Table of Contents Alert: The EMBO Journal, Vol. 38, No. 22, 15 November 2019

The EMBO Journal Volume 38, Issue 22 15 November 2019

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News & Views

Mitochondrial cristae as insulated transformers of metabolic energy

Michael Schlame

EMBO J (2019) 38: e103472 | First Published: 16 October 2019

A new study reveals that individual cristae of the inner mitochondrial membrane act as primary carriers of the proton‐motive force and are functionally independent.

Correspondence

Open Access

Killing a zombie: a full deletion of the BUB1 gene in HAP1 cells

Jonne A Raaijmakers, René H Medema

EMBO J (2019) 38: e102423 | First Published: 22 October 2019

Response to Raaijmakers & Medema

Gang Zhang, Thomas Kruse, Claudia Guasch Boldú, Dimitriya H Garvanska, Fabian Coscia, Matthias Mann, Marin Barisic, Jakob Nilsson

EMBO J (2019) 38: e103547 | First Published: 22 October 2019

Articles

Open Access

Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing

Steven C Wilson, K Ian White, Qiangjun Zhou, Richard A Pfuetzner, Ucheor B Choi, Thomas C Südhof, Axel T Brunger

EMBO J (2019) 38: e101603 | First Published: 30 September 2019

The high‐resolution crystal structure of the trans‐synaptic cell adhesion complex neurexin‐neurexophilin‐1 adds insight into how alternative splicing can affect ligand binding.

Open Access Highlight

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent

Dane M Wolf, Mayuko Segawa, Arun Kumar Kondadi, Ruchika Anand, Sean T Bailey, Andreas S Reichert, Alexander M van der Bliek, David B Shackelford, Marc Liesa, Orian S Shirihai

EMBO J (2019) 38: e101056 | First Published: 14 October 2019

Crista junctions provide electrical insulation and sustain polarization of individual mitochondrial cristae within a single mitochondrion even when neighbouring cristae are damaged.

Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs

Yuexi Gu, Yakubu Princely Abudu, Suresh Kumar, Bhawana Bissa, Seong Won Choi, Jingyue Jia, Michael Lazarou, Eeva‐Liisa Eskelinen, Terje Johansen, Vojo Deretic

EMBO J (2019) 38: e101994 | First Published: 18 October 2019

Atg8 proteins bind to SNAP receptor (SNARE) proteins that contain LC3‐interacting regions and thereby control SNARE localization and autolysosomal biogenesis during autophagy in mammals.

Deep mutational scanning of the Neisseria meningitidis major pilin reveals the importance of pilus tip‐mediated adhesion

Paul Kennouche, Arthur Charles‐Orszag, Daiki Nishiguchi, Sylvie Goussard, Anne‐Flore Imhaus, Mathieu Dupré, Julia Chamot‐Rooke, Guillaume Duménil

EMBO J (2019) 38: e102145 | First Published: 14 October 2019

Systematic mutations in pilE uncover two successive modes of type IV pilus‐mediated host cell adhesion and the requirement for a pilus length threshold for bacterial aggregation in the meningococcus.

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

Giulia Manina, Anna Griego, Lalit Kumar Singh, John D McKinney, Neeraj Dhar

EMBO J (2019) 38: e101876 | First Published: 04 October 2019

Microfluidics and live‐imaging of individual bacteria shows that the effect of antimicrobial drugs depend on the extent of prior DNA integrity in each cell.

Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity

Khoa A Tran, Caleb M Dillingham, Rupa Sridharan

EMBO J (2019) 38: e101681 | First Published: 04 October 2019

Generation of iPSCs involves a coordination of Kdm3b‐mediated histone demethylation and Tet1 DNA methylation activities.

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