Table of Contents Alert: The EMBO Journal, Vol. 38, No. 13, 01 July 2019

The EMBO Journal Volume 38, Issue 13 01 July 2019

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News & Views

Of seeds and supplements: structural insights into extended microRNA–target pairing

Marc R Fabian

e102477 | First Published: 18 June 2019

A new study shows a previously underappreciated role of supplementary nucleotide pairing for miRNA target recognition by Ago2.

NLRP1 – One NLR to guard them all

Carolyn A Lacey, Edward A Miao

e102494 | First Published: 12 June 2019

New work reveals intriguing interplay between anthrax lethal toxin and NLRP1 inflammasome activation and degradation.

Review

Open Access

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

Katherine E Bohnsack, Markus T Bohnsack

e100278 | First Published: 14 May 2019

This review summarizes and integrates recent insights from loss‐of‐functions screens, genetic disorders and structural biology, which begin to close the gap in understanding human ribosome biogenesis compared to yeast.

Articles

Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2

Jessica Sheu‐Gruttadauria, Yao Xiao, Luca FR Gebert, Ian J MacRae

e101153 | First Published: 26 April 2019

The crystal structure of human Ago2 in complex with miRNA and target mRNA reveals features mediating increased miRNA target recognition via supplementary nucleotide pairing.

The N‐end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin

Hao Xu, Jianjin Shi, Hang Gao, Ying Liu, Zhenxiao Yang, Feng Shao, Na Dong

e101996 | First Published: 06 May 2019

Loss‐of‐function screens in combination with new pyroptosis reporter systems reveal that the anthrax lethal toxin metalloprotease collaborates with a cellular E3 ligase for proteolytic release of an inflammasomal CARD domain inducing downstream caspase‐1 activation.

Open Access

Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis

Daniel Fisch, Hironori Bando, Barbara Clough, Veit Hornung, Masahiro Yamamoto, Avinash R Shenoy, Eva‐Maria Frickel

e100926 | First Published: 03 June 2019

Differential host cell death pathway activation upon infection with either Toxoplasma or Salmonella pathogens is mediated by a common guanylate‐binding protein‐family detector.

Genome‐scale, single‐cell‐type resolution of microRNA activities within a whole plant organ

Christopher Andrew Brosnan, Alexis Sarazin, PeiQi Lim, Nicolas Gerardo Bologna, Matthias Hirsch‐Hoffmann, Olivier Voinnet

e100754 | First Published: 12 June 2019

Genome‐wide analysis of cell type‐specific miRNA loading and activity patterns in the Arabidopsis root tip provides novel insights into miRNA‐mediated gene regulation in a complex organ.

Open Access

RASSF1A controls tissue stiffness and cancer stem‐like cells in lung adenocarcinoma

Daniela Pankova, Yanyan Jiang, Maria Chatzifrangkeskou, Iolanda Vendrell, Jon Buzzelli, Anderson Ryan, Cameron Brown, Eric O'Neill

e100532 | First Published: 27 May 2019

Epigenetic silencing of tumor suppressor RASSF1A promotes nuclear YAP1 accumulation and collagen deposition in the ECM.

TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma

Parash Parajuli, Purba Singh, Zhe Wang, Lianna Li, Sailaja Eragamreddi, Seval Ozkan, Olivier Ferrigno, Celine Prunier, Mohammed S Razzaque, Keli Xu, Azeddine Atfi

e101067 | First Published: 31 May 2019

The TGF‐β regulator TGIF1 exerts unanticipated roles in antagonizing the pro‐malignant transcription factor Twist1 in pancreatic cancer.

PP4‐dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

Arnau Hervera, Luming Zhou, Ilaria Palmisano, Eilidh McLachlan, Guiping Kong, Thomas H Hutson, Matt C Danzi, Vance P Lemmon, John L Bixby, Andreu Matamoros‐Angles, Kirsi Forsberg, Francesco De Virgiliis, Dina P Matheos, Janine Kwapis, Marcelo A Wood, Radhika Puttagunta, José Antonio del Río, Simone Di Giovanni

e101032 | First Published: 22 May 2019

Calcium‐dependent activation of PP4/2 causes HDAC3 dephosphorylation leading to enhanced histone acetylation, expression of regeneration associated genes and neurite outgrowth of dorsal root ganglia sensory neurons upon injury.

Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resection

Kristina Kasaciunaite, Fergus Fettes, Maryna Levikova, Peter Daldrop, Roopesh Anand, Petr Cejka, Ralf Seidel

e101516 | First Published: 07 June 2019

Real‐time single‐molecule analyses of DNA unwinding activity of the S. cerevisiae RecQ helicase homolog uncover differential regulation of velocity, processivity, and affinity of Sgs1 through its binding partners Dna2, RPA, and Top3‐Rmi1.

Open Access

Coupling of ATPase activity, microtubule binding, and mechanics in the dynein motor domain

Stefan Niekamp, Nicolas Coudray, Nan Zhang, Ronald D Vale, Gira Bhabha

e101414 | First Published: 31 May 2019

Mutations in the dynein stalk demonstrate its role in coordinating conformational changes across the AAA ring of the motor domain, and in regulating microtubule‐dependent movement and ATPase activity.

Resource

Open Access

Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling

Harrison Tudor Evans, Joseph Benetatos, Marloes van Roijen, Liviu‐Gabriel Bodea, Jürgen Götz

e101174 | First Published: 22 May 2019

Analyses of brain samples from transgenic mice and human patients reveal that pathogenic tau alters de novo protein synthesis, suggesting a new mechanism underlying neurodegenerative disease pathology.

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