 |  |  |  |  | Table of ContentsNews & Views Science & Society Reviews Scientific Reports Articles |  Volume 20, Number 6 |
News & Views  | A study in this issue reports on an alternative variant of TAZ, called cTAZ, which fine‐tunes type I interferon‐induced JAK‐STAT signalling, thereby contributing to the tight control of antiviral innate immune responses. Sabrina Strano and Giovanni Blandino Published online 17.04.2019 |
 | A study in this issue shows that high intracellular levels of lactate activate mTORC1 in KRAS transformed cells independently of growth factor input, thereby supporting oncogenic growth and proliferation. Don Benjamin and Michael N Hall Published online 27.05.2019 |
Science & Society  | An interview with Dame Anne Glover on Brexit, science in politics and science policy. Adam Gristwood and Holger Breithaupt Published online 27.05.2019 |
 | The EU Data Protection Regulation has wide‐ranging implications for research based on anonymized personal genomic and genetic data given the realistic risk of re‐identification. Mahsa Shabani and Luca Marelli Published online 24.05.2019 |
 | The term interdisciplinarity is frequently used to describe the nature of new research fields. But it is not always clear what these terms mean and whether new research fields do fulfill the criteria for truly interdisciplinary research. Fulvio Mazzocchi Published online 30.04.2019 |
 | Scanning and other non‐invasive technologies not only help to address relatives’ concerns over invasive autopsy, but can even yield more information about the cause of death when used in combination. Philip Hunter Published online 22.05.2019 |
 | A growing number of amateur biologists tinker with DNA at home or in community labs. This do‐it‐yourself movement helps to improve science literacy but it also creates some security concerns. Karl Gruber Published online 22.05.2019 |
Reviews  | While most phages are pathogens that kill their bacterial hosts, filamentous phages live in cooperative relationships with their bacterial hosts. This review highlights the current knowledge of filamentous phage biology and provides insight into their diversity. Iain D Hay and Trevor Lithgow Published online 05.04.2019 |
 | Inflammasomes are intracellular multi‐protein complexes that act as signalling hubs of the innate immune system by inducing pyroptosis and by promoting the secretion of pro‐inflammatory cytokines. This review discusses the diverging roles of inflammasome‐produced cytokines in cancer. Hanne Van Gorp and Mohamed Lamkanfi Published online 17.05.2019 |
Scientific Reports  | JAK‐STAT signaling drives the expression of IFN‐stimulated genes to mediate antiviral immunity. A short TAZ variant, cTAZ, represses JAK‐STAT signaling and cellular antiviral responses in a Hippo pathway independent manner. Chuantao Fang, Jian Li, Sixian Qi, Yubin Lei, Yan Zeng, Pengcheng Yu, Zhaolan Hu, Yufeng Zhou, Yulong Wang, Ruping Dai, Jin Li, Shenglin Huang, Pinglong Xu, Kang Chen, Chen Ding and Fa‐Xing Yu Published online 11.04.2019 |
 | The orphan nuclear receptor COUP‐TFII transmits KRAS‐induced oncogenic signals to promote glycolysis in cancer. KRAS/MEK‐dependent upregulation of COUP‐TFII increases LDHA expression, resulting in lactate production and mTORC1 activation. Jun‐Kyu Byun, Mihyang Park, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, You Mie Lee, In‐Kyu Lee, Yeon‐Kyung Choi and Keun‐Gyu Park Published online 15.04.2019 |
 | Repositioning of nucleosomes occurs as human iPSC develop into neural progenitor cells, but a small number of nucleosome arrays remain in place at regulatory sites that control long‐range chromatin organisation. Janet C Harwood, Nicholas A Kent, Nicholas D Allen and Adrian J Harwood |
 | PfPH2 is a pan‐apicomplexan phosphoinositide‐binding protein important to attach and invade a red blood cell by the malaria parasite Plasmodium falciparum. It is implicated in the exocytosis of the micronemes secretory organelles. Zeinab Ebrahimzadeh, Angana Mukherjee, Marie‐Ève Crochetière, Audrey Sergerie, Souad Amiar, L Alexa Thompson, Dominic Gagnon, David Gaumond, Robert V Stahelin, Joel B Dacks and Dave Richard Published online 16.05.2019 |
Articles  | The RNA‐binding protein Gadd45α controls aversive learning and synaptic plasticity by post‐transcriptional regulation of a set of memory‐related transcripts, containing long 3′UTR extensions. Alejandro Aparisi Rey, Emil Karaulanov, Salim Sharopov, Khelifa Arab, Andrea Schäfer, Mathias Gierl, Stephan Guggenhuber, Caroline Brandes, Luigi Pennella, Wolfram H Gruhn, Ruth Jelinek, Christina Maul, Andrea Conrad, Werner Kilb, Heiko J Luhmann, Christof Niehrs and Beat Lutz |
 | Neural patterning in vertebrates is considered to follow a two‐step process with BMP antagonists first inducing anterior neural fate followed by a caudalization step in response to a Wnt morphogen gradient. New data in Xenopus challenges this paradigm. Hanna Polevoy, Yoni E Gutkovich, Ariel Michaelov, Yael Volovik, Yaniv M Elkouby and Dale Frank Published online 01.04.2019 |
 | The RNA binding protein IGF2BP1/IMP1 is upregulated in patients with Crohn's disease and ulcerative colitis. Imp1 deletion increases autophagy and recovery from colonic epithelial damage, suggesting that IMP1 modulates colonic inflammation and epithelial homeostasis. Priya Chatterji, Patrick A Williams, Kelly A Whelan, Fernando C Samper, Sarah F Andres, Lauren A Simon, Louis R Parham, Rei Mizuno, Emma T Lundsmith, David SM Lee, Shun Liang, HR Sagara Wijeratne, Stefanie Marti, Lillian Chau, Veronique Giroux, Benjamin J Wilkins, Gary D Wu, Premal Shah, Gian G Tartaglia and Kathryn E Hamilton Published online 06.05.2019 |
 | Tau accumulation, one hallmark of Alzheimer's disease, induces synaptic impairment by activating JAK2/STAT1 signaling, which transcriptionally suppresses N‐methyl‐D‐aspartate receptors. Downregulation of STAT1 ameliorates synaptic function and memory performance in mice. Xiao‐Guang Li, Xiao‐Yue Hong, Ya‐li Wang, Shu‐Juan Zhang, Jun‐Fei Zhang, Xia‐Chun Li, Yan‐Chao Liu, Dong‐Shen Sun, Qiong Feng, Jin‐Wang Ye, Yuan Gao, Dan Ke, Qun Wang, Hong‐lian Li, Keqiang Ye, Gong‐Ping Liu and Jian‐Zhi Wang Published online 13.05.2019 |
 | How the nucleus acquires its size is a fundamental cell biological question. This study identifies a novel mammalian nuclear size effector, and shows that pore complex number and transport factor levels tune nuclear import capacity and size. Predrag Jevtić, Andria C Schibler, Chase C Wesley, Gianluca Pegoraro, Tom Misteli and Daniel L Levy Published online 13.05.2019 |
 | Centriolar satellites are membraneless protein complex assemblies of the vertebrate centrosome/cilium complex. Depletion of satellites in cultured kidney epithelial cells reveals ciliary specific functions of centriolar satellites. Ezgi Odabasi, Seref Gul, Ibrahim H Kavakli and Elif N Firat‐Karalar |
 | The mitochondrial transcription elongation factor TEFM provides primers for mtDNA replication and is required for mtDNA transcription and also for RNA processing. Shan Jiang, Camilla Koolmeister, Jelena Misic, Stefan Siira, Inge Kühl, Eduardo Silva Ramos, Maria Miranda, Min Jiang, Viktor Posse, Oleksandr Lytovchenko, Ilian Atanassov, Florian A Schober, Rolf Wibom, Kjell Hultenby, Dusanka Milenkovic, Claes M Gustafsson, Aleksandra Filipovska and Nils‐Göran Larsson |
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