Nature Reviews Genetics Contents December 2018 Volume 19 Number 12

Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!  TABLE OF CONTENTS December 2018 Volume 19, Issue 12 Comment Research Highlights Reviews Perspectives Amendments & Corrections Advertisement KromaTiD Direct, Definitive Genomics See what you're missing Direct single cell measurement of simple, complex and multiple structural rearrangements including inversions.  Learn More Advertisement Focal Point on Vaccine Research  The future of vaccine research may be in Asia - The signs are there in funding levels, and combined with Asian governments' interest in biotechnology, and a highly skilled, highly educated workforce, pharma giants are looking east.    Comment The importance of genetic counselling in genome-wide sequencing    Alison M. Elliott & Jan M. Friedman pp735 - 736 | doi:10.1038/s41576-018-0057-3 Genome-wide sequencing (GWS) is the most sensitive test available for detecting pathogenic genetic variants but it generates complex results. It is important, therefore, that individuals undergoing GWS are offered both pre-test and post-test genetic counselling. Full Text | PDF Research Highlights UK Biobank — a new era in genomic medicine Orli G. Bahcall p737 | doi:10.1038/s41576-018-0065-3 Two studies in Nature describe the full data set of the UK Biobank resource, which contains genome-wide genetic data, clinical measurements and health records for ~500,000 individuals, and reveal insights into the brain's genetic architecture. PDF Spotlight on nucleosomes Dorothy Clyde pp738 - 739 | doi:10.1038/s41576-018-0070-6 Two new studies in Nature provide insight into the role of nucleosomes in gene regulation. One describes the genome-wide organization of nucleosomes and the other details how transcription factor binding to DNA is affected by the presence of nucleosomes. PDF Altered splicing in Alzheimer transcriptomes Linda Koch pp738 - 739 | doi:10.1038/s41576-018-0064-4 A study in Nature Genetics reports the analysis of transcriptomes of the ageing brain and highlights the impact of genetic variation underlying altered mRNA splicing in Alzheimer disease. PDF Navigating mouse cell types Darren J. Burgess p739 | doi:10.1038/s41576-018-0067-1 A new study reports the 'Tabula Muris', an atlas of single-cell RNA sequencing data from >100,000 cells across 20 mouse tissues. PDF Nature Reviews Genetics EVENT Spatial Genome Organization Conference 25.02.19 Nassau, Bahamas More science events from Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do   Reviews Towards quantitative and multiplexed in vivo functional cancer genomics    Ian P. Winters, Christopher W. Murray & Monte M. Winslow pp741 - 755 | doi:10.1038/s41576-018-0053-7 CRISPR–Cas genome editing and next-generation sequencing are driving advances in cancer modelling and functional cancer genomics. Their application to autochthonous mouse models of human cancer to generate and analyse multiplexed and/or combinatorial alterations in vivo is reviewed here. Full Text | PDF The phylogenomics of evolving virus virulence    Jemma L. Geoghegan & Edward C. Holmes pp756 - 769 | doi:10.1038/s41576-018-0055-5 The virulence of viruses is a major determinant of the health burden of viral infections in humans and other species. In this article, Geoghegan and Holmes discuss how largely disparate research fields — theoretical modelling of virulence evolution and experimental dissection of genetic virulence determinants in laboratory model systems — can be bridged by considering real genomic data of viral evolution in a phylogenetic context. They describe the underlying principles of virulence evolution and how they apply to real-world viral infections and outbreaks of global importance. Full Text | PDF Base editing: precision chemistry on the genome and transcriptome of living cells    Holly A. Rees & David R. Liu pp770 - 788 | doi:10.1038/s41576-018-0059-1 Genome editing through direct editing of bases holds promise for achieving precise genomic changes at single-nucleotide resolution while minimizing the occurrence of potentially mutagenic double-strand DNA breaks. In this Review, Rees and Liu provide a comprehensive account of the state of the art of base editing of DNA and RNA, including the progressive improvements to methodologies, understanding and avoiding unintended edits, cellular and organismal delivery of editing reagents and diverse applications in research and therapeutic settings. Full Text | PDF Perspectives Organizational principles of 3D genome architecture    M. Jordan Rowley & Victor G. Corces pp789 - 800 | doi:10.1038/s41576-018-0060-8 High-resolution studies of chromosome conformation are revealing that the 3D genome is organized into smaller structural features than was previously supposed and is primarily composed of compartmental domains and CTCF loops. In this Perspectives article Rowley and Corces describe the latest views on the organizational drivers and principles of the 3D genome, and the interplay between genome activity and organization. Full Text | PDF Amendments & Corrections Publisher Correction: Towards quantitative and multiplexed in vivo functional cancer genomics    Ian P. Winters, Christopher W. Murray & Monte M. Winslow p801 | doi:10.1038/s41576-018-0062-6 Full Text | PDF Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells    Holly A. Rees & David R. Liu p801 | doi:10.1038/s41576-018-0068-0 Full Text | PDF Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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