 |  |  |  |  | Table of ContentsEditorial News & Views Articles Resource |  Volume 37, Number 24 |
Editorial  | Open Access mandates in Europe raise the question if the priority is to reduce publishing costs, or the overdue conversion to Open Science communication. At risk are not only high‐quality journals, but also community institutions and international research collaboration. Bernd Pulverer Published online 03.12.2018 |
News & Views  | New phosphoproteomics studies identify the first physiological substrates of the neurodevelopmental disease‐associated CDKL5 kinase, highlighting potential roles in regulation of neuronal microtubule dynamics. Patrick A Eyers |
 | New work improving the properties of a fast channelrhodopsin to enable rapid light‐responsive auditory nerve activity may pave the way for optical cochlear implants. Emiliano Ronzitti, Valeria Zampini and Valentina Emiliani Published online 03.12.2018 |
 | A new study finds IKKβ to control mRNA decapping, illustrating how cellular signalling shapes gene expression via both mRNA synthesis and degradation. Neil D Perkins Published online 03.12.2018 |
Articles  | The IκB kinase binds mRNA decay factors and affects the formation of P bodies, extending its function beyond the canonical role as a regulator of NF‐kB‐dependent transcription. Nadine Mikuda, Marina Kolesnichenko, Patrick Beaudette, Oliver Popp, Bora Uyar, Wei Sun, Ahmet Bugra Tufan, Björn Perder, Altuna Akalin, Wei Chen, Philipp Mertins, Gunnar Dittmar, Michael Hinz and Claus Scheidereit Published online 22.11.2018 |
 | A new mouse model shows that the CCR4‐NOT complex ensures timely clearance of maternal mRNAs in developing oocytes, thereby preventing aberrant translation and meiotic defects. Qian‐Qian Sha, Jia‐Li Yu, Jing‐Xin Guo, Xing‐Xing Dai, Jun‐Chao Jiang, Yin‐Li Zhang, Chao Yu, Shu‐Yan Ji, Yu Jiang, Song‐Ying Zhang, Li Shen, Xiang‐Hong Ou and Heng‐Yu Fan Published online 26.11.2018 |
 | The protein kinase C delta restricts primitive hematopoietic cell contribution to the blood system to set a threshold for proliferation and regeneration. Tata Nageswara Rao, Manoj K Gupta, Samir Softic, Leo D Wang, Young C Jang, Thomas Thomou, Olivier Bezy, Rohit N Kulkarni, C Ronald Kahn and Amy J Wagers |
 | The finding of decreased microtubule affinity of CDKL5‐phosphorylated MAP1S provides new insights into a possible pathogenic pathway of neurodevelopmental CDKL5 deficiency disorder. Lucas L Baltussen, Priscilla D Negraes, Margaux Silvestre, Suzanne Claxton, Max Moeskops, Evangelos Christodoulou, Helen R Flynn, Ambrosius P Snijders, Alysson R Muotri and Sila K Ultanir |
Resource  | Identification of phosphorylation targets reveals a sequence preference for the neurodevelopmental disease‐linked CDKL5, and that pathogenic mutations decrease activity towards microtubule‐ and centrosome‐associated substrates. Ivan M Muñoz, Michael E Morgan, Julien Peltier, Florian Weiland, Mateusz Gregorczyk, Fiona CM Brown, Thomas Macartney, Rachel Toth, Matthias Trost and John Rouse |
 | Biophysical characterization and molecular engineering of the fast channelrhodopsin Chronos results in a new optogentics tool for controlling fast neural circuitries with high temporal fidelity. Daniel Keppeler, Ricardo Martins Merino, David Lopez de la Morena, Burak Bali, Antoine Tarquin Huet, Anna Gehrt, Christian Wrobel, Swati Subramanian, Tobias Dombrowski, Fred Wolf, Vladan Rankovic, Andreas Neef and Tobias Moser Published online 05.11.2018 |
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