The EMBO Journal Table of Contents for 03 December 2018; Vol. 37, No. 23

03 December 2018 | Volume 37, Number 23 Submit Table of Contents News & Views Articles Volume 37, Number 23 News & Views More is not always better: hyperglutamylation leads to neurodegeneration While tubulin glutamylation is needed to sustain intracellular transport in neurons, the formation of excessive polyglutamylation results in neurodegenerative phenotypes in mice and human patients. Anna Akhmanova and Casper C Hoogenraad Published online 23.11.2018 Friend and foe, HNRNPC takes on immunostimulatory RNAs in breast cancer cells An RNA‐binding protein prevents accumulation of endogenous Alu‐derived dsRNAs, in order to evade the anti‐cancer activity of interferons in tumor cells. Stephanie L Sarbanes, Jérémie Le Pen and Charles M Rice Published online 02.11.2018 Decapping enzymes STOP “cancer” ribosomes in their tracks The mRNA decapping coactivator PNRC1 disrupts rRNA processing and ribosome biogenesis, thereby acting as a tumour suppressor. Jeffrey S Mugridge and John D Gross Published online 19.11.2018 Optogenetic control of morphogenesis goes 3D Acto‐myosin contractility at the basal surface of the epithelium is essential for tissue invagination in Drosophila. Barry James Thompson Published online 21.11.2018 Articles Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma Oxidative phosphorylation and lipid metabolism specify distinct energetic set‐up of invasive brain tumor cells. Lan B Hoang‐Minh, Florian A Siebzehnrubl, Changlin Yang, Silveli Suzuki‐Hatano, Kyle Dajac, Tyler Loche, Nicholas Andrews, Michael Schmoll Massari, Jaimin Patel, Krisha Amin, Alvin Vuong, Ana Jimenez‐Pascual, Paul Kubilis, Timothy J Garrett, Craig Moneypenny, Christina A Pacak, Jianping Huang, Elias J Sayour, Duane A Mitchell, Matthew R Sarkisian, Brent A Reynolds and Loic P Deleyrolle Published online 15.10.2018 Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport Neurodegeneration in mice lacking the tubulin‐deglutamylating enzyme CCP1 occurs in a cell‐autonomous manner and in various parts of the central nervous system. Maria M Magiera, Satish Bodakuntla, Jakub Žiak, Sabrina Lacomme, Patricia Marques Sousa, Sophie Leboucher, Torben J Hausrat, Christophe Bosc, Annie Andrieux, Matthias Kneussel, Marc Landry, André Calas, Martin Balastik and Carsten Janke Published online 12.11.2018 Loss of tubulin deglutamylase CCP1 causes infantile‐onset neurodegeneration Aberrant tubulin polyglutamylation in rare human disease is characterized by severe cerebellar atrophy and motor neuron degeneration. Vandana Shashi, Maria M Magiera, Dennis Klein, Maha Zaki, Kelly Schoch, Sabine Rudnik‐Schöneborn, Andrew Norman, Osorio Lopes Abath Neto, Marina Dusl, Xidi Yuan, Luca Bartesaghi, Patrizia De Marco, Ahmed A Alfares, Ronit Marom, Stefan T Arold, Francisco J Guzmán‐Vega, Loren DM Pena, Edward C Smith, Maja Steinlin, Mohamed OE Babiker, Payam Mohassel, A Reghan Foley, Sandra Donkervoort, Rupleen Kaur, Partha S Ghosh, Valentina Stanley, Damir Musaev, Caroline Nava, Cyril Mignot, Boris Keren, Marcello Scala, Elisa Tassano, Paolo Picco, Paola Doneda, Chiara Fiorillo, Mahmoud Y Issa, Ali Alassiri, Ahmed Alahmad, Amanda Gerard, Pengfei Liu, Yaping Yang, Birgit Ertl‐Wagner, Peter G Kranz, Ingrid M Wentzensen, Rolf Stucka, Nicholas Stong, Andrew S Allen, David B Goldstein, Undiagnosed Diseases Network, Bened ikt Schoser, Kai M Rösler, Majid Alfadhel, Valeria Capra, Roman Chrast, Tim M Strom, Erik‐Jan Kamsteeg, Carsten G Bönnemann, Joseph G Gleeson, Rudolf Martini, Carsten Janke and Jan Senderek Published online 12.11.2018 Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response Repression of the RNA binding protein HNRNPC in breast cancer cells causes accumulation of endogenous dsRNA species leading to interferon response and tumor growth arrest. Yusheng Wu, Wenwei Zhao, Yang Liu, Xiangtian Tan, Xin Li, Qin Zou, Zhengtao Xiao, Hui Xu, Yuting Wang and Xuerui Yang Published online 29.08.2018 Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus Computational analysis of frequent cancer genome deletions reveals that mRNA decapping activity blocks ribosomal maturation and ablates oncogene‐induced proliferation. Marco Gaviraghi, Claudia Vivori, Yerma Pareja Sanchez, Francesca Invernizzi, Angela Cattaneo, Benedetta Maria Santoliquido, Michela Frenquelli, Simona Segalla, Angela Bachi, Claudio Doglioni, Vicent Pelechano, Davide Cittaro and Giovanni Tonon Published online 29.10.2018 Downregulation of basal myosin‐II is required for cell shape changes and tissue invagination Subcellular optogenetics demonstrate the key role of basal surface relaxation for inward folding of tissues during fly embryonic development. Daniel Krueger, Pietro Tardivo, Congtin Nguyen and Stefano De Renzis Published online 15.11.2018 Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation Modeling based on NMR and mass spectrometry data reveals how PINK1‐mediated phosphorylation allows E2 enzyme binding and subsequent remodeling of the autoinhibited multi‐domain E3 parkin into an active E3 ligase. Tara EC Condos, Karen M Dunkerley, E Aisha Freeman, Kathryn R Barber, Jacob D Aguirre, Viduth K Chaugule, Yiming Xiao, Lars Konermann, Helen Walden and Gary S Shaw Published online 16.11.2018 PIF4‐induced BR synthesis is critical to diurnal and thermomorphogenic growth The transcription factor PIF4 confers adaptation of plant hormone activation during warmth‐dependent hypocotyl growth. Cristina Martínez, Ana Espinosa‐Ruíz, Miguel de Lucas, Stella Bernardo‐García, José M Franco‐Zorrilla and Salomé Prat Published online 02.11.2018 Stress‐induced host membrane remodeling protects from infection by non‐motile bacterial pathogens Host membrane remodeling is a cell‐autonomous defense mechanism that protects epithelial cells from infection by Shigella. Caroline Tawk, Giulia Nigro, Ines Rodrigues Lopes, Carmen Aguilar, Clivia Lisowski, Miguel Mano, Philippe Sansonetti, Jörg Vogel and Ana Eulalio Published online 02.11.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.