Table of Contents Alert: The EMBO Journal, Vol. 38, No. 23, 02 December 2019

The EMBO Journal Volume 38, Issue 23 02 December 2019

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Editorial

Peer Review beyond Journals

Bernd Pulverer, Thomas Lemberger

EMBO J (2019) 38: e103998 | First Published: 02 December 2019

The EMBO Journal has extended its Transparent Process beyond journal confines to post referee comments alongside the preprint versions of papers and to partner with Review Commons, a pre‐journal peer‐review platform for Refereed Preprints in the life sciences.

News & Views

More or less – the same? mRNA fluctuations are balanced during translation

Itamar Kozlovski, Reuven Agami

EMBO J (2019) 38: e103651 | First Published: 22 October 2019

Analysis of estrogen receptor alpha signalling reveals an underappreciated capacity of the translation process to adjust the proteome in response to mRNA fluctuations.

Articles

Translational offsetting as a mode of estrogen receptor α‐dependent regulation of gene expression

Julie Lorent, Eric P Kusnadi, Vincent van Hoef, Richard J Rebello, Matthew Leibovitch, Johannes Ristau, Shan Chen, Mitchell G Lawrence, Krzysztof J Szkop, Baila Samreen, Preetika Balanathan, Francesca Rapino, Pierre Close, Patricia Bukczynska, Karin Scharmann, Itsuhiro Takizawa, Gail P Risbridger, Luke A Selth, Sebastian A Leidel, Qishan Lin, Ivan Topisirovic, Ola Larsson, Luc Furic

EMBO J (2019) 38: e101323 | First Published: 26 September 2019

In addition to its well‐established role in transcription, ERα also modulates levels of translation of selective transcripts that show alteration in their steady‐state levels following ERα perturbation, a phenomenon referred to as translational offsetting.

Open Access

Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease

Finn Peters, Hazal Salihoglu, Katrin Pratsch, Etienne Herzog, Martina Pigoni, Carmelo Sgobio, Stefan F Lichtenthaler, Ulf Neumann, Jochen Herms

EMBO J (2019) 38: e102345 | First Published: 07 November 2019

Long‐term in vivo imaging shows that depletion of the microtubule‐associated protein tau blocks progression, but not initiation of Aβ deposition in APPPS1 mice, by reducing local enrichment of the Aβ‐generating protease BACE1.

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Stella Victorelli, Anthony Lagnado, Jessica Halim, Will Moore, Duncan Talbot, Karen Barrett, James Chapman, Jodie Birch, Mikolaj Ogrodnik, Alexander Meves, Jeff S Pawlikowski, Diana Jurk, Peter D Adams, Diana van Heemst, Marian Beekman, P Eline Slagboom, David A Gunn, João F Passos

EMBO J (2019) 38: e101982 | First Published: 21 October 2019

Senescence in melanocytes of the ageing epidermis induces telomere damage and reduced proliferation of surrounding cells, which can be rescued by a senolytic drug.

The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

Jessica Y Vargas, Frida Loria, Yuan‐Ju Wu, Gonzalo Córdova, Takashi Nonaka, Sebastien Bellow, Sylvie Syan, Masato Hasegawa, Geeske M van Woerden, Capucine Trollet, Chiara Zurzolo

EMBO J (2019) 38: e101230 | First Published: 18 October 2019

Wnt‐mediated activation of actin‐binding CaMKII regulates tunneling nanotube formation and transfer of vesicles and pathological protein aggregates between neurons.

Lignin‐based barrier restricts pathogens to the infection site and confers resistance in plants

Myoung‐Hoon Lee, Hwi Seong Jeon, Seu Ha Kim, Joo Hee Chung, Daniele Roppolo, Hye‐Jung Lee, Hong Joo Cho, Yuki Tobimatsu, John Ralph, Ohkmae K Park

EMBO J (2019) 38: e101948 | First Published: 26 September 2019

Lignin deposition is required for innate immune defense during incompatible plant‐pathogen interactions in a manner dependent on Casparian strip organizer proteins.

Cul3‐Klhl18 ubiquitin ligase modulates rod transducin translocation during light‐dark adaptation

Taro Chaya, Ryotaro Tsutsumi, Leah Rie Varner, Yamato Maeda, Satoyo Yoshida, Takahisa Furukawa

EMBO J (2019) 38: e101409 | First Published: 07 November 2019

Ubiquitination‐dependent degradation of the transducin trafficking regulator Unc119 mediates adjustment of light sensitivity in rod photoreceptors.

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