 | EMBO reports Volume 20, Issue 12 05 December 2019 |
Editorial
Review Commons—pre‐journal peer review
EMBO Rep (2019) 20: e49663 | First Published: 02 December 2019
EMBO Press and ASAPbio launch Review Commons, a platform to provide authors with journal‐independent peer review of their manuscripts and preprints.
Opinion
Integrating Medical Humanities into medical school training
EMBO Rep (2019) 20: e48830 | First Published: 30 October 2019
Medical teaching must include new knowledge and technologies and how these affect patient care. The Medical Humanities can contribute to a more holistic and caring view of health and disease.
News & Views
A nuclear licence to silence transposons
EMBO Rep (2019) 20: e49262 | First Published: 16 October 2019
Transposon silencing requires the histone methyltransferase SETDB1. Two studies in this issue illustrate how the cofactor ATF7IP and its fly homolog Windei regulate SETDB1 via its nuclear licensing.
Science & Society
Revisiting published genomes with fresh eyes and new data : Revising old sequencing data can yield unexpected insights and identify errors
EMBO Rep (2019) 20: e49482 | First Published: 03 November 2019
Old data are like yesterday's leftovers: sapped of novelty and excitement. But revisiting old sequence data with a fresh mind and new techniques can yield new and unexpected results.
Open Access The troubles with peer review for allocating research funding : Funders need to experiment with versions of peer review and decision‐making
EMBO Rep (2019) 20: e49472 | First Published: 03 November 2019
Peer review to allocate funding for researchers and projects has faced difficulties lately and come under criticism. Various alternatives and improvements are being tested to address these problems.
Ancient DNA and contemporary politics : The analysis of ancient DNA challenges long‐held beliefs about identity and history with potential for political abuse
EMBO Rep (2019) 20: e49507 | First Published: 07 November 2019
The sequencing and analysis of ancient human DNA has helped to rewrite human history. But it is also tempting politicians, nationalists and supremacists to abuse this research for their agendas.
Polluted at the faucet : Exaggeration and hype of research results in the media often originate earlier at the press office
EMBO Rep (2019) 20: e49600 | First Published: 18 November 2019
The mass media are frequently accused of overhyping science and health stories. But often, the press releases by universities and research institutes are the source of hype and exaggeration.
Review
Causal roles of mitochondrial dynamics in longevity and healthy aging
EMBO Rep (2019) 20: e48395 | First Published: 31 October 2019
Mitochondria form a dynamic, interconnected network that is shaped by fusion, fission and trafficking. This review discusses how aging affects mitochondrial dynamics and how such alterations in turn might help the organism to cope with age‐dependent cellular impairments.
Reports
Open Access In vivo optochemical control of cell contractility at single‐cell resolution
EMBO Rep (2019) 20: e47755 | First Published: 30 October 2019
Uncaging EGTA with UV illumination in Drosophila embryos triggers a calcium burst and subsequent myosin‐mediated contraction of the apical surface of the cell.
Open Access Expression and phase separation potential of heterochromatin proteins during early mouse development
EMBO Rep (2019) 20: e47952 | First Published: 07 November 2019
Proteins of the constitutive heterochromatin proteome tend to contain intrinsically disordered regions. Their expression correlates with chromocenter formation and reduced cellular plasticity during mouse pre‐implantation development.
Open Access Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation
EMBO Rep (2019) 20: e47999 | First Published: 31 October 2019
An optogenetic method to control endogenous Delta activity with light reveals that the Notch receptor acts as an integrator of analog signals that generates a digital switch‐like behaviour at the level of target gene expression during tissue differentiation.
Articles
Open Access Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion
EMBO Rep (2019) 20: e48896 | First Published: 04 October 2019
Nuclei of apicomplexan parasites represent a major obstacle that needs to be squeezed through the junctional ring bridging the host cell and the parasite during invasion. This study proposes a push‐and‐pull mechanism whereby F‐actin machinery eases nuclear passage.
Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing
EMBO Rep (2019) 20: e48296 | First Published: 02 October 2019
Eggless/SETDB1 (Egg) is a H3K9 methyltransferase essential for piRNA‐mediated transposon silencing. Its nuclear monoubiquitination and the cofactor Wde independently regulate the catalytic activity and localization of Egg.
ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination
EMBO Rep (2019) 20: e48297 | First Published: 02 October 2019
Nuclear protein ATF7IP promotes the nuclear localization of the H3K9 methyltransferase SETDB1. The nuclear retention of SETDB1 increases its ubiquitination, which enhances its enzymatic activities.
Open Access Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
EMBO Rep (2019) 20: e47728 | First Published: 10 October 2019
Mitochondrial E3 ubiquitin ligase MITOL/March5 translocates from depolarized mitochondria to peroxisomes following mitophagy stimulation. Ubiquitylation of MITOL at K268 by Parkin is required for p97/VCP‐dependent extraction from damaged mitochondria.
Open Access Radial somatic F‐actin organization affects growth cone dynamics during early neuronal development
EMBO Rep (2019) 20: e47743 | First Published: 24 October 2019
During early neuronal development, centrosomes regulate F‐actin organization, thereby ensuring proper growth cone dynamics and neurite length.
Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress‐dependent mRNAs
EMBO Rep (2019) 20: e47964 | First Published: 03 November 2019
The RNA binding protein Mip6 interacts with the ubiquitin‐associated domain of Mex67 and attenuates the nuclear export of mRNAs regulated by the stress response Msn2/4 transcription factors.
Open Access SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes
EMBO Rep (2019) 20: e48029 | First Published: 06 November 2019
The trypanosome homeodomain protein SNF2PH functions as an epigenetic activator of bloodstream stage‐specific surface proteins. SUMOylated SNF2PH positively regulates monoallelic variant surface glycoprotein expression.
Open Access Caspase‐11 counteracts mitochondrial ROS‐mediated clearance of Staphylococcus aureus in macrophages
EMBO Rep (2019) 20: e48109 | First Published: 21 October 2019
Staphylococcus aureus exploits caspase‐11 to dissociate MRSA‐containing vacuoles from mitochondria. Caspase‐11 also promotes inflammasome activation and secretion of IL‐1α, IL‐1β, and CXCL1/KC in response to MRSA infection in macrophages.
TGF‐β‐activated lncRNA LINC00115 is a critical regulator of glioma stem‐like cell tumorigenicity
EMBO Rep (2019) 20: e48170 | First Published: 10 October 2019
The TGF‐β signaling pathway is critical for glioblastoma tumorigenicity. TGF‐β‐upregulated lncRNA LINC00115 acts as a miR‐200 sponge to maintain the self‐renewal capacity and tumorigenicity of glioma stem‐like cells.
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