The EMBO Journal Volume 38, Issue 23 02 December 2019 |
Editorial
Peer Review beyond Journals
EMBO J (2019) 38: e103998 | First Published: 02 December 2019
The EMBO Journal has extended its Transparent Process beyond journal confines to post referee comments alongside the preprint versions of papers and to partner with Review Commons, a pre‐journal peer‐review platform for Refereed Preprints in the life sciences.
News & Views
More or less – the same? mRNA fluctuations are balanced during translation
EMBO J (2019) 38: e103651 | First Published: 22 October 2019
Analysis of estrogen receptor alpha signalling reveals an underappreciated capacity of the translation process to adjust the proteome in response to mRNA fluctuations.
Articles
Translational offsetting as a mode of estrogen receptor α‐dependent regulation of gene expression
EMBO J (2019) 38: e101323 | First Published: 26 September 2019
In addition to its well‐established role in transcription, ERα also modulates levels of translation of selective transcripts that show alteration in their steady‐state levels following ERα perturbation, a phenomenon referred to as translational offsetting.
Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease
EMBO J (2019) 38: e102345 | First Published: 07 November 2019
Long‐term in vivo imaging shows that depletion of the microtubule‐associated protein tau blocks progression, but not initiation of Aβ deposition in APPPS1 mice, by reducing local enrichment of the Aβ‐generating protease BACE1.
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction
EMBO J (2019) 38: e101982 | First Published: 21 October 2019
Senescence in melanocytes of the ageing epidermis induces telomere damage and reduced proliferation of surrounding cells, which can be rescued by a senolytic drug.
The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes
EMBO J (2019) 38: e101230 | First Published: 18 October 2019
Wnt‐mediated activation of actin‐binding CaMKII regulates tunneling nanotube formation and transfer of vesicles and pathological protein aggregates between neurons.
Lignin‐based barrier restricts pathogens to the infection site and confers resistance in plants
EMBO J (2019) 38: e101948 | First Published: 26 September 2019
Lignin deposition is required for innate immune defense during incompatible plant‐pathogen interactions in a manner dependent on Casparian strip organizer proteins.
Cul3‐Klhl18 ubiquitin ligase modulates rod transducin translocation during light‐dark adaptation
EMBO J (2019) 38: e101409 | First Published: 07 November 2019
Ubiquitination‐dependent degradation of the transducin trafficking regulator Unc119 mediates adjustment of light sensitivity in rod photoreceptors.
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