Nature Neuroscience Contents: December 2018 Volume 21 Number 12

Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! TABLE OF CONTENTS December 2018 Volume 21, Issue 12 News & Views Brief Communications Articles Resources Advertisement Probing Neural Dynamics with Behavioural Genetics, 10-13 Apr This EMBO|EMBL Symposium will bring together experts on how the brain integrates information about sensory inputs and internal state into behavioural responses. Session topics include motor systems, predictive coding and processing, disorders and mathematical tools. Submit your abstract by 16 Jan   Advertisement Focal Point on Nanomedicine in Japan - A race against time and old age - Nanomedicine is on the frontline of Japan's efforts to revitalise its economy, and it may pre-emptively solve some of the world's toughest problems to boot.   Advertisement Focal Point on Vaccine Research The future of vaccine research may be in Asia - The signs are there in funding levels, and combined with Asian governments' interest in biotechnology, and a highly skilled, highly educated workforce, pharma giants are looking east.   News & Views Practice makes plasticity    pp1645 - 1646 Christopher J. Steele & Robert J. Zatorre doi:10.1038/s41593-018-0280-4 A giant step for spinal cord injury research    pp1647 - 1648 Chet Moritz doi:10.1038/s41593-018-0264-4 Same lesson, varied choices by frontal cortex    pp1648 - 1650 Huriye Atilgan & Alex C. Kwan doi:10.1038/s41593-018-0282-2 Nature Neuroscience EVENT 3rd HBP Student Conference On Interdisciplinary Brain Research 08.02.19 Ghent, Belgium More science events from Brief Communications Midbrain activity can explain perceptual decisions during an attention task    pp1651 - 1655 James P. Herman, Leor N. Katz & Richard J. Krauzlis doi:10.1038/s41593-018-0271-5 Herman et al. exploit the reliable effects of perturbing superior colliculus (SC) neuronal activity on perceptual choice behavior to demonstrate a plausible mechanism by which SC may contribute to perceptual judgments during covert attention tasks. Advertisement Reveal the Full Complexity of Neural Diversity with Single Cell Analysis Transform your research with a more detailed understanding of neural diversity-identify gene expression profiles, trace cell lineage, profile cell subtypes, and reveal neuronal activation. Get a more comprehensive molecular readout, cell by cell, with 10x Genomics' new single cell solutions.   Articles Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders    pp1656 - 1669 Raymond K. Walters, Renato Polimanti, Emma C. Johnson, Jeanette N. McClintick, Mark J. Adams et al. doi:10.1038/s41593-018-0275-1 Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders. Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing    pp1670 - 1679 William Renthal, Lisa D. Boxer, Sinisa Hrvatin, Emmy Li, Andrew Silberfeld et al. doi:10.1038/s41593-018-0270-6 The authors develop a single-cell RNA-seq approach to distinguish cells expressing wild-type or mutant genes in mosaic individuals with X-linked disorders and find that cell-type-specific DNA methylation predicts gene misregulation in Rett syndrome. Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes    pp1680 - 1688 Michael V. Lombardo, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, Richard A. I. Bethlehem et al. doi:10.1038/s41593-018-0281-3 Lombardo et al. find large-scale associations between the leukocyte transcriptome and neural responses to speech in toddlers, and these associations differ between toddlers with ASD who have good versus poor language outcomes. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a    pp1689 - 1703 Ying Cheng, Zhi-Meng Wang, Weiqi Tan, Xiaona Wang, Yujing Li et al. doi:10.1038/s41593-018-0261-7 Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits    pp1 - 13 Sheldon D. Michaelson, Emin D. Ozkan, Massimiliano Aceti, Sabyasachi Maity, Nerea Llamosas et al. doi:10.1038/s41593-018-0268-0 Michaelson et al. report that human SYNGAP1 variation alters touch-related sensory processing. Studies in Syngap1 mice revealed circuit-specific impairments in the somatosensory cortex that underlie reduced cortical activation in response to touch. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition    pp1717 - 1727 Elena Deliu, Niccolò Arecco, Jasmin Morandell, Christoph P. Dotter, Ximena Contreras et al. doi:10.1038/s41593-018-0266-2 Mutations in SETD5 are a frequent cause of intellectual disability and autism. Deliu et al. describe that deletion of one mouse Setd5 allele leads to a disruption of the transcriptional program associated with development and learning. Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury    pp1728 - 1741 Emanuele Formento, Karen Minassian, Fabien Wagner, Jean Baptiste Mignardot, Camille G. Le Goff-Mignardot et al. doi:10.1038/s41593-018-0262-6 Electrical spinal cord stimulation interferes with natural proprioceptive information in humans. Ecological stimulation protocols that preserve limb position awareness and proprioceptive circuit dynamics facilitate walking after spinal cord injury. Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations    pp1742 - 1752 Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava et al. doi:10.1038/s41593-018-0278-y How seizures emerge in epileptic brain remains an enigma. The authors show that the transition to seizure follows a ubiquitous dynamical principle inherent to many processes in nature characterized by repeated transitions between contrasting regimes. Thalamic regulation of switching between cortical representations enables cognitive flexibility    pp1753 - 1763 Rajeev V. Rikhye, Aditya Gilra & Michael M. Halassa doi:10.1038/s41593-018-0269-z Rikhye et al. recorded prefrontal and thalamic populations from mice performing attention selection across different contexts. By encoding context, the thalamus both enhances and suppresses prefrontal representations in a context-appropriate manner. Neuronal stability in medial frontal cortex sets individual variability in decision-making    pp1764 - 1773 Tomoki Kurikawa, Tatsuya Haga, Takashi Handa, Rie Harukuni & Tomoki Fukai doi:10.1038/s41593-018-0263-5 Behavioral responses vary considerably across individuals. Kurikawa et al. show experimentally and computationally how the observed spectrum of individual variances in decision-making emerges from neural dynamics of the medial frontal cortex. Motor primitives in space and time via targeted gain modulation in cortical networks    pp1774 - 1783 Jake P. Stroud, Mason A. Porter, Guillaume Hennequin & Tim P. Vogels doi:10.1038/s41593-018-0276-0 Many behavioral tasks require fast, reliable switching of the shape and duration of cortical activity. Stroud et al. show that modulation of neural excitability in recurrent network models provides flexible spatiotemporal control of neural activity. Advertisement Winners announced! We are delighted to announce the first ever winners of the Nature Research Awards for Inspiring Science and Innovating Science, in partnership with The Estée Lauder Companies. Congratulations to both our Award winners! See who's won > In partnership with The Estée Lauder Companies.   Resources Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development    pp1784 - 1792 Tomasz J. Nowakowski, Neha Rani, Mahdi Golkaram, Hongjun R. Zhou, Beatriz Alvarado et al. doi:10.1038/s41593-018-0265-3 Highly dynamic miRNA networks mediate developmental transitions during human brain development. Single-cell networks were detected by combining single-cell miRNA and mRNA profiling with HITS-CLIP analyzed with bipartite and co-expression networks. Advertisement Focal Point on Nanomedicine in Japan - A race against time and old age - Nanomedicine is on the frontline of Japan's efforts to revitalise its economy, and it may pre-emptively solve some of the world's toughest problems to boot.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

This email has been sent to edgeblog.alerts.2011.001@gmail.com. If you no longer wish to receive the email alerts from Nature Neuroscience click here to unsubscribe . If you wish to discontinue all email services from Nature Research please click here to unsubscribe . For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Macmillan Publishers Limited is a company incorporated in England & Wales under company number 785998 & whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. Nature Research | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature is part of Springer Nature. © 2018 Springer Nature Limited. All rights reserved.