EMBO reports Table of Contents for March 2019; Vol. 20, No. 3

March 2019 | Volume 20, Number 3 Submit Table of Contents Correspondence News & Views Science & Society Review Articles Volume 20, Number 3 Correspondence Pluralistic ignorance and social action on climate change A comment on “The Sense of Social Influence: Pluralistic Ignorance in Climate Change” by Esther M Kjeldahl & Vincent F. Hendricks. J Roger Jacobs Published online 21.02.2019 Response by the authors The response by the author. Esther Michelsen Kjeldahl and Vincent F Hendricks Published online 25.02.2019 Comment on “A planet too rich in fiber” Comment on “A planet to rich in fibre” by Melissa Suran. Jianli Liu, Bo Zhu and Weidong Gao Published online 04.02.2019 Response by the author The response by the author. Melissa Suran Published online 04.02.2019 News & Views Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholamban The orphan protease SPPL2c was considered to represent a non‐expressed pseudogene. Two studies in this issue now identify physiological substrates of SPPL2c, and show that it plays a role in vesicle trafficking, Ca2+ transport and spermatid development. Howard S Young and M Joanne Lemieux Published online 25.02.2019 Tuberculosis's cargoman: bacteria load RNA into host extracellular vesicles The mycobacterial Sec2 secretion system regulates the loading of bacterial RNA into macrophage‐derived extracellular vesicles. Secreted vesicles with mycobacterial RNA promote IFN‐β production upon entry into target cells, and induce bacterial clearance. Mirit Biton, Paula Abou Karam and Neta Regev‐Rudzki Published online 21.02.2019 Sex‐specific pheromone responses in Caenorhabditis elegans The G‐protein coupled receptor SRD‐1 mediates male attraction to volatile sex pheromones in Caenorhabditis elegans AWA neurons. Chen Wang and Oliver Hobert Published online 21.02.2019 Science & Society The anti‐vaccination debate and the microbiome: How paradigm shifts in the life sciences create new challenges for the vaccination debate Anti‐vaccine activists misuse findings from microbiome research to push their agenda. It requires a concerted response by the scientific community to confront the misinformation. Stephan Guttinger Published online 30.01.2019 Homeopathy—where is the science?: A current inventory on a pre‐scientific artifact Despite overwhelming evidence that it is neither effective nor rational, homeopathy still persists. We need a broad debate to discuss its damaging effects on public health and science itself. Natalie Grams Published online 14.02.2019 Finding levers for culture change in science—the power of glocal: Local initiatives to change the culture of science from competition to collaboration and cooperation To tackle the great challenges of our time, the culture of science needs to change to a more collaborative one. Such change would start locally to spread out into the global scientific community. Elinor Thompson Published online 01.02.2019 Have no fear: Heritable neural patterns offer new potential targets for treating anxiety disorders Anxiety is the most common mental disorder. New insights into the underlying neural patterns and new drug candidates offer prospects for long‐lasting relief. Philip Hunter Published online 21.02.2019 Review Genetic sleep deprivation: using sleep mutants to study sleep functions In this review, the authors discuss and argue for the use of genetic sleep deprivation animal models as a more specific and comprehensive approach for understanding sleep functions and the underpinning mechanisms. Henrik Bringmann Published online 25.02.2019 Articles The lysine‐specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer The histone methyltransferase KMT2C/MLL3 is commonly mutated in cancer and involved in the transcriptional regulation of several DNA repair genes. Its loss leads to increased DNA damage and dependence on PARP1/2. Theodoros Rampias, Dimitris Karagiannis, Margaritis Avgeris, Alexander Polyzos, Antonis Kokkalis, Zoi Kanaki, Evgenia Kousidou, Maria Tzetis, Emmanouil Kanavakis, Konstantinos Stravodimos, Kalliopi N Manola, Gabriel E Pantelias, Andreas Scorilas and Apostolos Klinakis Published online 21.01.2019 The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban The intramembrane protease SPPL2c is critical for the turnover of selected tail‐anchored proteins in spermatids and thereby supports differentiation and function of male germ cells. Johannes Niemeyer, Torben Mentrup, Ronny Heidasch, Stephan A Müller, Uddipta Biswas, Rieke Meyer, Alkmini A Papadopoulou, Verena Dederer, Martina Haug‐Kröper, Vivian Adamski, Renate Lüllmann‐Rauch, Martin Bergmann, Artur Mayerhofer, Paul Saftig, Gunther Wennemuth, Rolf Jessberger, Regina Fluhrer, Stefan F Lichtenthaler, Marius K Lemberg and Bernd Schröder Published online 07.02.2019 Signal Peptide Peptidase‐Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins Signal peptide peptidase‐like 2c (SPPL2c), thus far considered an orphan protease, is catalytically active and expressed in maturating spermatids. SPPL2c cleaves SNARE proteins and impairs vesicular transport and Golgi integrity. Alkmini A Papadopoulou, Stephan A Müller, Torben Mentrup, Merav D Shmueli, Johannes Niemeyer, Martina Haug‐Kröper, Julia von Blume, Artur Mayerhofer, Regina Feederle, Bernd Schröder, Stefan F Lichtenthaler and Regina Fluhrer Published online 07.02.2019 Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing Extracellular vesicles carry microbial components and have roles during host defence. EVs released from M. tuberculosis‐infected macrophages activate the cytosolic RNA sensing pathway, and potentiate antibiotic treatment in an infection model. Yong Cheng and Jeffery S Schorey Published online 25.01.2019 SRD‐1 in AWA neurons is the receptor for female volatile sex pheromones in C. elegans males The G‐protein coupled receptor SRD‐1 shows male‐specific expression in AWA neurons and acts as receptor for volatile sex pheromones in Caenorhabditis elegans and Caenorhabditis remanei. Xuan Wan, Yuan Zhou, Chung Man Chan, Hainan Yang, Christine Yeung and King L Chow Published online 21.02.2019 The E3 ligase Highwire promotes synaptic transmission by targeting the NAD‐synthesizing enzyme dNmnat The E3 ubiquitin ligase Highwire targets and downregulates the NAD+ synthesizing enzyme dNmnat to promote evoked synaptic transmission at the Drosophila larval neuromuscular junction. Alexandra Russo, Pragya Goel, EJ Brace, Chris Buser, Dion Dickman and Aaron DiAntonio Published online 28.01.2019 Myogenin promoter‐associated lncRNA Myoparr is essential for myogenic differentiation A promoter‐derived lncRNA, Myoparr, is a key regulator of myogenic differentiation by controlling neighboring myogenin expression and the interaction between Ddx17 and PCAF. Keisuke Hitachi, Masashi Nakatani, Akihiko Takasaki, Yuya Ouchi, Akiyoshi Uezumi, Hiroshi Ageta, Hidehito Inagaki, Hiroki Kurahashi and Kunihiro Tsuchida Published online 08.01.2019 YAP1‐LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis The Hippo pathway plays a critical role in controlling ovarian cell fates. This study identifies a YAP1‐LATS2 feedback loop that dictates senescent or malignant fate. Its disruption switches YAP1‐induced senescence to malignant transformation. Chunbo He, Xiangmin Lv, Cong Huang, Guohua Hua, Bowen Ma, Xingcheng Chen, Peter C Angeletti, Jixin Dong, Jin Zhou, Zhengfeng Wang, Bo R Rueda, John S Davis and Cheng Wang Published online 12.02.2019   Unsubscribe from or edit your subscription for this service. Copyright © 2019 by the European Molecular Biology Organisation.