TABLE OF CONTENTS
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December 2018 Volume 18, Issue 12 |
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| Research Highlights Reviews | | Advertisement | | | | Nature Outlook: Lymphoma
Ordinarily, the immune system protects us from harm. In lymphoma, elements of immunity turn against the body, becoming a malign threat. Fresh research on this disease, and the development of potential therapies, could blunt its deadly force.
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Focal Point on Nanomedicine in Japan - A race against time and old age - Nanomedicine is on the frontline of Japan's efforts to revitalise its economy, and it may pre-emptively solve some of the world's toughest problems to boot. | | | |
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Research Highlights | |
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Mapping innate variation Yvonne Bordon p727 | doi:10.1038/s41577-018-0086-3 Transcriptomics used to map variation in innate immune responses across species. PDF
| Translational target for checkpoint inhibitors Katie Kingwell pp728 - 729 | doi:10.1038/s41577-018-0091-6 Eukaryotic translation initiation complex eIF4F is identified as an upstream regulator of PD-L1 expression and is therefore a promising target for immunotherapy. PDF
| Tame or inflame: gut reactions to pro- and antibiotics Alexandra Flemming pp728 - 729 | doi:10.1038/s41577-018-0093-4 The gut microbiota and intestinal immune cells profoundly affect each other, an interaction that can be manipulated with antibiotics and probiotics. PDF
| A new guide to immunopharmacology Simon D. Harding, Elena Faccenda, Chris Southan, Pasquale Maffia & Jamie A. Davies p729 | doi:10.1038/s41577-018-0079-2 A new guide to immunopharmacology seeks to bring the most valuable pharmacological data into the hands of immunology researchers. PDF
| T cell help to stem cells Lucy Bird pp730 - 731 | doi:10.1038/s41577-018-0089-0 CD4+ T cell cytokines in the intestinal crypts balance intestinal stem cell renewal and differentiation. PDF
| Immune response by touch Kirsty Minton pp730 - 731 | doi:10.1038/s41577-018-0090-7 Using spiky microparticles, the authors show that physical cues, such as topological features on the surface of a pathogen, can trigger an immune response by exerting mechanical stress on immune cells. PDF
| CAR antigens beyond recognition Ulrike Harjes p731 | doi:10.1038/s41577-018-0082-7 Two studies describe distinct mechanisms of resistance to anti-CD19 chimeric antigen receptor (CAR) T cell therapy in relapsed leukaemia patients PDF
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Reviews | |
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Cardioimmunology: the immune system in cardiac homeostasis and disease Filip K. Swirski & Matthias Nahrendorf pp733 - 744 | doi:10.1038/s41577-018-0065-8 Recent studies have characterized complex interactions between resident and infiltrating immune cells in the heart and cardiac cells, including cardiomyocytes, fibroblasts and endothelial cells. This Review explores the role of immune cells in cardiac development and physiological function, as well as heart disease. Full Text | PDF
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The emerging role of ADAM metalloproteinases in immunity Bart N. Lambrecht, Matthias Vanderkerken & Hamida Hammad pp745 - 758 | doi:10.1038/s41577-018-0068-5 A-DAM good Review discussing the role of ADAM protein-mediated cleavage of a wide range of substrates in the development and regulation of the immune system, with a focus on ADAM10 and ADAM17. Full Text | PDF
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Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight Yang Shi & David M. Holtzman pp759 - 772 | doi:10.1038/s41577-018-0051-1 In this Review, Shi and Holtzman highlight our growing understanding of the innate immune mechanisms that contribute to Alzheimer disease with a specific focus on microglial cells, apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2). Full Text | PDF
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Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer Simon A. Jones & Brendan J. Jenkins pp773 - 789 | doi:10.1038/s41577-018-0066-7 This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer. Full Text | PDF
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Nature Outline: Ulcerative Colitis
Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.
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| | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | |
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