Nature Communications - 14 November 2018

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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Microfluidic active loading of single cells enables analysis of complex clinical specimens OPEN Nicholas L. Calistri, Robert J. Kimmerling, Seth W. Malinowski, Mehdi Touat, Mark M. Stevens, Selim Olcum, Keith L. Ligon & Scott R. Manalis Single-cell detection methods are limited by the trade-off between flow rate and measurement precision. Here the authors introduce active loading, an optically triggered microfluidic system to concentrate diluted cell samples, which reduces clogging and decreases processing time in single-cell assays. 14 November 2018 | doi: 10.1038/s41467-018-07283-x Assay systems  Lab-on-a-chip  Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways OPEN David L. Duffy, Gu Zhu, Xin Li, Marianna Sanna, Mark M. Iles, Leonie C. Jacobs, David M. Evans, Seyhan Yazar, Jonathan Beesley, Matthew H. Law, Peter Kraft, Alessia Visconti, John C. Taylor, Fan Lui, Margaret J. Wright, Anjali K. Henders, Lisa Bowdler, Dan Glass, Arfan M. Ikram, André G. Uitterlinden et al. Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter the nevus count. 14 November 2018 | doi: 10.1038/s41467-018-06649-5 Cancer genetics  Genetics  MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma OPEN Meiying Wu, Haixian Zhang, Changjun Tie, Chunhong Yan, Zhiting Deng, Qian Wan, Xin Liu, Fei Yan & Hairong Zheng Imaging tracking of the migration of cell-based drug delivery systems are needed for expanding their clinical application for glioma. Here they report inflammation activatable engineered neutrophils containing doxorubicin-loaded magnetic mesoporous silica nanoparticles to image and actively target brain tumors after resection. 14 November 2018 | doi: 10.1038/s41467-018-07250-6 Bioinspired materials  Nanobiotechnology  Two-step self-assembly of a spider silk molecular clamp OPEN Charlotte Rat, Julia C. Heiby, Jessica P. Bunz & Hannes Neuweiler Molecular details that underlie mechanical properties of spider silk are of great interest to material scientists. Here, the authors report a previously unknown three-state mechanism of folding and an expanded structure of a spider silk protein that may contribute to elasticity of spider silk. 14 November 2018 | doi: 10.1038/s41467-018-07227-5 Circular dichroism  Fluorescence spectroscopy  Kinetics  Scalable high performance radio frequency electronics based on large domain bilayer MoS2 OPEN Qingguo Gao, Zhenfeng Zhang, Xiaole Xu, Jian Song, Xuefei Li & Yanqing Wu Large area two-dimensional materials show promise for applications in DC and RF flexible electronics. Here, the authors report RF transistors based on chemical vapor deposited bilayer MoS2 with 23 GHz extrinsic maximum oscillation frequency, and gigahertz mixers on flexible polyimide substrates. 14 November 2018 | doi: 10.1038/s41467-018-07135-8 Electronic devices  Two-dimensional materials  Sound identity is represented robustly in auditory cortex during perceptual constancy OPEN Stephen M. Town, Katherine C. Wood & Jennifer K. Bizley Perceptual constancy requires neural representations selective for object identity, yet tolerant of identity-preserving transformations. Here, the authors show that sound identity is represented robustly in auditory cortex and that behavioral generalization requires precise timing of identity information. 14 November 2018 | doi: 10.1038/s41467-018-07237-3 Animal physiology  Cortex  Decision  Sensory processing  Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma OPEN Sébastien Corre, Nina Tardif, Nicolas Mouchet, Héloïse M. Leclair, Lise Boussemart, Arthur Gautron, Laura Bachelot, Anthony Perrot, Anatoly Soshilov, Aljosja Rogiers, Florian Rambow, Erwan Dumontet, Karin Tarte, Alban Bessede, Gilles J. Guillemin, Jean-Christophe Marine, Michael S. Denison, David Gilot & Marie-Dominique Galibert Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in melanoma bearing mice. 14 November 2018 | doi: 10.1038/s41467-018-06951-2 Cancer  Cancer genomics  Molecular biology  ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis OPEN Andrey N. Shkoporov, Ekaterina V. Khokhlova, C. Brian Fitzgerald, Stephen R. Stockdale, Lorraine A. Draper, R. Paul Ross & Colin Hill Bacteriophages of the crAssphage family have not yet been isolated, despite being highly abundant in the human gut. Here, Shkoporov et al. isolate in pure culture one of these viruses and show that it infects the human gut symbiont Bacteroides intestinalis. 14 November 2018 | doi: 10.1038/s41467-018-07225-7 Bacteriophages  Gastrointestinal system  Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer OPEN Naveed Ishaque, Mohammed L. Abba, Christine Hauser, Nitin Patil, Nagarajan Paramasivam, Daniel Huebschmann, Jörg Hendrik Leupold, Gnana Prakash Balasubramanian, Kortine Kleinheinz, Umut H. Toprak, Barbara Hutter, Axel Benner, Anna Shavinskaya, Chan Zhou, Zuguang Gu, Jules Kerssemakers, Alexander Marx, Marcin Moniuszko, Miroslaw Kozlowski, Joanna Reszec et al. The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part, are therapeutically actionable. 14 November 2018 | doi: 10.1038/s41467-018-07041-z Cancer genomics  Genome assembly algorithms  Conformational ensemble of the human TRPV3 ion channel OPEN Lejla Zubcevic, Mark A. Herzik Jr., Mengyu Wu, William F. Borschel, Marscha Hirschi, Albert S. Song, Gabriel C. Lander & Seok-Yong Lee Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization. 14 November 2018 | doi: 10.1038/s41467-018-07117-w Biophysics  Molecular biology  Permeation and transport  Transient receptor potential channels  An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules OPEN Gábor Bakos, Lu Yu, Igor A. Gak, Theodoros I. Roumeliotis, Dimitris Liakopoulos, Jyoti S. Choudhary & Jörg Mansfeld Ubiquitination and ubiquitin-like modifications of proteins regulate multiple cellular processes but identifying substrates of specific E2 and E3 enzymes remains challenging. Here, the authors conjugate E2 enzymes with enrichable ubiquitin derivatives to identify substrates of specific E2/E3 pairs by mass spectrometry. 14 November 2018 | doi: 10.1038/s41467-018-07251-5 Biochemical assays  Ligases  Sumoylation  Ubiquitylation  Myths and reality of HPbI3 in halide perovskite solar cells OPEN Weijun Ke, Ioannis Spanopoulos, Constantinos C. Stoumpos & Mercouri G. Kanatzidis Hydriodic acid or hydrogen lead iodide is widely used to stabilize all-inorganic perovskite cesium lead iodide to make high performing solar cells. Here Ke et al. reveal the real composition of the perovskites, where dimethylammonium partially take place of cesium cation at the A-site. 14 November 2018 | doi: 10.1038/s41467-018-07204-y Energy  Solar energy  Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis OPEN Yunshu Wu, Liang Xie, Mengyuan Wang, Qiuchan Xiong, Yuchen Guo, Yu Liang, Jing Li, Rui Sheng, Peng Deng, Yuan Wang, Rixin Zheng, Yizhou Jiang, Ling Ye, Qianming Chen, Xuedong Zhou, Shuibin Lin & Quan Yuan mRNA modifications have been shown to regulate mammalian development and disease. Here the authors show that the m6A methyltransferase Mettl3 ensures translational efficiency of the mesenchymal stem cell lineage allocator Pth1r, promoting osteogenesis and protecting from osteoporosis. 14 November 2018 | doi: 10.1038/s41467-018-06898-4 Mesenchymal stem cells  Osteoporosis  Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix OPEN A. E. Yuzhalin, A. N. Gordon-Weeks, M. L. Tognoli, K. Jones, B. Markelc, R. Konietzny, R. Fischer, A. Muth, E. O'Neill, P. R. Thompson, P. J. Venables, B. M. Kessler, S. Y. Lim & R. J. Muschel Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of citrullination could serve as therapeutic avenue in the treatment. 14 November 2018 | doi: 10.1038/s41467-018-07306-7 Cancer microenvironment  Gastrointestinal cancer  Mass spectrometry  Post-translational modifications  Tumour biomarkers  Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity OPEN Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller & Christophe Mulle Mutations in presenilin, which cleaves amyloid precursor protein, cause familial Alzheimer's Disease. Here, the authors show that loss of presenilin leads to loss of synaptotagmin 7, leading to impaired presynaptic release. 14 November 2018 | doi: 10.1038/s41467-018-06813-x Alzheimer's disease  Short-term potentiation  Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN OPEN Bin Liu, Shangwen Jiang, Min Li, Xuelian Xiong, Mingrui Zhu, Duanzhuo Li, Lei Zhao, Lili Qian, Linhui Zhai, Jing Li, Han Lu, Shengnan Sun, Jiandie Lin, Yan Lu, Xiaoying Li & Minjia Tan Ubiquitin-specific protease 14 (USP14) is a proteasome-associated deubiquitinating enzyme with known roles in physiology and disease. Here the authors show that fatty acid synthase (FASN) is a substrate of USP14, and that by stabilizing FASN, it plays a role in hepatosteatosis. 13 November 2018 | doi: 10.1038/s41467-018-07185-y Metabolic disorders  Non-alcoholic steatohepatitis  Post-translational modifications  Proteolysis  Proteomics  Experimental heatwaves compromise sperm function and cause transgenerational damage in a model insect OPEN Kris Sales, Ramakrishnan Vasudeva, Matthew E. Dickinson, Joanne L. Godwin, Alyson J. Lumley, Łukasz Michalczyk, Laura Hebberecht, Paul Thomas, Aldina Franco & Matthew J. G. Gage Animal physiology, including reproduction, could respond to climate change in complex ways. Here, the authors use experiments with an insect model system to show that simulated heatwaves harm male reproductive potential by reducing sperm number and viability, an effect which persisted into the next generation 13 November 2018 | doi: 10.1038/s41467-018-07273-z Animal physiology  Climate-change ecology  Evolutionary ecology  A web server for comparative analysis of single-cell RNA-seq data OPEN Amir Alavi, Matthew Ruffalo, Aiyappa Parvangada, Zhilin Huang & Ziv Bar-Joseph Publicly available single cell RNA-seq datasets represent valuable resources for comparative and meta-analysis. Here, the authors develop scQuery, a web server integrating over 500 different studies with over 300 unique cell types for comparative analysis of existing and new scRNA-seq data. 13 November 2018 | doi: 10.1038/s41467-018-07165-2 Machine learning  Software  A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults OPEN Lea B. S. Hansen, Henrik M. Roager, Nadja B. Søndertoft, Rikke J. Gøbel, Mette Kristensen, Mireia Vallès-Colomer, Sara Vieira-Silva, Sabine Ibrügger, Mads V. Lind, Rasmus B. Mærkedahl, Martin I. Bahl, Mia L. Madsen, Jesper Havelund, Gwen Falony, Inge Tetens, Trine Nielsen, Kristine H. Allin, Henrik L. Frandsen, Bolette Hartmann, Jens Juul Holst et al. Gluten-free diets are increasingly common in the general population. Here, the authors report the results of a randomised cross-over trial involving middle-aged, healthy Danish adults, showing evidence that a low-gluten diet leads to gut microbiome changes, possibly due to variations in dietary fibres. 13 November 2018 | doi: 10.1038/s41467-018-07019-x Gastroenterology  Metabolism  Microbiome  Unmasking GluN1/GluN3A excitatory glycine NMDA receptors OPEN Teddy Grand, Sarah Abi Gerges, Mélissa David, Marco A. Diana & Pierre Paoletti Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional GluN1/GluN3A receptors in the juvenile brain. 13 November 2018 | doi: 10.1038/s41467-018-07236-4 Molecular neuroscience  Neurotransmitters  Neural mechanisms for learning self and other ownership OPEN Patricia L. Lockwood, Marco K. Wittmann, Matthew A. J. Apps, Miriam C. Klein-Flügge, Molly J. Crockett, Glyn W. Humphreys & Matthew F. S. Rushworth The sense of ownership – of which objects belong to us and which to others - is an important part of our lives, but how the brain keeps track of ownership is poorly understood. Here, the authors show that specific brain areas are involved in ownership acquisition for the self, friends, and strangers. 12 November 2018 | doi: 10.1038/s41467-018-07231-9 Decision  Human behaviour  Learning and memory  Psychology  Large-area and adaptable electrospun silicon-based thermoelectric nanomaterials with high energy conversion efficiencies OPEN Alex Morata, Mercè Pacios, Gerard Gadea, Cristina Flox, Doris Cadavid, Andreu Cabot & Albert Tarancón To realize waste heat recovery solutions based on thermoelectricity, high-performance materials with device and manufacturing compatibility are required. Here, the authors demonstrate large-area paper-like nanostructured fabrics consisting of aligned nanotubes with high thermoelectric performance. 12 November 2018 | doi: 10.1038/s41467-018-07208-8 Metamaterials  Thermoelectric devices and materials  Thermoelectrics  Near-infrared STED nanoscopy with an engineered bacterial phytochrome OPEN Maria Kamper, Haisen Ta, Nickels A. Jensen, Stefan W. Hell & Stefan Jakobs Super-resolution microscopy using wavelengths in the near infrared (NIR) optical window is particularly appealing for live cell and tissue imaging, yet largely unexplored. Here the authors present NIR-STED nanoscopy of living mammalian cells using the new bacteriophytochrome-based fluorescent protein SNIFP. 12 November 2018 | doi: 10.1038/s41467-018-07246-2 Imaging  Super-resolution microscopy  Dehydrative π-extension to nanographenes with zig-zag edges OPEN Dominik Lungerich, Olena Papaianina, Mikhail Feofanov, Jia Liu, Mirunalini Devarajulu, Sergey I. Troyanov, Sabine Maier & Konstantin Amsharov Nanographenes with zig-zag peripheries are expected to have unique electronic properties, but their application in organic electronics has been curbed by their difficult synthesis. Here, the authors develop a facile route to zig-zag nanographenes based on a key dehydrative π-extension reaction. 12 November 2018 | doi: 10.1038/s41467-018-07095-z Synthetic chemistry methodology  Surface chemistry  Synthesis and processing  Synthesis of graphene  Dynamic Greenland ice sheet driven by pCO2 variations across the Pliocene Pleistocene transition OPEN Ning Tan, Jean-Baptiste Ladant, Gilles Ramstein, Christophe Dumas, Paul Bachem & Eystein Jansen Previous work has argued for a CO2 control on the development of the Plio-Pleistocene Transition (PPT, 3.0–2.5 Ma) Greenland Ice Sheet (GrIS). Here based on transient ice sheet experiments, the authors demonstrate the pivotal role of modern-like CO2 on the onset and dynamism of the PPT GrIS. 12 November 2018 | doi: 10.1038/s41467-018-07206-w Cryospheric science  Palaeoclimate  Designer liquid-liquid interfaces made from transient double emulsions OPEN Greet Dockx, Steffen Geisel, David G. Moore, Erin Koos, Andre R. Studart & Jan Vermant Surfaces with adsorbed and arrested colloids are of interest for the engineering of advanced mesostructured materials. Here the authors demonstrate a method for producing particle-stabilised droplets with controlled surface coverage and composition. 12 November 2018 | doi: 10.1038/s41467-018-07272-0 Fluid dynamics  Fluids  Microscopy  Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors OPEN Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka et al. Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tumors by whole-genome sequencing of tumors from mouse models of medulloblastoma or high grade gliomas. 12 November 2018 | doi: 10.1038/s41467-018-06925-4 Cancer genetics  Cancer models  DNA damage and repair  Calcium stabilizes the strongest protein fold OPEN Lukas F. Milles, Eduard M. Unterauer, Thomas Nicolaus & Hermann E. Gaub Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium. 12 November 2018 | doi: 10.1038/s41467-018-07145-6 Biological physics  Molecular biophysics  Protein folding  REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice OPEN Cristina Gontan, Hegias Mira-Bontenbal, Aristea Magaraki, Catherine Dupont, Tahsin Stefan Barakat, Eveline Rentmeester, Jeroen Demmers & Joost Gribnau REX1 has been shown to regulate pluripotency of ESCs, genomic imprinting and preimplantation development in mice. Here the authors provide evidence that REX1 is the prime target of RNF12 E3 ubiquitin ligase and that Rex1 removal rescues the Rnf12 knockout phenotype in imprinted X chromosome inactivation in mice. 12 November 2018 | doi: 10.1038/s41467-018-07060-w Dosage compensation  Embryology  5D operando tomographic diffraction imaging of a catalyst bed OPEN A. Vamvakeros, S. D. M. Jacques, M. Di Michiel, D. Matras, V. Middelkoop, I. Z. Ismagilov, E. V. Matus, V. V. Kuznetsov, J. Drnec, P. Senecal & A. M. Beale Multi-scale chemical imaging holds the potential to revolutionize our understanding of the relationships between structure and functionality in complex catalytic materials. Here the authors report the results from the first 5D tomographic diffraction imaging experiment of a complex Ni – Pd/ CeO2 – ZrO2/ Al2O3 catalyst used for methane reforming. 12 November 2018 | doi: 10.1038/s41467-018-07046-8 Chemistry  Solid-state chemistry  Structural insights into the function of type VI secretion system TssA subunits OPEN Samuel R. Dix, Hayley J. Owen, Ruyue Sun, Asma Ahmad, Sravanthi Shastri, Helena L. Spiewak, Daniel J. Mosby, Matthew J. Harris, Sarah L. Batters, Thomas A. Brooker, Svetomir B. Tzokov, Svetlana E. Sedelnikova, Patrick J. Baker, Per A. Bullough, David W. Rice & Mark S. Thomas TssA is an important component of the bacterial type VI secretion system (T6SS). Here, Dix et al. integrate structural, phylogenetic and functional analysis of the TssA subunits, providing new insights into their role in T6SS assembly and function. 12 November 2018 | doi: 10.1038/s41467-018-07247-1 Protein translocation  X-ray crystallography  Human adipose glycerol flux is regulated by a pH gate in AQP10 OPEN Kamil Gotfryd, Andreia Filipa Mósca, Julie Winkel Missel, Sigurd Friis Truelsen, Kaituo Wang, Mariana Spulber, Simon Krabbe, Claus Hélix-Nielsen, Umberto Laforenza, Graça Soveral, Per Amstrup Pedersen & Pontus Gourdon Uptake and release of glycerol from the small intestine and adipocytes is facilitated by a subclass of aquaporins (AQP), but how glycerol flow is regulated remains poorly understood. Here authors solve the crystal structure of AQP10 and show how lipolysis is coupled to AQP10 regulation in 12 November 2018 | doi: 10.1038/s41467-018-07176-z Fat metabolism  Membrane proteins  X-ray crystallography  Light-controlled switching of the spin state of iron(III) OPEN Sreejith Shankar, Morten Peters, Kim Steinborn, Bahne Krahwinkel, Frank D. Sönnichsen, Dirk Grote, Wolfram Sander, Thomas Lohmiller, Olaf Rüdiger & Rainer Herges Controlled switching of the spin state of transition metal ions is key in many enzymatic reactions, but difficult to replicate in synthetic systems. Here the authors report on an iron(III) porphyrin with a photochromic axial ligand that, in solution, reversibly switches between low-spin and high-spin upon irradiation with two different wavelengths. 12 November 2018 | doi: 10.1038/s41467-018-07023-1 Bioinorganic chemistry  Ligands  Organometallic chemistry  Photochemistry  Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection OPEN Anish Pandey, David W. Cleary, Jay R. Laver, Andrew Gorringe, Alice M. Deasy, Adam P. Dale, Paul D. Morris, Xavier Didelot, Martin C. J. Maiden & Robert C. Read Carriage of Neisseria lactamica, a harmless coloniser of the human respiratory tract, is inversely correlated with Neisseria meningitidis infection. Here, Pandey et al. provide insights into micro-evolutionary processes in N. lactamica during controlled infection of healthy volunteers. 12 November 2018 | doi: 10.1038/s41467-018-07235-5 Bacterial evolution  Bacterial genomics  Bacteriology  Deformation twinning and grain partitioning in a hexagonal close-packed magnesium alloy OPEN M. Arul Kumar, B. Clausen, L. Capolungo, R. J. McCabe, W. Liu, J. Z. Tischler & C. N. Tomé Magnesium deforms via twins that form in a grain then expand both forward and laterally, causing local stresses that have yet to be measured. Here, the authors measure the full strain and stress tensors around a twin in a bulk polycrystal and show that the twinning grain deforms heterogeneously. 12 November 2018 | doi: 10.1038/s41467-018-07028-w Mechanical properties  Metals and alloys  Pressure shock fronts formed by ultra-fast shear cracks in viscoelastic materials OPEN M. Gori, V. Rubino, A. J. Rosakis & N. Lapusta Propagating shear cracks in solids emit both shear and pressure waves, but it is usually thought that only shear waves coalesce to form shock fronts when the crack exceeds the shear wave speed. Here, the authors show that local material stiffening can further increase rupture speed and produce pressure shock fronts that hint at supersonic propagation. 12 November 2018 | doi: 10.1038/s41467-018-07139-4 Applied physics  Mechanical properties  Polymers  High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients OPEN Zhen Xu, Peilin Fang, Bingzhe Xu, Yufeng Lu, Jinghui Xiong, Feng Gao, Xin Wang, Jun Fan & Peng Shi In vitro chemotactic assays are often 2D, low-throughput and lack fine gradient control. Here the authors present a hydrogel-based microfluidic platform for high-throughput 3D chemotactic assays, and use it to study neuronal sensitivity to guidance molecule gradient steepness. 12 November 2018 | doi: 10.1038/s41467-018-07186-x Biomedical engineering  Neurotrophic factors  Vibrio cholerae motility exerts drag force to impede attack by the bacterial predator Bdellovibrio bacteriovorus OPEN Miles C. Duncan, John C. Forbes, Y Nguyen, Lauren M. Shull, Rebecca K. Gillette, David W. Lazinski, Afsar Ali, Robert M. Q. Shanks, Daniel E. Kadouri & Andrew Camilli Prey bacteria have evolved different strategies to counteract predation but the genetic basis remains unclear. Here, Duncan et al. identify key genes involved in Vibrio cholerae sensitivity to Bdellovibrio bacteriovorus predation, providing new insights into prey resistance mechanisms. 12 November 2018 | doi: 10.1038/s41467-018-07245-3 Bacterial pathogenesis  Cellular motility  Microbial ecology  Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface OPEN Jordi Gouilly, Qian Chen, Johan Siewiera, Géraldine Cartron, Claude Levy, Martine Dubois, Reem Al-Daccak, Jacques Izopet, Nabila Jabrane-Ferrat & Hicham El Costa Hepatitis E virus (HEV) infection can result in severe placental disease, but mechanisms underlying pathogenicity are poorly understood. Here, the authors develop an ex vivo model for HEV infection at the maternal-fetal interface and compare pathogenicity of different HEV genotypes. 12 November 2018 | doi: 10.1038/s41467-018-07200-2 Experimental models of disease  Interferons  Mucosal immunology  Viral infection  Pathway-based subnetworks enable cross-disease biomarker discovery OPEN Syed Haider, Cindy Q. Yao, Vicky S. Sabine, Michal Grzadkowski, Vincent Stimper, Maud H. W. Starmans, Jianxin Wang, Francis Nguyen, Nathalie C. Moon, Xihui Lin, Camilla Drake, Cheryl A. Crozier, Cassandra L. Brookes, Cornelis J. H. van de Velde, Annette Hasenburg, Dirk G. Kieback, Christos J. Markopoulos, Luc Y. Dirix, Caroline Seynaeve, Daniel W. Rea et al. Accurate and actionable biomarkers that integrate diverse molecular, functional and clinical information hold great promise in precision medicine. Here, the authors develop SIMMS, a method for pathway-based cross-disease biomarker discovery. 12 November 2018 | doi: 10.1038/s41467-018-07021-3 Bioinformatics  Cancer genomics  Cancer microenvironment  Computational science  Predictive markers  Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium OPEN Stéphanie Cagnet, Dalya Ataca, George Sflomos, Patrick Aouad, Sonia Schuepbach-Mallepell, Henry Hugues, Andrée Krust, Ayyakkannu Ayyanan, Valentina Scabia & Cathrin Brisken Oestrogen receptors α (ERα) are expressed in a subset of mammary epithelial cells. Here, the authors identify cells with low-ERα protein levels and show that distinct cell populations have distinct requirements for the AF1 and AF2 domains of the ERα, and ERα acts in a biphasic manner dependent on developmental stage. 09 November 2018 | doi: 10.1038/s41467-018-07175-0 Cell proliferation  Development  Transcriptome-wide identification of transient RNA G-quadruplexes in human cells OPEN Sunny Y. Yang, Pauline Lejault, Sandy Chevrier, Romain Boidot, A. Gordon Robertson, Judy M. Y. Wong & David Monchaud In vivo existence of guanine-rich four-stranded RNA structures (G4-RNAs) has been a matter of debate. Here the authors developed a protocol, G4RP-seq, to capture and identify transcriptome-wide G4-RNA, providing insights into the formation of transient G4-RNA in live human cells. 09 November 2018 | doi: 10.1038/s41467-018-07224-8 Genomic analysis  RNA  Spontaneous formation of nanoparticles on electrospun nanofibres OPEN Norbert Radacsi, Fernando Diaz Campos, Calum R. I. Chisholm & Konstantinos P. Giapis Uniformly distributing nanoparticles on nanofibres can benefit electrocatalysis by increasing surface area, but it is complex. Here the authors use facile, inexpensive, nozzle-free electrospinning to produce dispersed nanoparticles on nanofibres, attaining increased voltage in a commercial-scale fuel cell. 09 November 2018 | doi: 10.1038/s41467-018-07243-5 Fuel cells  Synthesis and processing  Evidence of depolarization and ellipticity of high harmonics driven by ultrashort bichromatic circularly polarized fields OPEN Lou Barreau, Kévin Veyrinas, Vincent Gruson, Sébastien J. Weber, Thierry Auguste, Jean-François Hergott, Fabien Lepetit, Bertrand Carré, Jean-Christophe Houver, Danielle Dowek & Pascal Salières Polarization parameters of the high harmonics driven by bichromatic circularly polarized pulses are usually assumed near perfect. Here the authors use polarimetry measurement to show that depolarization and ellipticity can arise from symmetry breaking in the ionization of a medium by the ultrashort driving fields. 09 November 2018 | doi: 10.1038/s41467-018-07151-8 Atomic and molecular interactions with photons  Attosecond science  High-harmonic generation  Transition path times of coupled folding and binding reveal the formation of an encounter complex OPEN Flurin Sturzenegger, Franziska Zosel, Erik D. Holmstrom, Karin J. Buholzer, Dmitrii E. Makarov, Daniel Nettels & Benjamin Schuler How interactions between binding partners form or break is hidden in the transition paths from the encounter to the formation of a stable complex. Here authors use single‐molecule spectroscopy to measure the transition path times for the association of two intrinsically disordered proteins that form a folded dimer upon binding and identify a metastable encounter complex. 09 November 2018 | doi: 10.1038/s41467-018-07043-x Biophysics  Intrinsically disordered proteins  Kinetics  Molecular biophysics  Molecular conformation  Discovery of rare cells from voluminous single cell expression data OPEN Aashi Jindal, Prashant Gupta, Jayadeva & Debarka Sengupta Algorithms designed to find rare cells in single cell RNA-seq data sets cannot cope with data sets containing tens of thousands of cells. Here the authors present Finder of Rare Entities (FiRE), an algorithm that uses the Sketching technique to assign a rareness score to every expression profile in large RNA-seq data sets. 09 November 2018 | doi: 10.1038/s41467-018-07234-6 Gene expression profiling  Genomics  Software  Diffusion-limited association of disordered protein by non-native electrostatic interactions OPEN Jae-Yeol Kim, Fanjie Meng, Janghyun Yoo & Hoi Sung Chung Intrinsically disordered proteins (IDPs) usually fold during binding to target proteins which involves the formation of a transient complex (TC). Here authors use single-molecule FRET to show that the lifetime of TC for IDP binding is very long due to the stabilization by non-native electrostatic interactions, which makes fast association possible. 09 November 2018 | doi: 10.1038/s41467-018-06866-y Biophysics  Intrinsically disordered proteins  Single-molecule biophysics  A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates OPEN Vincent Denavit, Danny Lainé, Jacob St-Gelais, Paul A. Johnson & Denis Giguère Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively. 09 November 2018 | doi: 10.1038/s41467-018-06901-y Carbohydrate chemistry  Deoxy sugars  Monosaccharides  Natural product synthesis  Unusually complex phase of dense nitrogen at extreme conditions OPEN Robin Turnbull, Michael Hanfland, Jack Binns, Miguel Martinez-Canales, Mungo Frost, Miriam Marqués, Ross T. Howie & Eugene Gregoryanz Nitrogen has a complex phase diagram with rich polymorphism, which is challenging to characterize due to the extreme conditions and uncertain stability ranges needed to do so. Here the authors resolve one of the most elusive phases of this model system, reporting a crystalline structure with unusual complexity. 09 November 2018 | doi: 10.1038/s41467-018-07074-4 Chemical physics  Phase transitions and critical phenomena  Structure of solids and liquids  Thermal transport crossover from crystalline to partial-crystalline partial-liquid state OPEN Yanguang Zhou, Shiyun Xiong, Xiaoliang Zhang, Sebastian Volz & Ming Hu Phase-change materials are applied as thermoelectric converters and battery electrodes, but underlying mechanisms are not fully understood. Here, the authors comprehensively describe thermal transport mechanisms of lithium sulfide based on molecular dynamics and first-principles simulations. 09 November 2018 | doi: 10.1038/s41467-018-07027-x Computational chemistry  Phase transitions and critical phenomena  Neodymium isotope evidence for glacial-interglacial variability of deepwater transit time in the Pacific Ocean OPEN Rong Hu & Alexander M. Piotrowski The response of deep Pacific overturning to glacial-interglacial climate change is still debated. Here the authors show a generally faster deep Pacific overturning operated in recent glacial periods based on a novel application of Nd isotopes recorded in foraminifera. 09 November 2018 | doi: 10.1038/s41467-018-07079-z Palaeoceanography  Palaeoclimate  A model of temporal scaling correctly predicts that motor timing improves with speed OPEN Nicholas F. Hardy, Vishwa Goudar, Juan L. Romero-Sosa & Dean V. Buonomano Humans can perform complex motor movements at varying speeds. Here, the authors show that a recurrent neural network can be trained to exhibit temporal scaling obeying Weber's law as well as validate a prediction of the model of improved precision of movements at faster speeds. 09 November 2018 | doi: 10.1038/s41467-018-07161-6 Human behaviour  Network models  Selectively exciting quasi-normal modes in open disordered systems OPEN Matthieu Davy & Azriel Z. Genack The authors present a study of the modal contributions to the transmission matrix in a scattering medium. They show that the incident wave form can be manipulated to control the net energy deposited in the sample, as well as the energy deposited in a selected quasi-normal mode. 09 November 2018 | doi: 10.1038/s41467-018-07180-3 Materials for optics  Optical physics  Harnessing photoinduced electron transfer to optically determine protein sub-nanoscale atomic distances OPEN Antonios Pantazis, Karin Westerberg, Thorsten Althoff, Jeff Abramson & Riccardo Olcese Current Förster resonance energy transfer (FRET)-based fluorescence spectroscopy methods are suffering from some limitations in the field of structural biology. Here, the authors present an optical approach, distance-encoding photoinduced electron transfer (DEPET), capable of the simultaneous study of protein structure and function. 09 November 2018 | doi: 10.1038/s41467-018-07218-6 Structural biology  Structure determination  Fossilization transforms vertebrate hard tissue proteins into N-heterocyclic polymers OPEN Jasmina Wiemann, Matteo Fabbri, Tzu-Ruei Yang, Koen Stein, P. Martin Sander, Mark A. Norell & Derek E. G. Briggs Recent studies have reported preservation of proteinaceous soft tissues within dinosaur bones. Here, Wiemann et al. combine analyses of fossil vertebrate tissues and experimentally matured modern samples to elucidate the mechanism of soft tissue preservation and the environments that favor it. 09 November 2018 | doi: 10.1038/s41467-018-07013-3 Biogeochemistry  Palaeontology  Crystallographic and spectroscopic assignment of the proton transfer pathway in [FeFe]-hydrogenases OPEN Jifu Duan, Moritz Senger, Julian Esselborn, Vera Engelbrecht, Florian Wittkamp, Ulf-Peter Apfel, Eckhard Hofmann, Sven T. Stripp, Thomas Happe & Martin Winkler [FeFe]-hydrogenases catalyze H2-evolution and -oxidation at very high turnover-rates. Here the authors provide experimental evidence for the proposed proton-transfer (PT) pathway by kinetically, spectroscopically, and crystallographically characterizing eleven mutants from the two [FeFe]-hydrogenases CpI and HydA1. 09 November 2018 | doi: 10.1038/s41467-018-07140-x Enzyme mechanisms  X-ray crystallography  High-resolution ultramicroscopy of the developing and adult nervous system in optically cleared Drosophila melanogaster OPEN Marko Pende, Klaus Becker, Martina Wanis, Saiedeh Saghafi, Rashmit Kaur, Christian Hahn, Nika Pende, Massih Foroughipour, Thomas Hummel & Hans-Ulrich Dodt Optical aberrations due to pigments in the eye and cuticle have undermined the ability for high-resolution imaging of the intact Drosophila. Here, the authors report an improved tissue-clearing agent, light-sheet optics and a multi-view combining algorithm to overcome these limitations. 09 November 2018 | doi: 10.1038/s41467-018-07192-z Development of the nervous system  Olfactory system  Optics and photonics  Visual system  Active intermixing of indirect and direct neurons builds the striatal mosaic OPEN Andrea Tinterri, Fabien Menardy, Marco A. Diana, Ludmilla Lokmane, Maryama Keita, Fanny Coulpier, Sophie Lemoine, Caroline Mailhes, Benjamin Mathieu, Paloma Merchan-Sala, Kenneth Campbell, Ildiko Gyory, Rudolf Grosschedl, Daniela Popa & Sonia Garel Striatal projection neurons exist as two distinct classes and are anatomically mixed in the brain. Here, Tinterri and colleagues show the developmental mechanism of this cellular mosaicism that relies on an intrinsic transcription factor for cell type specification and intermixed cellular migration. 09 November 2018 | doi: 10.1038/s41467-018-07171-4 Development of the nervous system  Developmental biology  A common genetic mechanism underlies morphological diversity in fruits and other plant organs OPEN Shan Wu, Biyao Zhang, Neda Keyhaninejad, Gustavo R. Rodríguez, Hyun Jung Kim, Manohar Chakrabarti, Eudald Illa-Berenguer, Nathan K. Taitano, M. J Gonzalo, Aurora Díaz, Yupeng Pan, Courtney P. Leisner, Dennis Halterman, C. Robin Buell, Yiqun Weng, Shelley H. Jansky, Herman van Eck, Johan Willemsen, Antonio J. Monforte, Tea Meulia et al. Remarkable organ shape morphological diversity exists in fruits, vegetables and seeds. Here, the authors establish a link between OVATE Family Proteins and TONNEAU1 Recruiting Motif family proteins in the development pathway that governs fruit shape of tomato, melon, and cucumber as well as potato tuber shape. 09 November 2018 | doi: 10.1038/s41467-018-07216-8 Agricultural genetics  Plant development  Quantitative trait  Inflammation-induced Id2 promotes plasticity in regulatory T cells OPEN Sung-Min Hwang, Garima Sharma, Ravi Verma, Seohyun Byun, Dipayan Rudra & Sin-Hyeog Im Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability. 09 November 2018 | doi: 10.1038/s41467-018-07254-2 Gene regulation in immune cells  Regulatory T cells  T-helper 17 cells  Tumour immunology  The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance OPEN Fei Han, Chien-Feng Li, Zhen Cai, Xian Zhang, Guoxiang Jin, Wei-Na Zhang, Chuan Xu, Chi-Yun Wang, John Morrow, Shuxing Zhang, Dazhi Xu, Guihua Wang & Hui-Kuan Lin How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1. 09 November 2018 | doi: 10.1038/s41467-018-07188-9 Oncogenes  Phosphorylation  Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation OPEN Wataru Shihoya, Tamaki Izume, Asuka Inoue, Keitaro Yamashita, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Tomohiro Nishizawa & Osamu Nureki Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss mechanistic implications for receptor activation. 09 November 2018 | doi: 10.1038/s41467-018-07094-0 Hormone receptors  X-ray crystallography  Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1 OPEN Linda M. Suen, Makeda A. Tekle-Smith, Kevin S. Williamson, Joshua R. Infantine, Samuel K. Reznik, Paul S. Tanis, Tyler D. Casselman, Dan L. Sackett & James L. Leighton Step-economical and efficient syntheses of Spongistatin 1 analogs are desirable for the development of potent anti-proliferative agents. Here, the authors report a 22-step synthesis of a D-ring modified Spongistatin 1 analog with retained picomolar potency among a group of C(15) ester derivatives. 09 November 2018 | doi: 10.1038/s41467-018-07259-x Synthetic chemistry methodology  Natural product synthesis  Structure-based drug design  Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases OPEN Francesco Vallania, Andrew Tam, Shane Lofgren, Steven Schaffert, Tej D. Azad, Erika Bongen, Winston Haynes, Meia Alsup, Michael Alonso, Mark Davis, Edgar Engleman & Purvesh Khatri Cell type deconvolution from bulk expression data rely on a reference expression matrix. Here, the authors introduce a basis matrix built using data from both healthy and diseased samples profiled on 42 platforms, reducing biases introduced by single-platform matrices built using healthy samples. 09 November 2018 | doi: 10.1038/s41467-018-07242-6 Computational biology and bioinformatics  Immunology  Systems biology  Chemical bonding origin of the unexpected isotropic physical properties in thermoelectric Mg3Sb2 and related materials OPEN Jiawei Zhang, Lirong Song, Mattia Sist, Kasper Tolborg & Bo Brummerstedt Iversen The outstanding thermoelectric Mg3Sb2 is currently being intensely scrutinized. Here, the authors reveal a nearly isotropic three-dimensional chemical bonding network as the origin of isotropic physical properties in Mg3Sb2, indicating the breakdown of the simple layered Zintl phase view. 09 November 2018 | doi: 10.1038/s41467-018-06980-x Electronic materials  Thermoelectrics  Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling OPEN Lei Zhang, Chi Kin Ip, I-Chieh J. Lee, Yue Qi, Felicia Reed, Tim Karl, Jac Kee Low, Ronaldo F. Enriquez, Nicola J. Lee, Paul A. Baldock & Herbert Herzog Excess caloric intake leads to increased thermogenesis in brown adipose tissue, to limit weight gain. Here, the authors show that neuropeptide FF receptor-2 signalling promotes thermogenesis via control of NPY expression in the arcuate nucleus, and that it absence in mice leads to a failure of activation of diet-induced thermogenesis and the development of exacerbated obesity. 09 November 2018 | doi: 10.1038/s41467-018-06462-0 Hypothalamus  Metabolism  Obesity  MAIT cells contribute to protection against lethal influenza infection in vivo OPEN Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J. Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nüssing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F. Almeida, Lyudmila Kostenko, Sidonia B. G. Eckle, Bronwyn S. Meehan, Axel Kallies, Dale I. Godfrey, Patrick C. Reading et al. MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection. 09 November 2018 | doi: 10.1038/s41467-018-07207-9 Infection  Influenza virus  Pathogens  T cells  Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution OPEN Juliana G. Roscito, Katrin Sameith, Genis Parra, Bjoern E. Langer, Andreas Petzold, Claudia Moebius, Marc Bickle, Miguel Trefaut Rodrigues & Michael Hiller Cis-regulatory elements are important factors for morphological changes. Here, the authors show widespread divergence of limb and eye regulatory elements in limb loss in snakes and eye degeneration in subterranean mammals respectively. 09 November 2018 | doi: 10.1038/s41467-018-07122-z Comparative genomics  Evolutionary biology  Evolutionary developmental biology  Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy OPEN Bhanu P. Tewari, Lata Chaunsali, Susan L. Campbell, Dipan C. Patel, Adam E. Goode & Harald Sontheimer Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing. 09 November 2018 | doi: 10.1038/s41467-018-07113-0 Epilepsy  Inhibition–excitation balance  Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer OPEN Yunhua Liu, Jiangsheng Xu, Hyun Ho Choi, Cecil Han, Yuanzhang Fang, Yujing Li, Kevin Van der Jeught, Hanchen Xu, Lu Zhang, Michael Frieden, Lifei Wang, Haniyeh Eyvani, Yifan Sun, Gang Zhao, Yuntian Zhang, Sheng Liu, Jun Wan, Cheng Huang, Guang Ji, Xiongbin Lu et al. The 17q23 amplicon containing the WIP1 oncogene is frequently amplified in HER2+ breast cancer. Here they find MIR21 to be present in WIP1-containing amplicons, and report nanoparticle based co-delivery of WIP1 and miR-21 inhibitors to be effective in trastuzumab-resistant HER2+ breast cancer. 09 November 2018 | doi: 10.1038/s41467-018-07264-0 Breast cancer  Cancer genomics  Cancer therapy  N2H4 as traceless mediator for homo- and cross- aryl coupling OPEN Leiyang Lv, Zihang Qiu, Jianbin Li, Mingxin Liu & Chao-Jun Li Synthesis of biaryls by coupling strategies is unavoidably accompanied by stoichiometric metal waste. Here, the authors report the homo- and cross-electrophile coupling by using hydrazine as metal surrogate, only liberating N2 and H2 as side products. 09 November 2018 | doi: 10.1038/s41467-018-07198-7 Homogeneous catalysis  Synthetic chemistry methodology  Sustainability  Plant defences mediate interactions between herbivory and the direct foliar uptake of atmospheric reactive nitrogen OPEN Stuart A. Campbell & Dena M. Vallano Reactive nitrogen oxides can be assimilated by leaves, though the trophic and nitrogen cycling impacts of this are unclear. Here Campbell and Vallano show foliar uptake of NO2 increases defensive metabolites, reduces herbivore consumption and growth, and herbivory reduces foliar NO2 uptake. 09 November 2018 | doi: 10.1038/s41467-018-07134-9 Biodiversity  Ecology  Ecophysiology  Environmental impact  Plant ecology  Broadband highly directive 3D nanophotonic lenses OPEN Eric Johlin, Sander A. Mann, Sachin Kasture, A. Femius Koenderink & Erik C. Garnett While nanoscale emitters hold promise in single-photon devices, the directivity of their emission must be improved for practical applications. Here, Johlin et al. use an evolutionary algorithm to design a dielectric nanophotonic lens that greatly enhances the directivity of a semiconductor nanowire. 09 November 2018 | doi: 10.1038/s41467-018-07104-1 Nanophotonics and plasmonics  Nanowires  Sub-wavelength optics  Mapping knowledge gaps in marine diversity reveals a latitudinal gradient of missing species richness OPEN André Menegotto & Thiago F. Rangel Accurate understanding of species biogeographic patterns is contingent upon adequate sampling effort across space. Here, the authors analyse the distribution records for 35,000 marine species, highlighting data gaps caused by undersampling in the tropics. 09 November 2018 | doi: 10.1038/s41467-018-07217-7 Biogeography  Macroecology  Ocean sciences  A gas breathing hydrogen/air biofuel cell comprising a redox polymer/hydrogenase-based bioanode OPEN Julian Szczesny, Nikola Marković, Felipe Conzuelo, Sónia Zacarias, Inês A. C. Pereira, Wolfgang Lubitz, Nicolas Plumeré, Wolfgang Schuhmann & Adrian Ruff Hydrogen is an attractive alternative fuel, but many hydrogen-conversion electrocatalysts contain expensive materials. Here the authors report a dual-gas breathing hydrogen/air biofuel cell comprised of a modified polymer/hydrogenase bioanode and a bilirubin oxidase biocathode, delivering improved output. 09 November 2018 | doi: 10.1038/s41467-018-07137-6 Electrocatalysis  Fuel cells  HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome OPEN Patricia T. Illing, Phillip Pymm, Nathan P. Croft, Hugo G. Hilton, Vladimir Jojic, Alex S. Han, Juan L. Mendoza, Nicole A. Mifsud, Nadine L. Dudek, James McCluskey, Peter Parham, Jamie Rossjohn, Julian P. Vivian & Anthony W. Purcell Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity. 08 November 2018 | doi: 10.1038/s41467-018-07109-w Cellular immunity  Immunogenetics  Immunological deficiency syndromes  MHC class I  Southern Hemisphere forcing of South Asian monsoon precipitation over the past ~1 million years OPEN D. Gebregiorgis, E. C. Hathorne, L. Giosan, S. Clemens, D. Nürnberg & M. Frank The orbital-scale timing of South Asian monsoon precipitation is poorly understood. Here the authors show that the long held view that precession drove changes in monsoon strength is wrong, and that obliquity and eccentricity played a stronger role. 08 November 2018 | doi: 10.1038/s41467-018-07076-2 Palaeoceanography  Palaeoclimate  Src-transformed cells hijack mitosis to extrude from the epithelium OPEN Katarzyna A. Anton, Mihoko Kajita, Rika Narumi, Yasuyuki Fujita & Masazumi Tada Potentially cancerous cells undergo live apical extrusion from normal monolayers and vSrc expression induces this in zebrafish epithelia. Here, the authors show that vSrc coordinates cytokinetic ring formation, cell cycle progression, junctional integrity, cell survival and apicobasal polarity to induce extrusion of transformed cells. 08 November 2018 | doi: 10.1038/s41467-018-07163-4 Cancer  Cell biology  Developmental biology  Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs OPEN Hamid R. Noori, Lewis H. Mervin, Vahid Bokharaie, Özlem Durmus, Lisamon Egenrieder, Stefan Fritze, Britta Gruhlke, Giulia Reinhardt, Hans-Hendrik Schabel, Sabine Staudenmaier, Nikos K. Logothetis, Andreas Bender & Rainer Spanagel The precise relationship between neurobehavioural effects and neurotransmitter effects of psychiatric drugs are not always understood. Here the authors develop a database documenting the neurotransmitter response in rats to 258 different neuropsychiatric drugs, and conclude that this neurotransmitter response does not, in general, reflect the current categorisation of those drugs. 08 November 2018 | doi: 10.1038/s41467-018-07239-1 Diseases of the nervous system  Neurotransmitters  Pharmacodynamics  Electrochemically-mediated selective capture of heavy metal chromium and arsenic oxyanions from water OPEN Xiao Su, Akihiro Kushima, Cameron Halliday, Jian Zhou, Ju Li & T. Alan Hatton Chromium and arsenic are prevalent water pollutants, but their removal is currently limited by low selectivity. Here, the authors use redox-active metallopolymer electrodes based on poly(vinyl)ferrocene to selectively remove the two heavy metal oxyanions at concentrations as low as 100 ppb. 08 November 2018 | doi: 10.1038/s41467-018-07159-0 Chemical engineering  Electrochemistry  Pollution remediation  Polymers  Combined effusive-explosive silicic volcanism straddles the multiphase viscous-to-brittle transition OPEN Fabian B. Wadsworth, Taylor Witcher, Caron E. J. Vossen, Kai-Uwe Hess, Holly E. Unwin, Bettina Scheu, Jonathan M. Castro & Donald B. Dingwell Recent observations of silicic eruptions show that they can be both effusive and explosive at the same time. Here the authors use scaled experiments to demonstrate that magma in effusive eruptions will fracture during flow to the Earth's surface, accommodating mixed eruption styles. 08 November 2018 | doi: 10.1038/s41467-018-07187-w Glasses  Rheology  Volcanology  Overexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth OPEN Norma Fàbregas, Fidel Lozano-Elena, David Blasco-Escámez, Takayuki Tohge, Cristina Martínez-Andújar, Alfonso Albacete, Sonia Osorio, Mariana Bustamante, José Luis Riechmann, Takahito Nomura, Takao Yokota, Ana Conesa, Francisco Pérez Alfocea, Alisdair R. Fernie & Ana I. Caño-Delgado Drought resistant plants typically have reduced growth. Here the authors show that overexpression of the BRL3 brassinosteroid receptor confers drought tolerance and accumulation of osmoprotectant metabolites without penalizing growth, demonstrating that drought response and growth can be uncoupled. 08 November 2018 | doi: 10.1038/s41467-018-06861-3 Brassinosteroid  Drought  Plant biotechnology  Three-dimensional localization spectroscopy of individual nuclear spins with sub-Angstrom resolution OPEN J. Zopes, K. S. Cujia, K. Sasaki, J. M. Boss, K. M. Itoh & C. L. Degen Electron spins in nitrogen vacancy centres are perturbed by nearby nuclear spins, making it possible to infer some of the nuclear spins' properties. Here the authors demonstrate a technique that can determine the location of nuclear spins in three-dimensional space using only one electron spin. 08 November 2018 | doi: 10.1038/s41467-018-07121-0 NMR spectroscopy  Quantum physics  Techniques and instrumentation  Divergent trends in functional and phylogenetic structure in reptile communities across Africa OPEN Till Ramm, Juan L. Cantalapiedra, Philipp Wagner, Johannes Penner, Mark-Oliver Rödel & Johannes Müller The biogeographic drivers of reptile diversity are poorly understood relative to other animal groups. Here, using a dataset of distributions of African squamates, the authors show that environmental filtering explains diversity in stressful habitats while competition explains diversity in benign habitats. 08 November 2018 | doi: 10.1038/s41467-018-07107-y Biodiversity  Community ecology  Herpetology  Macroecology  Structural basis for the second step of group II intron splicing OPEN Russell T. Chan, Jessica K. Peters, Aaron R. Robart, Timothy Wiryaman, Kanagalaghatta R. Rajashankar & Navtej Toor Group II introns are large, self-splicing RNAs that catalyze their own excision from pre-mRNA molecules. Here the authors determine the 3.7 Å crystal structure of the group II intron in the stage immediately before the second step of splicing and present a complete model for the second step of group II intron splicing. 08 November 2018 | doi: 10.1038/s41467-018-06678-0 RNA  X-ray crystallography  Structural basis for the recognition of sulfur in phosphorothioated DNA OPEN Guang Liu, Wencheng Fu, Zhenyi Zhang, Yao He, Hao Yu, Yuli Wang, Xiaolei Wang, Yi-Lei Zhao, Zixin Deng, Geng Wu & Xinyi He DNA phosphorothioation (PT-DNA) is a DNA backbone sulfur modification that is recognized by the type-IV restriction endonuclease ScoMcrA. Here the authors provide insights into sulfur recognition by solving the crystal structure of the PT-DNA bound sulfur-binding domain (SBD) from ScoMcrA and they further show that SBD homologs are widely spread among prokaryotes. 08 November 2018 | doi: 10.1038/s41467-018-07093-1 Bacterial genetics  DNA  DNA restriction-modification enzymes  X-ray crystallography  A structural mechanism for directing corepressor-selective inverse agonism of PPARγ OPEN Richard Brust, Jinsai Shang, Jakob Fuhrmann, Sarah A. Mosure, Jared Bass, Andrew Cano, Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Anne-Laure Blayo, Patrick R. Griffin, Theodore M. Kamenecka, Travis S. Hughes & Douglas J. Kojetin Peroxisome proliferator-activated receptor gamma (PPARγ) is a target for insulin sensitizing drugs. Here the authors combine NMR, X-ray crystallography and MD simulations and report a structural mechanism for eliciting PPARγ inverse agonism, where coactivator binding is inhibited and corepressor binding promoted, which causes PPARγ repression. 08 November 2018 | doi: 10.1038/s41467-018-07133-w Nuclear receptors  Solution-state NMR  X-ray crystallography  TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure OPEN Ankur Chakravarthy, Lubaba Khan, Nathan Peter Bensler, Pinaki Bose & Daniel D. De Carvalho Changes in ECM are of predictive value in pancreatic and colorectal cancer prognosis. Here, the authors perform a pan-cancer analysis and find a subset of ECM genes that is linked to TGF-β signalling signature and is correlated with immunotherapy failure. 08 November 2018 | doi: 10.1038/s41467-018-06654-8 Cancer  Tumour immunology  Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA OPEN Julius Gudmundsson, Jon K. Sigurdsson, Lilja Stefansdottir, Bjarni A. Agnarsson, Helgi J. Isaksson, Olafur A. Stefansson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Michael L. Frigge, Simon N. Stacey, Patrick Sulem, Gisli H. Halldorsson, Vinicius Tragante, Hilma Holm, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Thorvaldur Jonsson, Eirikur Jonsson et al. Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk. 08 November 2018 | doi: 10.1038/s41467-018-06920-9 Cancer  Genetics  Adaptation to sub-optimal hosts is a driver of viral diversification in the ocean OPEN Hagay Enav, Shay Kirzner, Debbie Lindell, Yael Mandel-Gutfreund & Oded Béjà Marine cyanophages infect oceanic cyanobacteria that are important contributors to global primary production. By using an experimental evolution approach, here the authors show that adaptation to sub-optimal cyanobacterial hosts result in genomic diversification of cyanophage populations. 08 November 2018 | doi: 10.1038/s41467-018-07164-3 Microbial ecology  Molecular evolution  Virology  An interpretable approach for social network formation among heterogeneous agents OPEN Yuan Yuan, Ahmad Alabdulkareem & Alex 'Sandy' Pentland Complex networks can be a useful tool to investigate problems in social science. Here the authors use game theory to establish a network model and then use a machine learning approach to characterize the role of nodes within a social network. 08 November 2018 | doi: 10.1038/s41467-018-07089-x Computational science  Network topology  Sociology  Vibrational fingerprint of localized excitons in a two-dimensional metal-organic crystal OPEN M. Corva, A. Ferrari, M. Rinaldi, Z. Feng, M. Roiaz, C. Rameshan, G. Rupprechter, R. Costantini, M. Dell'Angela, G. Pastore, G. Comelli, N. Seriani & E. Vesselli Long-lived excitons in a two-dimensional metal-organic crystal can be produced by visible light and detected by infrared radiation. Here, the authors show that the excitonic state of a biomimetic macrocycle can be 'read' by measuring the vibrations of an adsorbed ligand. 08 November 2018 | doi: 10.1038/s41467-018-07190-1 Infrared spectroscopy  Optical properties and devices  Surfaces, interfaces and thin films  Two-dimensional materials  Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab OPEN S. Michael Chin, Christopher R. Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R. Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani & Javier Chaparro-Riggers The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody binding sites by mutational analysis, which is of interest for further 4-1BB therapeutics development. 08 November 2018 | doi: 10.1038/s41467-018-07136-7 Cancer  X-ray crystallography  Membrane association and remodeling by intraflagellar transport protein IFT172 OPEN Qianmin Wang, Michael Taschner, Kristina A. Ganzinger, Charlotte Kelley, Alethia Villasenor, Michael Heymann, Petra Schwille, Esben Lorentzen & Naoko Mizuno Cilia formation requires Intraflagellar transport (IFT) to move ciliary building blocks and signaling components into the cilium. Here authors use in vitro reconstitution and electron microscopy on IFT172 and reveal its ability to remodel large membrane surfaces into small vesicles. 08 November 2018 | doi: 10.1038/s41467-018-07037-9 Biochemistry  Biophysics  Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2 OPEN Zuqiang Liu, Yan Ge, Haiyan Wang, Congrong Ma, Mathilde Feist, Songguang Ju, Z. Sheng Guo & David L. Bartlett IL-2 is used systemically for cancer therapy but it is associated with severe toxicity. Here, the authors design a recombinant vaccinia virus expressing membrane-bound IL-2 that shows therapeutic efficacy alone or in combination with checkpoint inhibitors in colon cancer-bearing mice. 08 November 2018 | doi: 10.1038/s41467-018-06954-z Cancer immunotherapy  Immunization  Transient hydrodynamic effects influence organic carbon signatures in marine sediments OPEN Clayton R. Magill, Blanca Ausín, Pascal Wenk, Cameron McIntyre, Luke Skinner, Alfredo Martínez-García, David A. Hodell, Gerald H. Haug, William Kenney & Timothy I. Eglinton Marine sedimentary records and the proxies within play a central role in unlocking our understanding of past climates, yet interpreting the signals they contain can be complex. Here, the authors reveal and discuss the complex effects of hydrodynamics on carbon accumulation in the sediments off the Iberian margin. 08 November 2018 | doi: 10.1038/s41467-018-06973-w Carbon cycle  Physical oceanography  TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation OPEN Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang & Peng Jiang TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in glycolysis. 08 November 2018 | doi: 10.1038/s41467-018-07127-8 Cancer metabolism  Cell growth  Long term but not short term exposure to obesity related microbiota promotes host insulin resistance OPEN Kevin P. Foley, Soumaya Zlitni, Emmanuel Denou, Brittany M. Duggan, Rebecca W. Chan, Jennifer C. Stearns & Jonathan D. Schertzer Gut microbiota impact host metabolism and gut microbiome composition reflects dietary habits. Here the authors show that, in animals fed obesogenic diets, changes in gut microbiota precede changes in glucose homeostasis. Importantly, long term exposure of the host to the changed microbiota is required to impair glucose homeostasis. 08 November 2018 | doi: 10.1038/s41467-018-07146-5 Microbiology  Obesity  Pre-diabetes  Type 2 diabetes  A rice Serine/Threonine receptor-like kinase regulates arbuscular mycorrhizal symbiosis at the peri-arbuscular membrane OPEN Ronelle Roth, Marco Chiapello, Héctor Montero, Peter Gehrig, Jonas Grossmann, Kevin O'Holleran, Denise Hartken, Fergus Walters, Shu-Yi Yang, Stefan Hillmer, Karin Schumacher, Sarah Bowden, Melanie Craze, Emma J. Wallington, Akio Miyao, Ruairidh Sawers, Enrico Martinoia & Uta Paszkowski The peri-arbuscular membrane (PAM) mediates mutually-beneficial nutrient exchange between plants and arbuscular mycorrhizal (AM) fungi. Here the authors identify ARK1, a PAM-specific receptor-like kinase from rice that sustains AM symbiosis post-arbuscule development. 08 November 2018 | doi: 10.1038/s41467-018-06865-z Arbuscular mycorrhiza  Plant sciences  Plant symbiosis  Electrically induced and detected Néel vector reversal in a collinear antiferromagnet OPEN J. Godinho, H. Reichlová, D. Kriegner, V. Novák, K. Olejník, Z. Kašpar, Z. Šobáň, P. Wadley, R. P. Campion, R. M. Otxoa, P. E. Roy, J. Železný, T. Jungwirth & J. Wunderlich Controlling the Néel vector switching is crucial to the antiferromagnetic spintronics but so far limited to 90° reorientations. Here the authors report electrical Néel vector reversal and its detection in a fully compensated collinear antiferromagnet (AF) by exploiting the broken time reversal and spatial inversion symmetries of the AF. 08 November 2018 | doi: 10.1038/s41467-018-07092-2 Electronic and spintronic devices  Magnetic properties and materials  Spintronics  Manipulating azobenzene photoisomerization through strong light–molecule coupling OPEN J. Fregoni, G. Granucci, E. Coccia, M. Persico & S. Corni Manipulation of the photochemistry of molecules is traditionally achieved through synthetic chemical modifications. Here the authors use computational photochemistry to show how to control azobenzene photoisomerization through hybrid light–molecule states (polaritons). 08 November 2018 | doi: 10.1038/s41467-018-06971-y Nanophotonics and plasmonics  Photochemistry  Quantum chemistry  Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset OPEN Agarwal Priti, Hui Ting Ong, Yusuke Toyama, Anup Padmanabhan, Sabyasachi Dasgupta, Matej Krajnc & Ronen Zaidel-Bar Germline cells in many species are fused to form a syncytium but the mechanics behind the maintenance of these structures are poorly defined. Here, the authors propose an inner contractile actomyosin corset provides a supportive framework to maintain germline architecture in C. elegans. 08 November 2018 | doi: 10.1038/s41467-018-07149-2 Actin  Body patterning  Myosin  Oogenesis  Probing molecule-like isolated octahedra via—phase stabilization of zero-dimensional cesium lead halide nanocrystals OPEN Paulraj Arunkumar, Han Bin Cho, Kyeong Hun Gil, Sanjith Unithrattil, Yoon Hwa Kim & Won Bin Im Zero-dimensional cesium lead halides show interesting optoelectronic properties owing to the isolated octahedral structure, but their interaction with alien atoms remain elusive. Herein, Arunkumar et al. report manganese ion doping which leads to phase stabilization and higher quantum yield. 08 November 2018 | doi: 10.1038/s41467-018-07097-x Materials for devices  Materials for optics  Nanoscale materials  Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion OPEN Mario Buono, Marie-Laëtitia Thézénas, Alessandro Ceroni, Roman Fischer & Claus Nerlov c-Kit receptor–Kit ligand complex signaling is known to activate c-Kit and is essential for tissue development. Here, Buono et al. show that membrane-bound KitL signaling induces proliferation via CAML-Akt-CREB pathway activation, establishing a role for bidirectional signaling in tissue expansion. 08 November 2018 | doi: 10.1038/s41467-018-07024-0 Cell proliferation  Growth factor signalling  Lymphopoiesis    Nature Communications EVENT The Arab International Pharmacy Congress 27.11.18 Riyadh, Saudi Arabia More science events from     Latest Correspondence     The diamine cation is not a chemical example where density functional theory fails OPEN Zulfikhar A. Ali, Fredy W. Aquino & Bryan M. Wong 09 November 2018 | doi: 10.1038/s41467-018-07266-y Density functional theory  Photochemistry      Latest Author Corrections     Author Correction: The prognostic effects of somatic mutations in ER-positive breast cancer OPEN Obi L. Griffith , Nicholas C. Spies, Meenakshi Anurag, Malachi Griffith, Jingqin Luo, Dongsheng Tu, Belinda Yeo, Jason Kunisaki, Christopher A Miller, Kilannin Krysiak, Jasreet Hundal, Benjamin J Ainscough, Zachary L. Skidmore, Katie Campbell, Runjun Kumar, Catrina Fronick, Lisa Cook, Jacqueline E. Snider, Sherri Davies, Shyam M. Kavuri et al. 14 November 2018 | doi: 10.1038/s41467-018-07407-3 Breast cancer  Cancer genomics  Author Correction: Bi-directional cell-pericellular matrix interactions direct stem cell fate OPEN Silvia A. Ferreira , Meghna S. Motwani, Peter A. Faull, Alexis J. Seymour, Tracy T. L. Yu, Marjan Enayati, Dheraj K. Taheem, Christoph Salzlechner, Tabasom Haghighi, Ewa M. Kania, Oommen P. Oommen, Tarek Ahmed, Sandra Loaiza, Katarzyna Parzych, Francesco Dazzi, Oommen P. Varghese, Frederic Festy, Agamemnon E. Grigoriadis, Holger W. Auner, Ambrosius P. Snijders et al. 14 November 2018 | doi: 10.1038/s41467-018-07398-1 Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding OPEN 13 November 2018 | doi: 10.1038/s41467-018-07304-9 Antigen-presenting cells  Antigen processing and presentation  Infectious diseases  MHC class I  Author Correction: A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus OPEN Linh T. Bui, Nicholas A. Ivers & Erik J. Ragsdale 13 November 2018 | doi: 10.1038/s41467-018-07354-z Evolutionary developmental biology  Evolutionary genetics  Author Correction: Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control OPEN Peng Dong, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot & Lingchong You 13 November 2018 | doi: 10.1038/s41467-018-07169-y Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis OPEN Sean P. Pitroda , Nikolai N. Khodarev, Lei Huang, Abhineet Uppal, Sean C. Wightman, Sabha Ganai, Nora Joseph, Jason Pitt, Miguel Brown, Martin Forde, Kathy Mangold, Lai Xue, Christopher Weber, Jeremy P. Segal, Sabah Kadri, Melinda E. Stack, Sajid Khan, Philip Paty, Karen Kaul, Jorge Andrade et al. 13 November 2018 | doi: 10.1038/s41467-018-07303-w Cancer  Metastasis  Oncology  Author Correction: Limitation of Fermi level shifts by polaron defect states in hematite photoelectrodes OPEN Christian Lohaus, Andreas Klein & Wolfram Jaegermann 12 November 2018 | doi: 10.1038/s41467-018-07410-8 Electrochemistry  Electronic properties and materials  Photocatalysis  Surfaces, interfaces and thin films  Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks OPEN Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser & Bernard D. Keavney 12 November 2018 | doi: 10.1038/s41467-018-07399-0 Cardiovascular genetics  Chromatin structure  Gene regulation  Genetic variation      Latest Publisher Corrections     Publisher Correction: Complex virome in feces from Amerindian children in isolated Amazonian villages OPEN Juliana D. Siqueira, Maria Gloria Dominguez-Bello, Monica Contreras, Orlana Lander, Hortensia Caballero-Arias, Deng Xutao, Oscar Noya-Alarcon & Eric Delwart 14 November 2018 | doi: 10.1038/s41467-018-07337-0 Metagenomics  Microbiome  Virology  Publisher Correction: EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells OPEN Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis & Heide L. Ford 12 November 2018 | doi: 10.1038/s41467-018-07168-z Publisher Correction: Unravelling the structure of glycosyl cations via cold-ion infrared spectroscopy OPEN Eike Mucha, Mateusz Marianski, Fei-Fei Xu, Daniel A. Thomas, Gerard Meijer, Gert von Helden, Peter H. Seeberger & Kevin Pagel 08 November 2018 | doi: 10.1038/s41467-018-07184-z Carbohydrate chemistry  Infrared spectroscopy  Mass spectrometry      Advertisement Focal Point on Vaccine Research The future of vaccine research may be in Asia - The signs are there in funding levels, and combined with Asian governments' interest in biotechnology, and a highly skilled, highly educated workforce, pharma giants are looking east.    Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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