Nature Reviews Cancer contents December 2018 Volume 18 Number 12

TABLE OF CONTENTS December 2018 Volume 18, Issue 12 Research Highlights Reviews Perspectives Advertisement Monitor Cellular ATP Production in Real Time -A better measure of cellular function Learn how the Agilent Seahorse XF Real-Time ATP Rate Assay is used to: Understand metabolic mechanisms driving cancer cell behavior and proliferation. Uncover links between cancer markers with metabolism. Characterize fuel dependencies in cancer cells. Watch Webinar Now   Advertisement Focal Point on Vaccine Research The future of vaccine research may be in Asia - The signs are there in funding levels, and combined with Asian governments' interest in biotechnology, and a highly skilled, highly educated workforce, pharma giants are looking east.   Advertisement Focal Point on Nanomedicine in Japan - A race against time and old age - Nanomedicine is on the frontline of Japan's efforts to revitalise its economy, and it may pre-emptively solve some of the world's toughest problems to boot.   Research Highlights Ageing matrix promotes metastasis Sarah Seton-Rogers p721 | doi:10.1038/s41568-018-0079-3 Two studies from Ashani Weeraratna's group have examined how changes in the skin microenvironment associated with ageing promote melanoma metastasis and modify immune infiltration. PDF Waking up in a trap Anna Dart pp722 - 723 | doi:10.1038/s41568-018-0071-y Albrengues et al. have characterized a mechanism by which sustained lung inflammation can cause a switch from cancer dormancy to metastasis through the induction of neutrophil extracellular traps. PDF Sabotaging the host Maria Giuseppina Baratta pp722 - 723 | doi:10.1038/s41568-018-0078-4 Ye et al. show that leukaemia cells induce insulin resistance in the host to limit glucose consumption by healthy tissues, thereby augmenting the amount of available glucose for cancer growth. PDF CAR antigens beyond recognition Ulrike Harjes p723 | doi:10.1038/s41568-018-0075-7 Orlando et al. and Ruella, Xu, Barrett et al. identified distinct mechanisms of resistance to anti-CD19 chimeric antigen receptor (CAR) T cell therapy in relapsed leukaemia patients, based on loss of CD19 surface expression. PDF Stress management in T cells Ulrike Harjes pp724 - 725 | doi:10.1038/s41568-018-0082-8 Song et al. show that in patients with ovarian cancer, intratumoural T cells and ascites-resident T cells experience endoplasmic reticulum stress triggered by activation of IRE1α–XBP1 signalling, leading to reduced antitumour activity. PDF MYC in elongation and repression Eytan Zlotorynski pp724 - 725 | doi:10.1038/s41568-018-0077-5 Transcription elongation supported by the super elongation complex, and histone H3 lysine 9 methylation and gene repression by G9a mediate the oncogenic function of MYC. PDF Colony takeover Anna Dart p725 | doi:10.1038/s41568-018-0080-x Martincorena, Fowler et al. have characterized the mutational landscape of normal oesophageal tissue during ageing, which has provided important insights into early cancer development. PDF Nature Reviews Cancer EVENT 3rd PREDiCT Tumor Models San Francisco Summit 22.01.19 San Francisco, USA More science events from Reviews Tumour-targeting bacteria engineered to fight cancer    Shibin Zhou, Claudia Gravekamp, David Bermudes & Ke Liu pp727 - 743 | doi:10.1038/s41568-018-0070-z Therapy with live tumour-targeting bacteria represents a unique opportunity to address the limitations associated with molecularly targeted therapies and immunotherapies. In this Review, Zhou et al. discuss the benefits and challenges of this approach and outline advances in the engineering of bacteria, which have the potential to improve safety and efficacy. Full Text | PDF mTOR signalling and cellular metabolism are mutual determinants in cancer    Dirk Mossmann, Sujin Park & Michael N. Hall pp744 - 757 | doi:10.1038/s41568-018-0074-8 This Review discusses the interdependencies of mTOR signalling and metabolism pathways in cancer and how metabolic reprogramming in response to changes in mTOR signalling and vice versa can sustain tumorigenicity. The authors highlight therapeutic opportunities when targeting metabolism and mTOR. Full Text | PDF Advertisement Explore Tumor Heterogeneity with Single Cell Analysis Transform your research with a more detailed understanding of tumor heterogeneity and the tumor microenvironment-characterize cell types, states, and interactions, dissect tumor progression pathways, and identify novel biomarkers. Get a more comprehensive molecular readout, cell by cell, with 10x Genomics' new single cell solutions.   Perspectives Cell-in-cell phenomena in cancer    Stefano Fais & Michael Overholtzer pp758 - 766 | doi:10.1038/s41568-018-0073-9 This Opinion describes cell-in-cell processes in cancer, providing insight into their functional purpose in tumour tissue. Entosis is a unique process in which cancer cells are actively invaded by other cells, conferring them a competitive advantage that may drive cancer evolution. Full Text | PDF A model for RAS mutation patterns in cancers: finding the sweet spot    Siqi Li, Allan Balmain & Christopher M. Counter pp767 - 777 | doi:10.1038/s41568-018-0076-6 In this Opinion, Li et al. put forward the idea that there is a narrow window or 'sweet spot' in which oncogenic RAS signalling can promote tumour initiation in normal cells and present the evidence that RAS mutation patterns are the product of selection for optimal RAS mutations to achieve the ideal level of signalling. Full Text | PDF Advertisement Winners announced! We are delighted to announce the first ever winners of the Nature Research Awards for Inspiring Science and Innovating Science, in partnership with The Estée Lauder Companies. Congratulations to both our Award winners! See who's won > In partnership with The Estée Lauder Companies.   Advertisement =================================== Register for the latest nature.com webcast Use of Simoa Planar Protein Multiplex Arrays as a Sensitive Biomarker Platform in Oncology Clinical Trials – Wednesday, December 12, 2018 Register for FREE today Sponsored by: Quanterix ==================================   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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