 | The EMBO Journal Volume 39, Issue 2 15 January 2020 |
News & Views
Shugoshin 2—a new guardian for heat shock transcription
EMBO J (2020) 39: e104077 | First Published: 30 December 2019
New work finds heat response master regulator HSF1 co‐opting a pericentromeric protein for transcriptional activation and rescue of cells from proteotoxic stress.
Plant phosphate status drives host microbial preferences: a trade‐off between fungi and bacteria
EMBO J (2020) 39: e104144 | First Published: 30 December 2019
A new study shows that phosphate availability to the host plant drives microbial colonization versus immunity activation switch in response to bacterial volatile compounds.
Review
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis
EMBO J (2020) 39: e103397 | First Published: 03 December 2019
Broz and colleagues review the central role and regulation of the pore‐forming Gasdermin D protein in facilitating cell death as common effector of several distinct pathways.
Articles
Open Access ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast
EMBO J (2020) 39: e102586 | First Published: 05 December 2019
Micro‐ER‐phagy requires the Nem1‐Spo7 phosphatase complex and ESCRT proteins for membrane scission during uptake of multilamellar ER whorls into the lysosome.
Open Access Rhizobacterium‐derived diacetyl modulates plant immunity in a phosphate‐dependent manner
EMBO J (2020) 39: e102602 | First Published: 05 December 2019
A volatile compound produced by a plant growth‐promoting rhizobacterium differentially affects plant immunity and plant response to symbiont colonization depending on phosphate availability.
Open Access PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours
EMBO J (2020) 39: e103637 | First Published: 05 December 2019
Protein tyrosine phosphatase N2 inhibits tumour T‐cell infiltration and CAR T‐cell cytotoxicity and may thus be a therapeutic target to enhance solid‐tumour immunotherapy.
PLK4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome
EMBO J (2020) 39: e102201 | First Published: 25 November 2019
The centrosomal protein Spata2 is as a novel regulator of NEK7 phosphorylation and NLRP3‐mediated inflammatory responses.
Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments
EMBO J (2020) 39: e100789 | First Published: 18 December 2019
RNAi screening identifies the RZZ complex as mediator of early mitotic spindle attachment destabilization via high Polo kinase activity in Drosophila.
Human chromosome‐specific aneuploidy is influenced by DNA‐dependent centromeric features
EMBO J (2020) 39: e102924 | First Published: 21 November 2019
Missegregation rates vary among different chromosomes, with biased based on abundance of DNA‐dependent centromeric components rather than centromere length.
NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells
EMBO J (2020) 39: e102378 | First Published: 29 November 2019
Studies on acentrosomal human cells suggest that canonical centrosomal and NuMA/dynein‐mediated mechanisms may redundantly promote establishment of bipolar mitotic spindles after nuclear envelope breakdown.
UV‐B photoreceptor UVR8 interacts with MYB73/MYB77 to regulate auxin responses and lateral root development
EMBO J (2020) 39: e101928 | First Published: 28 November 2019
The UV‐B light inhibits auxin‐induced root and shoot growth via direct interaction between the photoreceptor UVR8 and auxin‐responsive transcription factors MYB73/MYB77.
Open Access LRRK2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK‐mediated ubiquitination pathway
EMBO J (2020) 39: e100875 | First Published: 10 December 2019
LRKK2 mutation counteracts PERK‐mediated activation of E3 ubiquitin ligases and controls mitochondria‐associated ER membrane formation.
Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2
EMBO J (2020) 39: e102591 | First Published: 29 November 2019
Cell type‐invariant chromatin association of zinc finger transcription factor Zfp281 facilitates bidirectional regulation of mouse naïve pluripotency.
The GTPase Rab39a promotes phagosome maturation into MHC‐I antigen‐presenting compartments
EMBO J (2020) 39: e102020 | First Published: 10 December 2019
Rab39a enhances antigen cross‐presentation by dendritic cells by stabilizing phagosomal antigens and peptide‐empty MHC‐I molecules, and by promoting peptide loading onto the latter.
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