 | EMBO reports Volume 20, Issue 7 July 2019 |
Opinion
The rat race
e48528 | First Published: 11 June 2019
Labmates are colleagues, friends, comforters…and competitors.
News & Views
A tale of two clocks: phosphorylation of NICD by CDKs links cell cycle and segmentation clock
e48247 | First Published: 22 May 2019
A study in this issue shows that phosphorylation of NICD by CDKs suppresses Notch activity by promoting NICD turnover, linking Notch pathway activity to the cell cycle and the embryonic segmentation clock.
Science & Society
Microgravity research in plants : A range of platforms and options allow research on plants in zero or low gravity that can yield important insights into plant physiology
e48541 | First Published: 14 June 2019
Experiments in space and on free‐fall platforms have yielded important insights into plant's reaction to low gravity with potential applications for space research and exploration.
Open Access Words, images and gender : Lessons from a survey on the public perception of synthetic biology and related disciplines
e48401 | First Published: 26 June 2019
A large survey of visitors at a science museum about the perception of biotechnology shows that names matter and that gender has an influence on people's attitude towards new technologies.
Bio‐art : A fusion of biology and art both raises awareness of and challenges science
e48563 | First Published: 26 June 2019
Art can challenge scientists and laypersons about controversial issues in research and bring reality and thoughtfulness from outside the lab into the lab.
The advent of AI and deep learning in diagnostics and imaging : Machine learning systems have potential to improve diagnostics in healthcare and imaging systems in research
e48559 | First Published: 17 June 2019
Machine learning systems are increasingly applied in health care and the life sciences with great potential for cancer diagnostics and optical microscopy.
Reviews
Open Access The non‐specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis
e47630 | First Published: 03 June 2019
This review discusses diverse functions of the NSL complex and NSL‐catalyzed lysine acetylation in transcriptional and signaling networks in health and disease.
Central metabolic interactions of immune cells and microbes: prospects for defeating infections
e47995 | First Published: 21 June 2019
Central carbon metabolism of immune cells is essential for an effective response to pathogens. This review discusses how metabolic interactions between innate immune cells and microbes determine their survival, and ways to manipulate metabolism as a therapeutic strategy.
Reports
Requirements for multivalent Yb body assembly in transposon silencing in Drosophila
e47708 | First Published: 30 April 2019
Yb bodies are membraneless organelles central for piRNA biogenesis in Drosophila ovarian somatic cells. Yb body formation depends on all three domains of Yb (RNA helicase, Hel‐C and eTud), and is specifically required for efficient production of transposon‐repressing piRNAs.
ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant
e46885 | First Published: 24 May 2019
ULK1 phosphorylates ATG16L1 on S278 to promote autophagic activity of wild‐type ATG16L1. In contrast, this regulation enhances caspase‐mediated degradation of Crohn‐associated (T300A) ATG16L1, thereby reducing xenophagy and bacterial clearance.
Articles
Open Access CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock
e46436 | First Published: 17 April 2019
CDK1 and CDK2 phosphorylate and regulate human NICD1 turnover in a cell cycle dependent way. CDK1/2 regulation of NICD turnover impacts upon the periodicity of the vertebrate segmentation clock and somite size.
VE‐PTP inhibition stabilizes endothelial junctions by activating FGD5
e47046 | First Published: 14 May 2019
Inflammation‐induced vascular permeability is suppressed by inhibiting the endothelial tyrosine phosphatase VE‐PTP. FGD5, a GEF for Cdc42, is essential for this effect and acts as a direct substrate of VE‐PTP, which stabilizes endothelial junctions.
Open Access Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice
e47055 | First Published: 22 May 2019
Thioperamide selectively increases the levels of the endosomal phospholipid lysobisphosphatidic acid and reduces the endosomal cholesterol overload in Niemann‐Pick type C patient fibroblasts or the livers of Npc1‐deficient mice.
Regulation of MAGE‐A3/6 by the CRL4‐DCAF12 ubiquitin ligase and nutrient availability
e47352 | First Published: 24 May 2019
The CRL4‐DCAF12 E3 ubiquitin ligase controls MAGE‐A3/6 protein abundance to tune autophagy in response to cellular starvation.
Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche
e47546 | First Published: 17 June 2019
Acute myeloid leukemia functionally remodels the bone marrow niche. AML cells constitutively release extracellular vesicles enriched in miR‐1246, that traffic to long‐term hematopoietic stem cells and induce quiescence and DNA damage.
Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53
e47563 | First Published: 22 May 2019
p53 recruits USP7 to the regulatory region of SLC7A11 to reduce H2B monoubiquitination, resulting in transcriptional repression of SCL7A11 and ferroptosis induction. These results uncover an epigenetic regulatory mechanism for the control of ferroptosis.
Open Access Dynamic expression of tRNA‐derived small RNAs define cellular states
e47789 | First Published: 12 June 2019
Transfer RNA‐derived small RNAs are important regulators of protein translation. A set of tsRNAs is upregulated during induced differentiation of mESCs and regulates their stem cell‐state by modulating transcript stability and translation of the pluripotency factor c‐Myc.
Corrigendum
Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks
e48152 | First Published: 26 June 2019
This article is a correction.
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