comment on "A microRNA cluster in the Fragile‐X region expressed during spermatogenesis targets FMR1" by Ramaiah et al.
Response to: X‐linked miR‐506 family miRNAs promote FMRP expression in mouse spermatogonia
EMBO Rep (2020) 21: e49354 | First Published: 06 December 2019
News & Views
One repressor to rule them all: ANCO1 links YAP and AIB1
EMBO Rep (2020) 21: e49647 | First Published: 02 December 2019
The co‐activators YAP and AIB1 individually promote breast cancer progression. A study in this issue now shows that YAP‐AIB1 form a physical complex that cooperates in both activation and repression of key breast cancer genes.
An extracellular microRNA can rescue lives in sepsis
EMBO Rep (2020) 21: e49193 | First Published: 14 November 2019
During sepsis, host proteins (Damage Associated Molecular Patterns) are released into the blood. A study in this issues shows that an extracellular microRNA inhibits one of these, thereby reducing pro‐inflammatory cytokine production.
Interview
Red lists, green lists and conservation : An interview with Thomas Brooks, Chief Scientist, International Union for the Conservation of Nature
EMBO Rep (2020) 21: e49802 | First Published: 27 December 2019
Science & Society
Open Access Rethinking the incentive system in science: animal study registries: Preregistering experiments using animals could greatly improve transparency and reliability of biomedical studies and improve animal welfare
EMBO Rep (2020) 21: e49709 | First Published: 23 December 2019
The Animal Study Registry offers scientists a range of benefits by preregistering their studies. Wider adoption could address the reproducibility problem in biomedical research and enhance animal welfare.
The deal with DEAL for open access: The recent publish‐and‐read deals have increased momentum for open‐access publishing but may not solve the challenge of open science
EMBO Rep (2020) 21: e49794 | First Published: 20 December 2019
Publish and read deals are a step forward for open access, but the devil is in the details as it does not resolve the problem of affordability for all authors.
Reports
Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression
EMBO Rep (2020) 21: e48741 | First Published: 02 December 2019
The nuclear co‐activator AIB1 recruits the tumor suppressor ANCO1 to the YAP‐TEAD transcription factor complex to repress breast cancer genes like S100A and SPRR. ANCO1 loss leads to their reactivation, promoting oncogenic YAP‐TEAD activity and disease progression.
Open Access A distinct metabolic state arises during the emergence of 2‐cell‐like cells
EMBO Rep (2020) 21: e48354 | First Published: 18 December 2019
2‐cell‐like cells share some metabolic features with the early mouse embryo, indicating a shift of the metabolic programme during 2‐cell‐like cell reprogramming.
Open Access 
HighlightPHF6 promotes non‐homologous end joining and G2 checkpoint recovery
EMBO Rep (2020) 21: e48460 | First Published: 29 November 2019
The PHD finger protein PHF6 is required for recovery from the DNA damage checkpoint and for viability after DSBs by promoting classical non‐homologous end joining.
Open Access PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis
EMBO Rep (2020) 21: e48503 | First Published: 11 December 2019
The APC/C, an E3 ubiquitin ligase, only becomes active when its co‐activator Cdc20 is associated with it. This study shows that PP2A‐B56 loaded on Apc1 plays a role in mitotic APC/C activation by dephosphorylating Cdc20.
Open Access MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex
EMBO Rep (2020) 21: e48833 | First Published: 13 November 2019
The mitochondrial genome encodes core subunits of the oxidative phosphorylation system. This study shows that MITRAC15 promotes the translation of the ND2 subunit of complex I as part of a ribosome‐nascent chain complex.
Articles
pH‐controlled histone acetylation amplifies melanocyte differentiation downstream of MITF
EMBO Rep (2020) 21: e48333 | First Published: 11 November 2019
Melanocyte differentiation is mediated by the transcription factor MITF. A feed‐forward loop involving MITF and the carbonic anhydrase 14 enables the rapid and selective expression of pigmentation genes via pH‐dependent epigenetic marks.
Open Access HighlightExtracellular microRNA 130b‐3p inhibits eCIRP‐induced inflammation
EMBO Rep (2020) 21: e48075 | First Published: 14 November 2019
The DAMP eCIRP is secreted during sepsis and induces pro‐inflammatory cytokine production in macrophages. Extracellular miR‐130b‐3p binds to eCIRP and inhibits its interaction with its receptor, subsequently inhibiting pro‐inflammatory cytokine production and sepsis.
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