The EMBO Journal Table of Contents for 15 November 2018; Vol. 37, No. 22

15 November 2018 | Volume 37, Number 22 Submit Table of Contents Commentary News & Views Articles Volume 37, Number 22 Commentary Putting a strain on diversity Quantitative proteomics identifies an ES cell‐specific form of a chromatin repressor complex, which shapes the particular chromatin state required for proliferation and self‐renewal of these cells. Colin Selman and William R Swindell Published online 02.11.2018 News & Views Are you TORCing tau me? Amyloid‐β blocks the conversation between lysosomes and mitochondria New work identifies a functional crosstalk between lysosomes and mitochondria that is disturbed in Alzheimer's disease. Juan Carlos Polanco and Jürgen Götz Published online 02.11.2018 Hepatic ERAD takes control of the organism Two new studies reveal a hepatic‐specific function of ERAD in modulating FGF21 levels in the liver thereby coordinating systemic energy metabolism and organismal physiology Lena‐Sophie Dreher and Thorsten Hoppe Published online 02.11.2018 Articles Distinct roles of VE‐cadherin for development and maintenance of specific lymph vessel beds Conditional deletion of vascular endothelial (VE)‐cadherin in mouse reveals a tissue‐specific role in lymph vessel bed development and maintenance, thus adding to the known requirement for VE‐cadherin in blood vessel formation. René Hägerling, Esther Hoppe, Cathrin Dierkes, Martin Stehling, Taija Makinen, Stefan Butz, Dietmar Vestweber and Friedemann Kiefer Published online 08.10.2018 A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers Activation of lysosomal mTORC1 by nutrients induces mitochondrial DNA synthesis in neurons and is inhibited by amyloid‐β oligomers in a tau‐dependent manner. Andrés Norambuena, Horst Wallrabe, Rui Cao, Dora Bigler Wang, Antonia Silva, Zdenek Svindrych, Ammasi Periasamy, Song Hu, Rudolph E Tanzi, Doo Yeon Kim and George S Bloom Published online 22.10.2018 HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination ER quality control pathways promote multi‐organ crosstalk during fasting‐feeding conditions in mice. Juncheng Wei, Lu Chen, Fei Li, Yanzhi Yuan, Yajun Wang, Wanjun Xia, Yuehui Zhang, Yuanming Xu, Zhao Yang, Beixue Gao, Chaozhi Jin, Johanna Melo‐Cardenas, Richard M Green, Hui Pan, Jian Wang, Fuchu He, Kezhong Zhang and Deyu Fang Published online 02.11.2018 Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH Conditional deletion of the ER‐associated degradation factor SEL1L in mouse livers alters key metabolic states in the whole organism via dysregulation of the FGF21 hepatokine. Asmita Bhattacharya, Shengyi Sun, Heting Wang, Ming Liu, Qiaoming Long, Lei Yin, Sander Kersten, Kezhong Zhang and Ling Qi Published online 02.11.2018 Local activation of mammalian separase in interphase promotes double‐strand break repair and prevents oncogenic transformation Intricate post‐translational modifications regulate separase recruitment to DNA breaks for local cohesin cleavage and efficient homologous recombination repair. Susanne Hellmuth, Cristina Gutiérrez‐Caballero, Elena Llano, Alberto M Pendás and Olaf Stemmann Published online 10.10.2018 Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth Hippo signaling controls glucose uptake and energy metabolism required for liver homeostasis in zebrafish and mouse. Andrew G Cox, Allison Tsomides, Dean Yimlamai, Katie L Hwang, Joel Miesfeld, Giorgio G Galli, Brendan H Fowl, Michael Fort, Kimberly Y Ma, Mark R Sullivan, Aaron M Hosios, Erin Snay, Min Yuan, Kristin K Brown, Evan C Lien, Sagar Chhangawala, Matthew L Steinhauser, John M Asara, Yariv Houvras, Brian Link, Matthew G Vander Heiden, Fernando D Camargo and Wolfram Goessling Published online 22.10.2018 Structure of the nucleation‐promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex New crystal structures reveal how WDS proteins facilitate Arp2/3‐dependent actin filament nucleation in the absence of pre‐existing filaments. Qing Luan, Su‐Ling Liu, Luke A Helgeson and Brad J Nolen Published online 15.10.2018 Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity Protein kinase D1 exerts physiological roles in fat tissue and functions to stimulate lipogenesis and triglyceride accumulation upon nutrient overload, regulating whole‐body energy homeostasis. Mona C Löffler, Alexander E Mayer, Jonathan Trujillo Viera, Angel Loza Valdes, Rabih El‐Merahbi, Carsten P Ade, Till Karwen, Werner Schmitz, Anja Slotta, Manuela Erk, Sudha Janaki‐Raman, Nuria Matesanz, Jorge L Torres, Miguel Marcos, Guadalupe Sabio, Martin Eilers, Almut Schulze and Grzegorz Sumara Published online 02.11.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.