The EMBO Journal Table of Contents for 15 May 2019; Vol. 38, No. 10

15 May 2019 | Volume 38, Number 10 Submit Table of Contents News & Views Articles Corrigendum Volume 38, Number 10 News & Views Chopping GSDMD: caspase‐8 has joined the team of pyroptosis‐mediating caspases While caspase‐8 is normally associated with apoptosis, recent studies show that it is also involved in pyroptosis, cleaving gasdermin D to trigger pyroptosis‐like cell death and IL‐1β release in macrophages. Anna M Gram, Lee M Booty and Clare E Bryant Published online 15.04.2019 Helping daughters succeed: asymmetric distribution of glucose transporter mRNA A new study shows that enrichment of the glucose transporter Hxt2 mRNA in the yeast bud following quiescence exit favors growth of daughter cells. Allyson F O'Donnell and Martin C Schmidt Published online 29.04.2019 Articles In situ and high‐resolution cryo‐EM structure of a bacterial type VI secretion system membrane complex The detailed structure of the membrane‐embedded T6SS complex from enteroaggregative E. coli reveals novel structural features essential for its assembly. Chiara Rapisarda, Yassine Cherrak, Romain Kooger, Victoria Schmidt, Riccardo Pellarin, Laureen Logger, Eric Cascales, Martin Pilhofer, Eric Durand and Rémi Fronzes Published online 15.03.2019 Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly Caspase‐8/9‐mediated apoptosis avoids lytic cell death despite initial gasdermin cleavage, with inflammasome activation instead being driven by the channel‐forming glycoprotein pannexin. Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar and Petr Broz Published online 22.03.2019 Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast Enrichment of the glucose transporter Hxt2 mRNA in the yeast bud following quiescence exit favors growth of daughter cells. Timo Stahl, Stefan Hümmer, Nikolaus Ehrenfeuchter, Nitish Mittal, Geoffrey Fucile and Anne Spang Published online 25.03.2019 Single‐cell damage elicits regional, nematode‐restricting ethylene responses in roots Tissue damage restricted to a limited root area triggers a non‐systemic ethylene response as a defense mechanism against microscopic invaders. Peter Marhavý, Andrzej Kurenda, Shahid Siddique, Valerie Dénervaud Tendon, Feng Zhou, Julia Holbein, M Shamim Hasan, Florian MW Grundler, Edward E Farmer and Niko Geldner Published online 06.05.2019 Regulation of death receptor signaling by the autophagy protein TP53INP2 The autophagy regulator TP53INP2 promotes death receptor‐induced apoptosis through TRAF6‐dependent ubiquitination of caspase‐8. Saška Ivanova, Mira Polajnar, Alvaro Jesus Narbona‐Perez, Maria Isabel Hernandez‐Alvarez, Petra Frager, Konstantin Slobodnyuk, Natalia Plana, Angel R Nebreda, Manuel Palacin, Roger R Gomis, Christian Behrends and Antonio Zorzano Published online 12.04.2019 Co‐degradation of interferon signaling factor DDX3 by PB1‐F2 as a basis for high virulence of 1918 pandemic influenza Comparative interactome analysis reveals a new mechanism for antagonizing interferon responses by the pandemic 1918 influenza strain, through proteasomal degradation of an antiviral innate immunity mediator. Eun‐Sook Park, Young Ho Byun, Soree Park, Yo Han Jang, Woo‐Ry Han, Juhee Won, Kyung Cho Cho, Doo Hyun Kim, Ah Ram Lee, Gu‐Choul Shin, Yong Kwang Park, Hong Seok Kang, Heewoo Sim, Yea Na Ha, Byeongjune Jae, Ahyun Son, Paul Kim, Jieun Yu, Hye‐Min Lee, Sun‐Bin Kwon, Kwang Pyo Kim, Seung‐Hyun Lee, Yeong‐Min Park, Baik L Seong and Kyun‐Hwan Kim Published online 12.04.2019 The yeast mitochondrial pyruvate carrier is a hetero‐dimer in its functional state Mpc1/Mpc3 and Mpc1/Mpc2 heterodimers constitute the functional unit of yeast mitochondrial pyruvate carrier complex in respiratory and fermentative conditions, respectively. Sotiria Tavoulari, Chancievan Thangaratnarajah, Vasiliki Mavridou, Michael E Harbour, Jean‐Claude Martinou and Edmund RS Kunji Published online 12.04.2019 OTUB1 inhibits CNS autoimmunity by preventing IFN‐γ‐induced hyperactivation of astrocytes Upregulation of the OTUB1 deubiquitinase in nervous system autoimmune conditions such as multiple sclerosis stabilizes the JAK/STAT inhibitor SOCS1 to reduce astrocyte‐mediated neuroinflammatory responses. Xu Wang, Floriana Mulas, Wenjing Yi, Anna Brunn, Gopala Nishanth, Sissy Just, Ari Waisman, Wolfgang Brück, Martina Deckert and Dirk Schlüter Published online 03.04.2019 YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells The transcription factor YY1 exerts binary roles in satellite cell energy metabolism and mitochondrial function during muscle development and in response to injury. Fengyuan Chen, Jiajian Zhou, Yuying Li, Yu Zhao, Jie Yuan, Yang Cao, Lijun Wang, Zongkang Zhang, Baoting Zhang, Chi Chiu Wang, Tom H Cheung, Zhenguo Wu, Carmen Chak‐Lui Wong, Hao Sun and Huating Wang Published online 12.04.2019 Corrigendum Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 Ruth Scherz‐Shouval, Elena Shvets, Ephraim Fass, Hagai Shorer, Lidor Gil and Zvulun Elazar Published online 15.05.2019   Unsubscribe from or edit your subscription for this service. Copyright © 2019 by the European Molecular Biology Organisation.