The EMBO Journal Table of Contents for 15 March 2019; Vol. 38, No. 6

15 March 2019 | Volume 38, Number 6 Submit Table of Contents News & Views Articles Volume 38, Number 6 News & Views Boosting adult neurogenesis to enhance sensory performance Expansion of adult neural stem cells in the subventricular zone, by altering cell cycle dynamics, enables mice to better discriminate highly similar sensory stimuli. Marcela Lipovsek and Matthew S Grubb Published online 20.02.2019 An ancient antisense‐driven RNA switch drives plant sex determination Discovery of the central module regulating sexual dimorphism in haploid early land plants open doors towards understanding evolution of sex chromosomes in ancestors of diploid plants. Frédéric Berger Published online 26.02.2019 Articles An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants Surplus olfactory neurons induced in adult mice are not only functionally and morphologically integrated, but can also contribute to enhanced sensory performance on a challenging olfactory task. Sara Bragado Alonso, Janine K Reinert, Nicolas Marichal, Simone Massalini, Benedikt Berninger, Thomas Kuner and Federico Calegari Published online 14.01.2019 A cis‐acting bidirectional transcription switch controls sexual dimorphism in the liverwort Female sexual differentiation in a basal land plant is determined by an antisense RNA‐regulated MYB‐type transcription factor, whose conservation in vascular plants suggests shared principles for gamete formation. Tetsuya Hisanaga, Keitaro Okahashi, Shohei Yamaoka, Tomoaki Kajiwara, Ryuichi Nishihama, Masaki Shimamura, Katsuyuki T Yamato, John L Bowman, Takayuki Kohchi and Keiji Nakajima Published online 04.01.2019 Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death Reactive oxygen species or deletion of deneddylase NEDP1 both induce accumulation of endogenous NEDD8 chains, some of which bind to and inhibit poly(ADP‐ribose) polymerase 1. Matthew J Keuss, Roland Hjerpe, Oliver Hsia, Robert Gourlay, Richard Burchmore, Matthias Trost and Thimo Kurz Published online 25.02.2019 ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination Loss of the substrate‐targeting ABRO1 subunit of BRISC deubiquitinase attenuates NLRP3‐associated inflammatory diseases in mice, making BRISC a potential new target for treatment of such conditions. Guangming Ren, Xuanyi Zhang, Yang Xiao, Wen Zhang, Yu Wang, Wenbing Ma, Xiaohan Wang, Pan Song, Lili Lai, Hui Chen, Yiqun Zhan, Jianhong Zhang, Miao Yu, Changhui Ge, Changyan Li, Ronghua Yin and Xiaoming Yang Published online 20.02.2019 Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction Inhibition of insulin signaling rescues mitochondrial dysfunction in C. elegans through metabolic rewiring centering on the AMPK/PKA axis and xanthine accumulation. Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera and Daniele Bano Published online 22.02.2019 STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation By restricting Th17 cell differentiation and promoting intestinal epithelial cell proliferation, the microbiota‐regulated cytokine LIF prevents intestinal inflammation in a mouse colitis model of inflammatory bowel disease. Yanan S Zhang, Dazhuan E Xin, Zhizhang Wang, Xinyang Song, Yanyun Sun, Quanli C Zou, Jichen Yue, Chenxi Zhang, Junxun M Zhang, Zhi Liu, Xiaoren Zhang, Ting C Zhao, Bing Su and Y Eugene Chin Published online 15.02.2019 Nuclear import of the DSCAM‐cytoplasmic domain drives signaling capable of inhibiting synapse formation A novel membrane‐to‐nucleus signaling mechanism of the cell adhesion receptors DSCAM and DSCAML1 affects the expression of neuronal target genes causing reduced neurite growth and decreased synapse formation. Sonja M Sachse, Sam Lievens, Luís F Ribeiro, Dan Dascenco, Delphine Masschaele, Katrien Horré, Anke Misbaer, Nele Vanderroost, Anne Sophie De Smet, Evgenia Salta, Maria‐Luise Erfurth, Yoshiaki Kise, Siegfried Nebel, Wouter Van Delm, Stéphane Plaisance, Jan Tavernier, Bart De Strooper, Joris De Wit and Dietmar Schmucker Published online 11.02.2019 A multifaceted small RNA modulates gene expression upon glucose limitation in Staphylococcus aureus A small non‐coding RNA RsaI represses translation initiation of mRNAs to adapt carbohydrate metabolism in response to glucose starvation. Delphine Bronesky, Emma Desgranges, Anna Corvaglia, Patrice François, Carlos J Caballero, Laura Prado, Alejandro Toledo‐Arana, Inigo Lasa, Karen Moreau, François Vandenesch, Stefano Marzi, Pascale Romby and Isabelle Caldelari Published online 13.02.2019   Unsubscribe from or edit your subscription for this service. Copyright © 2019 by the European Molecular Biology Organisation.