Nature Cell Biology contents: December 2018 Volume 20 Number 12

Advertisement Nikon's new A1R HD25 confocal system features the largest field of view on the market, enabling you to capture twice the data in a single shot. Increase your imaging throughput and gain better statistics with A1R HD25. Learn more TABLE OF CONTENTS December 2018 Volume 20, Issue 12 Editorial News & Views Review Articles Letters Articles Amendments & Corrections Advertisement Asia Pacific Vascular Biology Organization Conference, May 9-12, 2019, Guangzhou, China. Register Now More than thirty-four international renowned top speakers. Zhongshan Ophthalmic Center (ZOC), the largest eye hospital in China; the State Key Laboratory of Ophthalmology (SKLO), the only one of its kind in China; and the Asia Pacific Vascular Biology Organization (APVBO). Advertisement =================================== Register for the latest nature.com webcast Bioengineering Custom Cell Microenvironments with Versatile Maskless Photopatterning Register for FREE today Sponsored by: Alvéole ==================================   Editorial Social media for scientists    p1329 doi:10.1038/s41556-018-0253-6 News & Views TBK1 and IKKε restrain cell death    pp1330 - 1331 Klaus Heger & Vishva M. Dixit doi:10.1038/s41556-018-0239-4 Targeting BAF-perturbed cancers    pp1332 - 1333 Divya Reddy & Jerry L. Workman doi:10.1038/s41556-018-0246-5 CLN8 safeguards lysosome biogenesis    pp1333 - 1335 J. Paul Luzio doi:10.1038/s41556-018-0240-y CENP-T bears the load in mitosis    pp1335 - 1337 Yang Yang & Hongtao Yu doi:10.1038/s41556-018-0241-x Nature Cell Biology EVENT The 3rd International Conference on "Plant Cells & Tissues In Vitro" 15.02.19 Vienna, Austria More science events from Advertisement Cellular Metabolism This conference will discuss fundamental questions such as how cells sense their metabolic status, how cells regulate their metabolism and how cellular metabolism, in turn, controls signaling and cellular function in different physiological contexts. April 8-11, 2019 | Xiamen, China REGISTER NOW >>   Review Articles Autophagy and the cell biology of age-related disease    pp1338 - 1348 Andrew M. Leidal, Beth Levine & Jayanta Debnath doi:10.1038/s41556-018-0235-8 In this Review, Leidal et al. discuss the role and regulation of autophagy in aging. They cover how autophagy promotes longevity and restricts cellular damage, and discuss autophagy modulators for the potential treatment of age-related diseases. Tumour heterogeneity and metastasis at single-cell resolution    pp1349 - 1360 Devon A. Lawson, Kai Kessenbrock, Ryan T. Davis, Nicholas Pervolarakis & Zena Werb doi:10.1038/s41556-018-0236-7 Lawson et al. review recent advances in single-cell technologies and discuss in detail how they can be leveraged to understand tumour heterogeneity and metastasis. Letters Flexible fate determination ensures robust differentiation in the hair follicle    pp1361 - 1369 Tianchi Xin, David Gonzalez, Panteleimon Rompolas & Valentina Greco doi:10.1038/s41556-018-0232-y Xin et al. track stem cells in live mice to show that fate determination is a flexible process during homeostatic hair follicle growth, and progenitor cells can change differentiation outcomes as a consequence of dynamic relocation. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis    pp1370 - 1377 Alberto di Ronza, Lakshya Bajaj, Jaiprakash Sharma, Deepthi Sanagasetti, Parisa Lotfi et al. doi:10.1038/s41556-018-0228-7 di Ronza et al. identify CLN8 as a cargo receptor for lysosomal enzymes required for their endoplasmic-reticulum-to-Golgi transport, linking Batten disease caused by CLN8 mutations to defects in organelle biogenesis. Articles Multiple phosphorylations control recruitment of the KMN network onto kinetochores    pp1378 - 1388 Masatoshi Hara, Mariko Ariyoshi, Ei-ichi Okumura, Tetsuya Hori & Tatsuo Fukagawa doi:10.1038/s41556-018-0230-0 Hara et al. find that the recruitment of the KMN kinetochore protein network is mainly dependent on the CENP-T pathway and promoted by Cdk1-mediated phosphorylation of CENP-T in chicken DT40 cells. TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation    pp1389 - 1399 Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka et al. doi:10.1038/s41556-018-0229-6 Lafont et al. uncover a checkpoint mediated by TBK1 and IKKε, which phosphorylate RIPK1 in the TNFR1-SC. TBK1 and IKKε recruitment depends on M1 ubiquitylation and NEMO to restrict TNF-induced cell death. Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours    pp1400 - 1409 Alexandra Avgustinova, Aikaterini Symeonidi, Andrés Castellanos, Uxue Urdiroz-Urricelqui, Llorenç Solé-Boldo et al. doi:10.1038/s41556-018-0233-x Avgustinova et al. report that targeting the H3K9 methyltransferase G9a in skin cancer does not affect single nucleotide variant profiles, but leads to increased tumour aggressiveness after a prolonged latency. A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation    pp1410 - 1420 Brittany C. Michel, Andrew R. D'Avino, Seth H. Cassel, Nazar Mashtalir, Zachary M. McKenzie et al. doi:10.1038/s41556-018-0221-1 Michel et al. report unique localization of non-canonical BAF to CTCF sites and promoters, which confers synthetic lethality in canonical BAF-perturbed synovial sarcoma and malignant rhabdoid tumour cells. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling    pp1421 - 1433 Youn-Sang Jung, Sohee Jun, Moon Jong Kim, Sung Ho Lee, Han Na Suh et al. doi:10.1038/s41556-018-0219-8 Jung et al demonstrate that TMEM9 facilitates vacuolar-ATPase assembly to enhance vesicular acidification, thereby promoting activation of Wnt signalling and development of colorectal cancer. Amendments & Corrections Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation    p1434 Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling, Ran Wang, Guizhong Cui et al. doi:10.1038/s41556-018-0245-6 Publisher Correction: Multiple phosphorylations control recruitment of the KMN network onto kinetochores    p1434 Masatoshi Hara, Mariko Ariyoshi, Ei-ichi Okumura, Tetsuya Hori & Tatsuo Fukagawa doi:10.1038/s41556-018-0252-7 Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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