 | The EMBO Journal Volume 38, Issue 6 Pages: 1-20 15 March 2019 |
News & Views
Open Access Boosting adult neurogenesis to enhance sensory performance
e101589 | First Published: 20 February 2019
Expansion of adult neural stem cells in the subventricular zone, by altering cell cycle dynamics, enables mice to better discriminate highly similar sensory stimuli.
An ancient antisense‐driven RNA switch drives plant sex determination
e101685 | First Published: 26 February 2019
Discovery of the central module regulating sexual dimorphism in haploid early land plants open doors towards understanding evolution of sex chromosomes in ancestors of diploid plants.
Articles
Open Access 
HighlightAn increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants
e98791 | First Published: 14 January 2019
Surplus olfactory neurons induced in adult mice are not only functionally and morphologically integrated, but can also contribute to enhanced sensory performance on a challenging olfactory task.
Open Access A cis‐acting bidirectional transcription switch controls sexual dimorphism in the liverwort
e100240 | First Published: 04 January 2019
Female sexual differentiation in a basal land plant is determined by an antisense RNA‐regulated MYB‐type transcription factor, whose conservation in vascular plants suggests shared principles for gamete formation.
Open Access HighlightUnanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death
e100024 | First Published: 25 February 2019
Reactive oxygen species or deletion of deneddylase NEDP1 both induce accumulation of endogenous NEDD8 chains, some of which bind to and inhibit poly(ADP‐ribose) polymerase 1.
ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination
e100376 | First Published: 20 February 2019
Loss of the substrate‐targeting ABRO1 subunit of BRISC deubiquitinase attenuates NLRP3‐associated inflammatory diseases in mice, making BRISC a potential new target for treatment of such conditions.
Open Access Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
e99558 | First Published: 22 February 2019
Inhibition of insulin signaling rescues mitochondrial dysfunction in C. elegans through metabolic rewiring centering on the AMPK/PKA axis and xanthine accumulation.
STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation
Pages: 1-20 | First Published: 15 February 2019
By restricting Th17 cell differentiation and promoting intestinal epithelial cell proliferation, the microbiota‐regulated cytokine LIF prevents intestinal inflammation in a mouse colitis model of inflammatory bowel disease.
Nuclear import of the DSCAM‐cytoplasmic domain drives signaling capable of inhibiting synapse formation
e99669 | First Published: 11 February 2019
A novel membrane‐to‐nucleus signaling mechanism of the cell adhesion receptors DSCAM and DSCAML1 affects the expression of neuronal target genes causing reduced neurite growth and decreased synapse formation.
A multifaceted small RNA modulates gene expression upon glucose limitation in Staphylococcus aureus
e99363 | First Published: 13 February 2019
A small non‐coding RNA RsaI represses translation initiation of mRNAs to adapt carbohydrate metabolism in response to glucose starvation.
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