Table of Contents Alert: The EMBO Journal, Vol. 38, No. 21, 04 November 2019

The EMBO Journal Volume 38, Issue 21 04 November 2019

---

Commentary

Ethical considerations for human–animal neurological chimera research: mouse models and beyond

Insoo Hyun

EMBO J (2019) 38: e103331 | First Published: 10 October 2019

This commentary discusses moral concerns and implications of current efforts to generate human chimerism in the brain of experimental animals, offering practicable considerations to guide research.

News & Views

Role reversal: adaptive immunity instructs inflammasome activation for anti‐viral defence

Rebecca C Coll

EMBO J (2019) 38: e103533 | First Published: 16 October 2019

While signalling by innate immune cells is known to regulate the adaptive immune response to an infection, new findings show that the adaptive immune system also instructs the innate response via TRIM21‐mediated NLRP3 inflammasome activation and IL‐1β secretion.

To PARP or not to PARP?—Toward sensitizing acute myeloid leukemia stem cells to immunotherapy

Benjamin Heyman, Catriona Jamieson

EMBO J (2019) 38: e103479 | First Published: 21 October 2019

New research shows that leukemia stem cells evade immune surveillance by downregulating natural killer cell‐activating receptor ligands.

Articles

Open Access

Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection

Larisa I Labzin, Maria Bottermann, Pablo Rodriguez‐Silvestre, Stian Foss, Jan Terje Andersen, Marina Vaysburd, Dean Clift, Leo C James

EMBO J (2019) 38: e101365 | First Published: 29 August 2019

Viral infection promotes NLRP3 inflammasome activation via distinct pathways – one involving lysosomal damage‐mediated cell death, the other via cytosolic antibody receptor TRIM21 and innate immune sensor cGAS.

Open Access

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

Hui Jiang, Xiaoyu Xue, Swarupa Panda, Ajinkya Kawale, Richard M Hooy, Fengshan Liang, Jungsan Sohn, Patrick Sung, Nelson O Gekara

EMBO J (2019) 38: e102718 | First Published: 23 September 2019

The cytosolic innate immune sensor cGAS has an unexpected STING‐independent function in compacting nuclear DNA and impeding RAD51‐mediated recombination repair.

Open Access

SLC1A3 contributes to L‐asparaginase resistance in solid tumors

Jianhui Sun, Remco Nagel, Esther A Zaal, Alejandro Piñeiro Ugalde, Ruiqi Han, Natalie Proost, Ji‐Ying Song, Abhijeet Pataskar, Artur Burylo, Haigen Fu, Gerrit J Poelarends, Marieke van de Ven, Olaf van Tellingen, Celia R Berkers, Reuven Agami

EMBO J (2019) 38: e102147 | First Published: 16 September 2019

Amino acid transporter SLC1A3 facilitates cancer development by circumventing amino acid deprivation induced by asparaginase treatment.

Open Access Highlight

The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs

Francisco Acosta‐Reyes, Ritam Neupane, Joachim Frank, Israel S Fernández

EMBO J (2019) 38: e102226 | First Published: 14 October 2019

Single‐molecule cryo‐EM analyses provide structural insights into the mode of host ribosome hijacking employed by IAPV for viral protein production.

Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila

Tobias Reiff, Zeus A Antonello, Esther Ballesta‐Illán, Laura Mira, Salvador Sala, Maria Navarro, Luis M Martinez, Maria Dominguez

EMBO J (2019) 38: e101346 | First Published: 30 September 2019

The rate of steady‐state turnover in the Drosophila intestinal epithelium is adjusted via DIAP1‐regulated apoptosis of committed progenitor cells.

Open Access Highlight

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

Abhay Narayan Singh, Judith Oehler, Ignacio Torrecilla, Susan Kilgas, Shudong Li, Bruno Vaz, Claire Guérillon, John Fielden, Esperanza Hernandez‐Carralero, Elisa Cabrera, Iain DC Tullis, Mayura Meerang, Paul R Barber, Raimundo Freire, Jason Parsons, Borivoj Vojnovic, Anne E Kiltie, Niels Mailand, Kristijan Ramadan

EMBO J (2019) 38: e102361 | First Published: 15 October 2019

Chromatin extraction of RNF8 by the ubiquitin‐dependent segregase p97/VCP and the deubiquitinase ATX3 emerges as a key mechanism for balancing DNA repair pathway choice.

Open Access

An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

Luke A Perera, Claudia Rato, Yahui Yan, Lisa Neidhardt, Stephen H McLaughlin, Randy J Read, Steffen Preissler, David Ron

EMBO J (2019) 38: e102177 | First Published: 18 September 2019

The bifunctional enzymatic activity of FICD in regulating AMPylation of the endoplasmic reticulum chaperone BiP is conferred by transitions of its oligomeric state.

Resource

Open Access

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation

Gemma Hardman, Simon Perkins, Philip J Brownridge, Christopher J Clarke, Dominic P Byrne, Amy E Campbell, Anton Kalyuzhnyy, Ashleigh Myall, Patrick A Eyers, Andrew R Jones, Claire E Eyers

EMBO J (2019) 38: e100847 | First Published: 21 August 2019

A new phosphopeptide enrichment strategy vastly expands the human phospho proteome beyond Ser/Thr/Tyr phosphorylation.

You are receiving this content alert because you are subscribed to The EMBO Journal as edgeblog.alerts.2011.001@gmail.com.
If you no longer wish to receive these alerts you can unsubscribe here.
You can manage all of your EMBO Press content alerts at https://www.embopress.org.