Monday, November 26, 2018

Nature Reviews Immunology Contents December 2018 Volume 18 Number 12 pp 727-789

Nature Reviews Immunology

TABLE OF CONTENTS

December 2018 Volume 18, Issue 12

Research Highlights
Reviews

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Nature Outlook: Lymphoma

Ordinarily, the immune system protects us from harm. In lymphoma, elements of immunity turn against the body, becoming a malign threat. Fresh research on this disease, and the development of potential therapies, could blunt its deadly force.

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Research Highlights

Mapping innate variation
Yvonne Bordon
p727 | doi:10.1038/s41577-018-0086-3
Transcriptomics used to map variation in innate immune responses across species.
PDF



Translational target for checkpoint inhibitors
Katie Kingwell
pp728 - 729 | doi:10.1038/s41577-018-0091-6
Eukaryotic translation initiation complex eIF4F is identified as an upstream regulator of PD-L1 expression and is therefore a promising target for immunotherapy.
PDF



Tame or inflame: gut reactions to pro- and antibiotics
Alexandra Flemming
pp728 - 729 | doi:10.1038/s41577-018-0093-4
The gut microbiota and intestinal immune cells profoundly affect each other, an interaction that can be manipulated with antibiotics and probiotics.
PDF



A new guide to immunopharmacology
Simon D. Harding, Elena Faccenda, Chris Southan, Pasquale Maffia & Jamie A. Davies
p729 | doi:10.1038/s41577-018-0079-2
A new guide to immunopharmacology seeks to bring the most valuable pharmacological data into the hands of immunology researchers.
PDF



T cell help to stem cells
Lucy Bird
pp730 - 731 | doi:10.1038/s41577-018-0089-0
CD4+ T cell cytokines in the intestinal crypts balance intestinal stem cell renewal and differentiation.
PDF



Immune response by touch
Kirsty Minton
pp730 - 731 | doi:10.1038/s41577-018-0090-7
Using spiky microparticles, the authors show that physical cues, such as topological features on the surface of a pathogen, can trigger an immune response by exerting mechanical stress on immune cells.
PDF



CAR antigens beyond recognition
Ulrike Harjes
p731 | doi:10.1038/s41577-018-0082-7
Two studies describe distinct mechanisms of resistance to anti-CD19 chimeric antigen receptor (CAR) T cell therapy in relapsed leukaemia patients
PDF



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Reviews

Cardioimmunology: the immune system in cardiac homeostasis and disease   
Filip K. Swirski & Matthias Nahrendorf
pp733 - 744 | doi:10.1038/s41577-018-0065-8
Recent studies have characterized complex interactions between resident and infiltrating immune cells in the heart and cardiac cells, including cardiomyocytes, fibroblasts and endothelial cells. This Review explores the role of immune cells in cardiac development and physiological function, as well as heart disease.
Full Text | PDF



The emerging role of ADAM metalloproteinases in immunity   
Bart N. Lambrecht, Matthias Vanderkerken & Hamida Hammad
pp745 - 758 | doi:10.1038/s41577-018-0068-5
A-DAM good Review discussing the role of ADAM protein-mediated cleavage of a wide range of substrates in the development and regulation of the immune system, with a focus on ADAM10 and ADAM17.
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Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight   
Yang Shi & David M. Holtzman
pp759 - 772 | doi:10.1038/s41577-018-0051-1
In this Review, Shi and Holtzman highlight our growing understanding of the innate immune mechanisms that contribute to Alzheimer disease with a specific focus on microglial cells, apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2).
Full Text | PDF



Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer   
Simon A. Jones & Brendan J. Jenkins
pp773 - 789 | doi:10.1038/s41577-018-0066-7
This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer.
Full Text | PDF



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Nature Outline: Ulcerative Colitis

Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.

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