EMBO reports Table of Contents for April 2019; Vol. 20, No. 4

April 2019 | Volume 20, Number 4 Submit Table of Contents Opinion News & Views Science & Society Reviews Scientific Reports Articles Volume 20, Number 4 Opinion Brexit negotiations: what is next for science? Both the EU and the UK are firmly committed to ensure that international cooperation in research continues after Brexit. But as the date nears, the effects for science and foreign researchers in the UK are not clear yet. Karen H Vousden Published online 15.03.2019 Lamarck and Darwin revisited Evolution had been puzzled scholars for centuries until Lamarck and Darwin proposed their general theories of evolution. While Lamarck was shown to be wrong, Darwin's insights revolutionized biology. Ladislav Kováč Published online 06.03.2019 News & Views Beyond sensing DNA: a role for cGAS in the detection of extracellular cyclic di‐nucleotides cGAS is an innate immune receptor that detects pathogenic DNA in the cytosol. A study in this issue reports that cGAS can also bind endocytosed cyclic di‐nucleotides produced by extracellular bacteria, thereby enhancing STING‐dependent innate responses. Leonie Unterholzner Published online 19.03.2019 Oncogenes calling on a lysosomal Ca2+ channel Oncogene‐dependent cancers use lysosomal biogenesis for nutrient supply. A study in this issue reports that increased levels of the lysosomal channel TRPML1 and its activator PI(3,5)P2 are essential for cell proliferation and tumor growth. Daniella M Schwartz and Shmuel Muallem Published online 15.03.2019 Science & Society The Third Cognitive Revolution: The consequences and possibilities for biomedical research The Third Cognitive Revolution poses particular challenges for biomedical research to adopt new knowledge. Interdisciplinary education at all levels would help to address these. James B Hittner, Almira L Hoogesteijn, Jeanne M Fair, Marc HV van Regenmortel and Ariel L Rivas Published online 29.03.2019 One step ahead: Innovation in core facilities Core facilities—originally founded to give scientists access to a specific technology or service—have expanded to become incubators for new technologies and services. While it has many benefits, it also creates unique problems and challenges. Saskia Lippens, Christophe D'Enfert, Lilla Farkas, Anna Kehres, Bernhard Korn, Mònica Morales, Rainer Pepperkok, Lavanya Premvardhan, Ralph Schlapbach, Andreas Tiran, Doris Meder and Geert Van Minnebruggen Published online 14.03.2019 Changing times for science and the public: Science journalists’ roles for the responsible communication of science The increasing number of corrections in the scientific record and the debate about reproducibility affect journalists’ reporting about science and thereby public opinion on scientists and research. Suzana Liskauskas, Mariana D Ribeiro and Sonia MR Vasconcelos Published online 08.03.2019 Diet and exercise: Clinical studies and molecular biology show that diet and other lifestyle changes have significant potential for treating metabolic diseases Biomedical research and clinical studies provide evidence that a healthy diet and lifestyle along with psychological support could be more efficient in treating and managing metabolic disorders than medication. Philip Hunter Published online 12.03.2019 Reviews Microbiome diurnal rhythmicity and its impact on host physiology and disease risk Host‐microbiome interactions constitute key determinants of host physiology, while their deregulation is implicated in human disease. This review highlights the newest developments in understanding circadian host‐microbiome interplays, and discusses their relevance for health and disease. Samuel Philip Nobs, Timur Tuganbaev and Eran Elinav Published online 15.03.2019 Energy metabolism in cachexia This review discusses the contribution of different organs to energy wasting in cachexia, as well as the complex interplay of futile energy‐wasting circuits between organs and within cells. Maria Rohm, Anja Zeigerer, Juliano Machado and Stephan Herzig Published online 19.03.2019 Scientific Reports Clipped histone H3 is integrated into nucleosomes of DNA replication genes in the human malaria parasite Plasmodium falciparum Histone H3 is clipped at amino acid 21 in a stage‐specific manner in the malaria parasite Plasmodium falciparum. Truncated H3 is integrated into nucleosomes adjacent to genes with a role in DNA replication. Abril Marcela Herrera‐Solorio, Shruthi Sridhar Vembar, Cameron Ross MacPherson, Daniela Lozano‐Amado, Gabriela Romero Meza, Beatriz Xoconostle‐Cazares, Rafael Miyazawa Martins, Patty Chen, Miguel Vargas, Artur Scherf and Rosaura Hernández‐Rivas Published online 04.03.2019 miR‐132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity The miR‐132/212 cluster plays important roles in acute inflammation and infection. This study shows that during pathogen‐induced chronic inflammation miR‐132‐mediated regulation of ribosomal protein expression is critical for CD4+ T cell activation and protective immunity. James P Hewitson, Kunal M Shah, Najmeeyah Brown, Paul Grevitt, Sofia Hain, Katherine Newling, Tyson V Sharp, Paul M Kaye and Dimitris Lagos Published online 04.03.2019 Parental centrioles are dispensable for deuterosome formation and function during basal body amplification Deuterosomes serve as platforms for centriole biogenesis in mouse multiciliated cells. Analysis of mouse ependymal cells deficient in centrioles reveals that deuterosomes form and function independently from parental centrioles. Huijie Zhao, Qingxia Chen, Chuyu Fang, Qiongping Huang, Jun Zhou, Xiumin Yan and Xueliang Zhu Published online 04.03.2019 Articles Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages Lacteals are tube‐like lymphatic vessel in intestinal villae that serve for drainage of absorbed lipids. The gut microbiota is a crucial regulator for lacteal integrity and stimulates VEGF‐C production from intestinal villus macrophages. Sang Heon Suh, Kibaek Choe, Seon Pyo Hong, Seung‐hwan Jeong, Taija Mäkinen, Kwang Soon Kim, Kari Alitalo, Charles D Surh, Gou Young Koh and Joo‐Hye Song Published online 19.02.2019 cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity cGAS senses internalized extracellular cyclic dinucleotides, thereby promoting the formation of a cGAS/STING complex to activate innate immune responses. eCDNs thus are microbe‐ and danger‐associated molecular patterns that contribute to host‐microbe crosstalk. Haipeng Liu, Pedro Moura‐Alves, Gang Pei, Hans‐Joachim Mollenkopf, Robert Hurwitz, Xiangyang Wu, Fei Wang, Siyu Liu, Mingtong Ma, Yiyan Fei, Chenggang Zhu, Anne‐Britta Koehler, Dagmar Oberbeck‐Mueller, Karin Hahnke, Marion Klemm, Ute Guhlich‐Bornhof, Baoxue Ge, Anne Tuukkanen, Michael Kolbe, Anca Dorhoi and Stefan HE Ka ufmann Published online 14.03.2019 HRAS‐driven cancer cells are vulnerable to TRPML1 inhibition Tumors with oncogenic HRAS mutations upregulate endolysosomal biogenesis. Depletion or inhibition of the TRP channel TRPML1 attenuates proliferation of cancer cells, revealing a selective vulnerability of HRAS‐driven cancers to TRPML1 inhibition. Jewon Jung, Kwang‐Jin Cho, Ali K Naji, Kristen N Clemons, Ching On Wong, Mariana Villanueva, Steven Gregory, Nicholas E Karagas, Lingxiao Tan, Hong Liang, Morgan A Rousseau, Kelly M Tomasevich, Andrew G Sikora, Ilya Levental, Dharini van der Hoeven, Yong Zhou, John F Hancock and Kartik Venkatachalam Published online 20.02.2019 UBTD1 is a mechano‐regulator controlling cancer aggressiveness In lung and prostate cancer, low levels of UBTD1 are associated with poor survival, suggesting that it limits cancer progression. UBTD1 depletion affects the mechanical properties of cancer cells, decreases YAP ubiquitylation and promotes YAP activation. Stéphanie Torrino, François‐René Roustan, Lisa Kaminski, Thomas Bertero, Sabrina Pisano, Damien Ambrosetti, Maeva Dufies, Jay P Uhler, Emmanuel Lemichez, Amel Mettouchi, Maeva Gesson, Kathiane Laurent, Cedric Gaggioli, Jean‐Francois Michiels, Christophe Lamaze, Frédéric Bost and Stéphan Clavel Published online 25.02.2019 Ash1 counteracts Polycomb repression independent of histone H3 lysine 36 methylation This study shows that H3K36 methylation is not required for Polycomb repression. It indicates that the model that Trithorax group proteins methylate histone H3 to inhibit the histone methyltransferase activity of Polycomb complexes needs to be revised. Eshagh Dorafshan, Tatyana G Kahn, Alexander Glotov, Mikhail Savitsky, Matthias Walther, Gunter Reuter and Yuri B Schwartz Published online 04.03.2019 Cytoplasmic control of Rab family small GTPases through BAG6 BAG6 specifically recognizes exposed hydrophobic residues in the Switch I region of inactive, GDP‐bound Rab8a. BAG6 targets GDP‐Rab8a to proteasomal degradation to maintain the integrity of the Golgi and endosomal compartments. Toshiki Takahashi, Setsuya Minami, Yugo Tsuchiya, Kazu Tajima, Natsumi Sakai, Kei Suga, Shin‐ichi Hisanaga, Norihiko Ohbayashi, Mitsunori Fukuda and Hiroyuki Kawahara Published online 25.02.2019 Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism Msp1 removes mislocalized tail‐anchored proteins to safeguard mitochondrial function. Msp1 recognizes substrates through a dual recognition mechanism involving hydrophobic interactions in the cytoplasm and electrostatic interactions in the intermembrane space. Lanlan Li, Jing Zheng, Xi Wu and Hui Jiang Published online 11.03.2019 Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart The metabolite dihydrosphingosine (DHS), a potent HDAC inhibitor, accumulates in the heart in an age‐dependent manner. Elevated DHS levels result in cellular transcription‐dependent DNA damage, which ultimately causes ageing‐associated cardiac insufficiencies. Gaurav Ahuja, Deniz Bartsch, Wenjie Yao, Simon Geissen, Stefan Frank, Aitor Aguirre, Nicole Russ, Jan‐Erik Messling, Joanna Dodzian, Kim A Lagerborg, Natalia Emilse Vargas, Joscha Sergej Muck, Susanne Brodesser, Stephan Baldus, Agapios Sachinidis, Juergen Hescheler, Christoph Dieterich, Aleksandra Trifunovic, Argyris Papantonis, Michael Petrasc heck, Anna Klinke, Mohit Jain, Dario Riccardo Valenzano and Leo Kurian Published online 18.03.2019 Reporter‐based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation A combination of gene‐editing, lineage tracing and human stem cell technologies identifies human nephron progenitors in kidney organoids and shows that human kidney organoids lack a progenitor niche capable of self‐renewal and ongoing nephrogenesis. Sara E Howden, Jessica M Vanslambrouck, Sean B Wilson, Ker Sin Tan and Melissa H Little Published online 11.03.2019 Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β‐catenin modulator Annexin A1 Fusobacterium nucleatum specifically stimulates colorectal carcinoma cells by inducing the Wnt/β‐catenin modulator Annexin A1. This supports a model where driver mutations serve as the first, and microbial infection as the second “hit” to promote cancer progression. Mara Roxana Rubinstein, Jung Eun Baik, Stephen M Lagana, Richard P Han, William J Raab, Debashis Sahoo, Piero Dalerba, Timothy C Wang and Yiping W Han Published online 04.03.2019   Unsubscribe from or edit your subscription for this service. Copyright © 2019 by the European Molecular Biology Organisation.