Nature Biotechnology Contents: November 2018, Volume 36 No 11 pp1023-1120

TABLE OF CONTENTS November 2018 Volume 36, Issue 11 Editorial News Opinion and Comment Feature News and Views Research Careers and Recruitment Advertisement   Nature Index 2018 Rising Stars Creative minds drive the scientific enterprise. This supplement profiles up-and-coming researchers in the natural sciences who have achieved excellence in the Nature Index, and have demonstrated the passion, ambition and resilience to rise even higher in the competitive world of academia. Read the full supplement Advertisement =================================== Register for the latest nature.com webcast Quantitative approaches in discovery proteomics: How do they measure up? - Thursday, November 7, 2018 Register for FREE today Sponsored by: Thermo Fisher Scientific  ==================================   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Editorial Nobel work that galvanized an industry    p1023 doi:10.1038/nbt.4301 News No added sugar: antibody makers find an upside to 'no fucose'    pp1025 - 1027 Ken Garber doi:10.1038/nbt1118-1025 Another CRISPR win for Zhang and Broad    p1026 Michael Francisco doi:10.1038/nbt1118-1026 First preventive mAb for hereditary angioedema    p1027 Joana Osorio doi:10.1038/nbt1118-1027 Wnt is back in drugmakers' sights, but is it druggable?    pp1028 - 1029 Cormac Sheridan doi:10.1038/nbt1118-1028 Gilead injects own generics into shrinking HCV drug market    p1030 Christopher Morrison doi:10.1038/nbt1118-1030a Podcast PODCAST: First rounders: Christoph Lengauer    p1030 doi:10.1038/nbt1118-1030b FDA calls for subscription model to pay for anti-infectives    p1031 Melanie Senior doi:10.1038/nbt1118-1031 Bandit tusks    p1032 doi:10.1038/nbt1118-1032a Around the world in a month    p1032 doi:10.1038/nbt1118-1032b Data Page Q3 2018—The beat goes on    p1033 Laura DeFrancesco doi:10.1038/nbt.4295 Advertisement KACST Impact KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries. Learn more>>   Opinion and Comment Correspondence Evaluation of immune repertoire inference methods from RNA-seq data    p1034 Xihao Hu, Jian Zhang, Jun S Liu, Bo Li & Xiaole Shirley Liu doi:10.1038/nbt.4294 Reply to "Evaluation of immune repertoire inference methods from RNA-seq data"    pp1035 - 1036 Dmitriy A Bolotin, Stanislav Poslavsky, Alexey N Davydov & Dmitriy M Chudakov doi:10.1038/nbt.4296 Feature Translating microbiome futures    pp1037 - 1042 Gaspar Taroncher-Oldenburg, Susan Jones, Martin Blaser, Richard Bonneau, Peter Christey et al. doi:10.1038/nbt.4287 Patents The Reporting Items for Patent Landscapes statement    pp1043 - 1047 James A Smith, Zeeshaan Arshad, Anthony Trippe, Gary S Collins, David A Brindley et al. doi:10.1038/nbt.4291 Recent patents in endonucleases and genome editing    p1048 doi:10.1038/nbt.4300 News and Views Metagenomics meets read clouds    pp1049 - 1051 Jacqueline Goordial & Jennifer Ronholm doi:10.1038/nbt.4284 Proteomics goes parallel    pp1051 - 1053 Ben C Collins & Ruedi Aebersold doi:10.1038/nbt.4288 An avatar for precision cancer therapy    pp1053 - 1055 Shumei Kato & Razelle Kurzrock doi:10.1038/nbt.4293 Research Highlights    p1055 doi:10.1038/nbt.4290 Biotechnology JOBS of the week Biotechnology EVENT Global Biotechnology Summit (Bio-18) 02.12.18 Washington, USA More science events from Research Brief Communications Intron retention is a source of neoepitopes in cancer    pp1056 - 1058 Alicia C Smart, Claire A Margolis, Harold Pimentel, Meng Xiao He, Diana Miao et al. doi:10.1038/nbt.4239 Neoepitopes derived from intron retention events are processed and presented on MHC I in cancer cell lines. Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine    pp1059 - 1061 Hao Chi, Chao Liu, Hao Yang, Wen-Feng Zeng, Long Wu et al. doi:10.1038/nbt.4236 Peptide identification in proteomics data is improved using an efficient open search engine. Articles A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes    pp1062 - 1066 Kyros Kyrou, Andrew M Hammond, Roberto Galizi, Nace Kranjc, Austin Burt et al. doi:10.1038/nbt.4245 Complete population collapse of malaria vector Anopheles gambiae in cages is achieved using a gene drive that targets doublesex. High-quality genome sequences of uncultured microbes by assembly of read clouds    pp1067 - 1075 Alex Bishara, Eli L Moss, Mikhail Kolmogorov, Alma E Parada, Ziming Weng et al. doi:10.1038/nbt.4266 Individual microbes in metagenomic samples are sequenced by assembly of barcoded short reads Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures    pp1076 - 1082 Jagannath Swaminathan, Alexander A Boulgakov, Erik T Hernandez, Angela M Bardo, James L Bachman et al. doi:10.1038/nbt.4278 Single-protein molecules are identified in parallel through fluorescence monitoring of Edman degradation. Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase    pp1083 - 1090 Emily K Schutsky, Jamie E DeNizio, Peng Hu, Monica Yun Liu, Christopher S Nabel et al. doi:10.1038/nbt.4204 A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples. An integrative tissue-network approach to identify and test human disease genes    pp1091 - 1099 Victoria Yao, Rachel Kaletsky, William Keyes, Danielle E Mor, Aaron K Wong et al. doi:10.1038/nbt.4246 An integrative computational approach leverages data from model systems and human genome-wide studies to predict genes that have a functional role in disease. Rhizosphere microbiome structure alters to enable wilt resistance in tomato    pp1100 - 1109 Min-Jung Kwak, Hyun Gi Kong, Kihyuck Choi, Soon-Kyeong Kwon, Ju Yeon Song et al. doi:10.1038/nbt.4232 Tomato rhizosphere microbiome alterations that contribute to bacterial wilt resistance are detected using metagenomics. Letter Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides    pp1110 - 1116 Hila Wolf-Levy, Aaron Javitt, Avital Eisenberg-Lerner, Assaf Kacen, Adi Ulman et al. doi:10.1038/nbt.4279 Cleavage products of the proteasome are profiled by mass spectrometry. Author Correction: Rhizosphere microbiome structure alters to enable wilt resistance in tomato    p1117 Min-Jung Kwak, Hyun Gi Kong, Kihyuck Choi, Soon-Kyeong Kwon, Ju Yeon Song et al. doi:10.1038/nbt1118-1117 Careers and Recruitment Third-quarter biotech job picture    p1119 Michael Francisco doi:10.1038/nbt.4292 People People    p1120 doi:10.1038/nbt.4299 Advertisement =================================== Register for the latest nature.com webcast Begin with the End in Mind: Selection of an Antibody Discovery Platform - Thursday, November 8, 2018  Register for FREE today  Sponsored by: Ablexis    ==================================   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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