The EMBO Journal Table of Contents for 1 March 2019; Vol. 38, No. 5

1 March 2019 | Volume 38, Number 5 Submit Table of Contents News & Views Articles Corrigendum Volume 38, Number 5 News & Views Ubiquitin—a beacon for all during quality control on the ribosome Two recent studies reveal the importance of ribosomal protein ubiquitination within the unique structural context of collided ribosomes for mRNA no‐go decay and proteolysis of aborted nascent peptides. Liewei L Yan and Hani S Zaher Published online 15.02.2019 Length doesn't matter—telomere damage triggers cellular senescence in the ageing heart A new study shows that DNA damage at chromosome ends causes deterioration of post‐mitotic cardiomyocytes independently of telomere replication and length maintenance. Thomas Brand Published online 15.02.2019 Articles Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways Yeast Hel2 ubiquitin ligase functions in both ribosome‐associated protein quality control and canonical mRNA no‐go decay pathways coupled to disome units. Ken Ikeuchi, Petr Tesina, Yoshitaka Matsuo, Takato Sugiyama, Jingdong Cheng, Yasushi Saeki, Keiji Tanaka, Thomas Becker, Roland Beckmann and Toshifumi Inada Published online 04.01.2019 Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence Mitochondria derived reactive oxygen species trigger persistent DNA damage at telomeres, cardiomyocyte senescence and heart dysfunction during ageing. Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual‐Chalot, Marissa J Schafer, Carolyn M Roos, Jordan D Miller, Neil Robertson, Jelena Mann, Peter D Adams, Tamara Tch konia, James L Kirkland, Jeanne Mialet‐Perez, Gavin D Richardson and João F Passos Published online 08.02.2019 The herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐κB signaling and STING's dual role during MCMV infection The murine cytomegalovirus (MCMV) protein m152 specifically antagonizes the cGAS‐STING mediated antiviral type I IFN response but not STING‐mediated NF‐κB signaling to promote CMV infection. Markus Stempel, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Søren R Paludan, Nadia Füllbrunn, Niels AW Lemmermann and Melanie M Brinkmann Published online 29.01.2019 Abnormal TDP‐43 function impairs activity‐dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing Knock‐down, aggregation or neurodegeneration‐associated mutation of TDP‐43 equally culminate in impaired secretion of neurotrophin BDNF, whose restoration is sufficient to rescue major disease phenotypes caused by aberrant TDP‐43 activity. Jason Y Tann, Lik‐Wei Wong, Sreedharan Sajikumar and Carlos F Ibáñez Published online 28.01.2019 Localized incorporation of outer membrane components in the pathogen Brucella abortus Cell envelope proteins and saccharides of Brucella abortus are targeted to active membrane growth sites and exhibit low mobility increasing surface antigen variability. Victoria Vassen, Claire Valotteau, Cécile Feuillie, Cécile Formosa‐Dague, Yves F Dufrêne and Xavier De Bolle Published online 11.01.2019 EZH2 cooperates with gain‐of‐function p53 mutants to promote cancer growth and metastasis A non‐methyltransferase function of EZH2 controls cap‐independent translation of wildtype and mutant p53 in prostate cancer. Yu Zhao, Liya Ding, Dejie Wang, Zhenqing Ye, Yundong He, Linlin Ma, Runzhi Zhu, Yunqian Pan, Qiang Wu, Kun Pang, Xiaonan Hou, Saravut J Weroha, Conghui Han, Roger Coleman, Ilsa Coleman, R Jeffery Karnes, Jun Zhang, Peter S Nelson, Liguo Wang and Haojie Huang Published online 05.02.2019 Endophilin‐A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells Endophilins regulate Ca2+ channel abundance, Ca2+ influx and synaptic vesicle recycling in inner hair cells by coupling exocytosis to endocytosis, contributing to membrane retrieval and synaptic vesicle reformation. Jana Kroll, Lina M Jaime Tobón, Christian Vogl, Jakob Neef, Ilona Kondratiuk, Melanie König, Nicola Strenzke, Carolin Wichmann, Ira Milosevic and Tobias Moser Published online 07.02.2019 Structures of the heart specific SERCA2a Ca2+‐ATPase The first crystal structures of the major driver and regulator of heart contractility SERCA2a explain the kinetic differences between SERCA1a and SERCA2a. Aljona Sitsel, Joren De Raeymaecker, Nikolaj Düring Drachmann, Rita Derua, Susanne Smaardijk, Jacob Lauwring Andersen, Ilse Vandecaetsbeek, Jialin Chen, Marc De Maeyer, Etienne Waelkens, Claus Olesen, Peter Vangheluwe and Poul Nissen Published online 18.02.2019 Corrigendum Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1 María J Caloca, José L Zugaza, David Matallanas, Piero Crespo and Xosé R Bustelo Published online 01.03.2019   Unsubscribe from or edit your subscription for this service. Copyright © 2019 by the European Molecular Biology Organisation.