Nature Reviews Molecular Cell Biology contents December 2018 Volume 19 Number 12

Advertisement Winners announced! We are delighted to announce the first ever winners of the Nature Research Awards for Inspiring Science and Innovating Science, in partnership with The Estée Lauder Companies. Congratulations to both our Award winners! See who's won > In partnership with The Estée Lauder Companies. TABLE OF CONTENTS December 2018 Volume 19, Issue 12 Comment Research Highlights Reviews Amendments & Corrections Advertisement Nature Index 2018 Rising Stars Creative minds drive the scientific enterprise. This supplement profiles up-and-coming researchers in the natural sciences who have achieved excellence in the Nature Index, and have demonstrated the passion, ambition and resilience to rise even higher in the competitive world of academia. Read the full supplement   Comment One and one is not two: taking a fresh look at membrane interfaces    Brian Belardi & Daniel A. Fletcher pp747 - 748 | doi:10.1038/s41580-018-0057-3 Dan Fletcher's lab comments on the unique properties of membranes at cell–cell adhesions, suggesting that cell–cell interfaces are a separate cellular compartment. Full Text | PDF 150 years of Darwin's theory of intercellular flow of hereditary information    Yongsheng Liu & Qi Chen pp749 - 750 | doi:10.1038/s41580-018-0072-4 Full Text | PDF Research Highlights Myc in elongation and repression Eytan Zlotorynski p751 | doi:10.1038/s41580-018-0079-x Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc. PDF PrEView of cell–cell communication Paulina Strzyz pp752 - 753 | doi:10.1038/s41580-018-0073-3 Endothelial cells in white adipose tissue communicate with adipocytes through extracellular vesicles, relaying systemic metabolic information. PDF Inhibition by nuclear cGAS Grant Otto pp752 - 753 | doi:10.1038/s41580-018-0082-2 Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis. PDF Selenium cysteine and epileptic seizures Ueli Schibler p753 | doi:10.1038/s41580-018-0050-x Ueli Schibler explains why the phenotype of a mutation in a codon of the '21st amino acid' selenium cysteine was unexpectedly specific. PDF Nature Reviews Molecular Cell Biology EVENT Molecular Neurodegeneration 14.01.19 Hinxton, UK More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today!   Reviews A new era for understanding amyloid structures and disease    Matthew G. Iadanza, Matthew P. Jackson, Eric W. Hewitt, Neil A. Ranson & Sheena E. Radford pp755 - 773 | doi:10.1038/s41580-018-0060-8 The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. Recent advances in structural biology techniques have provided insight into how amyloid structure may affect the ability of fibrils to spread in a prion-like manner and into their roles in disease. Full Text | PDF Functions and mechanisms of epigenetic inheritance in animals    Ksenia Skvortsova, Nicola Iovino & Ozren Bogdanović pp774 - 790 | doi:10.1038/s41580-018-0074-2 Epigenetic profiling of germline and zygotic genomes has revealed that a fraction of mammalian genomes do not undergo epigenetic reprogramming during early development, highlighting the importance of epigenetic inheritance in animals. Inheritance of histone modifications, tRNA fragments and microRNAs can affect gene regulation in the offspring; however, in mammals, epigenetic inheritance rarely operates beyond two generations. Full Text | PDF Translation deregulation in human disease    Soroush Tahmasebi, Arkady Khoutorsky, Michael B. Mathews & Nahum Sonenberg pp791 - 807 | doi:10.1038/s41580-018-0034-x Translation deregulation causes many human diseases, which can be broadly categorized into tRNA or ribosomal dysfunction, and deregulation of the integrated stress response or the mTOR pathway. The complexity of the translation process and its cellular contexts could explain the phenotypic variability of these disorders. Full Text | PDF Collection: Translation and protein quality control Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do.   Amendments & Corrections Author Correction: Regulation of microRNA biogenesis and its crosstalk with other cellular pathways    Thomas Treiber, Nora Treiber & Gunter Meister p808 | doi:10.1038/s41580-018-0070-6 Full Text | PDF Publisher Correction: Post-transcriptional gene regulation by mRNA modifications    Boxuan Simen Zhao, Ian A. Roundtree & Chuan He p808 | doi:10.1038/s41580-018-0075-1 Full Text | PDF Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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